FR2676735B1 - Procede de preparation de benzothiazepines par cyclisation avec des acides phosphoniques. - Google Patents

Procede de preparation de benzothiazepines par cyclisation avec des acides phosphoniques.

Info

Publication number
FR2676735B1
FR2676735B1 FR9205861A FR9205861A FR2676735B1 FR 2676735 B1 FR2676735 B1 FR 2676735B1 FR 9205861 A FR9205861 A FR 9205861A FR 9205861 A FR9205861 A FR 9205861A FR 2676735 B1 FR2676735 B1 FR 2676735B1
Authority
FR
France
Prior art keywords
benzothiazepines
cyclisation
preparation
phosphonic acids
phosphonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9205861A
Other languages
English (en)
Other versions
FR2676735A1 (fr
Inventor
Claudio Giordano
Maurizio Paiocchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Original Assignee
Zambon Group SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA filed Critical Zambon Group SpA
Publication of FR2676735A1 publication Critical patent/FR2676735A1/fr
Application granted granted Critical
Publication of FR2676735B1 publication Critical patent/FR2676735B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
FR9205861A 1991-05-23 1992-05-14 Procede de preparation de benzothiazepines par cyclisation avec des acides phosphoniques. Expired - Fee Related FR2676735B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911426A IT1249318B (it) 1991-05-23 1991-05-23 Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici

Publications (2)

Publication Number Publication Date
FR2676735A1 FR2676735A1 (fr) 1992-11-27
FR2676735B1 true FR2676735B1 (fr) 1994-01-28

Family

ID=11359974

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9205861A Expired - Fee Related FR2676735B1 (fr) 1991-05-23 1992-05-14 Procede de preparation de benzothiazepines par cyclisation avec des acides phosphoniques.

Country Status (13)

Country Link
US (1) US5223612A (fr)
JP (1) JP3101841B2 (fr)
AT (1) AT401176B (fr)
BE (1) BE1005268A3 (fr)
CA (1) CA2068231C (fr)
CH (1) CH683100A5 (fr)
DE (1) DE4217103C2 (fr)
ES (1) ES2039166B1 (fr)
FR (1) FR2676735B1 (fr)
GB (1) GB2255973B (fr)
IT (1) IT1249318B (fr)
NL (1) NL194275C (fr)
SE (1) SE505880C2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104275A (en) * 1992-01-10 1998-04-05 Tanabe Seiyaku Co Process for preparing optically active benzothiazepine compounds by asymmetric reduction
TW438787B (en) * 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
HUP0101193A3 (en) 1997-12-19 2001-12-28 G D Searle & Co Chicago Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides
KR20160146787A (ko) * 2014-04-10 2016-12-21 아처 다니엘 미드랜드 캄파니 R-글루코시드, 당 알코올, 환원 당 알코올 및 환원 당 알코올의 퓨란 유도체의 합성

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641535B1 (fr) * 1989-01-11 1991-03-15 Synthelabo Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法
DE69015682T2 (de) * 1989-04-28 1995-05-11 Tanabe Seiyaku Co Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
US5128469A (en) * 1989-04-28 1992-07-07 Tanabe Seiyaku Co., Ltd. Process for preparing 1,5-benzothiazepine derivatives
AU628217B2 (en) * 1989-08-31 1992-09-10 Marion Merrell Dow Inc. Heterogeneous synthesis of azepinones from esters
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法

Also Published As

Publication number Publication date
GB2255973B (en) 1995-01-11
FR2676735A1 (fr) 1992-11-27
NL194275C (nl) 2001-11-05
CH683100A5 (it) 1994-01-14
DE4217103A1 (de) 1992-11-26
ES2039166B1 (es) 1994-04-01
ITMI911426A0 (it) 1991-05-23
GB2255973A (en) 1992-11-25
JP3101841B2 (ja) 2000-10-23
ES2039166A1 (es) 1993-08-16
ATA100292A (de) 1995-11-15
NL9200870A (nl) 1992-12-16
SE9201609D0 (sv) 1992-05-22
ITMI911426A1 (it) 1992-11-23
AT401176B (de) 1996-07-25
BE1005268A3 (fr) 1993-06-15
SE505880C2 (sv) 1997-10-20
GB9209636D0 (en) 1992-06-17
CA2068231C (fr) 2002-10-29
IT1249318B (it) 1995-02-22
DE4217103C2 (de) 2000-08-10
NL194275B (nl) 2001-07-02
JPH05222016A (ja) 1993-08-31
CA2068231A1 (fr) 1992-11-24
SE9201609L (sv) 1992-11-24
US5223612A (en) 1993-06-29

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20060131