IT1217988B - Procedimento per la risoluzione ottica di un pacemo - Google Patents
Procedimento per la risoluzione ottica di un pacemoInfo
- Publication number
- IT1217988B IT1217988B IT19234/88A IT1923488A IT1217988B IT 1217988 B IT1217988 B IT 1217988B IT 19234/88 A IT19234/88 A IT 19234/88A IT 1923488 A IT1923488 A IT 1923488A IT 1217988 B IT1217988 B IT 1217988B
- Authority
- IT
- Italy
- Prior art keywords
- optical resolution
- pacemo
- procedure
- salt
- acetylaminophenylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
- Eye Examination Apparatus (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19234/88A IT1217988B (it) | 1988-01-28 | 1988-01-28 | Procedimento per la risoluzione ottica di un pacemo |
DE68914480T DE68914480T2 (de) | 1988-01-28 | 1989-01-13 | Verfahren zur optischen Spaltung einer rakemischen Säure. |
EP89100551A EP0325965B1 (en) | 1988-01-28 | 1989-01-13 | A process for the optical resolution of a racemic acid |
ES89100551T ES2061737T3 (es) | 1988-01-28 | 1989-01-13 | Procedimiento para la resolucion optica de un acido racemico. |
AT89100551T ATE104274T1 (de) | 1988-01-28 | 1989-01-13 | Verfahren zur optischen spaltung einer rakemischen saeure. |
US07/297,993 US4931587A (en) | 1988-01-28 | 1989-01-17 | Process for the optical resolution of a racemic acid |
JP1014941A JP2619280B2 (ja) | 1988-01-28 | 1989-01-24 | ラセミ酸の光学的分割方法 |
CA000589257A CA1338034C (en) | 1988-01-28 | 1989-01-26 | Process for the optical resolution of a racemic acid |
US07/527,029 US5013834A (en) | 1988-01-28 | 1990-05-21 | Process for the preparation of an optically active benzothiazepinone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19234/88A IT1217988B (it) | 1988-01-28 | 1988-01-28 | Procedimento per la risoluzione ottica di un pacemo |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8819234A0 IT8819234A0 (it) | 1988-01-28 |
IT1217988B true IT1217988B (it) | 1990-03-30 |
Family
ID=11155988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT19234/88A IT1217988B (it) | 1988-01-28 | 1988-01-28 | Procedimento per la risoluzione ottica di un pacemo |
Country Status (8)
Country | Link |
---|---|
US (2) | US4931587A (it) |
EP (1) | EP0325965B1 (it) |
JP (1) | JP2619280B2 (it) |
AT (1) | ATE104274T1 (it) |
CA (1) | CA1338034C (it) |
DE (1) | DE68914480T2 (it) |
ES (1) | ES2061737T3 (it) |
IT (1) | IT1217988B (it) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE93516T1 (de) * | 1989-06-30 | 1993-09-15 | Richter Gedeon Vegyeszet | Verfahren zur resolution von threo-3-((2aminophenyl)-thio>-2-hydroxy-3-(4-methoxyphenyl)propions|ure. |
IT1234387B (it) * | 1989-07-12 | 1992-05-18 | Zambon Spa | Processo di purificazione di intermedi utili nella preparazione del diltiazem |
IT1232306B (it) * | 1989-07-27 | 1992-01-28 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione del diltiazem |
US4963671A (en) * | 1989-11-20 | 1990-10-16 | E. R. Squibb & Sons, Inc. | Process for resolving chiral intermediates used in making calcium channel blockers |
IT1237785B (it) * | 1989-11-23 | 1993-06-17 | F I S Fabbrica Italiana Sint | Procedimento per la risoluzione ottica dell'acido treo-2-idrossi-3- (2'-ammino feniltio)-3-(4"-metossifenil) propionico |
IT1240651B (it) * | 1990-05-17 | 1993-12-17 | Zambon Spa | Processo per la risoluzione di derivati glicidici |
ZW13191A1 (en) * | 1990-09-21 | 1992-02-05 | Smithkline Beecham Corp | Crystallization of optical isomers of leukotriene antagonists |
RU2145219C1 (ru) * | 1991-05-13 | 2000-02-10 | Дзе Бутс Компани ПЛС | Фармацевтическая композиция, содержащая s(-)-2-(4-изобутилфенил)пропионат натрия, способ получения натриевой соли энантиомера 2-(4-изобутилфенил)пропионовой кислоты, s(-)-2-(4-изобутилфенил)пропионат натрия дигидрат |
US5214201A (en) * | 1991-12-12 | 1993-05-25 | Smithkline Beecham Corporation | Crystallization of optical isomers of leukotriene antagonists |
US5248813A (en) * | 1992-10-14 | 1993-09-28 | Ethyl Corporation | Enantiomeric resolution |
US5256816A (en) * | 1992-10-14 | 1993-10-26 | Ethyl Corporation | Enantiomeric resolution |
US5278337A (en) * | 1992-10-14 | 1994-01-11 | Ethyl Corporation | Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids |
US5260482A (en) * | 1992-10-14 | 1993-11-09 | Ethyl Corporation | Enantiomeric resolution |
US5442117A (en) * | 1993-12-13 | 1995-08-15 | Albemarle Corporation | Enantiomeric resolution |
US6130352A (en) * | 1995-01-27 | 2000-10-10 | Council Of Scientific & Industrial Research | Method for producing (+) (2S,3S)-3-(2-aminophenylthio)-2-hydroxy-3(4'-methoxyphenyl)-propionic acid |
IT1274472B (it) * | 1995-05-11 | 1997-07-17 | Fabbrica Italiana Sintetici Spa | Procedimento per la preparazione del sale di cicloesilammina dell'acido (+)-treo-2-idrossi-3-(2'-amminofeniltio)-3- (4"-metossifenil)-propionico e del suo antipodo(-) |
EP0778272B1 (en) * | 1995-12-05 | 1998-12-23 | Tanabe Seiyaku Co., Ltd. | Optically active benzothiazepine compounds and process for preparing the same |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2940998A (en) * | 1953-10-15 | 1960-06-14 | Ajinomoto Kk | Process for resolution of racemic glutamic acid and salts thereof |
US3158648A (en) * | 1962-04-09 | 1964-11-24 | Merck & Co Inc | Direct resolution of alpha-methyl-3, 4-dihydroxyphenylalanine |
US3562257A (en) * | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
JPS57136581A (en) * | 1981-02-18 | 1982-08-23 | Nippon Kayaku Co Ltd | Preparation of 1,5-benzothiazepin derivative |
SE449611B (sv) * | 1982-07-09 | 1987-05-11 | Tanabe Seiyaku Co | Sett att framstella 1,5-bensotiazepinderivat |
-
1988
- 1988-01-28 IT IT19234/88A patent/IT1217988B/it active
-
1989
- 1989-01-13 AT AT89100551T patent/ATE104274T1/de not_active IP Right Cessation
- 1989-01-13 DE DE68914480T patent/DE68914480T2/de not_active Expired - Fee Related
- 1989-01-13 EP EP89100551A patent/EP0325965B1/en not_active Expired - Lifetime
- 1989-01-13 ES ES89100551T patent/ES2061737T3/es not_active Expired - Lifetime
- 1989-01-17 US US07/297,993 patent/US4931587A/en not_active Expired - Fee Related
- 1989-01-24 JP JP1014941A patent/JP2619280B2/ja not_active Expired - Lifetime
- 1989-01-26 CA CA000589257A patent/CA1338034C/en not_active Expired - Fee Related
-
1990
- 1990-05-21 US US07/527,029 patent/US5013834A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4931587A (en) | 1990-06-05 |
DE68914480D1 (de) | 1994-05-19 |
CA1338034C (en) | 1996-02-06 |
DE68914480T2 (de) | 1994-08-11 |
EP0325965A3 (en) | 1990-10-31 |
ATE104274T1 (de) | 1994-04-15 |
ES2061737T3 (es) | 1994-12-16 |
EP0325965A2 (en) | 1989-08-02 |
EP0325965B1 (en) | 1994-04-13 |
US5013834A (en) | 1991-05-07 |
IT8819234A0 (it) | 1988-01-28 |
JPH021466A (ja) | 1990-01-05 |
JP2619280B2 (ja) | 1997-06-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940128 |