AR241139A2 - Compuestos de 6alfa-cloro, bromo o yodo (r)-6beta (1'(r)-hidroxi-etilpenicilina, utiles como intermediarios para la sistensis de antibioticos carbapenem y penem y procedimiento para prepararlos. - Google Patents

Compuestos de 6alfa-cloro, bromo o yodo (r)-6beta (1'(r)-hidroxi-etilpenicilina, utiles como intermediarios para la sistensis de antibioticos carbapenem y penem y procedimiento para prepararlos.

Info

Publication number
AR241139A2
AR241139A2 AR29986185A AR29986185A AR241139A2 AR 241139 A2 AR241139 A2 AR 241139A2 AR 29986185 A AR29986185 A AR 29986185A AR 29986185 A AR29986185 A AR 29986185A AR 241139 A2 AR241139 A2 AR 241139A2
Authority
AR
Argentina
Prior art keywords
acetoxyazetidinone
stereocontrolled
6alpha
triisopropilsilyl
silile
Prior art date
Application number
AR29986185A
Other languages
English (en)
Other versions
AR241139A1 (es
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Application granted granted Critical
Publication of AR241139A2 publication Critical patent/AR241139A2/es
Publication of AR241139A1 publication Critical patent/AR241139A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

COMPUESTOS DE 6ALFA-NO SUSTITUIDOS O 6ALFA-CLORO, BROMO O YODO (R)-6BETA(1'(R)-HIDROXIETIL)-PENICILINA, UTILES PARA SINTETIZAR ANTIBIOTICOS CARBAPENEM Y PENEM, CARACTERIZADOS PORQUE RESPONDEN A LA FORMULA: II, EN LA QUE X (S), UN HALOGENO 9R0 Y R' REPRESENTA H O UN GRUPO HIDROXI-PROTECTOR CONVENCIONAL, ELEGIDO ENTRE TRIISOPROPILSILILO Y T-BUTIL-DIAQUIL SILILO.
AR299861A 1984-04-06 1985-03-25 Compuestos de 6alfa-cloro, bromo o yodo (r)-6beta (1'(r)-hidroxi-etilpenicilina, utiles como intermediarios para la sistensis de antibioticos carbapenem y penem y procedimiento para prepararlos. AR241139A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/597,765 US4596677A (en) 1984-04-06 1984-04-06 Anhydropenicillin intermediates

Publications (2)

Publication Number Publication Date
AR241139A2 true AR241139A2 (es) 1991-11-29
AR241139A1 AR241139A1 (es) 1991-11-29

Family

ID=24392838

Family Applications (1)

Application Number Title Priority Date Filing Date
AR299861A AR241139A1 (es) 1984-04-06 1985-03-25 Compuestos de 6alfa-cloro, bromo o yodo (r)-6beta (1'(r)-hidroxi-etilpenicilina, utiles como intermediarios para la sistensis de antibioticos carbapenem y penem y procedimiento para prepararlos.

Country Status (36)

Country Link
US (2) US4596677A (es)
JP (2) JPS6117586A (es)
KR (1) KR920006919B1 (es)
AR (1) AR241139A1 (es)
AT (1) AT388556B (es)
AU (1) AU580043B2 (es)
BE (1) BE902133A (es)
CA (1) CA1261318A (es)
CH (1) CH665420A5 (es)
CS (1) CS253724B2 (es)
CY (1) CY1572A (es)
DD (1) DD232132A5 (es)
DE (1) DE3512250A1 (es)
DK (1) DK156085A (es)
ES (1) ES8702422A1 (es)
FI (1) FI86852C (es)
FR (1) FR2562541B1 (es)
GB (1) GB2156814B (es)
GR (1) GR850879B (es)
HK (1) HK106090A (es)
HU (2) HU194250B (es)
IE (1) IE58409B1 (es)
IL (1) IL74799A (es)
IT (1) IT1190351B (es)
LU (1) LU85841A1 (es)
NL (1) NL8500986A (es)
NO (2) NO164902C (es)
NZ (1) NZ211457A (es)
OA (1) OA07984A (es)
PT (1) PT80235B (es)
SE (3) SE466201B (es)
SG (1) SG91090G (es)
SU (2) SU1400504A3 (es)
YU (3) YU45918B (es)
ZA (1) ZA852237B (es)
ZW (1) ZW5585A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1256444A (en) * 1986-04-30 1989-06-27 Kazunori Kan Process for preparing 4-acetoxy-3- hydroxyethylazetidin-2-one derivatives
US5075438A (en) * 1986-07-21 1991-12-24 Schering Corporation Synthesis of azetidinones
US4876338A (en) * 1986-07-21 1989-10-24 Schering Corporation Synthesis of azetidinones using CuCl
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US4948885A (en) * 1986-07-21 1990-08-14 Schering-Plough Corp. Synthesis of azetidinones
US4767853A (en) * 1986-07-21 1988-08-30 Schering Corporation Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
EP0290385B1 (de) * 1987-05-04 1992-10-21 Ciba-Geigy Ag Neues Verfahren zur Herstellung von 4-Acyloxy-3-hydroxyethyl-azetidinonen
US5274188A (en) * 1987-05-04 1993-12-28 Ciba-Geigy Corporation Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
WO2005023821A1 (ja) * 2003-09-03 2005-03-17 Otsuka Chemical Co., Ltd. ペニシラン酸化合物の製造方法
JP5300713B2 (ja) * 2007-03-09 2013-09-25 大塚化学株式会社 ６−ヒドロキシエチルペナム化合物の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3311638A (en) * 1961-08-16 1967-03-28 Bristol Myers Co Anhydropenicillins
US3950352A (en) * 1972-04-10 1976-04-13 Queen's University 2,2-Dimethyl-3R-carboxy-6S-phenyl(or phenoxy)acetamido-1-oxa-4-aza-5R-bicyclo[3,2,0]heptan-7-one and processes for their production
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4356120A (en) * 1979-07-23 1982-10-26 Merck & Co., Inc. 3-(1-Hydroxyethyl)-4-(but-2-ene)-azetidin-2-one and derivatives
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives

Also Published As

Publication number Publication date
DK156085A (da) 1985-10-07
FR2562541A1 (fr) 1985-10-11
IT1190351B (it) 1988-02-16
AU4086485A (en) 1985-10-10
JPH032157B2 (es) 1991-01-14
IL74799A (en) 1988-11-15
FI851324A0 (fi) 1985-04-02
IE850867L (en) 1985-10-06
HUT38349A (en) 1986-05-28
US4596677A (en) 1986-06-24
ES8702422A1 (es) 1987-01-01
YU134487A (en) 1988-02-29
GB2156814A (en) 1985-10-16
HUT40442A (en) 1986-12-28
YU57185A (en) 1988-02-29
ATA104285A (de) 1988-12-15
ES541866A0 (es) 1987-01-01
HK106090A (en) 1990-12-21
JPS6117586A (ja) 1986-01-25
FI86852C (fi) 1992-10-26
NO851310L (no) 1985-10-07
SE8501679D0 (sv) 1985-04-03
KR850007585A (ko) 1985-12-07
SE9000791D0 (sv) 1990-03-06
FI851324L (fi) 1985-10-07
DD232132A5 (de) 1986-01-15
DK156085D0 (da) 1985-04-03
NO166132B (no) 1991-02-25
YU45918B (sh) 1992-09-07
AR241139A1 (es) 1991-11-29
SG91090G (en) 1991-01-18
DE3512250A1 (de) 1985-10-17
YU46059B (sh) 1992-12-21
JPH0312072B2 (es) 1991-02-19
BE902133A (fr) 1985-10-07
HU194250B (en) 1988-01-28
SE8501679L (sv) 1985-10-07
GB2156814B (en) 1987-12-31
CS253724B2 (en) 1987-12-17
ZW5585A1 (en) 1985-11-06
CA1261318A (en) 1989-09-26
SE9000791L (sv) 1991-09-07
SE466201B (sv) 1992-01-13
KR920006919B1 (ko) 1992-08-22
SU1435154A3 (ru) 1988-10-30
YU134587A (en) 1988-02-29
NL8500986A (nl) 1985-11-01
IL74799A0 (en) 1985-07-31
IT8520246A0 (it) 1985-04-05
NO166132C (no) 1991-06-05
NO164902C (no) 1990-11-28
FR2562541B1 (fr) 1986-12-26
NO164902B (no) 1990-08-20
US4639335A (en) 1987-01-27
FI86852B (fi) 1992-07-15
SE9000790L (sv) 1991-09-07
IE58409B1 (en) 1993-09-22
AU580043B2 (en) 1988-12-22
SE9000790D0 (sv) 1990-03-06
HU193959B (en) 1987-12-28
CH665420A5 (de) 1988-05-13
JPS61171485A (ja) 1986-08-02
PT80235A (en) 1985-05-01
NZ211457A (en) 1989-03-29
GR850879B (es) 1985-11-25
GB8508847D0 (en) 1985-05-09
AT388556B (de) 1989-07-25
PT80235B (pt) 1987-10-20
NO860326L (no) 1985-10-07
OA07984A (fr) 1987-01-31
CY1572A (en) 1991-12-20
YU46060B (sh) 1992-12-21
SU1400504A3 (ru) 1988-05-30
ZA852237B (en) 1985-11-27
LU85841A1 (fr) 1985-12-16

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