FR2393795B1 - Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique - Google Patents
Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutiqueInfo
- Publication number
- FR2393795B1 FR2393795B1 FR7817167A FR7817167A FR2393795B1 FR 2393795 B1 FR2393795 B1 FR 2393795B1 FR 7817167 A FR7817167 A FR 7817167A FR 7817167 A FR7817167 A FR 7817167A FR 2393795 B1 FR2393795 B1 FR 2393795B1
- Authority
- FR
- France
- Prior art keywords
- preparation process
- therapeutic applications
- carbostyryl derivatives
- carbostyryl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MJXYFLJHTUSJGU-UHFFFAOYSA-N 7-amino-4-methyl-1h-quinolin-2-one Chemical class NC1=CC=C2C(C)=CC(=O)NC2=C1 MJXYFLJHTUSJGU-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6931977A JPS545981A (en) | 1977-06-10 | 1977-06-10 | Carbostyryl derivatives |
| JP7586377A JPS5412385A (en) | 1977-06-24 | 1977-06-24 | Carbostyril derivative |
| JP53023012A JPS6059912B2 (ja) | 1978-02-28 | 1978-02-28 | カルボスチリル誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2393795A1 FR2393795A1 (fr) | 1979-01-05 |
| FR2393795B1 true FR2393795B1 (fr) | 1986-07-25 |
Family
ID=27284068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7817167A Expired FR2393795B1 (fr) | 1977-06-10 | 1978-06-08 | Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4298739A (cg-RX-API-DMAC7.html) |
| AR (2) | AR224345A1 (cg-RX-API-DMAC7.html) |
| AT (1) | AT367038B (cg-RX-API-DMAC7.html) |
| AU (1) | AU510138B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1098907A (cg-RX-API-DMAC7.html) |
| CH (1) | CH636087A5 (cg-RX-API-DMAC7.html) |
| DE (1) | DE2825048A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK149449C (cg-RX-API-DMAC7.html) |
| ES (2) | ES470690A1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI69300C (cg-RX-API-DMAC7.html) |
| FR (1) | FR2393795B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2002745B (cg-RX-API-DMAC7.html) |
| IE (1) | IE46852B1 (cg-RX-API-DMAC7.html) |
| IT (1) | IT1108326B (cg-RX-API-DMAC7.html) |
| MX (1) | MX5527E (cg-RX-API-DMAC7.html) |
| NL (1) | NL178074C (cg-RX-API-DMAC7.html) |
| NO (1) | NO148813C (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ187452A (cg-RX-API-DMAC7.html) |
| PH (1) | PH14670A (cg-RX-API-DMAC7.html) |
| PT (1) | PT68157A (cg-RX-API-DMAC7.html) |
| SE (1) | SE444562B (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU843739A3 (ru) * | 1978-02-17 | 1981-06-30 | Карл Томэ Гмбх (Фирма) | Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ |
| AT383594B (de) * | 1980-02-29 | 1987-07-27 | Otsuka Pharma Co Ltd | Verfahren zum herstellen von neuen carbostyrilderivaten und ihren salzen |
| JPS56122356A (en) * | 1980-02-29 | 1981-09-25 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
| US4442111A (en) * | 1981-07-25 | 1984-04-10 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Antithrombotic sulfimino and sulfoximino indolinones-2 |
| FI80022C (fi) * | 1982-07-05 | 1990-04-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat. |
| CH655110A5 (de) * | 1982-09-03 | 1986-03-27 | Otsuka Pharma Co Ltd | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten. |
| US4663320A (en) * | 1983-02-16 | 1987-05-05 | Syntex (U.S.A.) Inc. | (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof |
| US4490371A (en) * | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
| ES8607299A1 (es) * | 1984-02-15 | 1986-06-01 | Syntex Inc | Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas |
| US4670434A (en) * | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
| US5227381A (en) * | 1988-05-02 | 1993-07-13 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative |
| JP2753622B2 (ja) | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| TW201305B (cg-RX-API-DMAC7.html) * | 1991-04-03 | 1993-03-01 | Otsuka Pharma Co Ltd | |
| KR930702307A (ko) * | 1991-08-23 | 1993-09-08 | 오오쓰까 아끼히꼬 | 카르보스티릴 유도체 및 혈소판 응집 억제제 |
| US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| TWI435729B (zh) | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法，組合物及套組 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| EP2196453A1 (en) * | 2008-12-10 | 2010-06-16 | Cellvir | Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| JP5649577B2 (ja) | 2009-08-21 | 2015-01-07 | 大塚製薬株式会社 | ベンゾ［ｂ］［１，４］ジアゼピン−２，４−ジオン化合物の製造方法 |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| KR102034748B1 (ko) | 2011-03-01 | 2019-10-21 | 시너지 파마슈티컬즈 인코포레이티드 | 구아닐레이트 사이클라제 c 작용제의 제조 방법 |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP3718557A3 (en) | 2013-02-25 | 2020-10-21 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| CA2920856A1 (en) | 2013-08-09 | 2015-02-12 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| CN114340631A (zh) | 2019-05-21 | 2022-04-12 | 阿德利克斯股份有限公司 | 用于降低患者的血清磷酸盐的组合 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR207554A1 (es) * | 1972-12-02 | 1976-10-15 | Otsuka Pharma Co Ltd | Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2) |
| JPS5239035B2 (cg-RX-API-DMAC7.html) * | 1972-12-14 | 1977-10-03 | ||
| JPS5234629B2 (cg-RX-API-DMAC7.html) * | 1973-02-03 | 1977-09-05 | ||
| SE431451B (sv) * | 1973-10-24 | 1984-02-06 | Otsuka Pharma Co Ltd | Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner |
| US4022784A (en) * | 1974-01-31 | 1977-05-10 | Otsuka Pharmaceutical Company Limited | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives |
| FI59246C (fi) * | 1974-06-24 | 1981-07-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin |
| JPS54119478A (en) * | 1978-03-06 | 1979-09-17 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
-
1978
- 1978-06-01 IE IE1104/78A patent/IE46852B1/en unknown
- 1978-06-01 NZ NZ187452A patent/NZ187452A/xx unknown
- 1978-06-06 AU AU36866/78A patent/AU510138B2/en not_active Expired
- 1978-06-07 FI FI781811A patent/FI69300C/fi not_active IP Right Cessation
- 1978-06-07 DE DE19782825048 patent/DE2825048A1/de active Granted
- 1978-06-08 NL NLAANVRAGE7806245,A patent/NL178074C/xx not_active IP Right Cessation
- 1978-06-08 FR FR7817167A patent/FR2393795B1/fr not_active Expired
- 1978-06-08 DK DK254878A patent/DK149449C/da not_active IP Right Cessation
- 1978-06-09 PT PT68157A patent/PT68157A/pt unknown
- 1978-06-09 IT IT68355/78A patent/IT1108326B/it active
- 1978-06-09 AT AT0421378A patent/AT367038B/de not_active IP Right Cessation
- 1978-06-09 MX MX787136U patent/MX5527E/es unknown
- 1978-06-09 NO NO782022A patent/NO148813C/no unknown
- 1978-06-09 CH CH632578A patent/CH636087A5/de not_active IP Right Cessation
- 1978-06-09 GB GB7826613A patent/GB2002745B/en not_active Expired
- 1978-06-09 ES ES470690A patent/ES470690A1/es not_active Expired
- 1978-06-09 SE SE7806710A patent/SE444562B/sv not_active IP Right Cessation
- 1978-06-09 PH PH21245A patent/PH14670A/en unknown
- 1978-06-09 CA CA305,102A patent/CA1098907A/en not_active Expired
- 1978-06-09 AR AR272511A patent/AR224345A1/es active
-
1979
- 1979-03-30 ES ES479138A patent/ES479138A1/es not_active Expired
-
1980
- 1980-02-05 AR AR279858A patent/AR225755A1/es active
- 1980-04-21 US US06/142,057 patent/US4298739A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2393795B1 (fr) | Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique | |
| FR2383157B1 (fr) | Derives de chalcone, leur procede de preparation et leur application en therapeutique | |
| BE867421A (fr) | Derives de mevalonolactone, leur procede de preparation et leur application therapeutique | |
| FR2387234B1 (fr) | Derives de cephalosporine, leur procede de preparation et leurs applications en therapeutique | |
| BE875174A (fr) | Nouveaux derives de carbostyrile, leur procede de preparation et leurs applications en therapeutique | |
| LU80081A1 (fr) | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique | |
| BE878723A (fr) | Derives de 4-anilinoquinazoline, leur procede de preparation et leur application en therapeutique | |
| FR2532648B1 (fr) | Derives de carbostyrile, leur procede de preparation et leur application en therapeutique | |
| BE851893A (fr) | Nouvelles aryl-3 oxazolidinones-2, leur procede de preparation et leur application en therapeutique | |
| BE854268A (fr) | Pyrrolidones, leur procede de preparation et leur application therapeutique | |
| BE862785A (fr) | Derives de pyrimido(6,1-a)isoquinoleine-2-one, leur procede de preparation et leur application en therapeutique | |
| FR2458547B2 (fr) | Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique | |
| BE864312A (fr) | Nouveaux derives de la pyrrolidine, leur procede de preparation et leur application en therapeutique | |
| FR2315925A1 (fr) | Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique | |
| FR2313063A1 (fr) | Derives de pyrrolotriazolopyrimidine leur procede de preparation et leurs applications en therapeutique | |
| BE854133A (fr) | 1,3-dihydro-heteroarylspito(isobenzofurannes)et leur procede de preparation et leur application therapeutique | |
| BE866676A (fr) | Derives de bisamidine, leur procede de preparation et leur application therapeutique | |
| BE883713A (fr) | Nouveau derives de carbostyrile, leur procede de preparation et leur application en therapeutique | |
| FR2351965A1 (fr) | Benzenesulfonylurees, leur procede de preparation et leur application therapeutique | |
| FR2353520A1 (fr) | 1-aryloxy-2-hydroxy-3-aminopropanes, leur procede de preparation et leurs applications therapeutiques | |
| BE882270A (fr) | Derives de benzothiazole, leur procede de preparation et leurs applications en therapeutique | |
| BE866928A (fr) | Benzene-sulfonyl urees, leur procede de preparation et leur application therapeutique | |
| BE868659A (fr) | Nouveaux derives de benzamidine, leur procede de preparation et leurs applications en therapeutique | |
| BE866648A (fr) | Derives de triazolothiadiazines, leur procede de preparation et leurs applications en therapeutique | |
| BE862878A (fr) | Alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5,-tetrahydro-1h-3-benzazepines, leurs procede de preparation et application en therapeutique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |