FR2656530B1 - Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase. - Google Patents

Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.

Info

Publication number
FR2656530B1
FR2656530B1 FR8917466A FR8917466A FR2656530B1 FR 2656530 B1 FR2656530 B1 FR 2656530B1 FR 8917466 A FR8917466 A FR 8917466A FR 8917466 A FR8917466 A FR 8917466A FR 2656530 B1 FR2656530 B1 FR 2656530B1
Authority
FR
France
Prior art keywords
protein
expression
eukaryotic cells
recombinant gene
urate oxidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8917466A
Other languages
English (en)
French (fr)
Other versions
FR2656530A1 (fr
Inventor
Pascal Leplatois
Gerard Loison
Marc Salome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8917466A priority Critical patent/FR2656530B1/fr
Priority to FR9001368A priority patent/FR2657785A2/fr
Priority to NZ234453A priority patent/NZ234453A/xx
Priority to PT94680A priority patent/PT94680B/pt
Priority to IL95057A priority patent/IL95057A/xx
Priority to ES90402023T priority patent/ES2095243T3/es
Priority to US07/920,519 priority patent/US5382518A/en
Priority to EP90402023A priority patent/EP0408461B1/fr
Priority to CA002035900A priority patent/CA2035900C/fr
Priority to KR1019910700276A priority patent/KR0159107B1/ko
Priority to DE2001199042 priority patent/DE10199042I2/de
Priority to AT90402023T priority patent/ATE144282T1/de
Priority to BR909006855A priority patent/BR9006855A/pt
Priority to MC@@@@D priority patent/MC2145A1/xx
Priority to SU4895030/13A priority patent/RU2105812C1/ru
Priority to JP2510514A priority patent/JP2664804B2/ja
Priority to IE255990A priority patent/IE77158B1/en
Priority to AU60523/90A priority patent/AU636637B2/en
Priority to DE69028884T priority patent/DE69028884T2/de
Priority to PCT/FR1990/000532 priority patent/WO1991000909A1/fr
Priority to DK90402023.7T priority patent/DK0408461T3/da
Priority to HU906046A priority patent/HU215948B/hu
Priority to FI911212A priority patent/FI105047B/fi
Priority to NO910982A priority patent/NO308139B1/no
Publication of FR2656530A1 publication Critical patent/FR2656530A1/fr
Application granted granted Critical
Publication of FR2656530B1 publication Critical patent/FR2656530B1/fr
Priority to US08/314,586 priority patent/US5541098A/en
Priority to GR960403531T priority patent/GR3022085T3/el
Priority to BR1100404-5A priority patent/BR1100404A/pt
Priority to HK97101519.4A priority patent/HK1000099B/xx
Priority to LVP-97-200A priority patent/LV12000B/lv
Priority to LU90781C priority patent/LU90781I2/fr
Priority to NL300046C priority patent/NL300046I2/nl
Priority to NO2001018C priority patent/NO2001018I2/no
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
FR8917466A 1989-07-13 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase. Expired - Lifetime FR2656530B1 (fr)

Priority Applications (32)

Application Number Priority Date Filing Date Title
FR8917466A FR2656530B1 (fr) 1989-12-29 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
FR9001368A FR2657785A2 (fr) 1989-12-29 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.
NZ234453A NZ234453A (en) 1989-07-13 1990-07-11 Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
IL95057A IL95057A (en) 1989-07-13 1990-07-12 Recombinant gene coding for a protein possessing urate oxidase activity
PT94680A PT94680B (pt) 1989-07-13 1990-07-12 Processo para a obtencao de uma proteina tendo actividade de urato oxidase gene recombinante que a codifica vector de expressao portador deste gene microorganismos procariotas e celulas eucariotas transformados por este vector de expressao
DK90402023.7T DK0408461T3 (da) 1989-07-13 1990-07-13 Protein med uratoxidase-aktivitet, rekombinant gen, der koder for proteinet, samt ekspressionsvektor, mikroorganismer og transformerede celler
EP90402023A EP0408461B1 (fr) 1989-07-13 1990-07-13 Protéine à activité urate oxydase, gène recombinant codant pour celle-ci, vecteur d'expression, micro-organismes et cellules transformées
CA002035900A CA2035900C (fr) 1989-07-13 1990-07-13 Proteine a activite urate oxydase, gene recombinant codant pour celle-ci, vecteur d'expression, micro-organismes et cellules transformees
KR1019910700276A KR0159107B1 (ko) 1989-07-13 1990-07-13 우레이트 산화효소 활성 단백질, 이 단백질을 암호화하는 재조합 유전자, 발현 벡터, 미생물 및 형질전환세포
DE2001199042 DE10199042I2 (de) 1989-07-13 1990-07-13 Protein mit Urate-Oxidase-Aktivit{t daf}r kodierendes rekombinantes Gen Expressionsvektor Mikroorganismen und Transformanten
AT90402023T ATE144282T1 (de) 1989-07-13 1990-07-13 Protein mit urate-oxidase-aktivität, dafür kodierendes rekombinantes gen, expressionsvektor, mikroorganismen und transformanten
BR909006855A BR9006855A (pt) 1989-07-13 1990-07-13 Proteina de atividade urato oxidase,gene recombinante que a codifica,vetor de expressao,microorganismos e celulas transformadas
MC@@@@D MC2145A1 (fr) 1989-07-13 1990-07-13 Proteine a activite urate oxydase,gene recombinant codant pour celle-ci,vecteur d'expression,micro-organismes et cellules transformees
SU4895030/13A RU2105812C1 (ru) 1989-07-13 1990-07-13 Полипептид, обладающий уратоксидазной активностью, фрагмент днк, обеспечивающий экспрессию полипептида с уратоксидазной активностью (варианты), вектор экспрессии, содержащий фрагмент днк, обеспечивающий экспрессию полипептида с уратоксидазной активностью (варианты), штамм, экспрессирующий полипептид, обладающий уратоксидазной активностью (варианты), способ получения полипептида, обладающего уратоксидазной активностью
JP2510514A JP2664804B2 (ja) 1989-07-13 1990-07-13 尿酸オキシダーゼ活性蛋白質、それをコードした組換え遺伝子、発現ベクター、微生物および形質転換細胞
IE255990A IE77158B1 (en) 1989-07-13 1990-07-13 Protein with urate oxidase activity recombinant gene coding therefor expression vector micro-organisms and transformed cells
ES90402023T ES2095243T3 (es) 1989-07-13 1990-07-13 Proteina de actividad urato oxidasa; gen recombinante codante para esta, vector de expresion, micro-organismos y celulas transformadas.
DE69028884T DE69028884T2 (de) 1989-07-13 1990-07-13 Protein mit Urate-Oxidase-Aktivität, dafür kodierendes rekombinantes Gen, Expressionsvektor, Mikroorganismen und Transformanten
PCT/FR1990/000532 WO1991000909A1 (fr) 1989-07-13 1990-07-13 Proteine a activite urate oxydase, gene recombinant codant pour celle-ci, vecteur d'expression, micro-organismes et cellules transformees
US07/920,519 US5382518A (en) 1989-07-13 1990-07-13 Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
HU906046A HU215948B (hu) 1989-07-13 1990-07-13 Eljárás urát-oxidáz aktivitással rendelkező protein, azt kódoló gén, expressziós vektor és mikroorganizmusok előállítására
AU60523/90A AU636637B2 (en) 1989-07-13 1990-07-13 Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
FI911212A FI105047B (fi) 1989-07-13 1991-03-12 Menetelmä uraattioksidaasiaktiivisuutta, omaavan yhdistelmäproteiinin valmistamiseksi, tätä proteiinia koodittava yhdistelmägeeni, ja tämän sisältävät ekspressiovektorit, mikro-organismit ja transformoidut solut
NO910982A NO308139B1 (no) 1989-07-13 1991-03-12 FremgangsmÕte for fremstilling av rekombinant protein som har spesifikk uratoksydaseaktivitet, rekombinant gen som koder for proteinet, ekspresjonsvektor samt vertsceller som inneholder de rekombinante gen
US08/314,586 US5541098A (en) 1989-07-13 1994-09-28 Urate oxidase activity protein, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
GR960403531T GR3022085T3 (en) 1989-07-13 1996-12-18 Protein with urate oxidase activity, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
BR1100404-5A BR1100404A (pt) 1989-12-29 1997-05-02 Gene recombianante para uma expressão nas células eucarióticas de uma proteìna tal como a urato oxidase
HK97101519.4A HK1000099B (en) 1989-07-13 1997-07-08 Protein with urate oxidase activity, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
LVP-97-200A LV12000B (lv) 1989-07-13 1997-10-15 Olbaltumviela ar urātoksidāzes aktivitāti un tās iegūšana
LU90781C LU90781I2 (fr) 1989-07-13 2001-05-23 Fasturtec -rasburicase
NL300046C NL300046I2 (nl) 1989-07-13 2001-06-12 Eiwit met uraat oxidase activiteit, recombinant gen dat hiervoor codeert, expressievector, micro-organismen en getransformeerde cellen.
NO2001018C NO2001018I2 (no) 1989-07-13 2001-10-30 Rasburicase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8917466A FR2656530B1 (fr) 1989-12-29 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.

Publications (2)

Publication Number Publication Date
FR2656530A1 FR2656530A1 (fr) 1991-07-05
FR2656530B1 true FR2656530B1 (fr) 1994-09-23

Family

ID=9389161

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8917466A Expired - Lifetime FR2656530B1 (fr) 1989-07-13 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
FR9001368A Granted FR2657785A2 (fr) 1989-07-13 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR9001368A Granted FR2657785A2 (fr) 1989-07-13 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.

Country Status (2)

Country Link
BR (1) BR1100404A (enExample)
FR (2) FR2656530B1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118497162B (zh) * 2024-05-24 2025-05-16 广东少和生物科技有限公司 黑酵母菌尿酸氧化酶及其突变体和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1529675A (fr) * 1967-03-29 1968-06-21 Applic Biochimiques Soc Et Urate oxydase à haute activité et sa préparation
DE3583194D1 (de) * 1984-07-27 1991-07-18 Unilever Nv Verfahren zur herstellung von einem polypeptid mittels eines transformierten mikroorganismus, ein dazu geeigneter transformierter mikroorganismus, und zur herstellung dieser mikroorganismen geeignete dns sequenzen.
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (ja) * 1988-08-17 1994-09-14 サッポロビール株式会社 ウリカーゼのｄｎａ配列および製法

Also Published As

Publication number Publication date
FR2657785A2 (fr) 1991-08-09
FR2656530A1 (fr) 1991-07-05
FR2657785B2 (enExample) 1995-03-10
BR1100404A (pt) 2000-06-06

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