GB1490558A - Phenylethylamine derivatives - Google Patents
Phenylethylamine derivativesInfo
- Publication number
- GB1490558A GB1490558A GB54157/74A GB5415774A GB1490558A GB 1490558 A GB1490558 A GB 1490558A GB 54157/74 A GB54157/74 A GB 54157/74A GB 5415774 A GB5415774 A GB 5415774A GB 1490558 A GB1490558 A GB 1490558A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- dec
- hexamethylene
- diamide
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000007925 phenylethylamine derivatives Chemical class 0.000 title 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PWZNDDIZIXKUEE-UHFFFAOYSA-N 6-oxo-6-(2,4,5-trichlorophenoxy)hexanoic acid Chemical compound OC(=O)CCCCC(=O)OC1=CC(Cl)=C(Cl)C=C1Cl PWZNDDIZIXKUEE-UHFFFAOYSA-N 0.000 abstract 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N Azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 abstract 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical class NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002959 anti-hypotensive effect Effects 0.000 abstract 1
- 229940124572 antihypotensive agent Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- FTQWRYSLUYAIRQ-UHFFFAOYSA-N n-[(octadecanoylamino)methyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCNC(=O)CCCCCCCCCCCCCCCCC FTQWRYSLUYAIRQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1490558 Phenethylamine derivatives SANDOZ Ltd 16 Dec 1974 [19 Dec 1973 23 Oct 1974 (2)] 54157/74 Heading C2C Compounds of the general formula (R 1,2 =H, C 1-5 alkyl) and their salts are prepared by (a) subjecting a corresponding bisdiether to acidolysis or hydrogenolysis or (b) reducing the corresponding bis-amide in which the (CH 2 ) 6 groups are replaced by (CH 2 ) 5 CO, optionally followed by salt formation. The preparation of starting materials for processes (a) and (b) and 2,4,5-trichlorophenyl hydrogen adipate, N 2 ,N<SP>1</SP> 2 -bis-(3,4-dimethoxyphenethyl) - N 1 ,N<SP>1</SP> 1 - hexamethylene bis - (adipic azid diamide) and hexamethylene - N,N<SP>1</SP> - 1 - bromocaproic acid diamide is described. The above compounds are antihypotensives, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1776973A CH588441A5 (en) | 1973-12-19 | 1973-12-19 | Antihypertensive hexamethylene-diamine derivs. - N,N'-bis(6-2-(3,4-dihydroxyphenyl)-ethylamino)-hexyl)-hexamethylene- ne-diamines and their acid addition salts |
| CH1417374 | 1974-10-23 | ||
| CH1417474 | 1974-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1490558A true GB1490558A (en) | 1977-11-02 |
Family
ID=27177125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB54157/74A Expired GB1490558A (en) | 1973-12-19 | 1974-12-16 | Phenylethylamine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5093930A (en) |
| AU (1) | AU7652474A (en) |
| DD (1) | DD119413A5 (en) |
| DE (1) | DE2458222A1 (en) |
| DK (1) | DK641174A (en) |
| FI (1) | FI355174A (en) |
| FR (1) | FR2255057B1 (en) |
| GB (1) | GB1490558A (en) |
| IL (1) | IL46266A0 (en) |
| NL (1) | NL7416235A (en) |
| NO (1) | NO744465L (en) |
| SE (1) | SE7415496L (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU561190B2 (en) * | 1983-01-21 | 1987-04-30 | Fisons Plc | Aromatic amines |
| CA1338764C (en) * | 1987-02-03 | 1996-12-03 | David M. Stemerick | Polyamine derivatives |
| US5753714A (en) * | 1987-02-03 | 1998-05-19 | Merrell Pharmaceuticals Inc. | Polyamine derivatives |
| JP2004292367A (en) * | 2003-03-27 | 2004-10-21 | Takuma Co Ltd | 2,4,5-trichlorophenoxyalkylcarboxylic acid and immunoassay for dioxins using the same |
-
1974
- 1974-12-09 DE DE19742458222 patent/DE2458222A1/en active Pending
- 1974-12-10 FI FI3551/74A patent/FI355174A/fi unknown
- 1974-12-10 DK DK641174A patent/DK641174A/da unknown
- 1974-12-10 SE SE7415496A patent/SE7415496L/xx not_active Application Discontinuation
- 1974-12-11 NO NO744465A patent/NO744465L/no unknown
- 1974-12-13 NL NL7416235A patent/NL7416235A/en unknown
- 1974-12-16 GB GB54157/74A patent/GB1490558A/en not_active Expired
- 1974-12-17 IL IL7446266A patent/IL46266A0/en unknown
- 1974-12-17 AU AU76524/74A patent/AU7652474A/en not_active Expired
- 1974-12-18 JP JP49144577A patent/JPS5093930A/ja active Pending
- 1974-12-18 FR FR7441715A patent/FR2255057B1/fr not_active Expired
- 1974-12-19 DD DD183218A patent/DD119413A5/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2458222A1 (en) | 1975-07-03 |
| JPS5093930A (en) | 1975-07-26 |
| AU7652474A (en) | 1976-06-17 |
| DK641174A (en) | 1975-08-25 |
| DD119413A5 (en) | 1976-04-20 |
| NL7416235A (en) | 1975-06-23 |
| IL46266A0 (en) | 1975-03-13 |
| FR2255057A1 (en) | 1975-07-18 |
| NO744465L (en) | 1975-07-14 |
| SE7415496L (en) | 1975-06-23 |
| FR2255057B1 (en) | 1978-07-21 |
| FI355174A (en) | 1975-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1220623A (en) | 0,4-dihydro-1-substituted-6,7-methylene-dioxy-4-oxo-3-quinoline carboxylic acid derivatives | |
| GB1418822A (en) | Imidazo-and pyrimido-2,1-b-quinazolin-2-ones and a process for the preparation thereof | |
| GB1262965A (en) | Butyrophenones | |
| GB1456627A (en) | Pyridobenzodiazepinones | |
| GB1363719A (en) | Diglycidyl derivatives of compounds containing two n-heterocyclic rings processes for the production of the derivatives and the use thereof | |
| GB1434147A (en) | Tripeptides | |
| GB1369999A (en) | Monomethyl-amino-triidobenzene compounds for use as x-ray shading agents | |
| GB1490558A (en) | Phenylethylamine derivatives | |
| GB1495163A (en) | Resolution of racemic pantolactone | |
| GB1462095A (en) | Substituted triazolo-1,5-benzodiazepines | |
| GB1299566A (en) | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones | |
| GB1449070A (en) | Aminotetralins and use in inducing anesthesia | |
| GB1283632A (en) | Phenylethanolamine derivatives | |
| GB1369580A (en) | Tricyclic diphenylamine derivatives | |
| GB1338459A (en) | Flavanone derivatives and process for inhibiting growth of microorganisms using such compounds | |
| GB1173562A (en) | Chloramphenicol Ester Salts, the Preparation therof and Compositions Containing them | |
| GB1480579A (en) | Substituted alkylenediamines | |
| GB1421580A (en) | Production of benzylamine derivatives | |
| GB1169990A (en) | Phenoxy Propan-2-Olamines | |
| GB1451389A (en) | Indolobenzazepines | |
| GB1446701A (en) | Vincamine 2-ketoglutarate and process for the production thereof | |
| GB1444717A (en) | Bicycloalkyl derivatives | |
| GB1282822A (en) | Butanolamine derivatives | |
| GB1300428A (en) | Optically active amines | |
| GB1475375A (en) | Diamines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |