GB1234635A - - Google Patents
Info
- Publication number
- GB1234635A GB1234635A GB4362768A GB1234635DA GB1234635A GB 1234635 A GB1234635 A GB 1234635A GB 4362768 A GB4362768 A GB 4362768A GB 1234635D A GB1234635D A GB 1234635DA GB 1234635 A GB1234635 A GB 1234635A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- substituted
- halophenyl
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Abstract
1,234,635. Triazolo [1,5-a]pyrimidine derivatives. IMPERIAL CHEMICAL INDUSTRIES Ltd. 11 Aug., 1969 [13 Sept., 1968; 1 May, 1969], Nos. 43627/68 and 22266/69. Heading C2C. [Also in Division A5] The invention comprises compounds of formula wherein R<SP>1</SP> is NH 2 (possibly substituted by 1 or 2 acyl, i.e. R<SP>4</SP>CO or R<SP>4</SP>CS radicals, where R<SP>4</SP> is C 1-6 alkyl or alkoxy, Ph or halophenyl), C 1-10 alkylamino, (up to C 15 ) phenylalkylamino or halophenylalkylamino, acylated derivatives of any of these 3 radicals where "acyl" is defined as above, ureido (optionally substituted by C 1-6 alkyl, Ph or halophenyl), CO 2 H, HOCH 2 , or (optionally C 1-6 alkyl-substituted) CONH 2 or CONHNH 2 ; R<SP>2</SP> is C 1-10 alkyl, C 3-6 cycloalkyl or C 2-4 alkenyl; R<SP>3</SP> is H, halogen or C 1-10 alkyl or hydroxyalkyl; one of X and Y is O= or S=, and the other is H or C 1-4 alkyl, the nucleus containing a double bond in one of the positions indicated by the broken line; and pharmaceutically acceptable base addition salts of such compounds containing an acidic group. These compounds may be prepared by commencing with a 3-R<SP>1</SP>-5-R<SP>2</SP>NH-triazole and forming the pyrimidine ring, by substitution of the corresponding triazolopyrimidines where R<SP>2</SP>=H, or by many other standard reactions described in the Specification. Further exemplified intermediates include substituted 4-isodithiobiurets and 2,4-diisodithiobiurets; and compounds of the above formula where R<SP>1</SP> is NCO, NCS or CO 2 Me, or where R<SP>1</SP> =NH 2 while R<SP>2</SP>=H, R<SP>3</SP>=CO 2 H, X=O and Y=Me.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4362768 | 1968-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1234635A true GB1234635A (en) | 1971-06-09 |
Family
ID=10429621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4362768A Expired GB1234635A (en) | 1968-09-13 | 1968-09-13 |
Country Status (6)
| Country | Link |
|---|---|
| AT (2) | AT292697B (en) |
| BR (1) | BR6912007D0 (en) |
| CS (1) | CS163196B2 (en) |
| GB (1) | GB1234635A (en) |
| PL (2) | PL80539B1 (en) |
| ZA (1) | ZA695832B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2805483A1 (en) * | 1977-02-11 | 1978-08-17 | Ici Ltd | EMERGING CHEMICAL COMPOSITIONS FOR PROTECTION AGAINST POISONING |
-
1968
- 1968-09-13 GB GB4362768A patent/GB1234635A/en not_active Expired
-
1969
- 1969-08-14 ZA ZA695832A patent/ZA695832B/en unknown
- 1969-08-15 PL PL1969139471A patent/PL80539B1/en unknown
- 1969-08-15 PL PL1969135379A patent/PL80261B1/en unknown
- 1969-08-29 BR BR212007/69A patent/BR6912007D0/en unknown
- 1969-09-03 CS CS6023A patent/CS163196B2/cs unknown
- 1969-09-12 AT AT866870A patent/AT292697B/en not_active IP Right Cessation
- 1969-09-12 AT AT871769A patent/AT292000B/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2805483A1 (en) * | 1977-02-11 | 1978-08-17 | Ici Ltd | EMERGING CHEMICAL COMPOSITIONS FOR PROTECTION AGAINST POISONING |
| US4269820A (en) | 1977-02-11 | 1981-05-26 | Imperial Chemical Industries Limited | Safeguarded toxic chemical compositions containing effective emesis-inducing S-triazolo-[1,5-α]pyrimidine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| PL80261B1 (en) | 1975-08-30 |
| PL80539B1 (en) | 1975-08-30 |
| AT292697B (en) | 1971-09-10 |
| BR6912007D0 (en) | 1973-04-19 |
| CS163196B2 (en) | 1975-08-29 |
| ZA695832B (en) | 1971-03-31 |
| AT292000B (en) | 1971-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |