IE34859L - Isoquinolines. - Google Patents
Isoquinolines.Info
- Publication number
- IE34859L IE34859L IE710006A IE671A IE34859L IE 34859 L IE34859 L IE 34859L IE 710006 A IE710006 A IE 710006A IE 671 A IE671 A IE 671A IE 34859 L IE34859 L IE 34859L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- formula
- alkoxy
- alkyl
- reducing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1335261 Isoquinolines HOFFMANN-LA ROCHE & CO AG 5 Jan 1971 [6 Jan 1970] 454/71 Heading C2C Compounds of the general formula (R = OH, C 1-4 alkoxy; R 1 = H, OH, C 1-4 alkoxy or R + R 1 = OCH 2 O; R 2 = H, C 1-4 alkyl; R 3 = C 1-4 alkyl, Ph(C 1-4 alkyl); R 4 = halogen, NO 2 NH 2 , C 1-4 alkylamino, di-(C 1-4 alkyl)amino; n = 1,2) and their acid addition salts are prepared by (a) cyclizing a compound of the formula (X = OH, acyloxy, halogen), (b) alkylating or aralkylating a compound of the formula (R 40 = halogen, NO 2 , dialkylamino), (c) reducing a compound of the formula (R 0 = C 1-4 alkoxy; R 10 = H, C 1-4 alkoxy or R 0 + R 10 = OCH 2 O; R 30 = C 1-4 alkyl, Ph(C 2-4 alkyl); R 41 = halogen, dialkylamino) under acidic conditions or reducing a compound of the formula (d) reducing a compound of the formula (R 11 = OH, C 1-4 alkoxy or R + R 11 = OCH 2 O; Y = anion), (e) reducing a compound of the formula (f) when R and/or R 1 = OH, subjecting a corresponding compound in which R and/or R 1 = alkoxy to acidic ether-cleavage, (g) when R 4 = NH 2 (R 3 not PhCH 2 ), reducing a corresponding compound in which R 4 = NO 2 , (h) when R 4 = alkylamino or dialkylamino, monoalkylating a corresponding compound in which R 4 = NH 2 or alkylamino, (i) when R and/or R 1 = OH (R 3 not PhCH 2 , R 4 not NO 2 ), hydrolytically debenzylating a corresponding compound but in which R and/or R 1 = PhCH 2 O, (j) when the product is optically active, resolving the racemate or using an optically active starting material or (k) when the product contains at least two asymmetric carbon atoms, separating an individual racemate from the diastereomer mixture, optionally followed in each case by salt formation. The starting materials are prepared by the following routes The above compounds are antidepressants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
[GB1335261A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH10370A CH527194A (en) | 1970-01-06 | 1970-01-06 | Process for the preparation of isoquinoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IE34859L true IE34859L (en) | 1971-07-06 |
IE34859B1 IE34859B1 (en) | 1975-09-03 |
Family
ID=4179328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE6/71A IE34859B1 (en) | 1970-01-06 | 1971-01-04 | Isoquinoline derivatives |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS5515476B1 (en) |
AT (1) | AT303041B (en) |
BE (1) | BE761219A (en) |
CA (1) | CA999866A (en) |
CH (2) | CH527194A (en) |
DE (1) | DE2062001C2 (en) |
DK (1) | DK125021B (en) |
ES (1) | ES387016A1 (en) |
FI (1) | FI49503C (en) |
FR (1) | FR2081412B1 (en) |
GB (1) | GB1335261A (en) |
IE (1) | IE34859B1 (en) |
IL (1) | IL35916A (en) |
NL (1) | NL171444C (en) |
NO (1) | NO135315C (en) |
PH (1) | PH9682A (en) |
SE (3) | SE368401B (en) |
YU (1) | YU33660B (en) |
ZA (1) | ZA708590B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595688A (en) * | 1983-06-23 | 1986-06-17 | Mcneilab, Inc. | Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof |
ZA844402B (en) * | 1983-06-23 | 1986-01-29 | Mcneil Pharmaceutical | Hexahydropyrrolo(2,1-a)isoquinoline derivatives |
US4719216A (en) * | 1983-06-23 | 1988-01-12 | Mcneilab, Inc. | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants |
GB2271566A (en) * | 1992-10-14 | 1994-04-20 | Merck & Co Inc | HIV integrase inhibitors |
RU2309953C2 (en) | 1999-11-03 | 2007-11-10 | Эймр Текнолоджи, Инк. | Aryl- and heteroaryl-substituted tetrahydroisoquinolines, pharmaceutical composition and method for treatment based on thereof |
CN100436420C (en) * | 1999-11-03 | 2008-11-26 | Amr科技公司 | 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US7163949B1 (en) * | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
EP1113007A1 (en) | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
CA2415532C (en) | 2000-07-11 | 2010-05-11 | Albany Molecular Research, Inc. | Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof |
KR101412339B1 (en) | 2004-07-15 | 2014-06-25 | 알바니 몰레큘라 리써치, 인크. | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
EP1899334B1 (en) | 2005-06-17 | 2008-09-24 | Janssen Pharmaceutica N.V. | Naphthyridine compounds |
CN101495184A (en) | 2005-07-15 | 2009-07-29 | Amr科技公司 | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
AR071997A1 (en) | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | CRYSTAL FORM OF 6 - ((4S) -2-METHYL-4- (2-NAFTIL) -1,2,3,4-TETRAHYDROISOQUINOLIN-7-IL) PIRIDAZIN-3-AMINA |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
US8815894B2 (en) | 2009-05-12 | 2014-08-26 | Bristol-Myers Squibb Company | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
US9034899B2 (en) | 2009-05-12 | 2015-05-19 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670694B2 (en) * | 1966-05-05 | 1976-07-22 | Hoechst Ag, 6000 Frankfurt | METHOD FOR MANUFACTURING TETRAHYDROISOCHINOLINES |
-
1970
- 1970-01-06 CH CH10370A patent/CH527194A/en not_active IP Right Cessation
- 1970-01-06 CH CH1011872A patent/CH538477A/en not_active IP Right Cessation
- 1970-12-16 SE SE17063/70A patent/SE368401B/xx unknown
- 1970-12-16 SE SE7313623A patent/SE386672B/en unknown
- 1970-12-16 DE DE2062001A patent/DE2062001C2/en not_active Expired
- 1970-12-21 ZA ZA708590A patent/ZA708590B/en unknown
- 1970-12-28 IL IL35916A patent/IL35916A/en unknown
- 1970-12-29 NL NLAANVRAGE7018956,A patent/NL171444C/en not_active IP Right Cessation
- 1970-12-31 FI FI703519A patent/FI49503C/en active
-
1971
- 1971-01-04 IE IE6/71A patent/IE34859B1/en unknown
- 1971-01-05 AT AT4571A patent/AT303041B/en not_active IP Right Cessation
- 1971-01-05 NO NO7121A patent/NO135315C/no unknown
- 1971-01-05 ES ES387016A patent/ES387016A1/en not_active Expired
- 1971-01-05 DK DK2571AA patent/DK125021B/en not_active IP Right Cessation
- 1971-01-05 BE BE761219A patent/BE761219A/en not_active IP Right Cessation
- 1971-01-05 FR FR7100097A patent/FR2081412B1/fr not_active Expired
- 1971-01-05 GB GB45471A patent/GB1335261A/en not_active Expired
- 1971-01-06 YU YU19/71A patent/YU33660B/en unknown
- 1971-01-06 CA CA102,060A patent/CA999866A/en not_active Expired
- 1971-01-06 JP JP7194A patent/JPS5515476B1/ja active Pending
- 1971-01-07 PH PH12087*UA patent/PH9682A/en unknown
-
1973
- 1973-10-05 SE SE7313622A patent/SE399879B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NL7018956A (en) | 1971-07-08 |
SE386672B (en) | 1976-08-16 |
PH9682A (en) | 1976-02-10 |
DE2062001A1 (en) | 1971-07-15 |
IL35916A0 (en) | 1971-02-25 |
BE761219A (en) | 1971-07-05 |
NO135315B (en) | 1976-12-13 |
NL171444C (en) | 1983-04-05 |
SE368401B (en) | 1974-07-01 |
DE2062001C2 (en) | 1986-10-16 |
ZA708590B (en) | 1971-09-29 |
FR2081412B1 (en) | 1974-04-12 |
ES387016A1 (en) | 1976-05-01 |
IL35916A (en) | 1973-11-28 |
DK125021B (en) | 1972-12-18 |
FI49503C (en) | 1975-07-10 |
IE34859B1 (en) | 1975-09-03 |
FI49503B (en) | 1975-04-01 |
FR2081412A1 (en) | 1971-12-03 |
CA999866A (en) | 1976-11-16 |
GB1335261A (en) | 1973-10-24 |
CH538477A (en) | 1973-06-30 |
SE399879B (en) | 1978-03-06 |
YU1971A (en) | 1977-06-30 |
NO135315C (en) | 1977-03-23 |
NL171444B (en) | 1982-11-01 |
CH527194A (en) | 1972-08-31 |
JPS5515476B1 (en) | 1980-04-23 |
AT303041B (en) | 1972-11-10 |
YU33660B (en) | 1977-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE34859L (en) | Isoquinolines. | |
GB1409693A (en) | Triazolobenzodiazepines | |
GB1474882A (en) | Alpha-aminomethyl-5-hydroxy-2-pyridinemethanols | |
GB1111451A (en) | Improvements in or relating to pharmacologically-active secondary amine compounds | |
GB1456627A (en) | Pyridobenzodiazepinones | |
GB1443692A (en) | 1,2-diphenylethanolamine derivatives and their salts and the preparation thereof | |
GB1394568A (en) | Diazepine derivatives and process for the production thereof | |
GB1434805A (en) | 5-phenoxy-4-amino pyrimidines | |
GB1462095A (en) | Substituted triazolo-1,5-benzodiazepines | |
GB1238777A (en) | ||
GB1434580A (en) | Disubstituted piperazines | |
GB1235399A (en) | Polymethylene diamine derivatives | |
GB1433078A (en) | Substituted phenethylamines | |
IE34590L (en) | Phenylethanolamine derivatives | |
GB1208231A (en) | beta-PHENETHYLAMINE DERIVATIVES AND A PROCESS FOR THE MANUFACTURE THEREOF | |
GB1345214A (en) | Isoxazoles | |
GB1451389A (en) | Indolobenzazepines | |
SE7415496L (en) | ||
GB1408984A (en) | Beta-adrenergic blocking aminopropanols | |
GB1234967A (en) | Alkanolamine derivatives | |
GB1211459A (en) | Hydroxy amines | |
GB1340407A (en) | Phenylethanolamine derivatives | |
GB1468079A (en) | Ethanolamine derivatives | |
SE333735B (en) | ||
GB1446164A (en) | Basic enol ethers their salts processes for their preparation and pharmaceutical preparations containing the same |