IT1295376B1 - Processo per il riciclo di un sottoprodotto della sintesi del diltiazem - Google Patents

Processo per il riciclo di un sottoprodotto della sintesi del diltiazem

Info

Publication number
IT1295376B1
IT1295376B1 IT97MI002374A ITMI972374A IT1295376B1 IT 1295376 B1 IT1295376 B1 IT 1295376B1 IT 97MI002374 A IT97MI002374 A IT 97MI002374A IT MI972374 A ITMI972374 A IT MI972374A IT 1295376 B1 IT1295376 B1 IT 1295376B1
Authority
IT
Italy
Prior art keywords
diltiazem
synthesis
recycling
product
iii
Prior art date
Application number
IT97MI002374A
Other languages
English (en)
Inventor
Pietro Allegrini
Gaetano Marchioro
Giuseppe Barreca
Marco Villa
Laura Russo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI002374A priority Critical patent/IT1295376B1/it
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to IL13453498A priority patent/IL134534A0/xx
Priority to SK560-2000A priority patent/SK284417B6/sk
Priority to PCT/EP1998/006467 priority patent/WO1999020603A1/en
Priority to HU0100997A priority patent/HU225099B1/hu
Priority to AU11531/99A priority patent/AU743612B2/en
Priority to JP2000516945A priority patent/JP2001520219A/ja
Priority to EP98954403A priority patent/EP1025080B1/en
Priority to DE69810653T priority patent/DE69810653T2/de
Priority to CA002304371A priority patent/CA2304371A1/en
Priority to CN98809527A priority patent/CN1121383C/zh
Priority to KR1020007004254A priority patent/KR20010031267A/ko
Priority to ES98954403T priority patent/ES2189263T3/es
Priority to AT98954403T priority patent/ATE230724T1/de
Priority to PL98339054A priority patent/PL194251B1/pl
Priority to ZA989559A priority patent/ZA989559B/xx
Priority to US09/176,189 priority patent/US6114523A/en
Publication of ITMI972374A1 publication Critical patent/ITMI972374A1/it
Application granted granted Critical
Publication of IT1295376B1 publication Critical patent/IT1295376B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT97MI002374A 1997-10-22 1997-10-22 Processo per il riciclo di un sottoprodotto della sintesi del diltiazem IT1295376B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT97MI002374A IT1295376B1 (it) 1997-10-22 1997-10-22 Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
CN98809527A CN1121383C (zh) 1997-10-22 1998-10-12 地尔硫䓬合成的废产物的再利用方法
PCT/EP1998/006467 WO1999020603A1 (en) 1997-10-22 1998-10-12 Process for the recycle of a waste product of diltiazem synthesis
HU0100997A HU225099B1 (en) 1997-10-22 1998-10-12 Process for the recycle of a waste product of diltiazem synthesis
AU11531/99A AU743612B2 (en) 1997-10-22 1998-10-12 Process for the recycle of a waste product of diltiazem synthesis
JP2000516945A JP2001520219A (ja) 1997-10-22 1998-10-12 ジルチアゼム合成における目的外生成物のリサイクル方法
EP98954403A EP1025080B1 (en) 1997-10-22 1998-10-12 Process for the recycle of a waste product of diltiazem synthesis
DE69810653T DE69810653T2 (de) 1997-10-22 1998-10-12 Verfahren zur wiederverwertung eines nebenproduktes aus der diltiazem-synthese
IL13453498A IL134534A0 (en) 1997-10-22 1998-10-12 Process for the recycle of a waste product of diltiazem synthesis
SK560-2000A SK284417B6 (sk) 1997-10-22 1998-10-12 Spôsob konverzie derivátov treo-(2R,3R)-2-hydroxy-3-(2- aminofenyltio)-3-(4-metoxyfenyl)propiónovej kyseliny
KR1020007004254A KR20010031267A (ko) 1997-10-22 1998-10-12 딜티아젬 합성의 폐기물을 재순환시키는 방법
ES98954403T ES2189263T3 (es) 1997-10-22 1998-10-12 Procedimiento para el reciclo de un producto de desecho de sintesis de diltiazem.
AT98954403T ATE230724T1 (de) 1997-10-22 1998-10-12 Verfahren zur wiederverwertung eines nebenproduktes aus der diltiazem-synthese
PL98339054A PL194251B1 (pl) 1997-10-22 1998-10-12 Sposób konwersji pochodnych kwasu treo-(2R,3R)-2-hydroksy-3-(2-aminofenylotio)-3-(4-metoksyfenylo)propionowego
CA002304371A CA2304371A1 (en) 1997-10-22 1998-10-12 Process for the recycle of a waste product of diltiazem synthesis
ZA989559A ZA989559B (en) 1997-10-22 1998-10-20 Process for the recycle of a waste product of diltiazem synthesis
US09/176,189 US6114523A (en) 1997-10-22 1998-10-21 Process for the recycle of a waste product of diltiazem synthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI002374A IT1295376B1 (it) 1997-10-22 1997-10-22 Processo per il riciclo di un sottoprodotto della sintesi del diltiazem

Publications (2)

Publication Number Publication Date
ITMI972374A1 ITMI972374A1 (it) 1999-04-22
IT1295376B1 true IT1295376B1 (it) 1999-05-12

Family

ID=11378079

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI002374A IT1295376B1 (it) 1997-10-22 1997-10-22 Processo per il riciclo di un sottoprodotto della sintesi del diltiazem

Country Status (17)

Country Link
US (1) US6114523A (it)
EP (1) EP1025080B1 (it)
JP (1) JP2001520219A (it)
KR (1) KR20010031267A (it)
CN (1) CN1121383C (it)
AT (1) ATE230724T1 (it)
AU (1) AU743612B2 (it)
CA (1) CA2304371A1 (it)
DE (1) DE69810653T2 (it)
ES (1) ES2189263T3 (it)
HU (1) HU225099B1 (it)
IL (1) IL134534A0 (it)
IT (1) IT1295376B1 (it)
PL (1) PL194251B1 (it)
SK (1) SK284417B6 (it)
WO (1) WO1999020603A1 (it)
ZA (1) ZA989559B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003241747A1 (en) * 2002-06-11 2003-12-22 Kaneka Corporation PROCESS FOR PRODUCING OPTICALLY ACTIVE ss-AMINO ALCOHOL
CN103755663B (zh) * 2014-01-26 2016-02-24 武汉工程大学 地尔硫卓中间体副产物L-cis-内酰胺的回收工艺
CN110284181A (zh) * 2019-08-07 2019-09-27 山东新华制药股份有限公司 地尔硫卓ab异构体的单晶制备方法
CN112279820B (zh) * 2020-12-18 2021-04-02 苏州开元民生科技股份有限公司 2-(4-甲氧苯基)-3-羟基-2,3-二氢-1,5-苯并硫氮杂卓酮的制备方法
CN118684635A (zh) * 2024-08-22 2024-09-24 苏州开元民生科技股份有限公司 一种地尔硫卓手性中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
EP0059335B1 (en) * 1981-02-27 1985-05-15 Tanabe Seiyaku Co., Ltd. Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
IT1230057B (it) * 1989-04-13 1991-09-27 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
JPH0798813B2 (ja) * 1989-04-28 1995-10-25 田辺製薬株式会社 １，５―ベンゾチアゼピン誘導体の製法
IT1232306B (it) * 1989-07-27 1992-01-28 Zambon Spa Processo di risoluzione di intermedi utili per la preparazione del diltiazem
IT1237526B (it) * 1989-12-06 1993-06-08 Zambon Spa Processo di preparazione di un intermedio per il diltiazem
JPH085869B2 (ja) * 1990-03-08 1996-01-24 田辺製薬株式会社 １，５−ベンゾチアゼピン誘導体の製法
NL9000763A (nl) * 1990-03-31 1991-10-16 Stamicarbon Werkwijze voor het bereiden van 1,5-benzothiazepine-derivaten.
IT1249318B (it) * 1991-05-23 1995-02-22 Zambon Spa Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici
FI93741C (fi) * 1993-03-24 1995-05-26 Orion Yhtymae Oy Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi
JPH07108982A (ja) * 1993-10-13 1995-04-25 Nippon Shokubai Co Ltd 浮き桟橋

Also Published As

Publication number Publication date
HU225099B1 (en) 2006-06-28
DE69810653D1 (de) 2003-02-13
ES2189263T3 (es) 2003-07-01
IL134534A0 (en) 2001-04-30
ATE230724T1 (de) 2003-01-15
HUP0100997A3 (en) 2002-11-28
JP2001520219A (ja) 2001-10-30
HUP0100997A2 (hu) 2001-08-28
ITMI972374A1 (it) 1999-04-22
CN1121383C (zh) 2003-09-17
CN1271340A (zh) 2000-10-25
AU1153199A (en) 1999-05-10
EP1025080A1 (en) 2000-08-09
ZA989559B (en) 1999-04-22
PL339054A1 (en) 2000-12-04
SK5602000A3 (en) 2000-09-12
CA2304371A1 (en) 1999-04-29
EP1025080B1 (en) 2003-01-08
PL194251B1 (pl) 2007-05-31
SK284417B6 (sk) 2005-03-04
DE69810653T2 (de) 2003-11-13
WO1999020603A1 (en) 1999-04-29
AU743612B2 (en) 2002-01-31
KR20010031267A (ko) 2001-04-16
US6114523A (en) 2000-09-05

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Legal Events

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