NO304515B1 - FremgangsmÕte for fremstilling av <beta>-fenylisoserin og analoger derav samt mellomprodukt - Google Patents
FremgangsmÕte for fremstilling av <beta>-fenylisoserin og analoger derav samt mellomproduktInfo
- Publication number
- NO304515B1 NO304515B1 NO943280A NO943280A NO304515B1 NO 304515 B1 NO304515 B1 NO 304515B1 NO 943280 A NO943280 A NO 943280A NO 943280 A NO943280 A NO 943280A NO 304515 B1 NO304515 B1 NO 304515B1
- Authority
- NO
- Norway
- Prior art keywords
- pct
- phenylisoserine
- general formula
- beta
- analogs
- Prior art date
Links
- RZARFIRJROUVLM-GVHYBUMESA-N (3r)-3-amino-2-hydroxy-3-phenylpropanoic acid Chemical compound OC(=O)C(O)[C@H](N)C1=CC=CC=C1 RZARFIRJROUVLM-GVHYBUMESA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000000719 anti-leukaemic effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000003934 aromatic aldehydes Chemical class 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9202821A FR2688499B1 (fr) | 1992-03-10 | 1992-03-10 | Procede de preparation de la beta-phenylisoserine et de ses analogues. |
| PCT/FR1993/000224 WO1993017997A1 (fr) | 1992-03-10 | 1993-03-08 | PROCEDE DE PREPARATION DE LA β-PHENYLISOSERINE ET DE SES ANALOGUES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO943280L NO943280L (no) | 1994-09-05 |
| NO943280D0 NO943280D0 (no) | 1994-09-05 |
| NO304515B1 true NO304515B1 (no) | 1999-01-04 |
Family
ID=9427518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO943280A NO304515B1 (no) | 1992-03-10 | 1994-09-05 | FremgangsmÕte for fremstilling av <beta>-fenylisoserin og analoger derav samt mellomprodukt |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US5608102A (enExample) |
| EP (1) | EP0630365B1 (enExample) |
| JP (1) | JP3278768B2 (enExample) |
| KR (1) | KR100272650B1 (enExample) |
| AT (1) | ATE159512T1 (enExample) |
| AU (1) | AU667886B2 (enExample) |
| CA (1) | CA2130333C (enExample) |
| CZ (1) | CZ283613B6 (enExample) |
| DE (1) | DE69314779T2 (enExample) |
| DK (1) | DK0630365T3 (enExample) |
| ES (1) | ES2109509T3 (enExample) |
| FI (1) | FI113640B (enExample) |
| FR (1) | FR2688499B1 (enExample) |
| GE (1) | GEP19981430B (enExample) |
| GR (1) | GR3025117T3 (enExample) |
| HU (1) | HU213621B (enExample) |
| MX (1) | MX9301268A (enExample) |
| NO (1) | NO304515B1 (enExample) |
| NZ (1) | NZ249899A (enExample) |
| PL (1) | PL171551B1 (enExample) |
| RU (1) | RU2103258C1 (enExample) |
| SK (1) | SK281297B6 (enExample) |
| TW (1) | TW252971B (enExample) |
| WO (1) | WO1993017997A1 (enExample) |
| ZA (1) | ZA931677B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO116549B1 (ro) * | 1994-07-26 | 2001-03-30 | Indena Spa | Derivati de taxan, procedeu pentru prepararea acestora, intermediar pentru prepararea acestora si compozitie farmaceutica care ii contine |
| US6765015B2 (en) * | 1995-12-13 | 2004-07-20 | Xechem International, Inc. | Halogenated paclitaxel derivatives |
| KR100225535B1 (ko) | 1996-08-27 | 1999-10-15 | 정지석 | 파클리탁셀의 제조방법 |
| NZ503206A (en) | 1997-08-21 | 2002-05-31 | Univ Florida State | Method of taxane synthesis by treating with a base (potassium hydride or potassium hexamethyldisilazide) and a silylating agent (trialkylsilyl halide) |
| WO1999025334A1 (en) * | 1997-11-19 | 1999-05-27 | Xechem International, Inc. | Halogenated paclitaxel derivatives |
| ITMI991483A1 (it) * | 1999-07-06 | 2001-01-06 | Indena Spa | Derivati tassanici e procedimenti per la loro preparazione |
| JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| JP2002080435A (ja) * | 2000-06-26 | 2002-03-19 | Kanegafuchi Chem Ind Co Ltd | ３−アミノ−２−ヒドロキシプロピオン酸誘導体の製造法 |
| KR100851515B1 (ko) | 2001-03-07 | 2008-08-11 | 다이이찌 세이야꾸 가부시기가이샤 | 2-아제티디논 유도체의 제조방법 |
| DE602007003312D1 (de) * | 2007-02-22 | 2009-12-31 | Indena Spa | Verfahren zur Herstellung von (2r,3s)-3-Phenylisoserin-Methylester-Acetatsalz |
| DK2080764T3 (da) | 2008-01-18 | 2012-09-24 | Indena Spa | Faste former af ortataxel |
| CN102408356A (zh) * | 2011-09-28 | 2012-04-11 | 北京东方协和医药生物技术有限公司 | 一种多西他赛手性侧链中间体的制备方法 |
| ES2896882T3 (es) * | 2014-02-03 | 2022-02-28 | Quadriga Biosciences Inc | Beta-aminoácidos beta sustituidos y análogos como agentes quimioterapéuticos |
| CN111100026A (zh) * | 2019-12-30 | 2020-05-05 | 重庆市碚圣医药科技股份有限公司 | 一种紫杉醇恶唑环侧链中间体的制备方法 |
| CN112574134A (zh) * | 2020-12-30 | 2021-03-30 | 重庆市碚圣医药科技股份有限公司 | 一种多西紫杉醇侧链的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
| IT1231751B (it) * | 1989-04-12 | 1991-12-21 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina |
| US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5304670A (en) * | 1989-08-23 | 1994-04-19 | Centre National De La Recherche Scientifique | Process for the enantioselective preparation of phenylisoserine derivatives |
| FR2658510B1 (fr) * | 1990-02-21 | 1992-04-30 | Rhone Poulenc Sante | Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi. |
| US5294737A (en) * | 1992-02-27 | 1994-03-15 | The Research Foundation State University Of New York | Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom |
-
1992
- 1992-03-10 FR FR9202821A patent/FR2688499B1/fr not_active Expired - Fee Related
-
1993
- 1993-03-08 ES ES93918746T patent/ES2109509T3/es not_active Expired - Lifetime
- 1993-03-08 PL PL93305059A patent/PL171551B1/pl unknown
- 1993-03-08 AT AT93918746T patent/ATE159512T1/de active
- 1993-03-08 HU HU9402590A patent/HU213621B/hu unknown
- 1993-03-08 CZ CZ942185A patent/CZ283613B6/cs not_active IP Right Cessation
- 1993-03-08 AU AU37557/93A patent/AU667886B2/en not_active Expired
- 1993-03-08 JP JP51539493A patent/JP3278768B2/ja not_active Expired - Lifetime
- 1993-03-08 US US08/295,677 patent/US5608102A/en not_active Expired - Lifetime
- 1993-03-08 DE DE69314779T patent/DE69314779T2/de not_active Expired - Lifetime
- 1993-03-08 MX MX9301268A patent/MX9301268A/es unknown
- 1993-03-08 KR KR1019940703156A patent/KR100272650B1/ko not_active Expired - Lifetime
- 1993-03-08 EP EP93918746A patent/EP0630365B1/fr not_active Expired - Lifetime
- 1993-03-08 NZ NZ249899A patent/NZ249899A/en not_active IP Right Cessation
- 1993-03-08 CA CA002130333A patent/CA2130333C/fr not_active Expired - Lifetime
- 1993-03-08 SK SK1085-94A patent/SK281297B6/sk not_active IP Right Cessation
- 1993-03-08 RU RU94045799A patent/RU2103258C1/ru active
- 1993-03-08 DK DK93918746.4T patent/DK0630365T3/da active
- 1993-03-08 WO PCT/FR1993/000224 patent/WO1993017997A1/fr not_active Ceased
- 1993-03-08 GE GEAP19932472A patent/GEP19981430B/en unknown
- 1993-03-09 ZA ZA931677A patent/ZA931677B/xx unknown
- 1993-03-10 TW TW082101775A patent/TW252971B/zh not_active IP Right Cessation
-
1994
- 1994-09-05 NO NO943280A patent/NO304515B1/no not_active IP Right Cessation
- 1994-09-09 FI FI944169A patent/FI113640B/fi not_active IP Right Cessation
-
1996
- 1996-08-23 US US08/697,420 patent/US5763628A/en not_active Expired - Lifetime
-
1997
- 1997-10-23 GR GR970401615T patent/GR3025117T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |