CH527194A - Process for the preparation of isoquinoline derivatives - Google Patents

Process for the preparation of isoquinoline derivatives

Info

Publication number
CH527194A
CH527194A CH10370A CH10370A CH527194A CH 527194 A CH527194 A CH 527194A CH 10370 A CH10370 A CH 10370A CH 10370 A CH10370 A CH 10370A CH 527194 A CH527194 A CH 527194A
Authority
CH
Switzerland
Prior art keywords
preparation
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
CH10370A
Other languages
German (de)
Inventor
Alfred Jr Dr Rheiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH1011872A priority Critical patent/CH538477A/en
Priority to CH10370A priority patent/CH527194A/en
Priority to DE2062001A priority patent/DE2062001C2/en
Priority to SE17063/70A priority patent/SE368401B/xx
Priority to SE7313623A priority patent/SE386672B/en
Priority to ZA708590A priority patent/ZA708590B/en
Priority to IL35916A priority patent/IL35916A/en
Priority to NLAANVRAGE7018956,A priority patent/NL171444C/en
Priority to FI703519A priority patent/FI49503C/en
Priority to IE6/71A priority patent/IE34859B1/en
Priority to GB45471A priority patent/GB1335261A/en
Priority to NO7121A priority patent/NO135315C/no
Priority to FR7100097A priority patent/FR2081412B1/fr
Priority to AT4571A priority patent/AT303041B/en
Priority to DK2571AA priority patent/DK125021B/en
Priority to ES387016A priority patent/ES387016A1/en
Priority to BE761219A priority patent/BE761219A/en
Priority to YU19/71A priority patent/YU33660B/en
Priority to CA102,060A priority patent/CA999866A/en
Priority to JP7194A priority patent/JPS5515476B1/ja
Priority to PH12087*UA priority patent/PH9682A/en
Publication of CH527194A publication Critical patent/CH527194A/en
Priority to US05/365,921 priority patent/US3947456A/en
Priority to SE7313622A priority patent/SE399879B/en
Priority to NO740555A priority patent/NO740555L/en
Priority to NO740554A priority patent/NO135062C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH10370A 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives CH527194A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
CH1011872A CH538477A (en) 1970-01-06 1970-01-06 Antidepressant 4-phenyl-tetrahydroquino- - lines
CH10370A CH527194A (en) 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives
DE2062001A DE2062001C2 (en) 1970-01-06 1970-12-16 1,2,3,4-Tetrahydro-4-phenylisoquinoline derivatives, their acid addition salts, process for their production and pharmaceutical preparation
SE17063/70A SE368401B (en) 1970-01-06 1970-12-16
SE7313623A SE386672B (en) 1970-01-06 1970-12-16 INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF ISOKINOLINE DERIVATIVES
ZA708590A ZA708590B (en) 1970-01-06 1970-12-21 Isoquinoline derivatives
IL35916A IL35916A (en) 1970-01-06 1970-12-28 1,2,3,4-tetrahydro-4-phenyl iso-quinoline derivatives and their preparation
NLAANVRAGE7018956,A NL171444C (en) 1970-01-06 1970-12-29 PROCESS FOR THE PREPARATION OF 1,2,3,4-TETRAHYDRO-4-PHENYLISOQUINOLINE DERIVATIVES, AND METHOD FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS WITH ANTIDEPRESSIVE PROPERTIES CONTAINING THESE DERIVATIVES
FI703519A FI49503C (en) 1970-01-06 1970-12-31 Analogous process for the preparation of 1,2,3,4-tetrahydro-4-phenylisoquinoline derivatives.
IE6/71A IE34859B1 (en) 1970-01-06 1971-01-04 Isoquinoline derivatives
NO7121A NO135315C (en) 1970-01-06 1971-01-05
GB45471A GB1335261A (en) 1970-01-06 1971-01-05 Isoquinoline derivatives
FR7100097A FR2081412B1 (en) 1970-01-06 1971-01-05
AT4571A AT303041B (en) 1970-01-06 1971-01-05 Process for the production of new isoquinoline derivatives and their salts
DK2571AA DK125021B (en) 1970-01-06 1971-01-05 Analogous process for the preparation of 1,2,3,4-tetrahydro-4-phenyl-isoquinoline derivatives or acid addition salts thereof or the corresponding optically active compounds.
ES387016A ES387016A1 (en) 1970-01-06 1971-01-05 Isoquinoline derivatives
BE761219A BE761219A (en) 1970-01-06 1971-01-05 ISOQUINOLEINE DERIVATIVES
YU19/71A YU33660B (en) 1970-01-06 1971-01-06 Process for preparing 1, 2, 3, 4-tetrahydro-4-phenylisoquinoline derivatives
CA102,060A CA999866A (en) 1970-01-06 1971-01-06 Isoquinoline derivatives
JP7194A JPS5515476B1 (en) 1970-01-06 1971-01-06
PH12087*UA PH9682A (en) 1970-01-06 1971-01-07 1,2,3,4-tetrahydro-4-phenyl-isoquinoline derivatives and pharmaceutical composition containing same
US05/365,921 US3947456A (en) 1970-01-06 1973-06-01 Substituted 4-phenyl isoquinolines
SE7313622A SE399879B (en) 1970-01-06 1973-10-05 CHEMICAL INTERMEDIATE USES FOR THE PREPARATION OF THERAPEUTIC VALUES 1,2,3,4-TETRAHYDRO-4-PHENYL-ISOKINOLINE DERIVATIVES
NO740555A NO740555L (en) 1970-01-06 1974-02-19 Isoquinoline derivatives for use as intermediates for the preparation of 2-alkyl- or 2-phenyl-lower alkyl-1,2,3,4-tetrahydro-4-isoquinoline derivatives.
NO740554A NO135062C (en) 1970-01-06 1974-02-19

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH10370A CH527194A (en) 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives

Publications (1)

Publication Number Publication Date
CH527194A true CH527194A (en) 1972-08-31

Family

ID=4179328

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1011872A CH538477A (en) 1970-01-06 1970-01-06 Antidepressant 4-phenyl-tetrahydroquino- - lines
CH10370A CH527194A (en) 1970-01-06 1970-01-06 Process for the preparation of isoquinoline derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH1011872A CH538477A (en) 1970-01-06 1970-01-06 Antidepressant 4-phenyl-tetrahydroquino- - lines

Country Status (19)

Country Link
JP (1) JPS5515476B1 (en)
AT (1) AT303041B (en)
BE (1) BE761219A (en)
CA (1) CA999866A (en)
CH (2) CH538477A (en)
DE (1) DE2062001C2 (en)
DK (1) DK125021B (en)
ES (1) ES387016A1 (en)
FI (1) FI49503C (en)
FR (1) FR2081412B1 (en)
GB (1) GB1335261A (en)
IE (1) IE34859B1 (en)
IL (1) IL35916A (en)
NL (1) NL171444C (en)
NO (1) NO135315C (en)
PH (1) PH9682A (en)
SE (3) SE386672B (en)
YU (1) YU33660B (en)
ZA (1) ZA708590B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA844402B (en) * 1983-06-23 1986-01-29 Mcneil Pharmaceutical Hexahydropyrrolo(2,1-a)isoquinoline derivatives
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
AU784280B2 (en) * 1999-11-03 2006-03-02 Albany Molecular Research, Inc. 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
ES2304984T3 (en) 1999-11-03 2008-11-01 Amr Technology, Inc. TETRA-HYDROISOQUINOLINAS OF ARILICA AND HETEROARILICA SUBSTITUTION AND ITS USE TO BLOCK THE RECOVERY OF NOREPINEFRINE, DOPAMINE AND SEROTONINE.
EP1113007A1 (en) 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
EP1299393A2 (en) 2000-07-11 2003-04-09 Bristol-Myers Squibb Pharma Company 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
NZ552397A (en) 2004-07-15 2011-04-29 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
PL1899334T3 (en) 2005-06-17 2009-04-30 Janssen Pharmaceutica Nv Naphthyridine compounds
KR101589551B1 (en) 2005-07-15 2016-02-02 알바니 몰레큘라 리써치, 인크. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
AR071997A1 (en) 2008-06-04 2010-07-28 Bristol Myers Squibb Co CRYSTAL FORM OF 6 - ((4S) -2-METHYL-4- (2-NAFTIL) -1,2,3,4-TETRAHYDROISOQUINOLIN-7-IL) PIRIDAZIN-3-AMINA
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
KR20120034644A (en) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
AU2010247735B2 (en) 2009-05-12 2015-07-16 Albany Molecular Research, Inc. Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
US8802696B2 (en) 2009-05-12 2014-08-12 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (en) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt METHOD FOR MANUFACTURING TETRAHYDROISOCHINOLINES

Also Published As

Publication number Publication date
SE399879B (en) 1978-03-06
DK125021B (en) 1972-12-18
YU33660B (en) 1977-12-31
YU1971A (en) 1977-06-30
NO135315C (en) 1977-03-23
DE2062001C2 (en) 1986-10-16
AT303041B (en) 1972-11-10
NO135315B (en) 1976-12-13
IL35916A0 (en) 1971-02-25
PH9682A (en) 1976-02-10
IE34859L (en) 1971-07-06
BE761219A (en) 1971-07-05
IL35916A (en) 1973-11-28
IE34859B1 (en) 1975-09-03
FI49503B (en) 1975-04-01
FR2081412A1 (en) 1971-12-03
SE386672B (en) 1976-08-16
NL171444B (en) 1982-11-01
NL7018956A (en) 1971-07-08
JPS5515476B1 (en) 1980-04-23
DE2062001A1 (en) 1971-07-15
NL171444C (en) 1983-04-05
SE368401B (en) 1974-07-01
FR2081412B1 (en) 1974-04-12
ES387016A1 (en) 1976-05-01
CA999866A (en) 1976-11-16
CH538477A (en) 1973-06-30
FI49503C (en) 1975-07-10
GB1335261A (en) 1973-10-24
ZA708590B (en) 1971-09-29

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