MX9301268A - Procedimiento para la preparacion de la beta-fenilisoserina y sus analogos y productos obtenidos mediante el mismo. - Google Patents

Procedimiento para la preparacion de la beta-fenilisoserina y sus analogos y productos obtenidos mediante el mismo.

Info

Publication number
MX9301268A
MX9301268A MX9301268A MX9301268A MX9301268A MX 9301268 A MX9301268 A MX 9301268A MX 9301268 A MX9301268 A MX 9301268A MX 9301268 A MX9301268 A MX 9301268A MX 9301268 A MX9301268 A MX 9301268A
Authority
MX
Mexico
Prior art keywords
pct
beta
phenylysoserine
analogs
procedure
Prior art date
Application number
MX9301268A
Other languages
English (en)
Inventor
Jean-Dominique Bourzat
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of MX9301268A publication Critical patent/MX9301268A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

En la presente se describe un procedimiento para la preparación de la beta-fenilisoserina y de sus análogos de fórmula general (I) a partir de un aldehído aromático y de una S-alfa-metilarilamina pasando de manera intermediaria por una lactama de fórmula general (II).
MX9301268A 1992-03-10 1993-03-08 Procedimiento para la preparacion de la beta-fenilisoserina y sus analogos y productos obtenidos mediante el mismo. MX9301268A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9202821A FR2688499B1 (fr) 1992-03-10 1992-03-10 Procede de preparation de la beta-phenylisoserine et de ses analogues.

Publications (1)

Publication Number Publication Date
MX9301268A true MX9301268A (es) 1993-09-01

Family

ID=9427518

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301268A MX9301268A (es) 1992-03-10 1993-03-08 Procedimiento para la preparacion de la beta-fenilisoserina y sus analogos y productos obtenidos mediante el mismo.

Country Status (25)

Country Link
US (2) US5608102A (es)
EP (1) EP0630365B1 (es)
JP (1) JP3278768B2 (es)
KR (1) KR100272650B1 (es)
AT (1) ATE159512T1 (es)
AU (1) AU667886B2 (es)
CA (1) CA2130333C (es)
CZ (1) CZ283613B6 (es)
DE (1) DE69314779T2 (es)
DK (1) DK0630365T3 (es)
ES (1) ES2109509T3 (es)
FI (1) FI113640B (es)
FR (1) FR2688499B1 (es)
GE (1) GEP19981430B (es)
GR (1) GR3025117T3 (es)
HU (1) HU213621B (es)
MX (1) MX9301268A (es)
NO (1) NO304515B1 (es)
NZ (1) NZ249899A (es)
PL (1) PL171551B1 (es)
RU (1) RU2103258C1 (es)
SK (1) SK281297B6 (es)
TW (1) TW252971B (es)
WO (1) WO1993017997A1 (es)
ZA (1) ZA931677B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2195844C (en) * 1994-07-26 2001-10-09 Ezio Bombardelli Semi-synthetic taxanes with anti-tumoural activity
US6765015B2 (en) * 1995-12-13 2004-07-20 Xechem International, Inc. Halogenated paclitaxel derivatives
RU2219161C2 (ru) 1997-08-21 2003-12-20 Флорида Стейт Юниверсити Способ синтеза таксанов
EP1105118A4 (en) * 1997-11-19 2003-02-26 Xechem Inc HALOGEN DERIVATIVES OF PACLITAXEL
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
JP2002080435A (ja) * 2000-06-26 2002-03-19 Kanegafuchi Chem Ind Co Ltd ３−アミノ−２−ヒドロキシプロピオン酸誘導体の製造法
KR100851515B1 (ko) 2001-03-07 2008-08-11 다이이찌 세이야꾸 가부시기가이샤 2-아제티디논 유도체의 제조방법
SI1961735T1 (sl) * 2007-02-22 2010-01-29 Indena Spa Postopek za pripravo acetatne soli (2r,3s)-3-fenilizoserin-metilestra
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
CN102408356A (zh) * 2011-09-28 2012-04-11 北京东方协和医药生物技术有限公司 一种多西他赛手性侧链中间体的制备方法
AU2015210638B2 (en) * 2014-02-03 2017-07-20 Quadriga Biosciences, Inc. Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
CN111100026A (zh) * 2019-12-30 2020-05-05 重庆市碚圣医药科技股份有限公司 一种紫杉醇恶唑环侧链中间体的制备方法
CN112574134A (zh) * 2020-12-30 2021-03-30 重庆市碚圣医药科技股份有限公司 一种多西紫杉醇侧链的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5304670A (en) * 1989-08-23 1994-04-19 Centre National De La Recherche Scientifique Process for the enantioselective preparation of phenylisoserine derivatives
FR2658510B1 (fr) * 1990-02-21 1992-04-30 Rhone Poulenc Sante Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom

Also Published As

Publication number Publication date
RU94045799A (ru) 1996-07-20
CA2130333A1 (fr) 1993-09-16
FI944169A0 (fi) 1994-09-09
KR950700234A (ko) 1995-01-16
HU213621B (en) 1997-08-28
EP0630365B1 (fr) 1997-10-22
NO304515B1 (no) 1999-01-04
AU667886B2 (en) 1996-04-18
CZ283613B6 (cs) 1998-05-13
AU3755793A (en) 1993-10-05
GEP19981430B (en) 1998-10-30
FI944169A (fi) 1994-09-09
SK281297B6 (sk) 2001-02-12
FI113640B (fi) 2004-05-31
CZ218594A3 (en) 1995-11-15
NO943280D0 (no) 1994-09-05
FR2688499B1 (fr) 1994-05-06
HU9402590D0 (en) 1994-11-28
US5608102A (en) 1997-03-04
HUT68540A (en) 1995-06-28
FR2688499A1 (fr) 1993-09-17
JPH07504425A (ja) 1995-05-18
DK0630365T3 (da) 1998-03-02
GR3025117T3 (en) 1998-01-30
ATE159512T1 (de) 1997-11-15
KR100272650B1 (ko) 2000-11-15
CA2130333C (fr) 2002-11-26
NZ249899A (en) 1996-01-26
TW252971B (es) 1995-08-01
EP0630365A1 (fr) 1994-12-28
DE69314779D1 (de) 1997-11-27
ZA931677B (en) 1993-10-06
WO1993017997A1 (fr) 1993-09-16
US5763628A (en) 1998-06-09
ES2109509T3 (es) 1998-01-16
RU2103258C1 (ru) 1998-01-27
DE69314779T2 (de) 1998-02-26
JP3278768B2 (ja) 2002-04-30
SK108594A3 (en) 1995-02-08
PL171551B1 (pl) 1997-05-30
NO943280L (no) 1994-09-05

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