GB1462095A - Substituted triazolo-1,5-benzodiazepines - Google Patents
Substituted triazolo-1,5-benzodiazepinesInfo
- Publication number
- GB1462095A GB1462095A GB1633474A GB1633474A GB1462095A GB 1462095 A GB1462095 A GB 1462095A GB 1633474 A GB1633474 A GB 1633474A GB 1633474 A GB1633474 A GB 1633474A GB 1462095 A GB1462095 A GB 1462095A
- Authority
- GB
- United Kingdom
- Prior art keywords
- april
- benzodiazepines
- substituted
- optionally
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1462095 Triazolobenzodiazepines BOEHRINGER INGELHEIM GmbH 11 April 1974 [13 April 1973] 16334/74 Heading C2C Compounds of the general formula (R 1 = H, C 1-4 alkyl, C 1-2 hydroxyalkyl, C 2-3 alkenyl, C 3-6 cycloalkyl, Ph, piperidyl; R 2 =Ph optionally o-substituted by F, Cl. Br, CF 3 or NO 2 , or α-Py; R 3 =H, F, Cl, Br, CF 3 , NO 2 , Me, OMe, CN, OH) and their acid addition salts are prepared by reacting a compound of the formula (X = removable atom or group) with optionally followed by salt formation. The reaction proceeds via the intermediate 2- acylhydrazino derivative. The above compounds are anticonvulsants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2318673A DE2318673A1 (en) | 1973-04-13 | 1973-04-13 | NEW SUBSTITUTED TRIAZOLO-1,5BENZODIAZEPINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1462095A true GB1462095A (en) | 1977-01-19 |
Family
ID=5877963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1633474A Expired GB1462095A (en) | 1973-04-13 | 1974-04-11 | Substituted triazolo-1,5-benzodiazepines |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5753797B2 (en) |
| AT (1) | AT336025B (en) |
| BE (1) | BE813677A (en) |
| CH (1) | CH591486A5 (en) |
| DE (1) | DE2318673A1 (en) |
| DK (1) | DK136821C (en) |
| ES (1) | ES425216A1 (en) |
| FI (1) | FI56837C (en) |
| FR (1) | FR2225164B1 (en) |
| GB (1) | GB1462095A (en) |
| NL (1) | NL7404884A (en) |
| NO (1) | NO140860C (en) |
| SE (1) | SE419989B (en) |
| SU (1) | SU730307A3 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2809591A1 (en) * | 1977-03-07 | 1978-09-14 | Hoffmann La Roche | BENZODIAZEPINE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES |
| US8063040B2 (en) | 2006-11-03 | 2011-11-22 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Triazabenzo[E]azulene derivatives for the treatment of tumors |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| DE3435972A1 (en) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | PHARMACEUTICAL COMPOSITIONS CONTAINING DIAZEPINE WITH PAF-ANTAGONISTIC EFFECT |
| JP4069159B2 (en) * | 2004-05-25 | 2008-04-02 | ファイザー・プロダクツ・インク | Tetraazabenzo [e] azulene derivatives and analogs thereof |
| KR100840852B1 (en) * | 2004-05-25 | 2008-06-23 | 화이자 프로덕츠 인크. | Tetraazabenzo[e]azulene derivatives and analogs thereof |
| DE102005061840A1 (en) | 2005-12-23 | 2007-06-28 | Merck Patent Gmbh | New polyaza-benzo-azulene compounds are transforming growth factor-beta receptor kinase inhibitors used for treating e.g. cancer, HIV infection and Alzheimer's disease |
-
1973
- 1973-04-13 DE DE2318673A patent/DE2318673A1/en not_active Withdrawn
-
1974
- 1974-03-26 AT AT248274A patent/AT336025B/en not_active IP Right Cessation
- 1974-04-09 CH CH493674A patent/CH591486A5/xx not_active IP Right Cessation
- 1974-04-09 FI FI1070/74A patent/FI56837C/en active
- 1974-04-10 NO NO741351A patent/NO140860C/en unknown
- 1974-04-10 NL NL7404884A patent/NL7404884A/xx not_active Application Discontinuation
- 1974-04-10 DK DK202474A patent/DK136821C/en not_active IP Right Cessation
- 1974-04-10 ES ES425216A patent/ES425216A1/en not_active Expired
- 1974-04-10 JP JP49040676A patent/JPS5753797B2/ja not_active Expired
- 1974-04-11 SU SU742015007A patent/SU730307A3/en active
- 1974-04-11 GB GB1633474A patent/GB1462095A/en not_active Expired
- 1974-04-11 SE SE7405021A patent/SE419989B/en unknown
- 1974-04-12 BE BE143167A patent/BE813677A/en not_active IP Right Cessation
- 1974-04-12 FR FR7413023A patent/FR2225164B1/fr not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2809591A1 (en) * | 1977-03-07 | 1978-09-14 | Hoffmann La Roche | BENZODIAZEPINE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES |
| US8063040B2 (en) | 2006-11-03 | 2011-11-22 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Triazabenzo[E]azulene derivatives for the treatment of tumors |
Also Published As
| Publication number | Publication date |
|---|---|
| NO140860B (en) | 1979-08-20 |
| AT336025B (en) | 1977-04-12 |
| ES425216A1 (en) | 1976-05-16 |
| DE2318673A1 (en) | 1974-11-07 |
| ATA248274A (en) | 1976-08-15 |
| NO140860C (en) | 1979-11-28 |
| SE419989B (en) | 1981-09-07 |
| JPS5052093A (en) | 1975-05-09 |
| CH591486A5 (en) | 1977-09-30 |
| NO741351L (en) | 1974-10-15 |
| FI56837C (en) | 1980-04-10 |
| BE813677A (en) | 1974-10-14 |
| DK136821B (en) | 1977-11-28 |
| DK136821C (en) | 1978-05-08 |
| FR2225164B1 (en) | 1977-05-06 |
| JPS5753797B2 (en) | 1982-11-15 |
| FI56837B (en) | 1979-12-31 |
| SU730307A3 (en) | 1980-04-25 |
| FR2225164A1 (en) | 1974-11-08 |
| NL7404884A (en) | 1974-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1409693A (en) | Triazolobenzodiazepines | |
| GB1493961A (en) | Aryloxyphenylpropylamines | |
| GB1335261A (en) | Isoquinoline derivatives | |
| GB1147379A (en) | 4-alkyl-dialkoxy-ª‡-methylphenethylamines and pharmacologically acceptable salts | |
| GB1462095A (en) | Substituted triazolo-1,5-benzodiazepines | |
| GB1456627A (en) | Pyridobenzodiazepinones | |
| ES375203A1 (en) | Benzothiazepine derivatives | |
| GB1394568A (en) | Diazepine derivatives and process for the production thereof | |
| GB1462036A (en) | Aminoindane derivatives | |
| GB1443692A (en) | 1,2-diphenylethanolamine derivatives and their salts and the preparation thereof | |
| GB1434805A (en) | 5-phenoxy-4-amino pyrimidines | |
| GB1434580A (en) | Disubstituted piperazines | |
| GB1425150A (en) | Therapeutically active phenoxyalkylamines | |
| ES426664A1 (en) | 2-Substituted phenyl-s-triazolo[5,1-a] isoquinoline compounds | |
| GB1235399A (en) | Polymethylene diamine derivatives | |
| GB1504862A (en) | Terpeno-phenoxyalkylamines | |
| GB1391862A (en) | Benzodiazepines | |
| GB1290381A (en) | ||
| ES376688A1 (en) | Benzdiazepine derivatives | |
| GB1338459A (en) | Flavanone derivatives and process for inhibiting growth of microorganisms using such compounds | |
| GB1291442A (en) | Adamantylamino-5,8-dihydronaphthyloxy-propanols and related compounds | |
| SE7412147L (en) | ||
| GB1254270A (en) | Benzoxazepine derivatives | |
| GB1199126A (en) | 3-Amino-1,2,3,4-Tetrahydrofluorenes | |
| GB1468079A (en) | Ethanolamine derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |