ES370068A1 - 2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines - Google Patents

2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines

Info

Publication number
ES370068A1
ES370068A1 ES370068A ES370068A ES370068A1 ES 370068 A1 ES370068 A1 ES 370068A1 ES 370068 A ES370068 A ES 370068A ES 370068 A ES370068 A ES 370068A ES 370068 A1 ES370068 A1 ES 370068A1
Authority
ES
Spain
Prior art keywords
compounds
above formula
pyrimidines
hnr
allyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES370068A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19681795030 external-priority patent/DE1795030A1/en
Priority claimed from DE19691933427 external-priority patent/DE1933427A1/en
Priority claimed from DE19691933428 external-priority patent/DE1933428A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES370068A1 publication Critical patent/ES370068A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention comprises compounds of formula wherein R 1 is C 1-3 alkyl, allyl or benzyl, R 2 is C 1-3 alkyl or allyl (or NR 1 R 2 is piperidino substituted by 1 or 2 Me or Et groups in the 2,3 and/or 6-positions, or is 1,2,5,6-tetrahydropyridino, hexamethyleneimino, heptamethyleneimino, 3,6 - ethylenehexamethyleneimino, indolino or 1,2,3,4-tetrahydroisoquinolino), and R 3 , R 4 are each C 2-3 -hydroxyalkyl. These compounds are prepared by (1) oxidizing the corresponding 1,2,3,4-tetrahydropyrimido[5,4-d]- pyrimidines (formed by reducing compounds of the above formula having additionally a 4- NR 1 R 2 group), or (2) reacting a compound of the above formula, having a replaceable substituent in place of one or more of the amino groups shown, with HNR 1 R 2 or HNR 3 R 4 . Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which are physiologically active on the heart and circulation, and inhibit thrombocyte aggregation.
ES370068A 1968-07-31 1969-07-30 2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines Expired ES370068A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19681795030 DE1795030A1 (en) 1968-07-31 1968-07-31 New 2,6-bis (diaethanolamino) pyrimido [5,4-d] pyrimidines
DE19691933427 DE1933427A1 (en) 1969-07-01 1969-07-01 2,6-Bis-(dialkanolamino)-8-aminopyrimido-(5,4,d)-pyrimidines
DE19691933428 DE1933428A1 (en) 1969-07-01 1969-07-01 2,6-Bis-(dialkanolamino)-8-aminopyrimido-(5,4,d)-pyrimidines

Publications (1)

Publication Number Publication Date
ES370068A1 true ES370068A1 (en) 1971-04-01

Family

ID=27181475

Family Applications (2)

Application Number Title Priority Date Filing Date
ES370068A Expired ES370068A1 (en) 1968-07-31 1969-07-30 2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines
ES370067A Expired ES370067A1 (en) 1968-07-31 1969-07-30 2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES370067A Expired ES370067A1 (en) 1968-07-31 1969-07-30 2,6-bis-(dialkanolamino)-pyrimido[5,4-d] pyrimidines

Country Status (13)

Country Link
AT (2) AT297717B (en)
BE (1) BE736917A (en)
CA (1) CA932331A (en)
CH (2) CH513881A (en)
ES (2) ES370068A1 (en)
FR (1) FR2014089B1 (en)
GB (1) GB1237788A (en)
IL (1) IL32739A (en)
NL (1) NL6911721A (en)
PL (1) PL80164B1 (en)
RO (1) RO56153A (en)
SE (1) SE351849B (en)
SU (1) SU429582A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2004201A1 (en) * 1970-01-30 1971-08-05 Thomae Gmbh Dr K New 2,6-bis (dialkanolamino) -pyrimido- [5,4-d] pyrimidines and process for their preparation
US4963541A (en) * 1989-02-22 1990-10-16 Abbott Laboratories Pyrimido-pyrimidine lipoxygenase inhibiting compounds

Also Published As

Publication number Publication date
CA932331A (en) 1973-08-21
RO56153A (en) 1974-03-01
AT296992B (en) 1972-03-10
CH513881A (en) 1971-10-15
IL32739A0 (en) 1969-09-25
SE351849B (en) 1972-12-11
SU429582A3 (en) 1974-05-25
IL32739A (en) 1973-07-30
NL6911721A (en) 1970-02-03
BE736917A (en) 1970-02-02
FR2014089B1 (en) 1974-08-09
PL80164B1 (en) 1975-08-30
GB1237788A (en) 1971-06-30
CH529143A (en) 1972-10-15
ES370067A1 (en) 1971-04-01
FR2014089A1 (en) 1970-04-10
AT297717B (en) 1972-04-10

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