IT1232306B - Processo di risoluzione di intermedi utili per la preparazione del diltiazem - Google Patents

Processo di risoluzione di intermedi utili per la preparazione del diltiazem

Info

Publication number
IT1232306B
IT1232306B IT8921338A IT2133889A IT1232306B IT 1232306 B IT1232306 B IT 1232306B IT 8921338 A IT8921338 A IT 8921338A IT 2133889 A IT2133889 A IT 2133889A IT 1232306 B IT1232306 B IT 1232306B
Authority
IT
Italy
Prior art keywords
diltiazem
preparation
resolution process
useful intermediates
intermediates
Prior art date
Application number
IT8921338A
Other languages
English (en)
Other versions
IT8921338A0 (it
Inventor
Claudio Giordano
Dario Tentorio
Roberto Casagrande
Placido Bertin
Valeriano Merli
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IT8921338A0 publication Critical patent/IT8921338A0/it
Priority to IT8921338A priority Critical patent/IT1232306B/it
Priority to CH2245/90A priority patent/CH680855A5/it
Priority to GB9015302A priority patent/GB2234243B/en
Priority to JP2189251A priority patent/JP2873609B2/ja
Priority to CA002021342A priority patent/CA2021342C/en
Priority to FR909009492A priority patent/FR2650272B1/fr
Priority to BE9000745A priority patent/BE1003314A3/fr
Priority to US07/557,808 priority patent/US5097059A/en
Priority to ES909002010A priority patent/ES2020789A6/es
Priority to SE9002499A priority patent/SE509635C2/sv
Priority to AT0156790A priority patent/AT400143B/de
Priority to DE4023773A priority patent/DE4023773B4/de
Priority to NL9001710A priority patent/NL194371C/nl
Application granted granted Critical
Publication of IT1232306B publication Critical patent/IT1232306B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
IT8921338A 1989-07-27 1989-07-27 Processo di risoluzione di intermedi utili per la preparazione del diltiazem IT1232306B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT8921338A IT1232306B (it) 1989-07-27 1989-07-27 Processo di risoluzione di intermedi utili per la preparazione del diltiazem
CH2245/90A CH680855A5 (it) 1989-07-27 1990-07-05
GB9015302A GB2234243B (en) 1989-07-27 1990-07-12 Optical resolution of aminophenylthio propionic esters
JP2189251A JP2873609B2 (ja) 1989-07-27 1990-07-16 トレオ―２―ヒドロキシ―３―（２―アミノフェニルチオ）―３―（４―メトキシフェニル）プロピオン酸低級アルキルエステルの光学分割法
CA002021342A CA2021342C (en) 1989-07-27 1990-07-17 Resolution process of intermediates useful for the preparation of diltiazem
FR909009492A FR2650272B1 (fr) 1989-07-27 1990-07-25 Procede de dedoublement d'intermediaires interessants dans la preparation de diltiazem
BE9000745A BE1003314A3 (fr) 1989-07-27 1990-07-26 Procede de dedoublement d'intermediaires interessants dans la preparation de diltiazem.
US07/557,808 US5097059A (en) 1989-07-27 1990-07-26 Resolution process of intermediates useful for the preparation of diltiazem
ES909002010A ES2020789A6 (es) 1989-07-27 1990-07-26 Procedimiento de resolucion de intermedios utiles para la preparacion de diltiazem.
SE9002499A SE509635C2 (sv) 1989-07-27 1990-07-26 Förfarande för optisk upplösning av lägre estrar av treo-2- hydroxi-3-(2-aminofenyltio)-3-(4-metoxifenyl) propionsyra
AT0156790A AT400143B (de) 1989-07-27 1990-07-26 Verfahren zum auftrennen der niedrigen ester der threo-2-hydroxy-3-(2-aminophenylthio)-3-(4- methoxyphenyl)-propionsäure
DE4023773A DE4023773B4 (de) 1989-07-27 1990-07-26 Verfahren zur optischen Auftrennung von zur Herstellung von Diltiazem geeigneten Zwischenprodukten
NL9001710A NL194371C (nl) 1989-07-27 1990-07-27 Resolutiewerkwijze van een mengsel van enantiomeren van een threo-2-hydroxy-3-(2-aminofenylthio)-3-(4-methoxyfenyl)- propionzuurester.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921338A IT1232306B (it) 1989-07-27 1989-07-27 Processo di risoluzione di intermedi utili per la preparazione del diltiazem

Publications (2)

Publication Number Publication Date
IT8921338A0 IT8921338A0 (it) 1989-07-27
IT1232306B true IT1232306B (it) 1992-01-28

Family

ID=11180324

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8921338A IT1232306B (it) 1989-07-27 1989-07-27 Processo di risoluzione di intermedi utili per la preparazione del diltiazem

Country Status (13)

Country Link
US (1) US5097059A (it)
JP (1) JP2873609B2 (it)
AT (1) AT400143B (it)
BE (1) BE1003314A3 (it)
CA (1) CA2021342C (it)
CH (1) CH680855A5 (it)
DE (1) DE4023773B4 (it)
ES (1) ES2020789A6 (it)
FR (1) FR2650272B1 (it)
GB (1) GB2234243B (it)
IT (1) IT1232306B (it)
NL (1) NL194371C (it)
SE (1) SE509635C2 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102592A (en) * 1992-07-21 1996-09-12 Teva Pharma Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid
FI93741C (fi) * 1993-03-24 1995-05-26 Orion Yhtymae Oy Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi
IT1295376B1 (it) * 1997-10-22 1999-05-12 Zambon Spa Processo per il riciclo di un sottoprodotto della sintesi del diltiazem

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
JPS59110668A (ja) * 1982-12-17 1984-06-26 Tokawa Tetsuo ２−置換−３−（ｐ−メトキシフエニル）−３−〔（２−置換）フエニルチオ〕プロピオン酸の光学分割法
US4552695A (en) * 1983-04-21 1985-11-12 Shionogi & Co., Ltd. Process for production of diltiazem hydrochloride
EP0320532A1 (en) * 1986-07-15 1989-06-21 Nihon Iyakuhin Kogyo Co., Ltd. Novel optically active carboxylic acid derivative l-lysine salt and process for production thereof
IT1217988B (it) * 1988-01-28 1990-03-30 Ind Chimica Profarmaco Spa Procedimento per la risoluzione ottica di un pacemo
US4908469A (en) * 1988-05-18 1990-03-13 Marion Laboratories, Inc. 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines
IT1226300B (it) * 1988-07-26 1990-12-27 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem.

Also Published As

Publication number Publication date
NL194371B (nl) 2001-10-01
FR2650272B1 (fr) 1992-08-28
SE509635C2 (sv) 1999-02-15
GB2234243A (en) 1991-01-30
GB9015302D0 (en) 1990-08-29
DE4023773A1 (de) 1991-01-31
NL194371C (nl) 2002-02-04
CA2021342A1 (en) 1991-01-28
CH680855A5 (it) 1992-11-30
ATA156790A (de) 1995-02-15
JPH03188059A (ja) 1991-08-16
FR2650272A1 (fr) 1991-02-01
NL9001710A (nl) 1991-02-18
JP2873609B2 (ja) 1999-03-24
IT8921338A0 (it) 1989-07-27
DE4023773B4 (de) 2004-01-08
CA2021342C (en) 2002-01-29
US5097059A (en) 1992-03-17
BE1003314A3 (fr) 1992-02-25
GB2234243B (en) 1992-11-25
ES2020789A6 (es) 1991-09-16
AT400143B (de) 1995-10-25
SE9002499L (sv) 1991-01-28
SE9002499D0 (sv) 1990-07-26

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970612