IT1295376B1 - Processo per il riciclo di un sottoprodotto della sintesi del diltiazem - Google Patents
Processo per il riciclo di un sottoprodotto della sintesi del diltiazemInfo
- Publication number
- IT1295376B1 IT1295376B1 IT97MI002374A ITMI972374A IT1295376B1 IT 1295376 B1 IT1295376 B1 IT 1295376B1 IT 97MI002374 A IT97MI002374 A IT 97MI002374A IT MI972374 A ITMI972374 A IT MI972374A IT 1295376 B1 IT1295376 B1 IT 1295376B1
- Authority
- IT
- Italy
- Prior art keywords
- diltiazem
- synthesis
- recycling
- product
- iii
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI002374A IT1295376B1 (it) | 1997-10-22 | 1997-10-22 | Processo per il riciclo di un sottoprodotto della sintesi del diltiazem |
CN98809527A CN1121383C (zh) | 1997-10-22 | 1998-10-12 | 地尔硫䓬合成的废产物的再利用方法 |
PCT/EP1998/006467 WO1999020603A1 (en) | 1997-10-22 | 1998-10-12 | Process for the recycle of a waste product of diltiazem synthesis |
HU0100997A HU225099B1 (en) | 1997-10-22 | 1998-10-12 | Process for the recycle of a waste product of diltiazem synthesis |
AU11531/99A AU743612B2 (en) | 1997-10-22 | 1998-10-12 | Process for the recycle of a waste product of diltiazem synthesis |
JP2000516945A JP2001520219A (ja) | 1997-10-22 | 1998-10-12 | ジルチアゼム合成における目的外生成物のリサイクル方法 |
EP98954403A EP1025080B1 (en) | 1997-10-22 | 1998-10-12 | Process for the recycle of a waste product of diltiazem synthesis |
DE69810653T DE69810653T2 (de) | 1997-10-22 | 1998-10-12 | Verfahren zur wiederverwertung eines nebenproduktes aus der diltiazem-synthese |
IL13453498A IL134534A0 (en) | 1997-10-22 | 1998-10-12 | Process for the recycle of a waste product of diltiazem synthesis |
SK560-2000A SK284417B6 (sk) | 1997-10-22 | 1998-10-12 | Spôsob konverzie derivátov treo-(2R,3R)-2-hydroxy-3-(2- aminofenyltio)-3-(4-metoxyfenyl)propiónovej kyseliny |
KR1020007004254A KR20010031267A (ko) | 1997-10-22 | 1998-10-12 | 딜티아젬 합성의 폐기물을 재순환시키는 방법 |
ES98954403T ES2189263T3 (es) | 1997-10-22 | 1998-10-12 | Procedimiento para el reciclo de un producto de desecho de sintesis de diltiazem. |
AT98954403T ATE230724T1 (de) | 1997-10-22 | 1998-10-12 | Verfahren zur wiederverwertung eines nebenproduktes aus der diltiazem-synthese |
PL98339054A PL194251B1 (pl) | 1997-10-22 | 1998-10-12 | Sposób konwersji pochodnych kwasu treo-(2R,3R)-2-hydroksy-3-(2-aminofenylotio)-3-(4-metoksyfenylo)propionowego |
CA002304371A CA2304371A1 (en) | 1997-10-22 | 1998-10-12 | Process for the recycle of a waste product of diltiazem synthesis |
ZA989559A ZA989559B (en) | 1997-10-22 | 1998-10-20 | Process for the recycle of a waste product of diltiazem synthesis |
US09/176,189 US6114523A (en) | 1997-10-22 | 1998-10-21 | Process for the recycle of a waste product of diltiazem synthesis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI002374A IT1295376B1 (it) | 1997-10-22 | 1997-10-22 | Processo per il riciclo di un sottoprodotto della sintesi del diltiazem |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI972374A1 ITMI972374A1 (it) | 1999-04-22 |
IT1295376B1 true IT1295376B1 (it) | 1999-05-12 |
Family
ID=11378079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT97MI002374A IT1295376B1 (it) | 1997-10-22 | 1997-10-22 | Processo per il riciclo di un sottoprodotto della sintesi del diltiazem |
Country Status (17)
Country | Link |
---|---|
US (1) | US6114523A (it) |
EP (1) | EP1025080B1 (it) |
JP (1) | JP2001520219A (it) |
KR (1) | KR20010031267A (it) |
CN (1) | CN1121383C (it) |
AT (1) | ATE230724T1 (it) |
AU (1) | AU743612B2 (it) |
CA (1) | CA2304371A1 (it) |
DE (1) | DE69810653T2 (it) |
ES (1) | ES2189263T3 (it) |
HU (1) | HU225099B1 (it) |
IL (1) | IL134534A0 (it) |
IT (1) | IT1295376B1 (it) |
PL (1) | PL194251B1 (it) |
SK (1) | SK284417B6 (it) |
WO (1) | WO1999020603A1 (it) |
ZA (1) | ZA989559B (it) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003241747A1 (en) * | 2002-06-11 | 2003-12-22 | Kaneka Corporation | PROCESS FOR PRODUCING OPTICALLY ACTIVE ss-AMINO ALCOHOL |
CN103755663B (zh) * | 2014-01-26 | 2016-02-24 | 武汉工程大学 | 地尔硫卓中间体副产物L-cis-内酰胺的回收工艺 |
CN110284181A (zh) * | 2019-08-07 | 2019-09-27 | 山东新华制药股份有限公司 | 地尔硫卓ab异构体的单晶制备方法 |
CN112279820B (zh) * | 2020-12-18 | 2021-04-02 | 苏州开元民生科技股份有限公司 | 2-(4-甲氧苯基)-3-羟基-2,3-二氢-1,5-苯并硫氮杂卓酮的制备方法 |
CN118684635A (zh) * | 2024-08-22 | 2024-09-24 | 苏州开元民生科技股份有限公司 | 一种地尔硫卓手性中间体的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1236467A (en) * | 1967-10-28 | 1971-06-23 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
EP0059335B1 (en) * | 1981-02-27 | 1985-05-15 | Tanabe Seiyaku Co., Ltd. | Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester |
SE449611B (sv) * | 1982-07-09 | 1987-05-11 | Tanabe Seiyaku Co | Sett att framstella 1,5-bensotiazepinderivat |
IT1152721B (it) * | 1982-10-15 | 1987-01-07 | Luso Farmaco Inst | Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico |
IT1230057B (it) * | 1989-04-13 | 1991-09-27 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine |
JPH0798813B2 (ja) * | 1989-04-28 | 1995-10-25 | 田辺製薬株式会社 | 1,5―ベンゾチアゼピン誘導体の製法 |
IT1232306B (it) * | 1989-07-27 | 1992-01-28 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione del diltiazem |
IT1237526B (it) * | 1989-12-06 | 1993-06-08 | Zambon Spa | Processo di preparazione di un intermedio per il diltiazem |
JPH085869B2 (ja) * | 1990-03-08 | 1996-01-24 | 田辺製薬株式会社 | 1,5−ベンゾチアゼピン誘導体の製法 |
NL9000763A (nl) * | 1990-03-31 | 1991-10-16 | Stamicarbon | Werkwijze voor het bereiden van 1,5-benzothiazepine-derivaten. |
IT1249318B (it) * | 1991-05-23 | 1995-02-22 | Zambon Spa | Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici |
FI93741C (fi) * | 1993-03-24 | 1995-05-26 | Orion Yhtymae Oy | Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi |
JPH07108982A (ja) * | 1993-10-13 | 1995-04-25 | Nippon Shokubai Co Ltd | 浮き桟橋 |
-
1997
- 1997-10-22 IT IT97MI002374A patent/IT1295376B1/it active IP Right Grant
-
1998
- 1998-10-12 ES ES98954403T patent/ES2189263T3/es not_active Expired - Lifetime
- 1998-10-12 JP JP2000516945A patent/JP2001520219A/ja active Pending
- 1998-10-12 CA CA002304371A patent/CA2304371A1/en not_active Abandoned
- 1998-10-12 KR KR1020007004254A patent/KR20010031267A/ko not_active Application Discontinuation
- 1998-10-12 AU AU11531/99A patent/AU743612B2/en not_active Ceased
- 1998-10-12 EP EP98954403A patent/EP1025080B1/en not_active Expired - Lifetime
- 1998-10-12 AT AT98954403T patent/ATE230724T1/de active
- 1998-10-12 DE DE69810653T patent/DE69810653T2/de not_active Expired - Lifetime
- 1998-10-12 PL PL98339054A patent/PL194251B1/pl not_active IP Right Cessation
- 1998-10-12 IL IL13453498A patent/IL134534A0/xx not_active IP Right Cessation
- 1998-10-12 WO PCT/EP1998/006467 patent/WO1999020603A1/en not_active Application Discontinuation
- 1998-10-12 CN CN98809527A patent/CN1121383C/zh not_active Expired - Fee Related
- 1998-10-12 HU HU0100997A patent/HU225099B1/hu not_active IP Right Cessation
- 1998-10-12 SK SK560-2000A patent/SK284417B6/sk unknown
- 1998-10-20 ZA ZA989559A patent/ZA989559B/xx unknown
- 1998-10-21 US US09/176,189 patent/US6114523A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HU225099B1 (en) | 2006-06-28 |
DE69810653D1 (de) | 2003-02-13 |
ES2189263T3 (es) | 2003-07-01 |
IL134534A0 (en) | 2001-04-30 |
ATE230724T1 (de) | 2003-01-15 |
HUP0100997A3 (en) | 2002-11-28 |
JP2001520219A (ja) | 2001-10-30 |
HUP0100997A2 (hu) | 2001-08-28 |
ITMI972374A1 (it) | 1999-04-22 |
CN1121383C (zh) | 2003-09-17 |
CN1271340A (zh) | 2000-10-25 |
AU1153199A (en) | 1999-05-10 |
EP1025080A1 (en) | 2000-08-09 |
ZA989559B (en) | 1999-04-22 |
PL339054A1 (en) | 2000-12-04 |
SK5602000A3 (en) | 2000-09-12 |
CA2304371A1 (en) | 1999-04-29 |
EP1025080B1 (en) | 2003-01-08 |
PL194251B1 (pl) | 2007-05-31 |
SK284417B6 (sk) | 2005-03-04 |
DE69810653T2 (de) | 2003-11-13 |
WO1999020603A1 (en) | 1999-04-29 |
AU743612B2 (en) | 2002-01-31 |
KR20010031267A (ko) | 2001-04-16 |
US6114523A (en) | 2000-09-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |