FR2488604A1 - Derives d'heteroprostaglandines ainsi que leurs procedes de preparation - Google Patents

Derives d'heteroprostaglandines ainsi que leurs procedes de preparation Download PDF

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Publication number
FR2488604A1
FR2488604A1 FR8114910A FR8114910A FR2488604A1 FR 2488604 A1 FR2488604 A1 FR 2488604A1 FR 8114910 A FR8114910 A FR 8114910A FR 8114910 A FR8114910 A FR 8114910A FR 2488604 A1 FR2488604 A1 FR 2488604A1
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FR
France
Prior art keywords
derivatives
hydroxy
formula
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8114910A
Other languages
English (en)
French (fr)
Other versions
FR2488604B1 (enEXAMPLES
Inventor
Stephan Gero
Jean-Claude Barriere
Jeanine Cleophax
Andre Cier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of FR2488604A1 publication Critical patent/FR2488604A1/fr
Application granted granted Critical
Publication of FR2488604B1 publication Critical patent/FR2488604B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
FR8114910A 1980-08-12 1981-07-31 Derives d'heteroprostaglandines ainsi que leurs procedes de preparation Granted FR2488604A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8026240 1980-08-12
GB8113487 1981-05-01

Publications (2)

Publication Number Publication Date
FR2488604A1 true FR2488604A1 (fr) 1982-02-19
FR2488604B1 FR2488604B1 (enEXAMPLES) 1984-11-09

Family

ID=26276527

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8114910A Granted FR2488604A1 (fr) 1980-08-12 1981-07-31 Derives d'heteroprostaglandines ainsi que leurs procedes de preparation
FR8204877A Granted FR2509306A1 (fr) 1980-08-12 1982-03-23 Nouveaux derives de cyclopentene utiles comme intermediaires de synthese et leur procede de preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8204877A Granted FR2509306A1 (fr) 1980-08-12 1982-03-23 Nouveaux derives de cyclopentene utiles comme intermediaires de synthese et leur procede de preparation

Country Status (27)

Country Link
US (1) US4377704A (enEXAMPLES)
AU (2) AU542975B2 (enEXAMPLES)
BG (1) BG36345A3 (enEXAMPLES)
CH (2) CH655716A5 (enEXAMPLES)
DD (3) DD202428A5 (enEXAMPLES)
DE (1) DE3131616A1 (enEXAMPLES)
DK (1) DK356481A (enEXAMPLES)
ES (2) ES8301465A1 (enEXAMPLES)
FI (1) FI812468L (enEXAMPLES)
FR (2) FR2488604A1 (enEXAMPLES)
GR (1) GR74314B (enEXAMPLES)
HU (1) HU191416B (enEXAMPLES)
IL (1) IL63369A (enEXAMPLES)
IS (1) IS1184B6 (enEXAMPLES)
IT (1) IT1214436B (enEXAMPLES)
LU (1) LU83547A1 (enEXAMPLES)
NL (1) NL8103710A (enEXAMPLES)
NO (1) NO812720L (enEXAMPLES)
NZ (1) NZ197729A (enEXAMPLES)
OA (1) OA06879A (enEXAMPLES)
PL (2) PL137212B1 (enEXAMPLES)
PT (1) PT73457B (enEXAMPLES)
RO (2) RO82680B (enEXAMPLES)
SE (2) SE442297B (enEXAMPLES)
SU (1) SU1187716A3 (enEXAMPLES)
YU (2) YU193781A (enEXAMPLES)
ZW (1) ZW17881A1 (enEXAMPLES)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8510277D0 (en) * 1985-04-23 1985-05-30 Glaxo Group Ltd Carbocyclic compounds
AU635065B2 (en) * 1989-09-08 1993-03-11 Emmanouilidis, Theo Mountable washing device
AU758370B2 (en) * 1997-08-08 2003-03-20 Duke University Compositions, apparatus and methods for facilitating surgical procedures
US6711436B1 (en) 1997-08-08 2004-03-23 Duke University Compositions, apparatus and methods for facilitating surgical procedures

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430934A1 (fr) * 1978-07-11 1980-02-08 Glaxo Group Ltd Nouveaux prostanoides et procede pour leur preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664502A (en) * 1970-06-26 1972-05-23 Bird Machine Co Slurry screen and process of making it
US4229592A (en) * 1978-02-06 1980-10-21 Kansas University Endowment Association Intermediate for prostaglandins and process for preparing the intermediate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430934A1 (fr) * 1978-07-11 1980-02-08 Glaxo Group Ltd Nouveaux prostanoides et procede pour leur preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL JOURNAL, vol.132, 1973, (GB) *

Also Published As

Publication number Publication date
BG36345A3 (bg) 1984-10-15
ES514592A0 (es) 1983-04-16
SE442297B (sv) 1985-12-16
CH655716A5 (fr) 1986-05-15
AU542975B2 (en) 1985-03-28
NO812720L (no) 1982-02-15
DD223712A5 (de) 1985-06-19
YU86183A (en) 1984-04-30
FI812468A7 (fi) 1982-02-13
AU3406784A (en) 1985-01-31
OA06879A (fr) 1983-02-28
IT8123455A0 (it) 1981-08-10
US4377704A (en) 1983-03-22
FI812468L (fi) 1982-02-13
AU7400781A (en) 1982-03-04
PT73457A (en) 1981-08-01
NL8103710A (nl) 1982-03-01
LU83547A1 (fr) 1981-12-01
IL63369A0 (en) 1981-10-30
ES504681A0 (es) 1982-12-01
IT1214436B (it) 1990-01-18
ZW17881A1 (en) 1981-10-14
CH650251A5 (fr) 1985-07-15
RO87011A (ro) 1985-05-20
IS1184B6 (is) 1985-05-13
IL63369A (en) 1985-11-29
HUT34147A (en) 1985-02-28
SU1187716A3 (ru) 1985-10-23
RO82680B (ro) 1984-06-30
IS2661A7 (is) 1982-02-13
PL232567A1 (en) 1983-01-03
HU191416B (en) 1987-02-27
DE3131616A1 (de) 1982-04-22
PL133879B1 (en) 1985-07-31
DD202428A5 (de) 1983-09-14
SE8502007L (sv) 1985-04-25
DK356481A (da) 1982-02-13
YU193781A (en) 1984-02-29
DD213437A5 (de) 1984-09-12
NZ197729A (en) 1985-03-20
RO82680A (ro) 1984-05-12
FR2509306A1 (fr) 1983-01-14
GR74314B (enEXAMPLES) 1984-06-22
ES8305710A1 (es) 1983-04-16
PT73457B (en) 1982-10-15
FR2509306B1 (enEXAMPLES) 1984-04-13
ES8301465A1 (es) 1982-12-01
PL137212B1 (en) 1986-05-31
FR2488604B1 (enEXAMPLES) 1984-11-09
SE8104703L (sv) 1982-02-13
SE8502007D0 (sv) 1985-04-25

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Legal Events

Date Code Title Description
ER Errata listed in the french official journal (bopi)

Free format text: 7/82

ST Notification of lapse