FR2679903B1 - Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. - Google Patents

Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.

Info

Publication number
FR2679903B1
FR2679903B1 FR9109908A FR9109908A FR2679903B1 FR 2679903 B1 FR2679903 B1 FR 2679903B1 FR 9109908 A FR9109908 A FR 9109908A FR 9109908 A FR9109908 A FR 9109908A FR 2679903 B1 FR2679903 B1 FR 2679903B1
Authority
FR
France
Prior art keywords
alkyl
mono
substd
halogen
opt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9109908A
Other languages
English (en)
French (fr)
Other versions
FR2679903A1 (fr
Inventor
Jean Wagnon
Claude Plouzane
Claudine Serradeil-Legal
Dino Nisato
Bernard Tonnerre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elf Sanofi SA
Original Assignee
Elf Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9109908A priority Critical patent/FR2679903B1/fr
Application filed by Elf Sanofi SA filed Critical Elf Sanofi SA
Priority to BR9205336A priority patent/BR9205336A/pt
Priority to JP5503337A priority patent/JP2633085B2/ja
Priority to RU93005168A priority patent/RU2104268C1/ru
Priority to PCT/FR1992/000758 priority patent/WO1993003013A1/fr
Priority to ZA925781A priority patent/ZA925781B/xx
Priority to LVP-92-87A priority patent/LV10091B/lv
Priority to CZ1993682A priority patent/CZ288173B6/cs
Priority to NZ243795A priority patent/NZ243795A/en
Priority to MX9204487A priority patent/MX9204487A/es
Priority to SK426-93A priority patent/SK283463B6/sk
Priority to UA93002340A priority patent/UA27238C2/uk
Priority to KR1019930701034A priority patent/KR100241583B1/ko
Priority to CA002093221A priority patent/CA2093221C/en
Priority to AU24758/92A priority patent/AU658664B2/en
Priority to IL102703A priority patent/IL102703A/xx
Priority to LTIP114A priority patent/LT3064B/lt
Priority to IL11759292A priority patent/IL117592A/xx
Priority to HU9300951A priority patent/HUT68927A/hu
Priority to PH44760A priority patent/PH30661A/en
Priority to MYPI92001379A priority patent/MY110517A/en
Priority to CA002206776A priority patent/CA2206776C/en
Priority to US07/923,839 priority patent/US5338755A/en
Priority to EP92402213A priority patent/EP0526348B1/fr
Priority to ES92402213T priority patent/ES2117038T3/es
Priority to SG1996002367A priority patent/SG47501A1/en
Priority to DE69224450T priority patent/DE69224450T2/de
Priority to AT92402213T priority patent/ATE163289T1/de
Priority to DK92402213T priority patent/DK0526348T3/da
Publication of FR2679903A1 publication Critical patent/FR2679903A1/fr
Priority to FI931476A priority patent/FI104069B1/fi
Priority to NO931262A priority patent/NO180047C/no
Application granted granted Critical
Publication of FR2679903B1 publication Critical patent/FR2679903B1/fr
Priority to US08/240,360 priority patent/US5397801A/en
Priority to US08/348,150 priority patent/US5481005A/en
Priority to AU11541/95A priority patent/AU691223B2/en
Priority to US08/458,614 priority patent/US5578633A/en
Priority to HU95P/P00474P priority patent/HU211884A9/hu
Priority to IL11759296A priority patent/IL117592A0/xx
Priority to FI980175A priority patent/FI107048B/fi
Priority to HK98108861A priority patent/HK1008741A1/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
FR9109908A 1990-07-31 1991-08-02 Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. Expired - Fee Related FR2679903B1 (fr)

Priority Applications (39)

Application Number Priority Date Filing Date Title
FR9109908A FR2679903B1 (fr) 1991-08-02 1991-08-02 Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.
CA002206776A CA2206776C (en) 1991-08-02 1992-07-31 N-sulfonylindoline derivatives carrying an amide functional group, their preparation and the pharmaceutical compositions in which they are present
RU93005168A RU2104268C1 (ru) 1991-08-02 1992-07-31 Индолиновые производные, способ их получения, промежуточные соединения, фармацевтическая композиция
JP5503337A JP2633085B2 (ja) 1991-08-02 1992-07-31 アミド官能基を有するインドリン誘導体、それらの調製、およびそれらが内在する医薬組成物
ZA925781A ZA925781B (en) 1991-08-02 1992-07-31 Indoline derivatives carrying an amide functional group, their preparation and the pharmaceutical compositions in which they are present.
LVP-92-87A LV10091B (en) 1991-08-02 1992-07-31 Amidoindoline derivatives, method of preparation thereof and pharmaceutical composition containing them
CZ1993682A CZ288173B6 (en) 1991-08-02 1992-07-31 Indoline derivatives, process of their preparation, intermediates for this process and pharmaceutical preparation in which these derivatives are comprised
NZ243795A NZ243795A (en) 1991-08-02 1992-07-31 2-carbonylamino-1-sulphonyl indoline derivatives, preparatory processes and pharmaceutical compositions
MX9204487A MX9204487A (es) 1991-08-02 1992-07-31 Derivados de indolina y proceso para su obtencion.
SK426-93A SK283463B6 (sk) 1991-08-02 1992-07-31 Indolínové deriváty, spôsob ich prípravy, medziprodukty tohto spôsobu a farmaceutický prostriedok obsahujúci tieto deriváty
UA93002340A UA27238C2 (uk) 1991-08-02 1992-07-31 Індолінові похідні, а також їх фармацевтично прийнятні солі, що є антагоністами вазопресинових v1-рецепторів, спосіб їх одержання, проміжні продукти і фармацевтична композиція
KR1019930701034A KR100241583B1 (ko) 1991-08-02 1992-07-31 아미드 작용기를 갖는 인돌린 유도체, 그의 제조방법 및 그를 함유하는 약학적 조성물
CA002093221A CA2093221C (en) 1991-08-02 1992-07-31 N-sulfonylindoline derivatives carrying an amide functional group, their preparation, and the pharmaceutical compositions in which they are present
AU24758/92A AU658664B2 (en) 1991-08-02 1992-07-31 Indoline derivatives having an amide function, their preparation, and pharmaceutical compositions containing them
IL102703A IL102703A (en) 1991-08-02 1992-07-31 N-sulfonyl indoline derivatives carrying an amide functional group, their preparation and pharmaceutical compositions containing them
LTIP114A LT3064B (en) 1991-08-02 1992-07-31 Indolineamide derivatives, process for the preparation thereof and pharmaceutical compositions containing the same
IL11759292A IL117592A (en) 1991-08-02 1992-07-31 N-substituted sulfonamidobenzene compounds
HU9300951A HUT68927A (en) 1991-08-02 1992-07-31 Process for producing indoline derivatives and pharmaceutical compositions containing them
PH44760A PH30661A (en) 1991-08-02 1992-07-31 N-sulfonylindoline derivatives their preparation and the pharmaceutical compositions in which tey are present
MYPI92001379A MY110517A (en) 1991-08-02 1992-07-31 Indoline derivatives carrying an amide functional group their preparation and the pharmaceutical compositions in which they are present.
BR9205336A BR9205336A (pt) 1991-08-02 1992-07-31 Composto,processo para a preparacao do mesmo,utilizacao do composto e composicao farmaceutica
PCT/FR1992/000758 WO1993003013A1 (fr) 1991-08-02 1992-07-31 Derives d'indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant
DK92402213T DK0526348T3 (da) 1991-08-02 1992-08-03 Indolderivater, der bærer en amidfunktion, samt deres fremstilling og farmaceutiske sammensætninger indeholdende sådanne
EP92402213A EP0526348B1 (fr) 1991-08-02 1992-08-03 Dérivés d'indoline portant une fonction amidique, leur préparation, les compositions pharmaceutiques en contenant
ES92402213T ES2117038T3 (es) 1991-08-02 1992-08-03 Derivados de indolina que llevan una funcion amidica, su preparacion, las composiciones farmaceuticas que los contienen.
SG1996002367A SG47501A1 (en) 1991-08-02 1992-08-03 N-sulfonyl indoline derivatives carrying an amide functional group their preparation and the pharmaceutical compositions in which they are present
DE69224450T DE69224450T2 (de) 1991-08-02 1992-08-03 Indolinderivate mit einer Amidgruppe, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US07/923,839 US5338755A (en) 1990-07-31 1992-08-03 N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
AT92402213T ATE163289T1 (de) 1991-08-02 1992-08-03 Indolinderivate mit einer amidgruppe, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen
NO931262A NO180047C (no) 1991-08-02 1993-04-01 Indolinderivater med en amidgruppe og farmasöytiske blandinger som inneholder dem
FI931476A FI104069B1 (fi) 1991-08-02 1993-04-01 Menetelmä terapeuttisesti käyttökelpoisten 3-(fenyyli- tai sykloalkyyli)-3-hydroksi-1-fenyylisulfonyyli-2-indoliinikarboksamidijohdannaisten valmistamiseksi
US08/240,360 US5397801A (en) 1990-07-31 1994-05-10 N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
US08/348,150 US5481005A (en) 1990-07-31 1994-11-28 N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
AU11541/95A AU691223B2 (en) 1991-08-02 1995-02-03 Intermediates useful in the preparation of indoline derivatives carrying an amide functional group
US08/458,614 US5578633A (en) 1990-07-31 1995-06-02 N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
HU95P/P00474P HU211884A9 (en) 1991-08-02 1995-06-28 Indoline derivatives and pharmaceutical compositions containing them
IL11759296A IL117592A0 (en) 1991-08-02 1996-03-21 N-substituted sulfonamidobenzene compounds
FI980175A FI107048B (fi) 1991-08-02 1998-01-27 2-sulfonamidofenonijohdannaisia
HK98108861A HK1008741A1 (en) 1991-08-02 1998-07-03 Indoline derivatives carrying an amide function their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9109908A FR2679903B1 (fr) 1991-08-02 1991-08-02 Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.

Publications (2)

Publication Number Publication Date
FR2679903A1 FR2679903A1 (fr) 1993-02-05
FR2679903B1 true FR2679903B1 (fr) 1993-12-03

Family

ID=9415909

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9109908A Expired - Fee Related FR2679903B1 (fr) 1990-07-31 1991-08-02 Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.

Country Status (29)

Country Link
EP (1) EP0526348B1 (sk)
JP (1) JP2633085B2 (sk)
KR (1) KR100241583B1 (sk)
AT (1) ATE163289T1 (sk)
AU (2) AU658664B2 (sk)
BR (1) BR9205336A (sk)
CA (2) CA2093221C (sk)
CZ (1) CZ288173B6 (sk)
DE (1) DE69224450T2 (sk)
DK (1) DK0526348T3 (sk)
ES (1) ES2117038T3 (sk)
FI (2) FI104069B1 (sk)
FR (1) FR2679903B1 (sk)
HK (1) HK1008741A1 (sk)
HU (2) HUT68927A (sk)
IL (3) IL117592A (sk)
LT (1) LT3064B (sk)
LV (1) LV10091B (sk)
MX (1) MX9204487A (sk)
MY (1) MY110517A (sk)
NO (1) NO180047C (sk)
NZ (1) NZ243795A (sk)
PH (1) PH30661A (sk)
RU (1) RU2104268C1 (sk)
SG (1) SG47501A1 (sk)
SK (1) SK283463B6 (sk)
UA (1) UA27238C2 (sk)
WO (1) WO1993003013A1 (sk)
ZA (1) ZA925781B (sk)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665441B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
FR2708608B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant.
FR2756736B1 (fr) * 1996-12-05 1999-03-05 Sanofi Sa Compositions pharmaceutiques contenant des derives de n-sulfonyl indoline
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en) 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
EP0994896A1 (en) * 1997-07-31 2000-04-26 Elan Pharmaceuticals, Inc. Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4
CA2290749A1 (en) * 1997-07-31 1999-02-11 Elan Pharmaceuticals, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
IL133641A0 (en) * 1997-07-31 2001-04-30 Elan Pharm Inc Compounds which inhibit leukocyte adhesion mediated by vla-4
US6291453B1 (en) 1997-07-31 2001-09-18 Athena Neurosciences, Inc. 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
FR2775598A1 (fr) * 1998-03-06 1999-09-10 Sanofi Sa Compositions pharmaceutiques contenant en association un antagoniste selectif des recepteurs v1a de l'arginine-vasopressine et un antagoniste selectif des recepteur v2 de l'arginine-vasopressine
FR2778103A1 (fr) * 1998-04-29 1999-11-05 Sanofi Sa Compositions pharmaceutiques contenant en association un antagoniste v1a de l'arginine-vasopressine et un antagoniste des recepteurs at1 de l'angiotensine ii
FR2786486B3 (fr) * 1998-11-16 2000-12-08 Sanofi Sa Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates
CN1220683C (zh) 1999-01-22 2005-09-28 依兰制药公司 用于治疗与vla－4有关的疾病的酰基衍生物
TW593284B (en) 1999-01-22 2004-06-21 Elan Pharm Inc Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
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FR2679903A1 (fr) 1993-02-05
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LV10091B (en) 1995-04-20
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