JPS57136581A - Preparation of 1,5-benzothiazepin derivative - Google Patents
Preparation of 1,5-benzothiazepin derivativeInfo
- Publication number
- JPS57136581A JPS57136581A JP2141281A JP2141281A JPS57136581A JP S57136581 A JPS57136581 A JP S57136581A JP 2141281 A JP2141281 A JP 2141281A JP 2141281 A JP2141281 A JP 2141281A JP S57136581 A JPS57136581 A JP S57136581A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- benzothiazepin
- compound
- alumina
- silica gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound having coronary vessel dilating activity, etc. and useful as a drug, in high yield, by condensation reaction, etc. of a 1,5-benzothiazepin derivative in the presence of silica gel or alumina, using an aprotic polar solvent.
CONSTITUTION: A 1,5-benzothiazepin derivative of formulaI(Ar is phenyl substituted with lower alkoxy group; R is lower alkyl) is converted to its alkali metal salt at the 5-position nitrogen atom by adding sodium hydride to the derivative in an aprotic polar solvent such as dimethylsulfoxide, sulfolane, etc. in the presence of silica gel or alumina, and the resultant metal salt is condensed with a compound of formula II (R1 and R2 are lower alkyl; Y is lower alkylene; Z is halogen) at 5W60°C to obtain the objective compound of formula III.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2141281A JPS57136581A (en) | 1981-02-18 | 1981-02-18 | Preparation of 1,5-benzothiazepin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2141281A JPS57136581A (en) | 1981-02-18 | 1981-02-18 | Preparation of 1,5-benzothiazepin derivative |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6869084A Division JPS59231065A (en) | 1984-04-05 | 1984-04-05 | Novel propionic acid derivative salt and optical resolution of propionic acid derivative |
JP6868984A Division JPS59231074A (en) | 1984-04-05 | 1984-04-05 | Preparation of 1,5-benzothiazepine derivative |
JP6869184A Division JPS59231075A (en) | 1984-04-05 | 1984-04-05 | Preparation of 1,5-benzothiazepine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57136581A true JPS57136581A (en) | 1982-08-23 |
JPS6317831B2 JPS6317831B2 (en) | 1988-04-15 |
Family
ID=12054302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2141281A Granted JPS57136581A (en) | 1981-02-18 | 1981-02-18 | Preparation of 1,5-benzothiazepin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57136581A (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985000810A1 (en) * | 1983-08-12 | 1985-02-28 | Takeda Chemical Industries, Ltd. | Fused 7-membered ring compounds and process for their preparation |
WO1985001730A1 (en) * | 1983-10-13 | 1985-04-25 | Takeda Chemical Industries, Ltd. | Fused 7-membered ring compounds and process for their preparation |
JPS60155168A (en) * | 1984-01-24 | 1985-08-15 | Toubishi Yakuhin Kogyo Kk | Production of 1,5-benzothiazepine derivative |
EP0158303A2 (en) * | 1984-04-13 | 1985-10-16 | Abic Ltd. | A process for the preparation of benzothiazepin derivatives |
US4552695A (en) * | 1983-04-21 | 1985-11-12 | Shionogi & Co., Ltd. | Process for production of diltiazem hydrochloride |
JPS6133164A (en) * | 1984-07-25 | 1986-02-17 | Nippon Chemiphar Co Ltd | Optical resolution of propionic acid derivative |
JPS6165875A (en) * | 1984-09-06 | 1986-04-04 | Toubishi Yakuhin Kogyo Kk | Production of 1,5-benzothiazepine derivative |
JPS61145160A (en) * | 1984-12-20 | 1986-07-02 | Nippon Chemiphar Co Ltd | Production of optically active propionic acid derivative |
JPS61145159A (en) * | 1984-12-20 | 1986-07-02 | Nippon Chemiphar Co Ltd | Novel optically active propionic acid ester derivative and preparation thereof |
JPH021466A (en) * | 1988-01-28 | 1990-01-05 | Ind Chim Profarmaco Spa | Optical resolution of racemic acid |
-
1981
- 1981-02-18 JP JP2141281A patent/JPS57136581A/en active Granted
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4552695A (en) * | 1983-04-21 | 1985-11-12 | Shionogi & Co., Ltd. | Process for production of diltiazem hydrochloride |
WO1985000810A1 (en) * | 1983-08-12 | 1985-02-28 | Takeda Chemical Industries, Ltd. | Fused 7-membered ring compounds and process for their preparation |
WO1985001730A1 (en) * | 1983-10-13 | 1985-04-25 | Takeda Chemical Industries, Ltd. | Fused 7-membered ring compounds and process for their preparation |
JPH0585549B2 (en) * | 1984-01-24 | 1993-12-07 | Tanabe Seiyaku Co | |
JPS60155168A (en) * | 1984-01-24 | 1985-08-15 | Toubishi Yakuhin Kogyo Kk | Production of 1,5-benzothiazepine derivative |
EP0158303A2 (en) * | 1984-04-13 | 1985-10-16 | Abic Ltd. | A process for the preparation of benzothiazepin derivatives |
JPS6133164A (en) * | 1984-07-25 | 1986-02-17 | Nippon Chemiphar Co Ltd | Optical resolution of propionic acid derivative |
JPS6165875A (en) * | 1984-09-06 | 1986-04-04 | Toubishi Yakuhin Kogyo Kk | Production of 1,5-benzothiazepine derivative |
JPH0573748B2 (en) * | 1984-09-06 | 1993-10-15 | Tanabe Seiyaku Co | |
JPS61145159A (en) * | 1984-12-20 | 1986-07-02 | Nippon Chemiphar Co Ltd | Novel optically active propionic acid ester derivative and preparation thereof |
JPH0461867B2 (en) * | 1984-12-20 | 1992-10-02 | Nippon Chemiphar Co | |
JPS61145160A (en) * | 1984-12-20 | 1986-07-02 | Nippon Chemiphar Co Ltd | Production of optically active propionic acid derivative |
JPH021466A (en) * | 1988-01-28 | 1990-01-05 | Ind Chim Profarmaco Spa | Optical resolution of racemic acid |
JP2619280B2 (en) * | 1988-01-28 | 1997-06-11 | プロファルマコ ノベル エッセ エッレ エッレ | Optical resolution of racemic acid |
Also Published As
Publication number | Publication date |
---|---|
JPS6317831B2 (en) | 1988-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK304382A (en) | PROCEDURE FOR PREPARING SUBSTITUTED IMIDAZOLD DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS | |
JPS57136581A (en) | Preparation of 1,5-benzothiazepin derivative | |
JPS57203072A (en) | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient | |
JPS57206656A (en) | Preparation of indole compound | |
JPS56104890A (en) | Preparation of organosilane | |
JPS54151987A (en) | Preparation of 3',5'-disubstituted-2'-deoxy-beta-uridines and 2'-deoxy-beta-urdines | |
ES8307236A1 (en) | Process for the preparation of a furan derivative. | |
IT1150955B (en) | 3H-NAFT (1.2-D) -IMIDAZOLIC DERIVATIVES THE PROCEDURE FOR THEIR PREPARATION, THEIR USE AS ANTI-INFLAMMATORY AGENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
ES2001676A6 (en) | Propionamidine derivatives. | |
JPS5634646A (en) | Preparation of phenoxyalkene derivative | |
IE790924L (en) | 1,3-benzodioxin derivatives | |
ES8506606A1 (en) | Process for the preparation of basic oxime ethers | |
JPS5622765A (en) | Novel method of preparing pindolol | |
JPS5677266A (en) | Synthesis of 2,3-dioxopiperazine derivative | |
JPS5767584A (en) | Thiazolo(3,2-a)pyrimidine derivative, its preparation, and drug containing the same | |
JPS5492990A (en) | Preparation of 1-(5-oxo-hexyl) theobromine | |
JPS5461193A (en) | Preparation of 1-(5-oxohexyl)theobromine | |
JPS5511502A (en) | Preparation of condensed heterocyclic compound | |
JPS577465A (en) | Preparation of indole derivative | |
JPS56113795A (en) | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same | |
JPS5659732A (en) | Preparation of phenoxycarboxylic acid derivative | |
JPS5572190A (en) | Preparation of 1-(5'-oxohexyl)-3,7-dimethyl-xanthine | |
JPS56152461A (en) | Preparation of indole derivative | |
JPS5740497A (en) | Preparation of 5-halogeno-2'-deoxyuridine | |
JPS5634648A (en) | Preparation of phenoxyalkene derivative |