GB0317466D0 - Use - Google Patents

Use

Info

Publication number
GB0317466D0
GB0317466D0 GBGB0317466.1A GB0317466A GB0317466D0 GB 0317466 D0 GB0317466 D0 GB 0317466D0 GB 0317466 A GB0317466 A GB 0317466A GB 0317466 D0 GB0317466 D0 GB 0317466D0
Authority
GB
United Kingdom
Prior art keywords
mediates
inhibits
medicament
gene
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0317466.1A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sheffield
Original Assignee
University of Sheffield
Newcastle University of Upon Tyne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27772701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB0317466(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Sheffield, Newcastle University of Upon Tyne filed Critical University of Sheffield
Priority to GBGB0317466.1A priority Critical patent/GB0317466D0/en
Publication of GB0317466D0 publication Critical patent/GB0317466D0/en
Priority to AT04743564T priority patent/ATE516353T1/de
Priority to PT04743564T priority patent/PT1649017E/pt
Priority to CA2533332A priority patent/CA2533332C/en
Priority to US10/555,507 priority patent/US8859562B2/en
Priority to EP04743564.9A priority patent/EP1649017B2/en
Priority to DK04743564.9T priority patent/DK1649017T4/da
Priority to DK04743516.9T priority patent/DK1660095T3/da
Priority to PL04743516T priority patent/PL1660095T3/pl
Priority to PCT/GB2004/003235 priority patent/WO2005012524A1/en
Priority to CA2533423A priority patent/CA2533423C/en
Priority to MXPA06000993A priority patent/MXPA06000993A/es
Priority to DE602004025123T priority patent/DE602004025123D1/de
Priority to US10/898,653 priority patent/US7351701B2/en
Priority to KR1020067001725A priority patent/KR101138471B1/ko
Priority to JP2006520907A priority patent/JP5519097B2/ja
Priority to AU2004261462A priority patent/AU2004261462B2/en
Priority to PL04743564T priority patent/PL1649017T5/pl
Priority to NZ544989A priority patent/NZ544989A/en
Priority to CN201210332472.8A priority patent/CN102935230B/zh
Priority to ES04743564.9T priority patent/ES2367433T5/es
Priority to PT04743516T priority patent/PT1660095E/pt
Priority to KR1020067001650A priority patent/KR101136702B1/ko
Priority to AU2004261779A priority patent/AU2004261779B2/en
Priority to JP2006521648A priority patent/JP5466814B2/ja
Priority to ES04743516T priority patent/ES2339663T3/es
Priority to HK06106961.6A priority patent/HK1084602B/en
Priority to EP04743516A priority patent/EP1660095B1/en
Priority to HK07100334.8A priority patent/HK1094006B/xx
Priority to CN2004800272941A priority patent/CN1856572B/zh
Priority to US10/565,308 priority patent/US7531530B2/en
Priority to GB0603874A priority patent/GB2419882B/en
Priority to AT04743516T priority patent/ATE454893T1/de
Priority to PCT/GB2004/003183 priority patent/WO2005012305A2/en
Priority to BRPI0412899-0A priority patent/BRPI0412899B1/pt
Priority to NZ545307A priority patent/NZ545307A/en
Priority to RU2006105652/04A priority patent/RU2404183C2/ru
Priority to CN2004800273183A priority patent/CN1856313B/zh
Priority to BRPI0412909-1A priority patent/BRPI0412909B1/pt
Priority to SI200431370T priority patent/SI1660095T1/sl
Priority to ZA2006/00679A priority patent/ZA200600679B/en
Priority to IL173336A priority patent/IL173336A/en
Priority to ZA200601386A priority patent/ZA200601386B/en
Priority to NO20060906A priority patent/NO338398B1/no
Priority to NO20060928A priority patent/NO334610B1/no
Priority to CY20101100309T priority patent/CY1110335T1/el
Priority to JP2011246988A priority patent/JP5547164B2/ja
Priority to JP2011260401A priority patent/JP5580280B2/ja
Priority to JP2013147532A priority patent/JP5848728B2/ja
Priority to HK13109407.3A priority patent/HK1182016B/xx
Priority to US14/322,759 priority patent/US20150005327A1/en
Priority to US15/650,459 priority patent/US20180000822A1/en
Priority to US16/598,808 priority patent/US20200237762A1/en
Priority to US17/528,034 priority patent/US20220062286A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/0203—NAD+ ADP-ribosyltransferase (2.4.2.30), i.e. tankyrase or poly(ADP-ribose) polymerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Lubricants (AREA)
GBGB0317466.1A 2003-07-25 2003-07-25 Use Ceased GB0317466D0 (en)

Priority Applications (54)

Application Number Priority Date Filing Date Title
GBGB0317466.1A GB0317466D0 (en) 2003-07-25 2003-07-25 Use
AT04743564T ATE516353T1 (de) 2003-07-25 2004-07-23 Verwendung von rnai mit inhibierender parp aktivität zur herstelllung eines arzneimittels zur behandlung von krebs
PT04743564T PT1649017E (pt) 2003-07-25 2004-07-23 Utilização de arni inibidor da actividade de parp para o fabrico de um medicamento para tratamento do cancro
CA2533332A CA2533332C (en) 2003-07-25 2004-07-23 Therapeutic compounds
US10/555,507 US8859562B2 (en) 2003-07-25 2004-07-23 Use of RNAI inhibiting PARP activity for the manufacture of a medicament for the treatment of cancer
EP04743564.9A EP1649017B2 (en) 2003-07-25 2004-07-23 Use of rnai inhibiting parp activity for the manufacture of a medicament for the treatment of cancer
DK04743564.9T DK1649017T4 (da) 2003-07-25 2004-07-23 Anvendelse af RNA i inhiberende PARP aktivitet til fremstillingen af et lægemiddel til behandlingen af cancer
DK04743516.9T DK1660095T3 (da) 2003-07-25 2004-07-23 Tricykliske PARP-inhibitorer
PL04743516T PL1660095T3 (pl) 2003-07-25 2004-07-23 Tricykliczne inhibitory PARP
PCT/GB2004/003235 WO2005012524A1 (en) 2003-07-25 2004-07-23 Use of rnai inhibiting parp activtiy for the manufacture of a medicament for the treatment of cancer
CA2533423A CA2533423C (en) 2003-07-25 2004-07-23 Use of rnai inhibiting parp activity for the manufacture of a medicament for the treatment of cancer
MXPA06000993A MXPA06000993A (es) 2003-07-25 2004-07-23 Inhbidores triciclicos de parp.
DE602004025123T DE602004025123D1 (en) 2003-07-25 2004-07-23 Tricyclische parp-hemmer
US10/898,653 US7351701B2 (en) 2003-07-25 2004-07-23 Therapeutic compounds
KR1020067001725A KR101138471B1 (ko) 2003-07-25 2004-07-23 트리시클로 ｐａｒｐ 저해제
JP2006520907A JP5519097B2 (ja) 2003-07-25 2004-07-23 癌を治療するための医薬の製造におけるＰＡＲＰ活性阻害性ＲＮＡｉの使用
AU2004261462A AU2004261462B2 (en) 2003-07-25 2004-07-23 Tricyclic PARP inhibitors
PL04743564T PL1649017T5 (pl) 2003-07-25 2004-07-23 Zastosowanie aktywności PARP hamującej RNAI do wytwarzania leku do leczenia raka
NZ544989A NZ544989A (en) 2003-07-25 2004-07-23 Tricyclic PARP inhibitors
CN201210332472.8A CN102935230B (zh) 2003-07-25 2004-07-23 抑制PARP活性的RNAi用于生产治疗癌症的药物的用途
ES04743564.9T ES2367433T5 (es) 2003-07-25 2004-07-23 Uso de la actividad PARP inhibidora de ARNI para la fabricación de un medicamento para el tratamiento del cáncer
PT04743516T PT1660095E (pt) 2003-07-25 2004-07-23 Inibidores tricíclicos de parp
KR1020067001650A KR101136702B1 (ko) 2003-07-25 2004-07-23 암 치료용 약제를 제조하기 위한 ｐａｒｐ 활성을 억제하는ｒｎａｉ의 용도
AU2004261779A AU2004261779B2 (en) 2003-07-25 2004-07-23 Use of RNAi inhibiting PARP activity for the manufacture of a medicament for the treatment of cancer
JP2006521648A JP5466814B2 (ja) 2003-07-25 2004-07-23 治療用化合物
ES04743516T ES2339663T3 (es) 2003-07-25 2004-07-23 Inhibidores de parp triciclicos.
HK06106961.6A HK1084602B (en) 2003-07-25 2004-07-23 Tricyclic parp inhibitors
EP04743516A EP1660095B1 (en) 2003-07-25 2004-07-23 Tricyclic parp inhibitors
HK07100334.8A HK1094006B (en) 2003-07-25 2004-07-23 Use of rnai inhibiting parp activtiy for the manufacture of a medicament for the treatment of cancer
CN2004800272941A CN1856572B (zh) 2003-07-25 2004-07-23 抑制PARP活性的RNAi用于生产治疗癌症的药物的用途
US10/565,308 US7531530B2 (en) 2003-07-25 2004-07-23 Therapeutic compounds
GB0603874A GB2419882B (en) 2003-07-25 2004-07-23 Use of rnai inhibiting parp activity for the manufacture of a medicament for the treatment of cancer
AT04743516T ATE454893T1 (de) 2003-07-25 2004-07-23 Tricyclische parp-hemmer
PCT/GB2004/003183 WO2005012305A2 (en) 2003-07-25 2004-07-23 Tricyclic parp inhibitors
BRPI0412899-0A BRPI0412899B1 (pt) 2003-07-25 2004-07-23 Uso de um composto ou um sal farmaceuticamente aceitável do mesmo para a manufatura de um medicamento citotóxico para o tratamento de câncer de ovário, câncer de mama, câncer de próstata ou câncer pancreático
NZ545307A NZ545307A (en) 2003-07-25 2004-07-23 Use of RNAI inhibiting parp activity for the manufacture of a medicament for the treatment of cancer
RU2006105652/04A RU2404183C2 (ru) 2003-07-25 2004-07-23 Трициклические ингибиторы парп
CN2004800273183A CN1856313B (zh) 2003-07-25 2004-07-23 治疗化合物
BRPI0412909-1A BRPI0412909B1 (pt) 2003-07-25 2004-07-23 Uso de um inibidor de poli (adp-ribose) polimerase 1 (parp-1) para a fabricação de um medicamento para o tratamento de células de câncer defeituosas em recombinação homóloga
SI200431370T SI1660095T1 (sl) 2003-07-25 2004-07-23 Triciklični parp inhibitorji
ZA2006/00679A ZA200600679B (en) 2003-07-25 2006-01-24 Therapeutic compounds
IL173336A IL173336A (en) 2003-07-25 2006-01-24 Derivatives of epsilon-lactam fused with indole and benzimidazole for the treatment of cancer caused by a genetic defect in the gene
ZA200601386A ZA200601386B (en) 2003-07-25 2006-02-16 Use of RNAI inhibiting PARP activity for the manufacture of a medicament for the treatment of cancer
NO20060906A NO338398B1 (no) 2003-07-25 2006-02-24 Anvendelse av en poly(ADP-ribose) polymerase (PARP)-inhibitor for fremstilling av et medikament for behandling av cancerceller som er defekte med hensyn på homolog rekombinasjon (HR) og en poly(ADP-ribose) polymerase (PARP)-inhibitor for anvendelse ved behandling av cancerceller som er defekte med hensyn på homolog rekombinasjon (HR).
NO20060928A NO334610B1 (no) 2003-07-25 2006-02-24 Terapeutiske forbindelser og anvendelse av en terapeutisk effektiv mengde av forbindelsene for fremstilling av et cytotoksisk medikament for behandling av kreft, hvor kreften er forårsaket av en genetisk defekt i et gen som medierer homolog rekombinasjon
CY20101100309T CY1110335T1 (el) 2003-07-25 2010-03-31 Τρικυκλικοι αναστολεις parp
JP2011246988A JP5547164B2 (ja) 2003-07-25 2011-11-11 癌を治療するための医薬の製造におけるＰＡＲＰ活性阻害性ＲＮＡｉの使用
JP2011260401A JP5580280B2 (ja) 2003-07-25 2011-11-29 治療用化合物
JP2013147532A JP5848728B2 (ja) 2003-07-25 2013-07-16 癌を治療するための医薬の製造におけるＰＡＲＰ活性阻害性ＲＮＡｉの使用
HK13109407.3A HK1182016B (en) 2003-07-25 2013-08-12 Use of rnai inhibiting parp activtiy for the manufacture of a medicament for the treatment of cancer
US14/322,759 US20150005327A1 (en) 2003-07-25 2014-07-02 Use of RNAI Inhibiting PARP Activity for the Manufacture of a Medicament for the Treatment of Cancer
US15/650,459 US20180000822A1 (en) 2003-07-25 2017-07-14 Use of RNAI Inhibiting PARP Activity for the Manufacture of a Medicament for the Treatment of Cancer
US16/598,808 US20200237762A1 (en) 2003-07-25 2019-10-10 Use of rnai inhibiting parp activity for the manufacture of a medicament for the treatment of cancer
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US8859562B2 (en) 2014-10-14
NO20060906L (no) 2006-04-25
PT1649017E (pt) 2011-09-30
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ES2367433T3 (es) 2011-11-03
ATE516353T1 (de) 2011-07-15
JP5547164B2 (ja) 2014-07-09
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EP1649017B1 (en) 2011-07-13
AU2004261779B2 (en) 2008-07-24
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CN102935230A (zh) 2013-02-20
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US20180000822A1 (en) 2018-01-04
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EP1649017A1 (en) 2006-04-26
BRPI0412909B1 (pt) 2022-04-12
US20150005327A1 (en) 2015-01-01
EP1649017B2 (en) 2014-08-27
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US20200237762A1 (en) 2020-07-30
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