FR2688499B1 - Procede de preparation de la beta-phenylisoserine et de ses analogues. - Google Patents

Procede de preparation de la beta-phenylisoserine et de ses analogues.

Info

Publication number
FR2688499B1
FR2688499B1 FR9202821A FR9202821A FR2688499B1 FR 2688499 B1 FR2688499 B1 FR 2688499B1 FR 9202821 A FR9202821 A FR 9202821A FR 9202821 A FR9202821 A FR 9202821A FR 2688499 B1 FR2688499 B1 FR 2688499B1
Authority
FR
France
Prior art keywords
pct
phenylisoserine
general formula
beta
date sep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9202821A
Other languages
English (en)
French (fr)
Other versions
FR2688499A1 (fr
Inventor
Jean-Dominique Bourzat
Alain Commercon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9202821A priority Critical patent/FR2688499B1/fr
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to AU37557/93A priority patent/AU667886B2/en
Priority to MX9301268A priority patent/MX9301268A/es
Priority to US08/295,677 priority patent/US5608102A/en
Priority to EP93918746A priority patent/EP0630365B1/fr
Priority to JP51539493A priority patent/JP3278768B2/ja
Priority to DK93918746.4T priority patent/DK0630365T3/da
Priority to PCT/FR1993/000224 priority patent/WO1993017997A1/fr
Priority to RU94045799A priority patent/RU2103258C1/ru
Priority to CA002130333A priority patent/CA2130333C/fr
Priority to AT93918746T priority patent/ATE159512T1/de
Priority to CZ942185A priority patent/CZ283613B6/cs
Priority to HU9402590A priority patent/HU213621B/hu
Priority to ES93918746T priority patent/ES2109509T3/es
Priority to SK1085-94A priority patent/SK281297B6/sk
Priority to KR1019940703156A priority patent/KR100272650B1/ko
Priority to DE69314779T priority patent/DE69314779T2/de
Priority to GEAP19932472A priority patent/GEP19981430B/en
Priority to PL93305059A priority patent/PL171551B1/pl
Priority to NZ249899A priority patent/NZ249899A/en
Priority to ZA931677A priority patent/ZA931677B/xx
Priority to TW082101775A priority patent/TW252971B/zh
Publication of FR2688499A1 publication Critical patent/FR2688499A1/fr
Application granted granted Critical
Publication of FR2688499B1 publication Critical patent/FR2688499B1/fr
Priority to NO943280A priority patent/NO304515B1/no
Priority to FI944169A priority patent/FI113640B/fi
Priority to US08/697,420 priority patent/US5763628A/en
Priority to US08/852,611 priority patent/US5939561A/en
Priority to GR970401615T priority patent/GR3025117T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR9202821A 1992-03-10 1992-03-10 Procede de preparation de la beta-phenylisoserine et de ses analogues. Expired - Fee Related FR2688499B1 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR9202821A FR2688499B1 (fr) 1992-03-10 1992-03-10 Procede de preparation de la beta-phenylisoserine et de ses analogues.
KR1019940703156A KR100272650B1 (ko) 1992-03-10 1993-03-08 베타-페닐이소세린 및 그의 동족체를 제조하는 방법
US08/295,677 US5608102A (en) 1992-03-10 1993-03-08 Process for the preparation of β-phenylisoserine and its analogues
EP93918746A EP0630365B1 (fr) 1992-03-10 1993-03-08 Procede de preparation de la beta-phenylisoserine et de ses analogues
JP51539493A JP3278768B2 (ja) 1992-03-10 1993-03-08 β−フェニルイソセリン及びその類似体の製造法
DK93918746.4T DK0630365T3 (da) 1992-03-10 1993-03-08 Fremgangsmåde til fremstilling af beta-phenylisoserin og analoge deraf
PCT/FR1993/000224 WO1993017997A1 (fr) 1992-03-10 1993-03-08 PROCEDE DE PREPARATION DE LA β-PHENYLISOSERINE ET DE SES ANALOGUES
RU94045799A RU2103258C1 (ru) 1992-03-10 1993-03-08 СПОСОБ ПОЛУЧЕНИЯ β -ФЕНИЛИЗОСЕРИНА И ЕГО АНАЛОГОВ, ПРОИЗВОДНЫХ α -ФЕНИЛИЗОСЕРИНА, ПРОИЗВОДНЫЕ АЗЕТИДИНОНА
CA002130333A CA2130333C (fr) 1992-03-10 1993-03-08 Procede de preparation de la .beta.-phenylisoserine et de ses analogues
AT93918746T ATE159512T1 (de) 1992-03-10 1993-03-08 Prozess zur herstellung von beta-phenylisoserin und analogen verbindungen
CZ942185A CZ283613B6 (cs) 1992-03-10 1993-03-08 Způsob přípravy beta-fenylisoserinu a jeho analogů
HU9402590A HU213621B (en) 1992-03-10 1993-03-08 Process for preparing beta-phenylisoserine derivatives
ES93918746T ES2109509T3 (es) 1992-03-10 1993-03-08 Procedimiento para la preparacion de beta-fenilisoserina y de sus analogos.
SK1085-94A SK281297B6 (sk) 1992-03-10 1993-03-08 Spôsob prípravy beta-fenylizoserínu, jeho analógov a medziprodukt
AU37557/93A AU667886B2 (en) 1992-03-10 1993-03-08 Method for preparing beta-phenylisoserine and analogues thereof
NZ249899A NZ249899A (en) 1992-03-10 1993-03-08 Preparation of phenylisoserine, lactam precursors
MX9301268A MX9301268A (es) 1992-03-10 1993-03-08 Procedimiento para la preparacion de la beta-fenilisoserina y sus analogos y productos obtenidos mediante el mismo.
PL93305059A PL171551B1 (pl) 1992-03-10 1993-03-08 Sposób wytwarzania ß -fenyloizoseryny i jej analogów PL PL
GEAP19932472A GEP19981430B (en) 1992-03-10 1993-03-08 Method for Production of -Phenylizoserin and its Derivatives
DE69314779T DE69314779T2 (de) 1992-03-10 1993-03-08 Prozess zur herstellung von beta-phenylisoserin und analogen verbindungen
ZA931677A ZA931677B (en) 1992-03-10 1993-03-09 Process for the preparation of beta-phenylisoserine and analogues thereof
TW082101775A TW252971B (enExample) 1992-03-10 1993-03-10
NO943280A NO304515B1 (no) 1992-03-10 1994-09-05 FremgangsmÕte for fremstilling av <beta>-fenylisoserin og analoger derav samt mellomprodukt
FI944169A FI113640B (fi) 1992-03-10 1994-09-09 Menetelmä beta-fenyyli-isoseriinin ja sen analogien valmistamiseksi, menetelmässä käytettävän lähtöaineen valmistus ja lähtöaine
US08/697,420 US5763628A (en) 1992-03-10 1996-08-23 Process for the preparation of β-phenylisoserine and its analogues
US08/852,611 US5939561A (en) 1992-03-10 1997-05-07 Process for the preparation of β-phenylisoserine and β-lactam and their analogues
GR970401615T GR3025117T3 (en) 1992-03-10 1997-10-23 METHOD FOR PREPARING -g(b)-PHENYLISOSERINE AND ANALOGUES THEREOF.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9202821A FR2688499B1 (fr) 1992-03-10 1992-03-10 Procede de preparation de la beta-phenylisoserine et de ses analogues.

Publications (2)

Publication Number Publication Date
FR2688499A1 FR2688499A1 (fr) 1993-09-17
FR2688499B1 true FR2688499B1 (fr) 1994-05-06

Family

ID=9427518

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9202821A Expired - Fee Related FR2688499B1 (fr) 1992-03-10 1992-03-10 Procede de preparation de la beta-phenylisoserine et de ses analogues.

Country Status (25)

Country Link
US (2) US5608102A (enExample)
EP (1) EP0630365B1 (enExample)
JP (1) JP3278768B2 (enExample)
KR (1) KR100272650B1 (enExample)
AT (1) ATE159512T1 (enExample)
AU (1) AU667886B2 (enExample)
CA (1) CA2130333C (enExample)
CZ (1) CZ283613B6 (enExample)
DE (1) DE69314779T2 (enExample)
DK (1) DK0630365T3 (enExample)
ES (1) ES2109509T3 (enExample)
FI (1) FI113640B (enExample)
FR (1) FR2688499B1 (enExample)
GE (1) GEP19981430B (enExample)
GR (1) GR3025117T3 (enExample)
HU (1) HU213621B (enExample)
MX (1) MX9301268A (enExample)
NO (1) NO304515B1 (enExample)
NZ (1) NZ249899A (enExample)
PL (1) PL171551B1 (enExample)
RU (1) RU2103258C1 (enExample)
SK (1) SK281297B6 (enExample)
TW (1) TW252971B (enExample)
WO (1) WO1993017997A1 (enExample)
ZA (1) ZA931677B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO116549B1 (ro) * 1994-07-26 2001-03-30 Indena Spa Derivati de taxan, procedeu pentru prepararea acestora, intermediar pentru prepararea acestora si compozitie farmaceutica care ii contine
US6765015B2 (en) * 1995-12-13 2004-07-20 Xechem International, Inc. Halogenated paclitaxel derivatives
KR100225535B1 (ko) 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
NZ503206A (en) 1997-08-21 2002-05-31 Univ Florida State Method of taxane synthesis by treating with a base (potassium hydride or potassium hexamethyldisilazide) and a silylating agent (trialkylsilyl halide)
WO1999025334A1 (en) * 1997-11-19 1999-05-27 Xechem International, Inc. Halogenated paclitaxel derivatives
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
JP2002080435A (ja) * 2000-06-26 2002-03-19 Kanegafuchi Chem Ind Co Ltd ３−アミノ−２−ヒドロキシプロピオン酸誘導体の製造法
KR100851515B1 (ko) 2001-03-07 2008-08-11 다이이찌 세이야꾸 가부시기가이샤 2-아제티디논 유도체의 제조방법
DE602007003312D1 (de) * 2007-02-22 2009-12-31 Indena Spa Verfahren zur Herstellung von (2r,3s)-3-Phenylisoserin-Methylester-Acetatsalz
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
CN102408356A (zh) * 2011-09-28 2012-04-11 北京东方协和医药生物技术有限公司 一种多西他赛手性侧链中间体的制备方法
ES2896882T3 (es) * 2014-02-03 2022-02-28 Quadriga Biosciences Inc Beta-aminoácidos beta sustituidos y análogos como agentes quimioterapéuticos
CN111100026A (zh) * 2019-12-30 2020-05-05 重庆市碚圣医药科技股份有限公司 一种紫杉醇恶唑环侧链中间体的制备方法
CN112574134A (zh) * 2020-12-30 2021-03-30 重庆市碚圣医药科技股份有限公司 一种多西紫杉醇侧链的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5304670A (en) * 1989-08-23 1994-04-19 Centre National De La Recherche Scientifique Process for the enantioselective preparation of phenylisoserine derivatives
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom

Also Published As

Publication number Publication date
DE69314779D1 (de) 1997-11-27
GR3025117T3 (en) 1998-01-30
FI944169A0 (fi) 1994-09-09
NO943280L (no) 1994-09-05
US5608102A (en) 1997-03-04
NO304515B1 (no) 1999-01-04
GEP19981430B (en) 1998-10-30
FI113640B (fi) 2004-05-31
FI944169L (fi) 1994-09-09
ATE159512T1 (de) 1997-11-15
HUT68540A (en) 1995-06-28
AU667886B2 (en) 1996-04-18
NO943280D0 (no) 1994-09-05
KR950700234A (ko) 1995-01-16
PL171551B1 (pl) 1997-05-30
EP0630365A1 (fr) 1994-12-28
CA2130333C (fr) 2002-11-26
HU9402590D0 (en) 1994-11-28
TW252971B (enExample) 1995-08-01
EP0630365B1 (fr) 1997-10-22
CZ218594A3 (en) 1995-11-15
AU3755793A (en) 1993-10-05
JPH07504425A (ja) 1995-05-18
SK108594A3 (en) 1995-02-08
JP3278768B2 (ja) 2002-04-30
FR2688499A1 (fr) 1993-09-17
KR100272650B1 (ko) 2000-11-15
NZ249899A (en) 1996-01-26
RU94045799A (ru) 1996-07-20
DK0630365T3 (da) 1998-03-02
DE69314779T2 (de) 1998-02-26
HU213621B (en) 1997-08-28
WO1993017997A1 (fr) 1993-09-16
CA2130333A1 (fr) 1993-09-16
CZ283613B6 (cs) 1998-05-13
MX9301268A (es) 1993-09-01
ZA931677B (en) 1993-10-06
SK281297B6 (sk) 2001-02-12
ES2109509T3 (es) 1998-01-16
US5763628A (en) 1998-06-09
RU2103258C1 (ru) 1998-01-27

Similar Documents

Publication Publication Date Title
FR2688499B1 (fr) Procede de preparation de la beta-phenylisoserine et de ses analogues.
DE69711391D1 (de) Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern
ES2032382T3 (es) Metodo para preparar un medicamento para la prevencion o tratamiento de la endometriosis.
ES542319A0 (es) Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
AU1331588A (en) Method for treatment of alcohol abuse
ZA959451B (en) 2,2-Dichloroalkanecarboxylic acids process of their production and pharmaceutical agents containing these
EP0270362A3 (en) Pyridinylpyrimidine derivatives, method for production thereof and a fungicide containing them as the active ingredient
GR3002299T3 (en) Composition of pregnanolole comprising a stable oil-in-water emulsion
GB9126725D0 (en) Process
DK0823909T3 (da) Hidtil ukendte heterocykliske forbindelser
ATE232387T1 (de) Verwendung eines inositoltriphosphatester, zur herstellung eines medikamentes
BR9610175A (pt) Composto processo de preparação do composto composição farmacêutica e utilização do composto
DE59610819D1 (de) Arzneistoffe zur selektiven bekämpfung von tumorgewebe
HU9503099D0 (en) New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components
ES2139934T3 (es) Procedimiento mejorado para preparar derivados de cadena lateral de ciclohexapeptidil lipopeptidos.
PT1214315E (pt) Esteres derivados do acido 1,4-di-hidropiridina-5-carboxilico e metodo para a sua preparacao
IT1246778B (it) Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1247508B (it) Composizioni farmaceutiche contenenti l&#39;estere 4-(2 metilamminoetil)- 1,2- fenilenicodell`acido 2-metilpropanoico per il trattamento della neurootticopatia glaucomatosa
ES2039260T3 (es) Derivado de 4-oxo-1,3-benzodioxano.

Legal Events

Date Code Title Description
ST Notification of lapse