FR2432022A1 - Procede de production de piperazine-1-carboxylates de 2-methyl-2-hydroxypropyle - Google Patents
Procede de production de piperazine-1-carboxylates de 2-methyl-2-hydroxypropyleInfo
- Publication number
- FR2432022A1 FR2432022A1 FR7912569A FR7912569A FR2432022A1 FR 2432022 A1 FR2432022 A1 FR 2432022A1 FR 7912569 A FR7912569 A FR 7912569A FR 7912569 A FR7912569 A FR 7912569A FR 2432022 A1 FR2432022 A1 FR 2432022A1
- Authority
- FR
- France
- Prior art keywords
- methyl
- carboxylates
- hydroxypropyl
- piperazine
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
L'invention concerne un procédé de préparation de pipérazine-1-carboxylates de 2-méthyl-2-hydroxypropyle. Le carbonate d'isobutylène et certains composés de pipérazine substitués en position 1 sont amenés à réagir dans un procédé de formation de pipérazine-1-carboxylates de 2-méthyl-2-hydroxypropyle substitués en position 4. Les conditions essentielles du procédé permettent de préparer le carboxylate de 2-méthyl-2-hydroxypropyle dans un rapport d'environ 9 : 1 avec l'isomère structural 1,1-diméthyl-2-hydroxyéthylique correspondant, qui n'est pas désiré. Les pipérazine-1-carboxylates de 2-méthyl-2-hydroxypropyle substitués en position 4 sont des substances médicinales ou des composés intermédiaires pour la synthèse de ces substances.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90708278A | 1978-05-18 | 1978-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2432022A1 true FR2432022A1 (fr) | 1980-02-22 |
FR2432022B1 FR2432022B1 (fr) | 1983-07-08 |
Family
ID=25423490
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7912569A Granted FR2432022A1 (fr) | 1978-05-18 | 1979-05-17 | Procede de production de piperazine-1-carboxylates de 2-methyl-2-hydroxypropyle |
FR7923128A Granted FR2429788A1 (fr) | 1978-05-18 | 1979-09-17 | Procede de production de piperazine-1-carboxylates de 2-methyl-2-hydroxypropyle |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7923128A Granted FR2429788A1 (fr) | 1978-05-18 | 1979-09-17 | Procede de production de piperazine-1-carboxylates de 2-methyl-2-hydroxypropyle |
Country Status (42)
Country | Link |
---|---|
US (1) | US4550164A (fr) |
JP (1) | JPS5946512B2 (fr) |
AR (1) | AR220195A1 (fr) |
AT (1) | AT375357B (fr) |
AU (1) | AU510441B2 (fr) |
BE (1) | BE876311A (fr) |
BG (1) | BG31228A3 (fr) |
CA (1) | CA1097643A (fr) |
CH (1) | CH638796A5 (fr) |
CS (1) | CS236762B2 (fr) |
DD (1) | DD143428A5 (fr) |
DE (1) | DE2919799C2 (fr) |
DK (6) | DK153878C (fr) |
EG (1) | EG13904A (fr) |
ES (1) | ES480669A1 (fr) |
FI (1) | FI64588C (fr) |
FR (2) | FR2432022A1 (fr) |
GB (1) | GB2021107B (fr) |
GR (1) | GR72720B (fr) |
GT (1) | GT197957903A (fr) |
HK (1) | HK13484A (fr) |
HU (1) | HU180282B (fr) |
IE (1) | IE48048B1 (fr) |
IL (1) | IL57295A (fr) |
IN (1) | IN151190B (fr) |
IT (1) | IT1114238B (fr) |
KE (1) | KE3353A (fr) |
LU (1) | LU81271A1 (fr) |
MX (1) | MX6289E (fr) |
MY (1) | MY8500095A (fr) |
NL (1) | NL183190C (fr) |
NO (1) | NO151156C (fr) |
NZ (1) | NZ190473A (fr) |
PH (2) | PH15546A (fr) |
PL (1) | PL118664B1 (fr) |
PT (1) | PT69623A (fr) |
RO (1) | RO76812A (fr) |
SE (1) | SE446183B (fr) |
SG (1) | SG65783G (fr) |
SU (1) | SU1007557A3 (fr) |
YU (1) | YU41633B (fr) |
ZA (1) | ZA792391B (fr) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1096204A (fr) * | 1949-06-30 | 1955-06-16 | Saint Gobain | Procédé de fabrication d'uréthanes dérivées des glycols |
FR62617E (fr) * | 1951-06-29 | 1955-06-15 | Saint Gobain | Procédé de fabrication d'uréthanes dérivées des glycols |
DE1249852B (de) * | 1964-10-07 | 1967-09-14 | Dr Christian Brunnengraber Che mische Fabrik &. Co mbH Lübeck | Verfahren zur Herstellung von Carbamm saureestern von a Glycermathern |
US3703538A (en) * | 1969-02-03 | 1972-11-21 | Jefferson Chem Co Inc | Production of anhydrous beta-hydroxy-alkyl carbamates |
US3935213A (en) * | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
-
1979
- 1979-03-08 DK DK095979A patent/DK153878C/da active
- 1979-03-08 IN IN166/DEL/79A patent/IN151190B/en unknown
- 1979-04-17 CH CH360979A patent/CH638796A5/fr not_active IP Right Cessation
- 1979-05-03 BG BG7943441A patent/BG31228A3/xx unknown
- 1979-05-04 HU HU79PI675A patent/HU180282B/hu unknown
- 1979-05-04 SU SU792763448A patent/SU1007557A3/ru active
- 1979-05-05 PL PL1979215383A patent/PL118664B1/pl unknown
- 1979-05-06 CS CS793161A patent/CS236762B2/cs unknown
- 1979-05-07 RO RO7997441A patent/RO76812A/fr unknown
- 1979-05-07 DD DD79212699A patent/DD143428A5/de unknown
- 1979-05-15 EG EG288/79A patent/EG13904A/xx active
- 1979-05-15 YU YU1139/79A patent/YU41633B/xx unknown
- 1979-05-16 DE DE2919799A patent/DE2919799C2/de not_active Expired
- 1979-05-16 GR GR59103A patent/GR72720B/el unknown
- 1979-05-16 NO NO791641A patent/NO151156C/no unknown
- 1979-05-16 GB GB7916996A patent/GB2021107B/en not_active Expired
- 1979-05-16 IL IL57295A patent/IL57295A/xx unknown
- 1979-05-16 AU AU47102/79A patent/AU510441B2/en not_active Expired
- 1979-05-16 CA CA327,766A patent/CA1097643A/fr not_active Expired
- 1979-05-16 SE SE7904313A patent/SE446183B/sv not_active IP Right Cessation
- 1979-05-16 PH PH22498A patent/PH15546A/en unknown
- 1979-05-16 LU LU81271A patent/LU81271A1/fr unknown
- 1979-05-17 NL NLAANVRAGE7903892,A patent/NL183190C/xx not_active IP Right Cessation
- 1979-05-17 JP JP54060999A patent/JPS5946512B2/ja not_active Expired
- 1979-05-17 AT AT0366579A patent/AT375357B/de not_active IP Right Cessation
- 1979-05-17 ZA ZA792391A patent/ZA792391B/xx unknown
- 1979-05-17 NZ NZ190473A patent/NZ190473A/xx unknown
- 1979-05-17 PT PT69623A patent/PT69623A/pt unknown
- 1979-05-17 BE BE0/195204A patent/BE876311A/fr not_active IP Right Cessation
- 1979-05-17 MX MX797985U patent/MX6289E/es unknown
- 1979-05-17 FI FI791579A patent/FI64588C/fi not_active IP Right Cessation
- 1979-05-17 GT GT197957903A patent/GT197957903A/es unknown
- 1979-05-17 ES ES480669A patent/ES480669A1/es not_active Expired
- 1979-05-17 FR FR7912569A patent/FR2432022A1/fr active Granted
- 1979-05-17 IT IT22759/79A patent/IT1114238B/it active
- 1979-05-18 AR AR276570A patent/AR220195A1/es active
- 1979-08-08 IE IE962/79A patent/IE48048B1/en not_active IP Right Cessation
- 1979-09-17 FR FR7923128A patent/FR2429788A1/fr active Granted
-
1980
- 1980-02-07 PH PH23617A patent/PH16236A/en unknown
-
1981
- 1981-04-24 US US06/257,365 patent/US4550164A/en not_active Expired - Lifetime
-
1983
- 1983-11-02 SG SG65783A patent/SG65783G/en unknown
- 1983-11-22 KE KE3353A patent/KE3353A/xx unknown
-
1984
- 1984-02-16 HK HK134/84A patent/HK13484A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY95/85A patent/MY8500095A/xx unknown
-
1987
- 1987-01-15 DK DK019587A patent/DK153880C/da not_active IP Right Cessation
- 1987-01-15 DK DK019487A patent/DK153840C/da not_active IP Right Cessation
- 1987-01-15 DK DK019387A patent/DK153879C/da active
- 1987-01-15 DK DK019687A patent/DK153881C/da active
- 1987-01-15 DK DK019287A patent/DK19287D0/da not_active Application Discontinuation
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