DK144068C - Analogifremgangsmaade til fremstilling af 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroxypregna-1,4-dien-3,20-dion-21-monoestere eller -17alfa,21-diestere - Google Patents

Analogifremgangsmaade til fremstilling af 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroxypregna-1,4-dien-3,20-dion-21-monoestere eller -17alfa,21-diestere

Info

Publication number
DK144068C
DK144068C DK61575A DK61575A DK144068C DK 144068 C DK144068 C DK 144068C DK 61575 A DK61575 A DK 61575A DK 61575 A DK61575 A DK 61575A DK 144068 C DK144068 C DK 144068C
Authority
DK
Denmark
Prior art keywords
17alfa
9alfa
trihydroxypregna
6beta
11beta
Prior art date
Application number
DK61575A
Other languages
English (en)
Other versions
DK144068B (da
DK61575A (da
Inventor
M Riva
L Toscano
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of DK61575A publication Critical patent/DK61575A/da
Priority to DK280280A priority Critical patent/DK280280A/da
Publication of DK144068B publication Critical patent/DK144068B/da
Application granted granted Critical
Publication of DK144068C publication Critical patent/DK144068C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/0026Oxygen-containing hetero ring cyclic ketals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/0026Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK61575A 1974-02-27 1975-02-19 Analogifremgangsmaade til fremstilling af 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroxypregna-1,4-dien-3,20-dion-21-monoestere eller -17alfa,21-diestere DK144068C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK280280A DK280280A (da) 1974-02-27 1980-06-27 Analogifremgangsmaade til fremstilling af 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroxypregna-1,4-dien-3,20-dion-17-monoestere

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB892874 1974-02-27
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
GB2998474 1974-07-05
GB2998474 1974-07-05
GB3294574 1974-07-25
GB3294574 1974-07-25
GB4998274 1974-11-19
GB4998274 1974-11-19

Publications (3)

Publication Number Publication Date
DK61575A DK61575A (da) 1975-10-27
DK144068B DK144068B (da) 1981-11-30
DK144068C true DK144068C (da) 1982-05-03

Family

ID=27447687

Family Applications (1)

Application Number Title Priority Date Filing Date
DK61575A DK144068C (da) 1974-02-27 1975-02-19 Analogifremgangsmaade til fremstilling af 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroxypregna-1,4-dien-3,20-dion-21-monoestere eller -17alfa,21-diestere

Country Status (18)

Country Link
JP (1) JPS5614677B2 (da)
AR (1) AR218601A1 (da)
BE (1) BE826030A (da)
CA (1) CA1064476A (da)
CH (1) CH608243A5 (da)
DE (3) DE2508136C3 (da)
DK (1) DK144068C (da)
ES (3) ES435067A1 (da)
FI (1) FI56188C (da)
FR (1) FR2261776B1 (da)
GB (1) GB1499822A (da)
IE (1) IE42112B1 (da)
LU (1) LU71908A1 (da)
NO (1) NO144527C (da)
NZ (1) NZ176716A (da)
RO (1) RO78881A (da)
SE (1) SE410736B (da)
YU (3) YU108381A (da)

Also Published As

Publication number Publication date
NZ176716A (en) 1978-07-10
DE2533377C3 (de) 1979-08-02
RO78881A (ro) 1982-07-06
CA1064476A (en) 1979-10-16
DE2508136A1 (de) 1975-10-30
FR2261776A1 (da) 1975-09-19
IE42112L (en) 1975-08-27
DK144068B (da) 1981-11-30
DE2508136B2 (de) 1978-11-02
IE42112B1 (en) 1980-06-04
DE2533323A1 (de) 1976-02-12
BE826030A (fr) 1975-06-16
FR2261776B1 (da) 1978-07-21
NO750633L (da) 1975-08-28
SE410736B (sv) 1979-10-29
DK61575A (da) 1975-10-27
NO144527B (no) 1981-06-09
DE2533377A1 (de) 1976-02-05
DE2508136C3 (de) 1979-06-21
SE7502146L (da) 1975-08-28
FI750537A (da) 1975-08-28
NO144527C (no) 1981-09-23
CH608243A5 (en) 1978-12-29
FI56188B (fi) 1979-08-31
GB1499822A (en) 1978-02-01
DE2533377B2 (de) 1978-11-16
ES435067A1 (es) 1977-07-01
ES455933A1 (es) 1978-05-01
YU108381A (en) 1982-02-28
YU108481A (en) 1982-02-28
FI56188C (fi) 1979-12-10
ES455934A1 (es) 1978-05-01
LU71908A1 (da) 1975-06-24
JPS50126652A (da) 1975-10-04
JPS5614677B2 (da) 1981-04-06
AR218601A1 (es) 1980-06-30
YU108281A (en) 1982-02-28
DE2533323C3 (de) 1979-07-12
DE2533323B2 (de) 1978-11-16

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