GB1340407A - Phenylethanolamine derivatives - Google Patents
Phenylethanolamine derivativesInfo
- Publication number
- GB1340407A GB1340407A GB2245571A GB2245571A GB1340407A GB 1340407 A GB1340407 A GB 1340407A GB 2245571 A GB2245571 A GB 2245571A GB 2245571 A GB2245571 A GB 2245571A GB 1340407 A GB1340407 A GB 1340407A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- compound
- group
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1340407 Phenylethanolamine derivatives BOEHRINGER INGELHEIM GmbH 19 April 1971 [25 Feb 1970] 22455/71 Heading C2C Compounds of the general formula (A = phenyl or substituted phenyl group, or condensed bicyclic group wherein the ring not directly bonded to the chain is carbocyclic or heterocyclic and saturated or aromatic; R 1 = H, alkyl, alkoxy; R 2 = H, Me, Et; R 3 = H, Me; R 4 = H, alkyl; R 5 = H, OH) and their salts are prepared by (a) removing the protecting group(s) in a compound of the formula (R 6,7 = H, protecting group (not both H)) or (b) reducing a compound of the formula (B = CO, CHOH), optionally followed in either case by isomer separation and/or salt formation. The preparation of starting materials for processes (a) and (b) by standard methods is described. The above compounds are of interest in the treatment of cardiac insufficiency and for stabilizing the circulation. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702008654 DE2008654A1 (en) | 1970-02-25 | 1970-02-25 | Ammoathanoldenvate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1340407A true GB1340407A (en) | 1973-12-12 |
Family
ID=5763256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2245571A Expired GB1340407A (en) | 1970-02-25 | 1971-04-19 | Phenylethanolamine derivatives |
Country Status (18)
| Country | Link |
|---|---|
| AT (3) | AT305250B (en) |
| BE (1) | BE763408A (en) |
| BG (3) | BG18856A3 (en) |
| CH (4) | CH568269A5 (en) |
| CS (3) | CS166748B2 (en) |
| DE (1) | DE2008654A1 (en) |
| ES (3) | ES388561A1 (en) |
| FR (1) | FR2081541B1 (en) |
| GB (1) | GB1340407A (en) |
| IE (1) | IE34970B1 (en) |
| IL (1) | IL36269A (en) |
| NL (1) | NL7102432A (en) |
| NO (1) | NO131983C (en) |
| PL (3) | PL82843B1 (en) |
| RO (3) | RO60182A (en) |
| SE (1) | SE377561B (en) |
| SU (2) | SU421181A3 (en) |
| ZA (1) | ZA711204B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA791403B (en) * | 1978-04-10 | 1980-05-28 | Draco Ab | Composition of matter |
| FI70205C (en) * | 1978-05-17 | 1986-09-15 | Degussa | FOERFARANDE FOER FRAMSTAELLNING AV NYA TERAPEUTISKT ANVAENDBARA L- / 3-HYDROXI-3-PHENYLPROPYL- (2) / - / 3-OXO-PROPYL / AMINER |
| US4853381A (en) * | 1984-04-17 | 1989-08-01 | Glaxo Group Limited | Ethanolamine compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE630296A (en) * | 1962-03-31 |
-
1970
- 1970-02-25 DE DE19702008654 patent/DE2008654A1/en active Pending
-
1971
- 1971-01-22 AT AT54671A patent/AT305250B/en not_active IP Right Cessation
- 1971-01-22 AT AT204672A patent/AT306707B/en not_active IP Right Cessation
- 1971-01-22 AT AT204572A patent/AT306706B/en not_active IP Right Cessation
- 1971-02-10 RO RO65888A patent/RO60182A/ro unknown
- 1971-02-10 CS CS982A patent/CS166748B2/cs unknown
- 1971-02-10 RO RO68598A patent/RO58559A/ro unknown
- 1971-02-10 CS CS3276*A patent/CS166750B2/cs unknown
- 1971-02-10 RO RO68599A patent/RO62244A/ro unknown
- 1971-02-10 CS CS3275*A patent/CS166749B2/cs unknown
- 1971-02-17 SU SU1752084A patent/SU421181A3/ru active
- 1971-02-17 SU SU1752085A patent/SU424349A3/ru active
- 1971-02-23 CH CH875475A patent/CH568269A5/xx not_active IP Right Cessation
- 1971-02-23 CH CH258671A patent/CH568268A5/xx not_active IP Right Cessation
- 1971-02-23 CH CH875575A patent/CH568270A5/xx not_active IP Right Cessation
- 1971-02-23 CH CH875675A patent/CH568271A5/xx not_active IP Right Cessation
- 1971-02-23 IL IL36269A patent/IL36269A/en unknown
- 1971-02-24 ZA ZA711204A patent/ZA711204B/en unknown
- 1971-02-24 NO NO679/71A patent/NO131983C/no unknown
- 1971-02-24 PL PL1971146464A patent/PL82843B1/pl unknown
- 1971-02-24 BE BE763408A patent/BE763408A/en unknown
- 1971-02-24 BG BG18287A patent/BG18856A3/xx unknown
- 1971-02-24 ES ES388561A patent/ES388561A1/en not_active Expired
- 1971-02-24 PL PL1971174914A patent/PL84395B1/pl unknown
- 1971-02-24 PL PL1971174913A patent/PL84268B1/pl unknown
- 1971-02-24 BG BG18286A patent/BG18855A3/xx unknown
- 1971-02-24 NL NL7102432A patent/NL7102432A/xx unknown
- 1971-02-24 BG BG16892A patent/BG19130A3/xx unknown
- 1971-02-25 IE IE239/71A patent/IE34970B1/en unknown
- 1971-02-25 SE SE7102409A patent/SE377561B/xx unknown
- 1971-02-25 FR FR7106442A patent/FR2081541B1/fr not_active Expired
- 1971-04-19 GB GB2245571A patent/GB1340407A/en not_active Expired
- 1971-10-20 ES ES396174A patent/ES396174A1/en not_active Expired
- 1971-10-20 ES ES396175A patent/ES396175A1/en not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |