ES2039166B1 - Proceso para la preparacion de benzodiacepinas por ciclizacion con acidos fosfonicos. - Google Patents
Proceso para la preparacion de benzodiacepinas por ciclizacion con acidos fosfonicos.Info
- Publication number
- ES2039166B1 ES2039166B1 ES9201053A ES9201053A ES2039166B1 ES 2039166 B1 ES2039166 B1 ES 2039166B1 ES 9201053 A ES9201053 A ES 9201053A ES 9201053 A ES9201053 A ES 9201053A ES 2039166 B1 ES2039166 B1 ES 2039166B1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- preparation
- alkyl
- cycling
- benzodiacepines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
PROCESO PARA LA PREPARACION DE LA BENZOTIACEPINA (2S,3S)2,3-DIHIDRO-3-HIDROXI-2-(4-METOXIFENIL)-1,5-BENZOTIACEPIN4(5H)-ONA, DE FORMULA (I), EN LA QUE LOS ASTERISCOS INDICAN ATOMOS DE CARBONO ASIMETRICOS. EL PROCESO CONSISTE EN LA CICLACION DIRECTA DEL COMPUESTO DE FORMULA (II), EN LA QUE R ES UN ALQUILO C1-C3, Y LOS ASTERISCOS INDICAN ATOMOS DE CARBONO ASIMETRICOS, CON UNA CANTIDAD CATALITICA DE UN ACIDO FOSFONICO DE FORMULA (III), EN LA QUE R1 ES UN ALQUILO C1-C5 O UN ALQUENILO C2-C5, EN UN DISOLVENTE INERTE. EL COMPUESTO (I) SE USA COMO PRODUCTO INTERMEDIO EN LA SINTESIS DE DILTIAZEM. OJO FORMULA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI911426A IT1249318B (it) | 1991-05-23 | 1991-05-23 | Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2039166A1 ES2039166A1 (es) | 1993-08-16 |
| ES2039166B1 true ES2039166B1 (es) | 1994-04-01 |
Family
ID=11359974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9201053A Expired - Fee Related ES2039166B1 (es) | 1991-05-23 | 1992-05-22 | Proceso para la preparacion de benzodiacepinas por ciclizacion con acidos fosfonicos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5223612A (es) |
| JP (1) | JP3101841B2 (es) |
| AT (1) | AT401176B (es) |
| BE (1) | BE1005268A3 (es) |
| CA (1) | CA2068231C (es) |
| CH (1) | CH683100A5 (es) |
| DE (1) | DE4217103C2 (es) |
| ES (1) | ES2039166B1 (es) |
| FR (1) | FR2676735B1 (es) |
| GB (1) | GB2255973B (es) |
| IT (1) | IT1249318B (es) |
| NL (1) | NL194275C (es) |
| SE (1) | SE505880C2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL104275A (en) * | 1992-01-10 | 1998-04-05 | Tanabe Seiyaku Co | Process for preparing optically active benzothiazepine compounds by asymmetric reduction |
| IL123352A0 (en) | 1997-02-27 | 1998-09-24 | Tanabe Seiyaku Co | Process for preparing an optically active trans-3-substituted glycidic acid ester |
| IT1295376B1 (it) * | 1997-10-22 | 1999-05-12 | Zambon Spa | Processo per il riciclo di un sottoprodotto della sintesi del diltiazem |
| US6369220B1 (en) | 1997-12-19 | 2002-04-09 | Jinglin (James T.) Li | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides |
| US20170029393A1 (en) * | 2014-04-10 | 2017-02-02 | Archer Daniels Midland Company | Synthesis of r-glucosides, sugar alcohols, reduced sugar alcohols, and furan derivatives of reduced sugar alcohols |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641535B1 (fr) * | 1989-01-11 | 1991-03-15 | Synthelabo | Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4 |
| ES2069003T3 (es) * | 1989-04-28 | 1995-05-01 | Tanabe Seiyaku Co | Procedimiento para preparar derivados de 1,5-benzotiazepina. |
| US5128469A (en) * | 1989-04-28 | 1992-07-07 | Tanabe Seiyaku Co., Ltd. | Process for preparing 1,5-benzothiazepine derivatives |
| JPH0798813B2 (ja) * | 1989-04-28 | 1995-10-25 | 田辺製薬株式会社 | １，５―ベンゾチアゼピン誘導体の製法 |
| ZA906810B (en) * | 1989-08-31 | 1991-10-30 | Marion Merrell Dow Inc | Heterogeneous synthesis of azepinones from esters |
| JPH085869B2 (ja) * | 1990-03-08 | 1996-01-24 | 田辺製薬株式会社 | １，５−ベンゾチアゼピン誘導体の製法 |
-
1991
- 1991-05-23 IT ITMI911426A patent/IT1249318B/it active IP Right Grant
-
1992
- 1992-05-01 JP JP04157237A patent/JP3101841B2/ja not_active Expired - Fee Related
- 1992-05-04 CH CH1419/92A patent/CH683100A5/it not_active IP Right Cessation
- 1992-05-05 GB GB9209636A patent/GB2255973B/en not_active Expired - Fee Related
- 1992-05-08 CA CA002068231A patent/CA2068231C/en not_active Expired - Lifetime
- 1992-05-11 BE BE9200430A patent/BE1005268A3/fr not_active IP Right Cessation
- 1992-05-13 US US07/882,512 patent/US5223612A/en not_active Expired - Lifetime
- 1992-05-14 FR FR9205861A patent/FR2676735B1/fr not_active Expired - Fee Related
- 1992-05-15 AT AT0100292A patent/AT401176B/de not_active IP Right Cessation
- 1992-05-18 NL NL9200870A patent/NL194275C/nl not_active IP Right Cessation
- 1992-05-22 DE DE4217103A patent/DE4217103C2/de not_active Expired - Fee Related
- 1992-05-22 SE SE9201609A patent/SE505880C2/sv not_active IP Right Cessation
- 1992-05-22 ES ES9201053A patent/ES2039166B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2676735A1 (fr) | 1992-11-27 |
| NL194275B (nl) | 2001-07-02 |
| FR2676735B1 (fr) | 1994-01-28 |
| IT1249318B (it) | 1995-02-22 |
| DE4217103C2 (de) | 2000-08-10 |
| SE9201609D0 (sv) | 1992-05-22 |
| NL194275C (nl) | 2001-11-05 |
| US5223612A (en) | 1993-06-29 |
| NL9200870A (nl) | 1992-12-16 |
| ES2039166A1 (es) | 1993-08-16 |
| CA2068231A1 (en) | 1992-11-24 |
| CA2068231C (en) | 2002-10-29 |
| DE4217103A1 (de) | 1992-11-26 |
| SE9201609L (sv) | 1992-11-24 |
| BE1005268A3 (fr) | 1993-06-15 |
| ATA100292A (de) | 1995-11-15 |
| GB2255973B (en) | 1995-01-11 |
| ITMI911426A0 (it) | 1991-05-23 |
| JPH05222016A (ja) | 1993-08-31 |
| GB2255973A (en) | 1992-11-25 |
| JP3101841B2 (ja) | 2000-10-23 |
| CH683100A5 (it) | 1994-01-14 |
| ITMI911426A1 (it) | 1992-11-23 |
| SE505880C2 (sv) | 1997-10-20 |
| AT401176B (de) | 1996-07-25 |
| GB9209636D0 (en) | 1992-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050523 |