JPS57136581A - Preparation of 1,5-benzothiazepin derivative - Google Patents

Preparation of 1,5-benzothiazepin derivative

Info

Publication number
JPS57136581A
JPS57136581A JP2141281A JP2141281A JPS57136581A JP S57136581 A JPS57136581 A JP S57136581A JP 2141281 A JP2141281 A JP 2141281A JP 2141281 A JP2141281 A JP 2141281A JP S57136581 A JPS57136581 A JP S57136581A
Authority
JP
Japan
Prior art keywords
derivative
benzothiazepin
compound
alumina
silica gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2141281A
Other languages
Japanese (ja)
Other versions
JPS6317831B2 (en
Inventor
Susumu Nagao
Katsuhiko Kurabayashi
Nobuyuki Futamura
Hidefumi Kinoshita
Toshio Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP2141281A priority Critical patent/JPS57136581A/en
Publication of JPS57136581A publication Critical patent/JPS57136581A/en
Publication of JPS6317831B2 publication Critical patent/JPS6317831B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled compound having coronary vessel dilating activity, etc. and useful as a drug, in high yield, by condensation reaction, etc. of a 1,5-benzothiazepin derivative in the presence of silica gel or alumina, using an aprotic polar solvent.
CONSTITUTION: A 1,5-benzothiazepin derivative of formulaI(Ar is phenyl substituted with lower alkoxy group; R is lower alkyl) is converted to its alkali metal salt at the 5-position nitrogen atom by adding sodium hydride to the derivative in an aprotic polar solvent such as dimethylsulfoxide, sulfolane, etc. in the presence of silica gel or alumina, and the resultant metal salt is condensed with a compound of formula II (R1 and R2 are lower alkyl; Y is lower alkylene; Z is halogen) at 5W60°C to obtain the objective compound of formula III.
COPYRIGHT: (C)1982,JPO&Japio
JP2141281A 1981-02-18 1981-02-18 Preparation of 1,5-benzothiazepin derivative Granted JPS57136581A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2141281A JPS57136581A (en) 1981-02-18 1981-02-18 Preparation of 1,5-benzothiazepin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2141281A JPS57136581A (en) 1981-02-18 1981-02-18 Preparation of 1,5-benzothiazepin derivative

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP6869084A Division JPS59231065A (en) 1984-04-05 1984-04-05 Novel propionic acid derivative salt and optical resolution of propionic acid derivative
JP6868984A Division JPS59231074A (en) 1984-04-05 1984-04-05 Preparation of 1,5-benzothiazepine derivative
JP6869184A Division JPS59231075A (en) 1984-04-05 1984-04-05 Preparation of 1,5-benzothiazepine derivative

Publications (2)

Publication Number Publication Date
JPS57136581A true JPS57136581A (en) 1982-08-23
JPS6317831B2 JPS6317831B2 (en) 1988-04-15

Family

ID=12054302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2141281A Granted JPS57136581A (en) 1981-02-18 1981-02-18 Preparation of 1,5-benzothiazepin derivative

Country Status (1)

Country Link
JP (1) JPS57136581A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000810A1 (en) * 1983-08-12 1985-02-28 Takeda Chemical Industries, Ltd. Fused 7-membered ring compounds and process for their preparation
WO1985001730A1 (en) * 1983-10-13 1985-04-25 Takeda Chemical Industries, Ltd. Fused 7-membered ring compounds and process for their preparation
JPS60155168A (en) * 1984-01-24 1985-08-15 Toubishi Yakuhin Kogyo Kk Production of 1,5-benzothiazepine derivative
EP0158303A2 (en) * 1984-04-13 1985-10-16 Abic Ltd. A process for the preparation of benzothiazepin derivatives
US4552695A (en) * 1983-04-21 1985-11-12 Shionogi & Co., Ltd. Process for production of diltiazem hydrochloride
JPS6133164A (en) * 1984-07-25 1986-02-17 Nippon Chemiphar Co Ltd Optical resolution of propionic acid derivative
JPS6165875A (en) * 1984-09-06 1986-04-04 Toubishi Yakuhin Kogyo Kk Production of 1,5-benzothiazepine derivative
JPS61145160A (en) * 1984-12-20 1986-07-02 Nippon Chemiphar Co Ltd Production of optically active propionic acid derivative
JPS61145159A (en) * 1984-12-20 1986-07-02 Nippon Chemiphar Co Ltd Novel optically active propionic acid ester derivative and preparation thereof
JPH021466A (en) * 1988-01-28 1990-01-05 Ind Chim Profarmaco Spa Optical resolution of racemic acid

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552695A (en) * 1983-04-21 1985-11-12 Shionogi & Co., Ltd. Process for production of diltiazem hydrochloride
WO1985000810A1 (en) * 1983-08-12 1985-02-28 Takeda Chemical Industries, Ltd. Fused 7-membered ring compounds and process for their preparation
WO1985001730A1 (en) * 1983-10-13 1985-04-25 Takeda Chemical Industries, Ltd. Fused 7-membered ring compounds and process for their preparation
JPH0585549B2 (en) * 1984-01-24 1993-12-07 Tanabe Seiyaku Co
JPS60155168A (en) * 1984-01-24 1985-08-15 Toubishi Yakuhin Kogyo Kk Production of 1,5-benzothiazepine derivative
EP0158303A2 (en) * 1984-04-13 1985-10-16 Abic Ltd. A process for the preparation of benzothiazepin derivatives
JPS6133164A (en) * 1984-07-25 1986-02-17 Nippon Chemiphar Co Ltd Optical resolution of propionic acid derivative
JPS6165875A (en) * 1984-09-06 1986-04-04 Toubishi Yakuhin Kogyo Kk Production of 1,5-benzothiazepine derivative
JPH0573748B2 (en) * 1984-09-06 1993-10-15 Tanabe Seiyaku Co
JPS61145159A (en) * 1984-12-20 1986-07-02 Nippon Chemiphar Co Ltd Novel optically active propionic acid ester derivative and preparation thereof
JPH0461867B2 (en) * 1984-12-20 1992-10-02 Nippon Chemiphar Co
JPS61145160A (en) * 1984-12-20 1986-07-02 Nippon Chemiphar Co Ltd Production of optically active propionic acid derivative
JPH021466A (en) * 1988-01-28 1990-01-05 Ind Chim Profarmaco Spa Optical resolution of racemic acid
JP2619280B2 (en) * 1988-01-28 1997-06-11 プロファルマコ ノベル エッセ エッレ エッレ Optical resolution of racemic acid

Also Published As

Publication number Publication date
JPS6317831B2 (en) 1988-04-15

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