FI56188C - Foerfarande foer framstaellning av 2-brom-6beta 9alfa-difluor-11beta-hydroxipregna-1,4-dien-3,20-dionderivat med antiinflammatorisk verkan - Google Patents

Foerfarande foer framstaellning av 2-brom-6beta 9alfa-difluor-11beta-hydroxipregna-1,4-dien-3,20-dionderivat med antiinflammatorisk verkan

Info

Publication number
FI56188C
FI56188C FI750537A FI750537A FI56188C FI 56188 C FI56188 C FI 56188C FI 750537 A FI750537 A FI 750537A FI 750537 A FI750537 A FI 750537A FI 56188 C FI56188 C FI 56188C
Authority
FI
Finland
Prior art keywords
hydroxipregna
dionderivat
9alfa
flamming
6beta
Prior art date
Application number
FI750537A
Other languages
English (en)
Finnish (fi)
Other versions
FI56188B (fi
FI750537A (da
Inventor
Mario Riva
Luciano Toscano
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of FI750537A publication Critical patent/FI750537A/fi
Publication of FI56188B publication Critical patent/FI56188B/fi
Application granted granted Critical
Publication of FI56188C publication Critical patent/FI56188C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI750537A 1974-02-27 1975-02-25 Foerfarande foer framstaellning av 2-brom-6beta 9alfa-difluor-11beta-hydroxipregna-1,4-dien-3,20-dionderivat med antiinflammatorisk verkan FI56188C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
GB2998474 1974-07-05
GB3294574 1974-07-25
GB4998274 1974-11-19

Publications (3)

Publication Number Publication Date
FI750537A FI750537A (da) 1975-08-28
FI56188B FI56188B (fi) 1979-08-31
FI56188C true FI56188C (fi) 1979-12-10

Family

ID=27447687

Family Applications (1)

Application Number Title Priority Date Filing Date
FI750537A FI56188C (fi) 1974-02-27 1975-02-25 Foerfarande foer framstaellning av 2-brom-6beta 9alfa-difluor-11beta-hydroxipregna-1,4-dien-3,20-dionderivat med antiinflammatorisk verkan

Country Status (18)

Country Link
JP (1) JPS5614677B2 (da)
AR (1) AR218601A1 (da)
BE (1) BE826030A (da)
CA (1) CA1064476A (da)
CH (1) CH608243A5 (da)
DE (3) DE2508136C3 (da)
DK (1) DK144068C (da)
ES (3) ES435067A1 (da)
FI (1) FI56188C (da)
FR (1) FR2261776B1 (da)
GB (1) GB1499822A (da)
IE (1) IE42112B1 (da)
LU (1) LU71908A1 (da)
NO (1) NO144527C (da)
NZ (1) NZ176716A (da)
RO (1) RO78881A (da)
SE (1) SE410736B (da)
YU (3) YU108381A (da)

Also Published As

Publication number Publication date
IE42112L (en) 1975-08-27
DE2508136B2 (de) 1978-11-02
NO144527C (no) 1981-09-23
NZ176716A (en) 1978-07-10
SE7502146L (da) 1975-08-28
DE2533377B2 (de) 1978-11-16
CA1064476A (en) 1979-10-16
NO750633L (da) 1975-08-28
JPS50126652A (da) 1975-10-04
FR2261776B1 (da) 1978-07-21
DE2533323B2 (de) 1978-11-16
ES455934A1 (es) 1978-05-01
ES435067A1 (es) 1977-07-01
AR218601A1 (es) 1980-06-30
RO78881A (ro) 1982-07-06
FI56188B (fi) 1979-08-31
FR2261776A1 (da) 1975-09-19
DE2508136C3 (de) 1979-06-21
DK61575A (da) 1975-10-27
CH608243A5 (en) 1978-12-29
DK144068B (da) 1981-11-30
YU108281A (en) 1982-02-28
DE2508136A1 (de) 1975-10-30
SE410736B (sv) 1979-10-29
GB1499822A (en) 1978-02-01
DK144068C (da) 1982-05-03
DE2533323C3 (de) 1979-07-12
LU71908A1 (da) 1975-06-24
FI750537A (da) 1975-08-28
YU108381A (en) 1982-02-28
JPS5614677B2 (da) 1981-04-06
DE2533323A1 (de) 1976-02-12
DE2533377C3 (de) 1979-08-02
ES455933A1 (es) 1978-05-01
BE826030A (fr) 1975-06-16
NO144527B (no) 1981-06-09
IE42112B1 (en) 1980-06-04
YU108481A (en) 1982-02-28
DE2533377A1 (de) 1976-02-05

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: PIERREL S.P.A.