ES2099479T3 - Procedimiento para la preparacion estereoselectiva de un derivado de la beta-fenilisoserina y su utilizacion para la preparacion de derivados del taxano. - Google Patents

Procedimiento para la preparacion estereoselectiva de un derivado de la beta-fenilisoserina y su utilizacion para la preparacion de derivados del taxano.

Info

Publication number
ES2099479T3
ES2099479T3 ES93921981T ES93921981T ES2099479T3 ES 2099479 T3 ES2099479 T3 ES 2099479T3 ES 93921981 T ES93921981 T ES 93921981T ES 93921981 T ES93921981 T ES 93921981T ES 2099479 T3 ES2099479 T3 ES 2099479T3
Authority
ES
Spain
Prior art keywords
formula
pct
preparation
iii
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921981T
Other languages
English (en)
Inventor
Jean-Noel Denis
Andrew Greene
Alice Kanazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2099479T3 publication Critical patent/ES2099479T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C27/00—Processes involving the simultaneous production of more than one class of oxygen-containing compounds
    • C07C27/20—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction
    • C07C27/22—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction with the use of catalysts which are specific for this process
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCESO DE PREPARACION ESTEREOSELECTIVA DE UN DERIVADO DE LA BETA-FENILISOSERINA DE FORMULA (I) POR ACCION DE UNA NCARBONILBENCILIMINA DE FORMULA (II) SOBRE N AMIDO OPTICAMENTE ACTIVO DE UN ACIDO HIDROXIACETICO PROTEGIDO DE LA FORMULA (II), SEGUIDA DE LA HIDROLISIS DE PRODUCTO OBTENIDO. EN LAS FORMULAS (I), (II) O (III), R REPRESENTA UN RADICAL FENILO EVENTUALMENTE SUSTITUIDO O R1-O, AR, REPRESENTA UN RADICAL ARILO EVENTUALMENTE SUSTITUIDO Y G1 REPRESENTA UN GRUPO PROTECTOR DE LA FUNCION HIDROXI. EL PRODUCTO DE FORMULA (I) ES PARTICULARMENTE UTIL PARA LA PREPARCION DEL TAXOL Y DEL TAXOLTERE QUE PRESENTAN PROPIEDADES ANTIUMORALES NOTABLES.
ES93921981T 1992-10-05 1993-10-04 Procedimiento para la preparacion estereoselectiva de un derivado de la beta-fenilisoserina y su utilizacion para la preparacion de derivados del taxano. Expired - Lifetime ES2099479T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211740A FR2696454B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation stéréosélective d'un dérivé de la beta-phénylisosérine et son utilisation pour la préparation de dérivés du Taxane.

Publications (1)

Publication Number Publication Date
ES2099479T3 true ES2099479T3 (es) 1997-05-16

Family

ID=9434118

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921981T Expired - Lifetime ES2099479T3 (es) 1992-10-05 1993-10-04 Procedimiento para la preparacion estereoselectiva de un derivado de la beta-fenilisoserina y su utilizacion para la preparacion de derivados del taxano.

Country Status (23)

Country Link
US (2) US5726346A (es)
EP (1) EP0663901B1 (es)
JP (1) JPH08502051A (es)
KR (1) KR100290664B1 (es)
AT (1) ATE150451T1 (es)
AU (1) AU682011B2 (es)
CA (1) CA2146374A1 (es)
CZ (1) CZ283290B6 (es)
DE (1) DE69309086T2 (es)
DK (1) DK0663901T3 (es)
ES (1) ES2099479T3 (es)
FI (1) FI951589A0 (es)
FR (1) FR2696454B1 (es)
GR (1) GR3022872T3 (es)
HU (1) HUT73171A (es)
MX (1) MX9305765A (es)
NZ (1) NZ256444A (es)
PL (2) PL173791B1 (es)
RU (1) RU2109010C1 (es)
SK (1) SK280576B6 (es)
TW (1) TW436476B (es)
WO (1) WO1994007847A1 (es)
ZA (1) ZA937317B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025516A (en) * 1998-10-14 2000-02-15 Chiragene, Inc. Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
WO2010024762A1 (en) * 2008-08-26 2010-03-04 Organoclick Aktiebolag PREPARATION OF β-PHENYL-ISOSERINE DERIVATIVES
WO2010062239A1 (en) * 2008-11-03 2010-06-03 Cordova Armando A catalytic asymmetric method for the preparation of the paclitaxel (taxol) c-13 side-chain derivatives and its use in the preparation of taxane derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
IL95436A (en) * 1989-08-23 1996-07-23 Centre Nat Rech Scient Process for preparing the history of phenylisosarine
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
US5684175A (en) * 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor

Also Published As

Publication number Publication date
TW436476B (en) 2001-05-28
PL173791B1 (pl) 1998-04-30
SK43795A3 (en) 1995-09-13
KR100290664B1 (ko) 2001-09-17
EP0663901A1 (fr) 1995-07-26
PL308240A1 (en) 1995-07-24
RU2109010C1 (ru) 1998-04-20
RU95111377A (ru) 1996-12-27
CZ283290B6 (cs) 1998-02-18
FR2696454B1 (fr) 1994-11-25
FI951589A (fi) 1995-04-04
HUT73171A (en) 1996-06-28
FR2696454A1 (fr) 1994-04-08
CZ84095A3 (en) 1995-09-13
HU9500966D0 (en) 1995-06-28
AU5114993A (en) 1994-04-26
KR950703499A (ko) 1995-09-20
AU682011B2 (en) 1997-09-18
NZ256444A (en) 1996-06-25
US5726346A (en) 1998-03-10
US6114550A (en) 2000-09-05
CA2146374A1 (fr) 1994-04-14
WO1994007847A1 (fr) 1994-04-14
SK280576B6 (sk) 2000-04-10
ATE150451T1 (de) 1997-04-15
DK0663901T3 (da) 1997-04-14
JPH08502051A (ja) 1996-03-05
DE69309086T2 (de) 1997-09-25
MX9305765A (es) 1994-05-31
DE69309086D1 (de) 1997-04-24
ZA937317B (en) 1994-04-22
GR3022872T3 (en) 1997-06-30
FI951589A0 (fi) 1995-04-04
EP0663901B1 (fr) 1997-03-19
PL176503B1 (pl) 1999-06-30

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