FR2522328B1 - Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments - Google Patents

Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments

Info

Publication number
FR2522328B1
FR2522328B1 FR8203338A FR8203338A FR2522328B1 FR 2522328 B1 FR2522328 B1 FR 2522328B1 FR 8203338 A FR8203338 A FR 8203338A FR 8203338 A FR8203338 A FR 8203338A FR 2522328 B1 FR2522328 B1 FR 2522328B1
Authority
FR
France
Prior art keywords
ceto
steroids
medicaments
application
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8203338A
Other languages
English (en)
French (fr)
Other versions
FR2522328A1 (fr
Inventor
Daniel Philibert
Jean Georges Teutsch
Germain Costerousse
Roger Deraedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8203338A priority Critical patent/FR2522328B1/fr
Priority to SE8300308A priority patent/SE8300308L/
Priority to MA19934A priority patent/MA19716A1/fr
Priority to ZA83982A priority patent/ZA83982B/xx
Priority to IL67920A priority patent/IL67920A0/xx
Priority to PH28558A priority patent/PH21308A/en
Priority to US06/469,042 priority patent/US4477445A/en
Priority to PCT/FR1983/000034 priority patent/WO1983003099A1/fr
Priority to GR70610A priority patent/GR78465B/el
Priority to DK89783A priority patent/DK89783A/da
Priority to EG133/83A priority patent/EG15881A/xx
Priority to BE0/210223A priority patent/BE896042A/fr
Priority to MX8310507U priority patent/MX7199E/es
Priority to YU00478/83A priority patent/YU47883A/xx
Priority to PT76307A priority patent/PT76307B/pt
Priority to CH1099/83A priority patent/CH657368A5/fr
Priority to AU11913/83A priority patent/AU562739B2/en
Priority to LU84667A priority patent/LU84667A1/fr
Priority to IT47820/83A priority patent/IT1197592B/it
Priority to CA000422503A priority patent/CA1206471A/fr
Priority to KR1019830000853A priority patent/KR880001870B1/ko
Priority to SU833561503A priority patent/SU1340593A3/ru
Priority to NL8300738A priority patent/NL8300738A/nl
Priority to FI830652A priority patent/FI80049C/fi
Priority to AT0071183A priority patent/AT396109B/de
Priority to GB08305558A priority patent/GB2118186B/en
Priority to AR83292260A priority patent/AR241187A1/es
Priority to ES520195A priority patent/ES520195A0/es
Priority to IE429/83A priority patent/IE54748B1/en
Priority to DE19833307143 priority patent/DE3307143A1/de
Priority to JP58031909A priority patent/JPS58201800A/ja
Priority to HU83690A priority patent/HU193269B/hu
Publication of FR2522328A1 publication Critical patent/FR2522328A1/fr
Priority to OA58138A priority patent/OA07567A/xx
Priority to US06/618,590 priority patent/US4540686A/en
Priority to CA000486788A priority patent/CA1215353A/fr
Application granted granted Critical
Publication of FR2522328B1 publication Critical patent/FR2522328B1/fr
Priority to FR888814868A priority patent/FR2639045B2/fr
Priority to US07/438,359 priority patent/US5064822A/en
Priority to JP2046023A priority patent/JPH02275895A/ja
Priority to US07/757,261 priority patent/US5182381A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
    • C07J7/003—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/0075—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8203338A 1982-03-01 1982-03-01 Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments Expired FR2522328B1 (fr)

Priority Applications (39)

Application Number Priority Date Filing Date Title
FR8203338A FR2522328B1 (fr) 1982-03-01 1982-03-01 Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
SE8300308A SE8300308L (sv) 1982-03-01 1983-01-21 Nya 3-keto- 4,9,19-nor-stereoider, deras framstellning, deras anvendning som lekemedel, kompositioner innehallande dem och deras nya erhallna mellanprodukter
MA19934A MA19716A1 (fr) 1982-03-01 1983-02-11 Procede de preparation de nouveaux derives 3- ceto a 4,9 19- norsteroides .
ZA83982A ZA83982B (en) 1982-03-01 1983-02-14 3-ceto delta 4,9 19-nor steroid derivatives,their preparation their use as medicaments,the compositions containing them and the intermediates thus obtained
IL67920A IL67920A0 (en) 1982-03-01 1983-02-15 New derivatives of 3-keto delta 4,9,19-nor steroids,their preparation,their application as medicaments,the compositions containing them and the new intermediates obtained
PH28558A PH21308A (en) 1982-03-01 1983-02-23 3-keto-19-nor-/4,9-steroids
US06/469,042 US4477445A (en) 1982-03-01 1983-02-23 3-Keto-19-nor-Δ4,9-steroids
PCT/FR1983/000034 WO1983003099A1 (fr) 1982-03-01 1983-02-25 3-ceto-delta 4,9-19-norsteroides
GR70610A GR78465B (enExample) 1982-03-01 1983-02-25
DK89783A DK89783A (da) 1982-03-01 1983-02-25 Fremgangsmaade til fremstilling af 3-keto-delta4,9-19-nor-steroidderivater
EG133/83A EG15881A (en) 1982-03-01 1983-02-27 Process for preparing of new products of 3-aceto delta 4,9,19 steroids
SU833561503A SU1340593A3 (ru) 1982-03-01 1983-02-28 Способ получени производных @ @ 19-норстероидов
YU00478/83A YU47883A (en) 1982-03-01 1983-02-28 Process for obtaining new 3-keto-delta-4,9,19-nor steroid derivatives
PT76307A PT76307B (fr) 1982-03-01 1983-02-28 Procede de preparation de nouveaux derives 3-ceto delta 4,9 19-nor steroides
CH1099/83A CH657368A5 (fr) 1982-03-01 1983-02-28 Derives de 3-ceto delta-4,9 19-nor-steroides, leur preparation, les compositions les renfermant et les produits de depart pour leur preparation.
AU11913/83A AU562739B2 (en) 1982-03-01 1983-02-28 3 keto delta4,9,19-nor steroid derivatives
LU84667A LU84667A1 (fr) 1982-03-01 1983-02-28 Nouveaux derives de 3-ceto delta 4,9 19-nor-steroides,leur preparation,leur application comme medicament,les compositions les reinfermant et les nouveaux intermediaires obtenus
IT47820/83A IT1197592B (it) 1982-03-01 1983-02-28 Derivati di 3-cheto delta 4,9 19-nor-steroidi,procedimento per la loro preparazione,loro impiego come medicamenti,composizioni che li contengono ed intermedi ottenuti
CA000422503A CA1206471A (fr) 1982-03-01 1983-02-28 Procede de preparation de nouveaux derives 3-ceto .delta.4,9 19-nor steroides
KR1019830000853A KR880001870B1 (ko) 1982-03-01 1983-02-28 3-케토 △ 4,9,19-노르 스테로이드 유도체의 제조방법
BE0/210223A BE896042A (fr) 1982-03-01 1983-02-28 Nouveaux derives de 3-ceto delta 4,9, 19-nor-steroides, leur preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
NL8300738A NL8300738A (nl) 1982-03-01 1983-02-28 Nieuwe derivaten van 3-keto-delta4.9-19-nor-steroiden, de bereiding daarvan, de toepassing daarvan als geneesmiddelen, de preparaten, die deze verbindingen bevatten, en de verkregen nieuwe intermediairen.
FI830652A FI80049C (fi) 1982-03-01 1983-02-28 Foerfarande foer framstaellning av terapeutiskt anvaendbara 19-nor-/ 4,9-steroider.
MX8310507U MX7199E (es) 1982-03-01 1983-02-28 Procedimiento para preparar derivados de 3-cetodelta-4,9,19-nor-esteroides
GB08305558A GB2118186B (en) 1982-03-01 1983-03-01 11-substituted steroid 4,9-dienes and 4-ene-9,10-epoxides
AT0071183A AT396109B (de) 1982-03-01 1983-03-01 Verfahren zur herstellung neuer 3-keto-delta 4,9,19-norsteroid-derivate
AR83292260A AR241187A1 (es) 1982-03-01 1983-03-01 Procedimiento para la preparacion de nuevos productos derivados de la estructura 3-ceto delta-4,9-19-nor esteroides e intermediarios para uso exclusivo en dicho procedimiento.
ES520195A ES520195A0 (es) 1982-03-01 1983-03-01 Procedimiento para preparar nuevos derivados de 3-ceto- 4,9,19-nor-esteroides.
IE429/83A IE54748B1 (en) 1982-03-01 1983-03-01 Steroid compounds
DE19833307143 DE3307143A1 (de) 1982-03-01 1983-03-01 Neue derivate der 3-keto-(delta)-4,9,19-nor-steroide, deren herstellung, deren verwendung als arzneimittel, die diese enthaltenden zusammensetzungen und erhaltene neue zwischenprodukte
JP58031909A JPS58201800A (ja) 1982-03-01 1983-03-01 ３―ケト―δ↑４‖↑９―１９―ノルステロイドの新誘導体、それらの製造法及びそれらを含む製薬組成物
HU83690A HU193269B (en) 1982-03-01 1983-03-01 Process for preparing 3-oxo-delta up 4,9 - and 3-oxo-delta up 4-9,11-epoxy-19-norsteroids
OA58138A OA07567A (fr) 1982-03-01 1983-10-13 3-céto-delta 4,9-19-norstéroides.
US06/618,590 US4540686A (en) 1982-03-01 1984-06-08 3-Keto-19-nor-Δ4,9 -steroids
CA000486788A CA1215353A (fr) 1982-03-01 1985-07-15 PROCEDE POUR LA PREPARATION DE DERIVES DE 3-CETO 5.alpha.- HYDROXY .DELTA.9 19-NORSTEROIDES ET LES DERIVES AINSI OBTENUS
FR888814868A FR2639045B2 (fr) 1982-03-01 1988-11-16 Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments
US07/438,359 US5064822A (en) 1982-03-01 1989-11-16 Novel 3-keto-19-nor-Δ4,9 -steroids
JP2046023A JPH02275895A (ja) 1982-03-01 1990-02-28 ３―ケト―△↑９―１９―ノルステロイドの新誘導体
US07/757,261 US5182381A (en) 1982-03-01 1991-09-10 Intermediates for 3-keto-19-nor-Δ4,9 -steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8203338A FR2522328B1 (fr) 1982-03-01 1982-03-01 Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
FR2522328A1 FR2522328A1 (fr) 1983-09-02
FR2522328B1 true FR2522328B1 (fr) 1986-02-14

Family

ID=9271439

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8203338A Expired FR2522328B1 (fr) 1982-03-01 1982-03-01 Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments

Country Status (32)

Country Link
US (2) US4477445A (enExample)
JP (2) JPS58201800A (enExample)
KR (1) KR880001870B1 (enExample)
AR (1) AR241187A1 (enExample)
AT (1) AT396109B (enExample)
AU (1) AU562739B2 (enExample)
BE (1) BE896042A (enExample)
CA (1) CA1206471A (enExample)
CH (1) CH657368A5 (enExample)
DE (1) DE3307143A1 (enExample)
DK (1) DK89783A (enExample)
EG (1) EG15881A (enExample)
ES (1) ES520195A0 (enExample)
FI (1) FI80049C (enExample)
FR (1) FR2522328B1 (enExample)
GB (1) GB2118186B (enExample)
GR (1) GR78465B (enExample)
HU (1) HU193269B (enExample)
IE (1) IE54748B1 (enExample)
IL (1) IL67920A0 (enExample)
IT (1) IT1197592B (enExample)
LU (1) LU84667A1 (enExample)
MA (1) MA19716A1 (enExample)
MX (1) MX7199E (enExample)
NL (1) NL8300738A (enExample)
PH (1) PH21308A (enExample)
PT (1) PT76307B (enExample)
SE (1) SE8300308L (enExample)
SU (1) SU1340593A3 (enExample)
WO (1) WO1983003099A1 (enExample)
YU (1) YU47883A (enExample)
ZA (1) ZA83982B (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2639045B2 (fr) * 1982-03-01 1994-07-29 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments
US5182381A (en) * 1982-03-01 1993-01-26 Roussel Ulcaf Intermediates for 3-keto-19-nor-Δ4,9 -steroids
DE3231827A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
EP0116974B1 (de) * 1983-02-18 1986-10-29 Schering Aktiengesellschaft 11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
IT1212835B (it) * 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
US4666898A (en) * 1983-12-28 1987-05-19 Jackson Lab. Treatment of obesity, diabetes and other symptoms of hypercorticoidism using etiocholanolones
DE3410880A1 (de) * 1984-03-21 1985-10-03 Schering AG, Berlin und Bergkamen, 1000 Berlin 17-substituierte estradiene und estratriene
DE3438500C1 (de) * 1984-10-18 1986-05-28 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung 11ß-substituierter Δ↑9↑-19-Norsteroide
FR2573657B1 (fr) * 1984-11-29 1989-05-12 Roussel Uclaf Produit comprenant une substance antiprogestomimetique et une substance uterotonique
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
CA1241947A (en) * 1985-05-31 1988-09-13 Pierre R. Proulx Conjugated polyene sterol derivatives as membrane probes
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids
US4686214A (en) * 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
FR2598421B1 (fr) * 1986-05-06 1988-08-19 Roussel Uclaf Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3625315A1 (de) * 1986-07-25 1988-01-28 Schering Ag 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
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ES8401495A1 (es) 1983-12-01
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ES520195A0 (es) 1983-12-01
YU47883A (en) 1986-04-30
JPH0443920B2 (enExample) 1992-07-20
CH657368A5 (fr) 1986-08-29
US4477445A (en) 1984-10-16
IL67920A0 (en) 1983-06-15
FI80049B (fi) 1989-12-29
ATA71183A (de) 1992-10-15
KR880001870B1 (ko) 1988-09-23
KR840003649A (ko) 1984-09-15
PT76307B (fr) 1986-01-27
IE54748B1 (en) 1990-01-31
PT76307A (fr) 1983-03-01
NL8300738A (nl) 1983-10-03
LU84667A1 (fr) 1983-09-08
HU193269B (en) 1987-09-28
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FI830652L (fi) 1983-09-02
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PH21308A (en) 1987-09-28
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AU1191383A (en) 1983-09-08
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EG15881A (en) 1991-06-30
ZA83982B (en) 1984-03-28
DK89783D0 (da) 1983-02-25
IT8347820A1 (it) 1984-08-28
SE8300308D0 (sv) 1983-01-21
US4540686A (en) 1985-09-10
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AR241187A1 (es) 1992-01-31

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