CA1064476A - Steroids and process for preparing the same - Google Patents

Steroids and process for preparing the same

Info

Publication number
CA1064476A
CA1064476A CA219,681A CA219681A CA1064476A CA 1064476 A CA1064476 A CA 1064476A CA 219681 A CA219681 A CA 219681A CA 1064476 A CA1064476 A CA 1064476A
Authority
CA
Canada
Prior art keywords
alpha
beta
bromo
pregna
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA219,681A
Other languages
English (en)
French (fr)
Other versions
CA219681S (en
Inventor
Luciano Toscano
Mario Riva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Application granted granted Critical
Publication of CA1064476A publication Critical patent/CA1064476A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA219,681A 1974-02-27 1975-02-10 Steroids and process for preparing the same Expired CA1064476A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
GB2998474 1974-07-05
GB3294574 1974-07-25
GB4998274 1974-11-19

Publications (1)

Publication Number Publication Date
CA1064476A true CA1064476A (en) 1979-10-16

Family

ID=27447687

Family Applications (1)

Application Number Title Priority Date Filing Date
CA219,681A Expired CA1064476A (en) 1974-02-27 1975-02-10 Steroids and process for preparing the same

Country Status (18)

Country Link
JP (1) JPS5614677B2 (da)
AR (1) AR218601A1 (da)
BE (1) BE826030A (da)
CA (1) CA1064476A (da)
CH (1) CH608243A5 (da)
DE (3) DE2508136C3 (da)
DK (1) DK144068C (da)
ES (3) ES435067A1 (da)
FI (1) FI56188C (da)
FR (1) FR2261776B1 (da)
GB (1) GB1499822A (da)
IE (1) IE42112B1 (da)
LU (1) LU71908A1 (da)
NO (1) NO144527C (da)
NZ (1) NZ176716A (da)
RO (1) RO78881A (da)
SE (1) SE410736B (da)
YU (3) YU108381A (da)

Also Published As

Publication number Publication date
NZ176716A (en) 1978-07-10
DE2533377C3 (de) 1979-08-02
RO78881A (ro) 1982-07-06
DE2508136A1 (de) 1975-10-30
FR2261776A1 (da) 1975-09-19
IE42112L (en) 1975-08-27
DK144068B (da) 1981-11-30
DE2508136B2 (de) 1978-11-02
IE42112B1 (en) 1980-06-04
DE2533323A1 (de) 1976-02-12
BE826030A (fr) 1975-06-16
FR2261776B1 (da) 1978-07-21
NO750633L (da) 1975-08-28
SE410736B (sv) 1979-10-29
DK61575A (da) 1975-10-27
NO144527B (no) 1981-06-09
DE2533377A1 (de) 1976-02-05
DE2508136C3 (de) 1979-06-21
SE7502146L (da) 1975-08-28
FI750537A (da) 1975-08-28
NO144527C (no) 1981-09-23
CH608243A5 (en) 1978-12-29
FI56188B (fi) 1979-08-31
GB1499822A (en) 1978-02-01
DK144068C (da) 1982-05-03
DE2533377B2 (de) 1978-11-16
ES435067A1 (es) 1977-07-01
ES455933A1 (es) 1978-05-01
YU108381A (en) 1982-02-28
YU108481A (en) 1982-02-28
FI56188C (fi) 1979-12-10
ES455934A1 (es) 1978-05-01
LU71908A1 (da) 1975-06-24
JPS50126652A (da) 1975-10-04
JPS5614677B2 (da) 1981-04-06
AR218601A1 (es) 1980-06-30
YU108281A (en) 1982-02-28
DE2533323C3 (de) 1979-07-12
DE2533323B2 (de) 1978-11-16

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