GB1335261A - Isoquinoline derivatives - Google Patents

Isoquinoline derivatives

Info

Publication number
GB1335261A
GB1335261A GB45471A GB45471A GB1335261A GB 1335261 A GB1335261 A GB 1335261A GB 45471 A GB45471 A GB 45471A GB 45471 A GB45471 A GB 45471A GB 1335261 A GB1335261 A GB 1335261A
Authority
GB
United Kingdom
Prior art keywords
compound
formula
alkoxy
alkyl
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45471A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1335261A publication Critical patent/GB1335261A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GB45471A 1970-01-06 1971-01-05 Isoquinoline derivatives Expired GB1335261A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH10370A CH527194A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten

Publications (1)

Publication Number Publication Date
GB1335261A true GB1335261A (en) 1973-10-24

Family

ID=4179328

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45471A Expired GB1335261A (en) 1970-01-06 1971-01-05 Isoquinoline derivatives

Country Status (19)

Country Link
JP (1) JPS5515476B1 (enExample)
AT (1) AT303041B (enExample)
BE (1) BE761219A (enExample)
CA (1) CA999866A (enExample)
CH (2) CH527194A (enExample)
DE (1) DE2062001C2 (enExample)
DK (1) DK125021B (enExample)
ES (1) ES387016A1 (enExample)
FI (1) FI49503C (enExample)
FR (1) FR2081412B1 (enExample)
GB (1) GB1335261A (enExample)
IE (1) IE34859B1 (enExample)
IL (1) IL35916A (enExample)
NL (1) NL171444C (enExample)
NO (1) NO135315C (enExample)
PH (1) PH9682A (enExample)
SE (3) SE368401B (enExample)
YU (1) YU33660B (enExample)
ZA (1) ZA708590B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
WO2006138714A3 (en) * 2005-06-17 2007-03-15 Janssen Pharmaceutica Nv Naphthyridine compounds

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
ZA844402B (en) * 1983-06-23 1986-01-29 Mcneil Pharmaceutical Hexahydropyrrolo(2,1-a)isoquinoline derivatives
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
KR20080065707A (ko) * 1999-11-03 2008-07-14 에이엠알 테크놀로지, 인크. 4-페닐-치환 테트라히드로이소퀴놀린, 및 노르에피네프린과도파민과 세로토닌의 재흡수를 차단하기 위한 이의 용도
ATE387429T1 (de) * 1999-11-03 2008-03-15 Amr Technology Inc Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin
EP1113007A1 (en) 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
CN100430401C (zh) 2000-07-11 2008-11-05 Amr科技公司 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
CN101119969B (zh) 2004-07-15 2014-04-09 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
EA019115B1 (ru) 2005-07-15 2014-01-30 Олбани Молекьюлар Рисерч, Инк. Арил- и гетероарилзамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
MX2011011900A (es) 2009-05-12 2012-01-20 Squibb Bristol Myers Co Formas cristalinas de (s)-7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4 -(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y usos de las misma.
WO2010132437A1 (en) 2009-05-12 2010-11-18 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CN102595902B (zh) 2009-05-12 2015-04-29 阿尔巴尼分子研究公司 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (de) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
WO2006138714A3 (en) * 2005-06-17 2007-03-15 Janssen Pharmaceutica Nv Naphthyridine compounds
US7417054B2 (en) 2005-06-17 2008-08-26 Janssen Pharmaceutica N.V. Naphthyridine compounds

Also Published As

Publication number Publication date
IE34859L (en) 1971-07-06
IL35916A (en) 1973-11-28
DE2062001C2 (de) 1986-10-16
AT303041B (de) 1972-11-10
CH527194A (de) 1972-08-31
IE34859B1 (en) 1975-09-03
SE386672B (sv) 1976-08-16
NO135315B (enExample) 1976-12-13
NO135315C (enExample) 1977-03-23
YU1971A (en) 1977-06-30
SE399879B (sv) 1978-03-06
FI49503C (fi) 1975-07-10
BE761219A (fr) 1971-07-05
IL35916A0 (en) 1971-02-25
PH9682A (en) 1976-02-10
NL7018956A (enExample) 1971-07-08
NL171444C (nl) 1983-04-05
FR2081412B1 (enExample) 1974-04-12
ES387016A1 (es) 1976-05-01
NL171444B (nl) 1982-11-01
FI49503B (enExample) 1975-04-01
FR2081412A1 (enExample) 1971-12-03
JPS5515476B1 (enExample) 1980-04-23
SE368401B (enExample) 1974-07-01
DK125021B (da) 1972-12-18
CA999866A (en) 1976-11-16
ZA708590B (en) 1971-09-29
YU33660B (en) 1977-12-31
DE2062001A1 (de) 1971-07-15
CH538477A (de) 1973-06-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee