DE68914480D1 - Verfahren zur optischen Spaltung einer rakemischen Säure. - Google Patents
Verfahren zur optischen Spaltung einer rakemischen Säure.Info
- Publication number
- DE68914480D1 DE68914480D1 DE68914480T DE68914480T DE68914480D1 DE 68914480 D1 DE68914480 D1 DE 68914480D1 DE 68914480 T DE68914480 T DE 68914480T DE 68914480 T DE68914480 T DE 68914480T DE 68914480 D1 DE68914480 D1 DE 68914480D1
- Authority
- DE
- Germany
- Prior art keywords
- optical resolution
- racemic acid
- salt
- racemic
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
- Eye Examination Apparatus (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19234/88A IT1217988B (it) | 1988-01-28 | 1988-01-28 | Procedimento per la risoluzione ottica di un pacemo |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68914480D1 true DE68914480D1 (de) | 1994-05-19 |
DE68914480T2 DE68914480T2 (de) | 1994-08-11 |
Family
ID=11155988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68914480T Expired - Fee Related DE68914480T2 (de) | 1988-01-28 | 1989-01-13 | Verfahren zur optischen Spaltung einer rakemischen Säure. |
Country Status (8)
Country | Link |
---|---|
US (2) | US4931587A (de) |
EP (1) | EP0325965B1 (de) |
JP (1) | JP2619280B2 (de) |
AT (1) | ATE104274T1 (de) |
CA (1) | CA1338034C (de) |
DE (1) | DE68914480T2 (de) |
ES (1) | ES2061737T3 (de) |
IT (1) | IT1217988B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0431121T3 (da) * | 1989-06-30 | 1993-10-11 | Richter Gedeon Vegyeszet | Fremgangsmåde til opspaltning af threo-((2-aminophenyl)-thio)-2-hydroxy-3-(4-methoxyphenyl)- propionsyre |
IT1234387B (it) * | 1989-07-12 | 1992-05-18 | Zambon Spa | Processo di purificazione di intermedi utili nella preparazione del diltiazem |
IT1232306B (it) * | 1989-07-27 | 1992-01-28 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione del diltiazem |
US4963671A (en) * | 1989-11-20 | 1990-10-16 | E. R. Squibb & Sons, Inc. | Process for resolving chiral intermediates used in making calcium channel blockers |
IT1237785B (it) * | 1989-11-23 | 1993-06-17 | F I S Fabbrica Italiana Sint | Procedimento per la risoluzione ottica dell'acido treo-2-idrossi-3- (2'-ammino feniltio)-3-(4"-metossifenil) propionico |
IT1240651B (it) * | 1990-05-17 | 1993-12-17 | Zambon Spa | Processo per la risoluzione di derivati glicidici |
IE913308A1 (en) * | 1990-09-21 | 1992-02-25 | Smithkline Beecham Corp | Crystallization of optical isomers of leukotriene¹antagonists |
DE69231359T2 (de) | 1991-05-13 | 2001-02-08 | Boots Co Ltd | Ibuprofen-salz enthaltende pharmazeutische zusammensetzung |
US5214201A (en) * | 1991-12-12 | 1993-05-25 | Smithkline Beecham Corporation | Crystallization of optical isomers of leukotriene antagonists |
US5256816A (en) * | 1992-10-14 | 1993-10-26 | Ethyl Corporation | Enantiomeric resolution |
US5260482A (en) * | 1992-10-14 | 1993-11-09 | Ethyl Corporation | Enantiomeric resolution |
US5278337A (en) * | 1992-10-14 | 1994-01-11 | Ethyl Corporation | Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids |
US5248813A (en) * | 1992-10-14 | 1993-09-28 | Ethyl Corporation | Enantiomeric resolution |
US5442117A (en) * | 1993-12-13 | 1995-08-15 | Albemarle Corporation | Enantiomeric resolution |
US6130352A (en) * | 1995-01-27 | 2000-10-10 | Council Of Scientific & Industrial Research | Method for producing (+) (2S,3S)-3-(2-aminophenylthio)-2-hydroxy-3(4'-methoxyphenyl)-propionic acid |
IT1274472B (it) * | 1995-05-11 | 1997-07-17 | Fabbrica Italiana Sintetici Spa | Procedimento per la preparazione del sale di cicloesilammina dell'acido (+)-treo-2-idrossi-3-(2'-amminofeniltio)-3- (4"-metossifenil)-propionico e del suo antipodo(-) |
EP0778272B1 (de) * | 1995-12-05 | 1998-12-23 | Tanabe Seiyaku Co., Ltd. | Optisch aktive Benzothiazepinderivate und Verfahren zu ihrer Herstellung |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2940998A (en) * | 1953-10-15 | 1960-06-14 | Ajinomoto Kk | Process for resolution of racemic glutamic acid and salts thereof |
US3158648A (en) * | 1962-04-09 | 1964-11-24 | Merck & Co Inc | Direct resolution of alpha-methyl-3, 4-dihydroxyphenylalanine |
US3562257A (en) * | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
JPS57136581A (en) * | 1981-02-18 | 1982-08-23 | Nippon Kayaku Co Ltd | Preparation of 1,5-benzothiazepin derivative |
SE449611B (sv) * | 1982-07-09 | 1987-05-11 | Tanabe Seiyaku Co | Sett att framstella 1,5-bensotiazepinderivat |
-
1988
- 1988-01-28 IT IT19234/88A patent/IT1217988B/it active
-
1989
- 1989-01-13 DE DE68914480T patent/DE68914480T2/de not_active Expired - Fee Related
- 1989-01-13 ES ES89100551T patent/ES2061737T3/es not_active Expired - Lifetime
- 1989-01-13 AT AT89100551T patent/ATE104274T1/de not_active IP Right Cessation
- 1989-01-13 EP EP89100551A patent/EP0325965B1/de not_active Expired - Lifetime
- 1989-01-17 US US07/297,993 patent/US4931587A/en not_active Expired - Fee Related
- 1989-01-24 JP JP1014941A patent/JP2619280B2/ja not_active Expired - Lifetime
- 1989-01-26 CA CA000589257A patent/CA1338034C/en not_active Expired - Fee Related
-
1990
- 1990-05-21 US US07/527,029 patent/US5013834A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0325965A2 (de) | 1989-08-02 |
ATE104274T1 (de) | 1994-04-15 |
IT1217988B (it) | 1990-03-30 |
ES2061737T3 (es) | 1994-12-16 |
DE68914480T2 (de) | 1994-08-11 |
US4931587A (en) | 1990-06-05 |
US5013834A (en) | 1991-05-07 |
EP0325965B1 (de) | 1994-04-13 |
IT8819234A0 (it) | 1988-01-28 |
EP0325965A3 (en) | 1990-10-31 |
JPH021466A (ja) | 1990-01-05 |
JP2619280B2 (ja) | 1997-06-11 |
CA1338034C (en) | 1996-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PROFARMACO S.R.L., MAILAND/MILANO, IT |
|
8339 | Ceased/non-payment of the annual fee |