GB1496319A - Cholesta-5,7-diene-1alpha,3beta,25-triol - Google Patents

Cholesta-5,7-diene-1alpha,3beta,25-triol

Info

Publication number
GB1496319A
GB1496319A GB6294/77A GB629477A GB1496319A GB 1496319 A GB1496319 A GB 1496319A GB 6294/77 A GB6294/77 A GB 6294/77A GB 629477 A GB629477 A GB 629477A GB 1496319 A GB1496319 A GB 1496319A
Authority
GB
United Kingdom
Prior art keywords
cholesta
diene
triol
infra
feb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6294/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of GB1496319A publication Critical patent/GB1496319A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1496319 Cholesta-5,7-diene derivative WISCONSIN ALUMNI RESEARCH FOUNDATION 27 Feb 1976 [28 Feb 1975] 06294/77 Divided out of 1496317 Heading C2U The invention comprises cholesta-5,7-diene- 1α,3#,25 - triol (I) and its preparation from cholesta - 1,5,7 - triene - 3#,25 - diol (VII) by reaction with a 4-substituted-1,2,4-triazoline- 3,5-dione to give V infra, epoxidation of which gives IV infra, reduction of which with a metal hydride (e.g. LiAlH 4 or LiBH 4 ) yields I (R is alkyl, aryl or monosubstituted aryl). IV may be accompanied by 1#,2#-epoxy epimer which is separated chromatographically. Conversion of I to 1α,25-dihydroxycholecalciferol is as described in parent Specification. Compound VII and precursors thereof are the subject of Specification 1,496,318.
GB6294/77A 1975-02-28 1976-02-27 Cholesta-5,7-diene-1alpha,3beta,25-triol Expired GB1496319A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50023827A JPS51100056A (en) 1975-02-28 1975-02-28 1 arufua 255 jihidorokishikorekarushifuerooruno seiho

Publications (1)

Publication Number Publication Date
GB1496319A true GB1496319A (en) 1977-12-30

Family

ID=12121191

Family Applications (3)

Application Number Title Priority Date Filing Date
GB6294/77A Expired GB1496319A (en) 1975-02-28 1976-02-27 Cholesta-5,7-diene-1alpha,3beta,25-triol
GB7890/76A Expired GB1496317A (en) 1975-02-28 1976-02-27 Previtamin derivative and process for preparing 1alpha,25-dihydroxycholecalciferol therefrom
GB6293/77A Expired GB1496318A (en) 1975-02-28 1976-02-27 Cholesta-1,5,7-triene-3beta,25-diol and 25-hydroxy-cholesta-1,5,7-trien-3-one

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB7890/76A Expired GB1496317A (en) 1975-02-28 1976-02-27 Previtamin derivative and process for preparing 1alpha,25-dihydroxycholecalciferol therefrom
GB6293/77A Expired GB1496318A (en) 1975-02-28 1976-02-27 Cholesta-1,5,7-triene-3beta,25-diol and 25-hydroxy-cholesta-1,5,7-trien-3-one

Country Status (6)

Country Link
JP (1) JPS51100056A (en)
CA (1) CA1069939A (en)
DK (1) DK85876A (en)
GB (3) GB1496319A (en)
NL (1) NL7602047A (en)
SE (3) SE409717B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014746A1 (en) * 1991-02-19 1992-09-03 Jenapharm Gmbh Starting compounds for preparing calcitriol and its derivatives, method for preparing these starting compounds and intermediate products for this method

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54103855A (en) * 1978-01-27 1979-08-15 Chugai Pharmaceut Co Ltd 1beta, 25-dihydroxyvitamin
FR2457282A1 (en) * 1979-05-23 1980-12-19 Roussel Uclaf NEW DERIVATIVE OF 1A, 25 DIHYDROXY CHOLECALCIFEROL, ITS PREPARATION METHOD AND ITS APPLICATION AS A MEDICAMENT
JPS5626820A (en) * 1979-08-10 1981-03-16 Chugai Pharmaceut Co Ltd Immunosuppressing agent
CA1189537A (en) * 1981-08-28 1985-06-25 John J. Partridge Cholecalciferol derivatives
JPS60163859A (en) * 1984-02-06 1985-08-26 Teijin Ltd 1-position labeled bitamin d3 derivative and its preparation
JPS61194065A (en) * 1985-02-21 1986-08-28 Taisho Pharmaceut Co Ltd Vitamin d3 derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014746A1 (en) * 1991-02-19 1992-09-03 Jenapharm Gmbh Starting compounds for preparing calcitriol and its derivatives, method for preparing these starting compounds and intermediate products for this method

Also Published As

Publication number Publication date
JPS51100056A (en) 1976-09-03
SE7601605L (en) 1976-08-30
GB1496317A (en) 1977-12-30
SE7811147L (en) 1978-10-26
CA1069939A (en) 1980-01-15
GB1496318A (en) 1977-12-30
JPS5732055B2 (en) 1982-07-08
SE409717B (en) 1979-09-03
SE7811146L (en) 1978-10-26
NL7602047A (en) 1976-08-31
DK85876A (en) 1976-08-29

Similar Documents

Publication Publication Date Title
Meyer 19-Hydroxylation of δ 4-androstene-3, 17-dione and dehydroepiandrosterone by bovine adrenals
GB1443680A (en) Manufacture of hydroxylated chloesterol derivatives
GB1475795A (en) Steroid 21-thioesters
GB1496319A (en) Cholesta-5,7-diene-1alpha,3beta,25-triol
EP0050325A3 (en) Process for the preparation of intermediates in the synthesis of vitamin-d3 metabolites, and intermediates
Agata et al. Oxidative rearrangements of pentacyclic triterpenes. A method for the synthesis of certain naturally occurring triterpenes from α-and β-amyrin1
GB1242194A (en) A new oestratriol and a process for its manufacture
DE59207057D1 (en) INITIAL CONNECTIONS FOR THE PRODUCTION OF CALCITRIOL AND ITS COLLECTORS, METHOD FOR THE PRODUCTION OF THESE OUTPUT CONNECTIONS AND INTERMEDIATE PRODUCTS FOR THIS PROCESS
Eriksson et al. Studies on the structure, biosynthesis and bacterial metabolism of 15‐hydroxylated steroids in the female rat
BHAVNANI et al. Formation of Steroids by the Pregnant Mare. III. Metabolism of 14C-Squalene and 3H-Dehydroisoandrosterone Injected into the Fetal Circulation1
Yamada et al. Synthesis of 6, 19-epidioxy-9, 10-secoergosta-5 (10), 7, 22-trien-3β-ols from vitamin D derivatives by oxidation with singlet oxygen
Tomita et al. Biosynthesis of sapogenins in tissue cultures of Dioscorea tokoro makino
Kondo et al. Microbiological Synthesis of 16-Keto Steroids from Steroidal Sapogenins
Akhtar et al. Studies on the biosynthesis of the ergosterol side chain
GB2080811A (en) Cyclovitamin d compounds and vitamin d compounds isotopically substituted at carbon 6
GB1514111A (en) 3alpha,5alpha-cyclo-6beta-alkoxy-25-hydroxy-steroid derivatives and their preparation
GB1530837A (en) 3beta-(1-alkoxyethoxy)-steroids and their use in the production of steroids from sarsaponin
Baldwin et al. Site-specific dehydrogenation of ring D in steroids
IE32868B1 (en) Halogenated steroids and process for the manufacture thereof
DE2531145C2 (en) Process for the preparation of 11beta-hydroxy-18-alkyl-steroids of the estran series
Yang et al. Synthesis of 25-fluorovitamin D3
US3033859A (en) Process for the manufacture of oxido-steroids
Kelly et al. Synthetic steroids. Part II. The deconjugation of Δ 4-3-oxo-steroids. An improved method for the preparation of 3β-hydroxyandrost-5-ene-11, 17-dione
Jones et al. A new approach to the introduction of corticoid-like C-17 functions via 2-lithio-1, 3-dithian–epoxide reactions
GB841003A (en) Improvements in or relating to 6-methyl steroid compounds

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee