GB1237788A - 2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines - Google Patents
2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidinesInfo
- Publication number
- GB1237788A GB1237788A GB38447/69A GB3844769A GB1237788A GB 1237788 A GB1237788 A GB 1237788A GB 38447/69 A GB38447/69 A GB 38447/69A GB 3844769 A GB3844769 A GB 3844769A GB 1237788 A GB1237788 A GB 1237788A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrimidines
- compounds
- july
- above formula
- pyrimido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
1,237,788. Pyrimido[5,4-d]pyrimidines. DR. KARL THOMAE G.m.b.H. 31 July, 1969 [31 July, 1968; 1 July, 1969 (2)], No. 38447/69. Heading C2C. The invention comprises compounds of formula wherein R 1 is C 1-3 alkyl, allyl or benzyl, R 2 is C 1-3 alkyl or allyl (or NR 1 R 2 is piperidino substituted by 1 or 2 Me or Et groups in the 2,3 and/or 6-positions, or is 1,2,5,6-tetrahydropyridino, hexamethyleneimino, heptamethyleneimino, 3,6 - ethylenehexamethyleneimino, indolino or 1,2,3,4-tetrahydroisoquinolino), and R 3 , R 4 are each C 2-3 -hydroxyalkyl. These compounds are prepared by (1) oxidizing the corresponding 1,2,3,4-tetrahydropyrimido[5,4-d]- pyrimidines (formed by reducing compounds of the above formula having additionally a 4- NR 1 R 2 group), or (2) reacting a compound of the above formula, having a replaceable substituent in place of one or more of the amino groups shown, with HNR 1 R 2 or HNR 3 R 4 . Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which are physiologically active on the heart and circulation, and inhibit thrombocyte aggregation.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19681795030 DE1795030A1 (en) | 1968-07-31 | 1968-07-31 | New 2,6-bis (diaethanolamino) pyrimido [5,4-d] pyrimidines |
DE19691933427 DE1933427A1 (en) | 1969-07-01 | 1969-07-01 | 2,6-Bis-(dialkanolamino)-8-aminopyrimido-(5,4,d)-pyrimidines |
DE19691933428 DE1933428A1 (en) | 1969-07-01 | 1969-07-01 | 2,6-Bis-(dialkanolamino)-8-aminopyrimido-(5,4,d)-pyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1237788A true GB1237788A (en) | 1971-06-30 |
Family
ID=27181475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB38447/69A Expired GB1237788A (en) | 1968-07-31 | 1969-07-31 | 2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines |
Country Status (12)
Country | Link |
---|---|
AT (2) | AT296992B (en) |
BE (1) | BE736917A (en) |
CA (1) | CA932331A (en) |
CH (2) | CH513881A (en) |
ES (2) | ES370067A1 (en) |
FR (1) | FR2014089B1 (en) |
GB (1) | GB1237788A (en) |
IL (1) | IL32739A (en) |
NL (1) | NL6911721A (en) |
PL (1) | PL80164B1 (en) |
RO (1) | RO56153A (en) |
SE (1) | SE351849B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2004201A1 (en) * | 1970-01-30 | 1971-08-05 | Thomae Gmbh Dr K | New 2,6-bis (dialkanolamino) -pyrimido- [5,4-d] pyrimidines and process for their preparation |
US4963541A (en) * | 1989-02-22 | 1990-10-16 | Abbott Laboratories | Pyrimido-pyrimidine lipoxygenase inhibiting compounds |
-
1969
- 1969-07-28 SE SE10590/69A patent/SE351849B/xx unknown
- 1969-07-30 ES ES370067A patent/ES370067A1/en not_active Expired
- 1969-07-30 RO RO62642A patent/RO56153A/ro unknown
- 1969-07-30 ES ES370068A patent/ES370068A1/en not_active Expired
- 1969-07-30 IL IL32739A patent/IL32739A/en unknown
- 1969-07-30 AT AT735369A patent/AT296992B/en not_active IP Right Cessation
- 1969-07-30 PL PL1969135130A patent/PL80164B1/pl unknown
- 1969-07-30 AT AT388571A patent/AT297717B/en not_active IP Right Cessation
- 1969-07-31 GB GB38447/69A patent/GB1237788A/en not_active Expired
- 1969-07-31 CH CH1169669D patent/CH513881A/en not_active IP Right Cessation
- 1969-07-31 BE BE736917D patent/BE736917A/xx unknown
- 1969-07-31 CH CH1187971A patent/CH529143A/en not_active IP Right Cessation
- 1969-07-31 NL NL6911721A patent/NL6911721A/xx unknown
- 1969-07-31 CA CA058376A patent/CA932331A/en not_active Expired
- 1969-07-31 FR FR6926306A patent/FR2014089B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES370068A1 (en) | 1971-04-01 |
FR2014089A1 (en) | 1970-04-10 |
SE351849B (en) | 1972-12-11 |
CH513881A (en) | 1971-10-15 |
NL6911721A (en) | 1970-02-03 |
PL80164B1 (en) | 1975-08-30 |
AT296992B (en) | 1972-03-10 |
CA932331A (en) | 1973-08-21 |
FR2014089B1 (en) | 1974-08-09 |
ES370067A1 (en) | 1971-04-01 |
CH529143A (en) | 1972-10-15 |
SU429582A3 (en) | 1974-05-25 |
IL32739A0 (en) | 1969-09-25 |
IL32739A (en) | 1973-07-30 |
BE736917A (en) | 1970-02-02 |
RO56153A (en) | 1974-03-01 |
AT297717B (en) | 1972-04-10 |
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