FR24C1021I1 - Modulateurs stéroïdiens non hormonaux de NF-KB pour le traitement d'une maladie - Google Patents

Modulateurs stéroïdiens non hormonaux de NF-KB pour le traitement d'une maladie

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Publication number
FR24C1021I1
FR24C1021I1 FR24C1021C FR24C1021C FR24C1021I1 FR 24C1021 I1 FR24C1021 I1 FR 24C1021I1 FR 24C1021 C FR24C1021 C FR 24C1021C FR 24C1021 C FR24C1021 C FR 24C1021C FR 24C1021 I1 FR24C1021 I1 FR 24C1021I1
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France
Prior art keywords
hormonal
steroidal
modulators
disease
treatment
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR24C1021C
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English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reveragen Biopharma Inc
Original Assignee
Reveragen Biopharma Inc
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Filing date
Publication date
Application filed by Reveragen Biopharma Inc filed Critical Reveragen Biopharma Inc
Publication of FR24C1021I1 publication Critical patent/FR24C1021I1/fr
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Publication number Priority date Publication date Assignee Title
EP3656385A1 (en) 2008-05-28 2020-05-27 ReveraGen BioPharma, Inc. Non-hormonal steroid modulators of nf-kb for treatment of disease
WO2011127048A2 (en) * 2010-04-05 2011-10-13 Validus Biopharma NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE
WO2013082253A2 (en) * 2011-11-29 2013-06-06 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of nf-kb for treatment of disease
CN103509075A (zh) * 2012-06-29 2014-01-15 中国药科大学 一种制备二氟泼尼酯的方法
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
HUE055199T2 (hu) * 2015-07-06 2021-11-29 Sage Therapeutics Inc Oxiszterolok és alkalmazási eljárásaik
IL264561A (en) * 2019-01-31 2020-08-31 Lydus Medical Ltd device for anastomosis
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US11857551B1 (en) 2020-07-10 2024-01-02 Ting Therapeutics Llc Methods for the prevention and treatment of hearing loss
EP4413976A1 (en) * 2023-02-07 2024-08-14 Santhera Pharmaceuticals (Schweiz) AG A new vamorolone preparation exhibiting improved solubility

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US619456A (en) * 1899-02-14 Adjustable partition-frame for trunks
GB787410A (en) 1954-05-21 1957-12-11 Pfizer & Co C Improvements in or relating to steroid compounds and the preparation thereof
GB843215A (en) 1954-10-05 1960-08-04 Schering Corp Improvements in or relating to steroid compounds
GB843214A (en) 1955-01-11 1960-08-04 Schering Corp Improvements in or relating to steroid compounds
US2957893A (en) 1955-01-20 1960-10-25 Schering Corp delta1, 4, 9(11)-pregnatrienes
US2776927A (en) 1955-12-27 1957-01-08 Pfizer & Co C Preparation of delta 1, 4-3-keto steroids from delta4 3-keto steroids by protaminobacter
US3164618A (en) 1957-07-22 1965-01-05 Schering Corp Alkylated steroids
US2838536A (en) 1957-11-29 1958-06-10 Upjohn Co 6-fluoro 9 alpha-halo-delta4-pregnenes and process for preparing same
GB912379A (en) 1958-06-19 1962-12-05 Merck & Co Inc Steroid compounds
GB928301A (en) 1958-06-20 1963-06-12 Scherico Ltd 9, 11-dihalogeno steroids
US2894963A (en) 1958-06-20 1959-07-14 Scherico Ltd 9,11-dihalogeno-4-pregnenes and 1,4-pregnadienes
US2980713A (en) 1958-09-05 1961-04-18 Merck & Co Inc 16-methyl-3alpha, 17alpha-dihydroxy steroids of the pregnane series
US3098086A (en) 1959-01-22 1963-07-16 Ciba Geigy Corp Process for the manufacture of 11beta-hydroxy-pregnane compounds
US3009933A (en) 1959-06-01 1961-11-21 Schering Corp Process for the manufacture of 9alpha, 11beta-dihalogenated steroids
FR1433301A (fr) 1959-06-12 1966-04-01 Merck & Co Inc Procédé de préparation de composés de 16alpha-méthyl, 1, 4-prégnadiène
US3004965A (en) 1959-08-07 1961-10-17 Smith Kline French Lab Process and intermediates for preparing steroidal 17->18 lactones
GB959378A (en) 1959-10-12 1964-06-03 Scherico Ltd 21-substituted 17ª‡, 21-dioxy steroids and processes for their preparation
FR1363865A (fr) 1960-06-16 1964-06-19 Roussel Uclaf Nouveaux stéroïdes polyhydroxylés et obtention de ces composés
US3053866A (en) 1961-03-02 1962-09-11 Merck & Co Inc Improved steroid dehydrogenation process
US3127425A (en) 1961-05-29 1964-03-31 Schering Corp 6, 17alpha-disubstituted 9alpha, 11beta-dihalogeno derivatives of a-ring unsaturated pregnane 3, 20-diones
US3047468A (en) 1961-06-06 1962-07-31 American Cyanamid Co Method of preparing delta1, 4-3-keto steroids of the pregnane series
US3087938A (en) 1961-08-02 1963-04-30 Schering Corp 17alpha-chloro and 17alpha-bromo-progesterones
US3284477A (en) 1963-07-10 1966-11-08 Schering Corp Diuretic 1, 4, 9(11)-pregnatrienes
US3463852A (en) 1966-01-14 1969-08-26 Schering Corp Treating allergies with steroids of the pregnane series
DE1938218C3 (de) 1969-07-24 1978-10-19 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9 a,21,21-Trichlor-ll ß-fluor- pregnene, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
HU164115B (zh) 1971-05-07 1973-12-28
BE785812A (fr) 1971-07-05 1973-01-04 Glaxo Lab Ltd Nouveaux composes steroides
BE795243A (fr) 1972-02-11 1973-08-09 Schering Ag Procede de preparation de steroides insatures en 16,17
GB1440063A (en) 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids
FR2244530B1 (zh) * 1973-07-27 1977-07-01 Roussel Uclaf
US4041055A (en) 1975-11-17 1977-08-09 The Upjohn Company Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes
ES445981A1 (es) 1976-03-11 1977-06-01 Aldo Union Calzada Y Cia S R C Procedimiento para la preparacion de un compuesto intermedioen la sintesis de 9 alfa-halogeno-16 beta-metil-prednisolo- na.
GB1544642A (en) 1976-06-04 1979-04-25 Bristol Myers Co 9,11-epoxy steroids and synthesis of corticosteroids therefrom
US4076708A (en) 1976-12-22 1978-02-28 Schering Corporation Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby
DE2748442C3 (de) 1977-10-26 1981-08-27 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17α-(3-Jodbenzoyloxy)-9α -chlor4-pregnen-3.20-dione, Zwischenprodukte und Verfahren zu ihrer Herstellung, 9α -chlor-17α, 21-dihydroxy-1,4-pregnadien-3,20-dion und dieses enthaltende Arzneimittel
US4427591A (en) 1980-01-31 1984-01-24 The Upjohn Company Reduced A ring-Δ9(11) -corticoids
US4318853A (en) 1980-01-31 1982-03-09 The Upjohn Company 9β,11β-Epoxy-5β-corticoids
US4336200A (en) 1980-01-31 1982-06-22 The Upjohn Company 17α-Acyloxy-5β-corticoids
US4444689A (en) 1980-01-31 1984-04-24 The Upjohn Company 17α-Acyloxy-5β-corticoids and 17α-acyloxy-5α-corticoids
ZA817929B (en) 1980-12-22 1982-10-27 Upjohn Co 5alpha-and 5beta-androstane-17beta-carboxylates
ATE8790T1 (de) 1981-02-02 1984-08-15 Schering Corporation Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
DE3109459A1 (de) 1981-03-09 1982-09-23 Schering Ag, 1000 Berlin Und 4619 Bergkamen (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden
DE3373189D1 (en) 1982-06-21 1987-10-01 Dainippon Ink & Chemicals Process for preparation of steroids
DE3227312A1 (de) 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
DE3322120A1 (de) * 1982-07-30 1984-02-02 The Upjohn Co., 49001 Kalamazoo, Mich. Verfahren zur umwandlung von 1,2-gesaettigten 3-ketosteroiden in 1,2-dehydrosteroide
DE3243482A1 (de) * 1982-11-22 1984-05-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6(alpha)-methylkortikoide, ihre herstellung und verwendung
US4994443A (en) 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US5001116A (en) 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
CA1226816A (en) 1982-12-20 1987-09-15 Moses J. Folkman Inhibition of angiogenesis
DE3315722A1 (de) 1983-04-27 1984-10-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 3-oxo-(delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch),(pfeil hoch)(pfeil hoch)4(pfeil hoch)-steroiden
DE3401680A1 (de) 1984-01-16 1985-07-18 Schering AG, 1000 Berlin und 4709 Bergkamen 6(alpha),16ss-dimethylkortikoide
DE3409554A1 (de) 1984-03-13 1985-09-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6(alpha)-methyl-d-homo-kortikoide
CA1310009C (en) 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
US4948533A (en) 1984-03-28 1990-08-14 The Upjohn Company 11a-hydroxy steroid diester
JPS611699A (ja) 1984-06-11 1986-01-07 ジ　アツプジヨン　カンパニー １６α‐メチル化法
US4990612A (en) 1984-06-11 1991-02-05 The Upjohn Company 16α-methylation process
US4613463A (en) 1984-11-01 1986-09-23 The Upjohn Company Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
WO1987001706A2 (en) 1985-09-12 1987-03-26 The Upjohn Company C20 through c26 amino steroids
US4975537A (en) 1985-10-23 1990-12-04 The Upjohn Company Δ9(11) -angiostatic steroids
US4771042A (en) 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
CN87104859A (zh) 1986-06-19 1988-04-27 Mba服务有限公司 带状电缆传输系统
AU7580187A (en) 1986-06-23 1988-01-12 Upjohn Company, The Androstane-type and cortical aminoesters
ES2078890T3 (es) 1986-10-09 1996-01-01 Upjohn Co Amino esteroides en c20 a c26.
CA1317283C (en) 1986-11-05 1993-05-04 Douglas Alan Livingston Steroidal 17–-silyl ethers and process to corticoids and progesterones
ATE94212T1 (de) 1987-03-12 1993-09-15 Upjohn Co 1-2-dehydrierung von steroid-21-estern mit a. simplex.
JPH02502824A (ja) 1987-04-03 1990-09-06 ジ・アップジョン・カンパニー アミノ‐９，１０‐セコステロイド類
US4920216A (en) * 1987-05-28 1990-04-24 The Trustees Of Columbia In The City Of New York Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates
US4910192A (en) 1987-12-04 1990-03-20 Sri International Topically active steroidal anti-inflammatory agents
US4876250A (en) 1988-10-31 1989-10-24 Alcon Laboratories, Inc. Methods for controlling ocular hypertension with angiostatic steroids
US5990099A (en) * 1988-10-31 1999-11-23 Alcon Laboratories, Inc. Angiostatic agents and methods and compositions for controlling ocular hypertension
AU5154990A (en) 1989-04-18 1990-11-16 Upjohn Company, The Topical anti-angiogenic as hair growth inhibitors
US4975536A (en) 1989-06-02 1990-12-04 The Upjohn Company Conversion of a delta16-steroid to a delta17(20)-20-silyl ether
AU5640390A (en) 1989-06-16 1991-01-08 Upjohn Company, The Suramin type compounds and angiostatic steroids to inhibit angiogenesis
CA2064478C (en) * 1989-08-28 2002-07-02 Abbot F. Clark Ophthalmic composition
US5077104A (en) 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
US6090794A (en) 1990-04-19 2000-07-18 The General Hospital Corporation Inhibition of neurofibrosarcoma growth and angiogenesis
US5972922A (en) 1990-06-11 1999-10-26 Alcon Laboratories, Inc. Steroids which inhibit angiogenesis
CA2081205C (en) 1990-06-11 2001-02-27 John W. Wilks Steroids which inhibit angiogenesis
FR2675146A1 (fr) 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
HU226413B1 (en) 1991-06-25 2008-11-28 Aventis Pharma Sa Novel 16-(nitro-substituted methyl)pregna-1,4-dien-3,20-dion derivatives and process for producing them
FR2678275B1 (fr) 1991-06-25 1995-06-23 Roussel Uclaf Nouveaux sterouides 16-methyl substitue derives de la pregna 1,4-diene 3,20-dione leur preparation, leur application a la preparation de sterouides 16-methylene et nouveaux intermediaires.
US5770592A (en) * 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
DK0614463T3 (da) * 1991-11-22 2003-03-31 Alcon Lab Inc Angiostatiske steroider
DE69321099D1 (de) 1992-01-28 1998-10-22 Schering Corp Neue steroid-zwischenprodukte und verfahren zu ihrer herstellung
HU212308B (en) 1992-06-09 1996-05-28 Richter Gedeon Vegyeszet Process for producing novel pregnane steroids and pharmaceutical compositions containing the same
FR2692266B1 (fr) 1992-06-11 1994-08-05 Roussel Uclaf Nouveau procede de preparation de sterouides 16 alpha-methyles.
US8178516B2 (en) 1992-06-30 2012-05-15 Sylvan Labs, LLC Compositions and method for treatment of chronic inflammatory diseases
US20050090553A1 (en) 1992-06-30 2005-04-28 Shapiro Howard K. Compositions and method for treatment of chronic inflammatory diseases
FR2700548B1 (fr) 1993-01-20 1995-03-03 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés.
US5686436A (en) 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5646136A (en) 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
US5502222A (en) 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
CA2196063A1 (en) 1994-09-01 1996-03-07 Ching-Chiang Su Cosolvent parenteral formulation of tirilazad
US6011012A (en) * 1995-06-05 2000-01-04 Human Genome Sciences, Inc. Human cystatin E
JP3394849B2 (ja) 1995-06-07 2003-04-07 ワイケイケイ株式会社 紐止め具
KR20000064495A (ko) 1995-12-20 2000-11-06 둘락 노먼 씨. 9,11b-에폭사이드스테로이드의제조방법
FR2747680B1 (fr) 1996-04-18 1998-07-03 Roussel Uclaf Nouveaux steroides, leur application a titre de medicaments, leur procede de preparation, les intermediaires de ce procede et les compositions pharmaceutiques les renfermant
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
US5851812A (en) 1997-07-01 1998-12-22 Tularik Inc. IKK-β proteins, nucleic acids and methods
US6011023A (en) 1997-08-27 2000-01-04 Alcon Laboratories, Inc. Angiostatic steroids
DE19739916C2 (de) 1997-09-11 2001-09-13 Hesch Rolf Dieter Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen
US6096778A (en) 1997-10-07 2000-08-01 Cephalon, Inc. α-ketoamide multicatalytic protease inhibitors
US6090798A (en) 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
US6030834A (en) 1997-12-30 2000-02-29 Chiron Corporation Human IKK-beta DNA constructs and cells
ES2136581B1 (es) * 1998-05-27 2000-09-16 Uriach & Cia Sa J Uso de derivados del acido-2-hidroxi-4-trifluorometilbenzoico para la preparacion de medicamentos utiles para inhibir el factor de transcripcion nuclear nf-kb.
ES2226203T3 (es) 1998-12-23 2005-03-16 Idea Ag Formulacion mejorada para aplicacion topica no invasiva.
RU2156256C1 (ru) 1999-12-20 2000-09-20 Андрюшина Валентина Александровна Способ получения кортикостероидов
AU2001287574A1 (en) * 2000-06-30 2002-01-08 Ingenium Pharmaceuticals Ag Human g protein-coupled receptor igpcr20, and uses thereof
AU3649502A (en) * 2000-11-29 2002-06-11 Oculex Pharm Inc Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
JP2003081836A (ja) * 2001-07-03 2003-03-19 Univ Nihon 低ナトリウム血症改善薬
ES2184628B1 (es) 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
ITMI20011762A1 (it) * 2001-08-10 2003-02-10 Cosmo Spa Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione
EP1336602A1 (en) 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
CA2489091A1 (en) 2002-06-10 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Inhibitors against activation of nf-kappab
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
US7985422B2 (en) 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
CA2496867A1 (en) 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
CA2570800A1 (en) 2004-06-18 2006-01-26 Wyeth Processes for preparing 6-alkyl-5-arylsulfonyl- dihydrophenanthridines
EP1618881A1 (en) * 2004-07-20 2006-01-25 Santhera Pharmaceuticals (Schweiz) GmbH Use of non-glucocorticoid steroids for the treatment of muscular dystrophy
CN100551929C (zh) 2005-07-14 2009-10-21 天津药业研究院有限公司 Δ9(11)甾体类化合物的制备方法
KR20080035650A (ko) 2005-07-21 2008-04-23 니리어스 파마슈티컬즈, 인코퍼레이션 인터루킨―1 및 종양괴사인자―ａ 조정자들, 이러한조정자들의 합성 및 이들의 사용 방법
NZ565470A (en) 2005-07-29 2010-11-26 4Sc Ag Novel heterocyclic NF-kB inhibitors
CN1907999B (zh) 2005-08-05 2010-04-28 天津天药药业股份有限公司 甲泼尼龙系列产品9,11-脱酯物生产工艺方法
US20070212751A1 (en) 2006-01-18 2007-09-13 Solvay Pharmaceuticals Gmbh Microbial method for the 11beta hydroxylation of 9beta, 10alpha-steriods
WO2008090417A2 (en) 2006-02-02 2008-07-31 The Cleveland Clinic Foundation Inhibition of nf-kb
EP2001455A2 (en) 2006-03-15 2008-12-17 Theralogics, Inc. Methods of treating muscular wasting diseases using nf-kb activation inhibitors
CN101347438A (zh) 2007-07-20 2009-01-21 天津药业研究院有限公司 一种减缓眼部新生血管生成的药物
CN101353368A (zh) 2007-07-27 2009-01-28 天津药业研究院有限公司 一种治疗肿瘤的孕甾药物
CN101397320A (zh) 2007-09-29 2009-04-01 天津天药药业股份有限公司 地塞米松及其系列产品的制备方法
CN101397319A (zh) 2007-09-29 2009-04-01 天津天药药业股份有限公司 倍他米松及其系列产品的制备方法
CN101412742B (zh) 2007-10-19 2013-07-31 天津金耀集团有限公司 一种抑制血管新生的硝酸酯药物
CN101434631B (zh) 2007-11-16 2012-08-08 天津金耀集团有限公司 一种抑制血管新生的雌甾硝酸酯药物
JP2009126852A (ja) 2007-11-27 2009-06-11 Meiji Milk Prod Co Ltd ピリミジン誘導体を有効成分として含有する医薬組成物
EP3656385A1 (en) 2008-05-28 2020-05-27 ReveraGen BioPharma, Inc. Non-hormonal steroid modulators of nf-kb for treatment of disease
CN101624414B (zh) 2008-07-07 2013-02-13 天津金耀集团有限公司 一种抑制血管新生的硝酸酯药物
KR101071305B1 (ko) 2008-10-08 2011-10-07 국립암센터 ＡＲＨ1 단백질 또는 이를 코딩하는 유전자를 포함하는 ＮＦ―κＢ 억제제
CN101759742B (zh) 2008-11-06 2012-07-04 天津金耀集团有限公司 一种16α-甲基甾体化合物的制备方法
WO2011127048A2 (en) * 2010-04-05 2011-10-13 Validus Biopharma NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE
WO2013082253A2 (en) 2011-11-29 2013-06-06 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of nf-kb for treatment of disease
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

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