FR2191887A1 - 7-Substd 5-hydroxy-imidazo pyrimidines - antiinflammatories, and immuno-suppressives, from 2-aminoimidazoline and substd ethyl acetates - Google Patents

7-Substd 5-hydroxy-imidazo pyrimidines - antiinflammatories, and immuno-suppressives, from 2-aminoimidazoline and substd ethyl acetates

Info

Publication number
FR2191887A1
FR2191887A1 FR7224618A FR7224618A FR2191887A1 FR 2191887 A1 FR2191887 A1 FR 2191887A1 FR 7224618 A FR7224618 A FR 7224618A FR 7224618 A FR7224618 A FR 7224618A FR 2191887 A1 FR2191887 A1 FR 2191887A1
Authority
FR
France
Prior art keywords
substd
aminoimidazoline
antiinflammatories
immuno
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7224618A
Other languages
French (fr)
Other versions
FR2191887B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Original Assignee
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Produits Chimiques Ugine Kuhlmann, Ugine Kuhlmann SA filed Critical Produits Chimiques Ugine Kuhlmann
Priority to FR7224618A priority Critical patent/FR2191887A1/en
Publication of FR2191887A1 publication Critical patent/FR2191887A1/en
Application granted granted Critical
Publication of FR2191887B1 publication Critical patent/FR2191887B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel imidazo 1,2-a pyrimidine derivs of formula (I) (where R1 is H, alkyl, benzyl or ethoxycarbonyl-alkyl, and R2 is >=3C alkyl, or alkenyl, cycloalkyl, carboxy, ethoxycarbonylalkyl, phenyl substd by halogen, alkyl, NO2, amino, alkoxy, benzoyloxy, OH or alkylsulphonyl, or R2 is heterocyclyl). are useful as antipyretics, antiinflammatories, antirheumatics and immuno-suppressive agents. They are prepd by reacting 2-aminoimidazoline with R2COCHR1COOC2H5.
FR7224618A 1972-07-07 1972-07-07 7-Substd 5-hydroxy-imidazo pyrimidines - antiinflammatories, and immuno-suppressives, from 2-aminoimidazoline and substd ethyl acetates Granted FR2191887A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7224618A FR2191887A1 (en) 1972-07-07 1972-07-07 7-Substd 5-hydroxy-imidazo pyrimidines - antiinflammatories, and immuno-suppressives, from 2-aminoimidazoline and substd ethyl acetates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7224618A FR2191887A1 (en) 1972-07-07 1972-07-07 7-Substd 5-hydroxy-imidazo pyrimidines - antiinflammatories, and immuno-suppressives, from 2-aminoimidazoline and substd ethyl acetates

Publications (2)

Publication Number Publication Date
FR2191887A1 true FR2191887A1 (en) 1974-02-08
FR2191887B1 FR2191887B1 (en) 1975-08-08

Family

ID=9101514

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7224618A Granted FR2191887A1 (en) 1972-07-07 1972-07-07 7-Substd 5-hydroxy-imidazo pyrimidines - antiinflammatories, and immuno-suppressives, from 2-aminoimidazoline and substd ethyl acetates

Country Status (1)

Country Link
FR (1) FR2191887A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858602B2 (en) 2001-06-12 2005-02-22 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2011970A1 (en) * 1970-03-13 1971-11-18 CH. Boehringer Sohn, 6507 Ingelheim Imidazo-(1, 2-a)- pyrimidines prepn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2011970A1 (en) * 1970-03-13 1971-11-18 CH. Boehringer Sohn, 6507 Ingelheim Imidazo-(1, 2-a)- pyrimidines prepn

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BULLETIN DES SOCIETES CHIMIQUES BELGES 59, 573-87 1950 .) *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858602B2 (en) 2001-06-12 2005-02-22 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US6916848B2 (en) 2001-06-12 2005-07-12 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US6924314B2 (en) 2001-06-12 2005-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US6946491B2 (en) 2001-06-12 2005-09-20 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7012071B2 (en) 2001-06-12 2006-03-14 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7041659B2 (en) 2001-06-12 2006-05-09 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7045541B2 (en) 2001-06-12 2006-05-16 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7101910B2 (en) 2001-06-12 2006-09-05 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7329782B2 (en) 2001-06-12 2008-02-12 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7547802B2 (en) 2001-06-12 2009-06-16 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7863475B2 (en) 2001-06-12 2011-01-04 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US8487000B2 (en) 2001-06-12 2013-07-16 Wellstat Therapertics Corporation Compound for the treatment of metabolic disorders
US8552062B2 (en) 2001-06-12 2013-10-08 Wellstat Therapeutics Corporation Methods for the treatment of metabolic disorders such as diabetes
US8604083B2 (en) 2001-06-12 2013-12-10 Wellstat Therapeutics Corporation Method for the treatment of metabolic disorders

Also Published As

Publication number Publication date
FR2191887B1 (en) 1975-08-08

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Legal Events

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TP Transmission of property
CD Change of name or company name
TP Transmission of property
ST Notification of lapse