BE867421A - Derives de mevalonolactone, leur procede de preparation et leur application therapeutique - Google Patents
Derives de mevalonolactone, leur procede de preparation et leur application therapeutiqueInfo
- Publication number
- BE867421A BE867421A BE187992A BE187992A BE867421A BE 867421 A BE867421 A BE 867421A BE 187992 A BE187992 A BE 187992A BE 187992 A BE187992 A BE 187992A BE 867421 A BE867421 A BE 867421A
- Authority
- BE
- Belgium
- Prior art keywords
- preparation process
- therapeutic application
- mevalonolactone derivatives
- mevalonolactone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6011077A JPS53147073A (en) | 1977-05-24 | 1977-05-24 | Mevalonolactone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BE867421A true BE867421A (fr) | 1978-11-24 |
Family
ID=13132633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE187992A BE867421A (fr) | 1977-05-24 | 1978-05-24 | Derives de mevalonolactone, leur procede de preparation et leur application therapeutique |
Country Status (9)
Country | Link |
---|---|
US (2) | US4198425A (fr) |
JP (1) | JPS53147073A (fr) |
BE (1) | BE867421A (fr) |
DE (1) | DE2822848A1 (fr) |
ES (1) | ES470209A1 (fr) |
FR (1) | FR2392016A1 (fr) |
GB (1) | GB1586152A (fr) |
NL (1) | NL7805647A (fr) |
SE (1) | SE7805879L (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0010951A1 (fr) * | 1978-10-30 | 1980-05-14 | Sankyo Company Limited | Dérivés de 4-hydroxy-2-pyrones, procédé pour leur préparation et leurs préparations pharmaceutiques |
US4322563A (en) | 1980-04-14 | 1982-03-30 | Merck & Co., Inc. | Substituted biphenyl-2-carboxaldehydes |
US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
US4801611A (en) * | 1987-05-07 | 1989-01-31 | G. D. Searle & Co. | 5-lipoxygenase inhibitors |
US5162365A (en) * | 1987-05-07 | 1992-11-10 | G. D. Searle & Co. | 5-lipoxygenase inhibitors |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA18559A1 (fr) * | 1978-09-05 | 1980-04-01 | Hoechst Lab | Nouveaux derives d'acides carboxyliques 6-alcools, halogenes, leurs procedes de preparation et medicaments les contenant |
US4459422A (en) * | 1979-08-17 | 1984-07-10 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
US4375475A (en) * | 1979-08-17 | 1983-03-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
US4710513A (en) * | 1979-08-17 | 1987-12-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
NZ194557A (en) * | 1979-08-17 | 1984-09-28 | Merck & Co Inc | Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions |
US4308378A (en) * | 1980-09-02 | 1981-12-29 | Merck & Co., Inc. | Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones |
US4440927A (en) * | 1981-06-19 | 1984-04-03 | Merck & Co., Inc. | Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase via a chiral synthon |
US5354772A (en) * | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
US4588715A (en) * | 1984-06-04 | 1986-05-13 | Sandoz, Inc. | Heptenoic acid derivatives |
US4588820A (en) * | 1984-06-11 | 1986-05-13 | Merck & Co., Inc. | Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one |
US4613610A (en) * | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
US4686237A (en) * | 1984-07-24 | 1987-08-11 | Sandoz Pharmaceuticals Corp. | Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof |
US4804679A (en) * | 1984-07-24 | 1989-02-14 | Sandoz Pharm. Corp. | Erythro-(E)-7-(3'-C1-3alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl)-3,5-dihydroxyhept-6-enoic acids and derivatives thereof |
US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
US5001255A (en) * | 1984-12-04 | 1991-03-19 | Sandoz Pharm. Corp. | Idene analogs of mevalonolactone and derivatives thereof |
AU5259486A (en) * | 1985-01-17 | 1986-07-24 | Usv Pharmaceutical Corp. | Arylalkoxyphenyl-allylic alcohols as agents for the treatment of hypersensitive ailments |
US4668794A (en) * | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
JPS6282997A (ja) * | 1985-10-04 | 1987-04-16 | 株式会社森本製作所 | 多針式ミシンの縫製装置 |
US4851427A (en) * | 1985-10-25 | 1989-07-25 | Sandoz Pharm. Corp. | Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use |
US4654363A (en) * | 1985-11-04 | 1987-03-31 | Merck & Co., Inc. | Synthetic analogs of mevinolin |
DE3615620A1 (de) * | 1986-05-09 | 1987-11-12 | Hoechst Ag | 4(r)-substituierte 6(s)-phenoxymethyl-, 6(s)-(beta)-phenylaethyl-und 6(s)-(beta)-styryl-tetrahydropyran-2-one, ein hochstereoselektives verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US4808733A (en) * | 1986-06-09 | 1989-02-28 | Stauffer Chemical Company | Certain 4-oxo-3-benzoylvalerolactones and thiolactones |
US5102893A (en) * | 1986-07-07 | 1992-04-07 | Warner-Lambert Company | Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US4957971A (en) * | 1986-07-07 | 1990-09-18 | Warner-Lambert Company | Trans-6-(2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl)-or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US4898949A (en) * | 1987-02-25 | 1990-02-06 | Bristol-Myers Company | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds |
US4897490A (en) * | 1987-02-25 | 1990-01-30 | Bristol-Meyers Company | Antihypercholesterolemic tetrazole compounds |
US5036105A (en) * | 1987-05-07 | 1991-07-30 | G. D. Searle & Co. | 5-lipoxygenase inhibitors |
US5091378A (en) * | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
US4904646A (en) * | 1987-05-22 | 1990-02-27 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-COA reductase inhibitors |
DE3722809A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | 3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte |
US5151545A (en) * | 1987-10-13 | 1992-09-29 | Pfizer Inc. | 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents |
WO1989004821A1 (fr) * | 1987-11-25 | 1989-06-01 | Pfizer Inc. | Acide glutaramique de n-(biphenylmethyl)-3-hydroxy et ses derives a titre d'agents hypocholesterolemiques |
US4761419A (en) * | 1987-12-07 | 1988-08-02 | Warner-Lambert Company | 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
US4863957A (en) * | 1987-12-21 | 1989-09-05 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
US5010205A (en) * | 1988-08-23 | 1991-04-23 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl intermediates |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
US4957940A (en) * | 1988-12-21 | 1990-09-18 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
US4906657A (en) * | 1988-12-21 | 1990-03-06 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
US5025017A (en) * | 1989-09-28 | 1991-06-18 | E. R. Squibb & Sons, Inc. | Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates |
US5189180A (en) * | 1989-09-28 | 1993-02-23 | E. R. Squibb & Sons, Inc. | Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates |
WO1992019240A1 (fr) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Traitement d'aberrations cellulaires avec des biomodulateurs |
WO1992019239A1 (fr) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Traitement d'etats cellulaires aberrants a l'aide de biomodulateurs |
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
IL113567A0 (en) * | 1994-05-06 | 1995-08-31 | Upjohn Co | Compounds useful to treat retroviral infections |
US5665333A (en) * | 1995-01-17 | 1997-09-09 | Homola; Andrew M. | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
US5961958A (en) * | 1996-07-16 | 1999-10-05 | Four Star Partners | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
US20040248972A1 (en) * | 2003-05-16 | 2004-12-09 | Ambit Biosciences Corporation | Compounds and uses thereof |
US20050182125A1 (en) * | 2003-05-16 | 2005-08-18 | Ambit Biosciences Corporation | Pyrrole compounds and uses thereof |
US20040242673A1 (en) * | 2003-05-16 | 2004-12-02 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
US7250444B2 (en) * | 2003-08-11 | 2007-07-31 | Pfizer Inc. | Pyrrole-based HMG-CoA reductase inhibitors |
CA2547573A1 (fr) * | 2003-12-05 | 2005-06-23 | Warner-Lambert Company Llc | Pyrroles de n-alkyl comme inhibiteurs de l'hmg-coa-reductase |
KR100836960B1 (ko) | 2007-09-07 | 2008-06-10 | 주식회사 서울제약 | 새로운 나이아신 제어방출형 제제 |
US8563066B2 (en) | 2007-12-17 | 2013-10-22 | New World Pharmaceuticals, Llc | Sustained release of nutrients in vivo |
WO2010019680A1 (fr) * | 2008-08-12 | 2010-02-18 | Homola Andrew M | Formulations pour système de délivrance active |
US20170202789A1 (en) | 2014-07-16 | 2017-07-20 | New World Pharmaceuticals, Llc | Methods and related compositions for improved drug bioavailability and disease treatment |
WO2016056658A1 (fr) * | 2014-10-10 | 2016-04-14 | 株式会社エーピーアイ コーポレーション | Procédé de purification de composé statine |
EP3277274B1 (fr) | 2015-04-01 | 2024-06-12 | Cedars-Sinai Medical Center | Analogues ou dérivés de lovastatine anti-méthanogènes et leurs utilisations |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3119842A (en) * | 1961-03-22 | 1964-01-28 | Frank H Hulcher | Process for the synthesis of mevalonic acid and its lactone and derivatives thereof |
US3075997A (en) * | 1961-10-24 | 1963-01-29 | Olin Mathieson | 3, 5-dihydroxy-3-fluoro-methylpentanoic acid and the delta lactone thereof |
US3346594A (en) * | 1965-08-25 | 1967-10-10 | Gen Aniline & Film Corp | Haloalkyl and polyhaloalkyl lactones |
DE1617812A1 (de) | 1967-06-05 | 1972-02-17 | Spezialchemie Gmbh & Co | Verfahren zur Herstellung von endoanaesthetisch wirkenden Loesungen von Kava-Wirkstoffen |
US3522245A (en) * | 1967-07-26 | 1970-07-28 | Spezialchemie Gmbh & Co | 4 - oxo - 6 - styryl - 3,4;5,6 - tetrahydro - alpha-pyron compounds,compositions containing same,and process of making same |
US3600403A (en) * | 1967-11-24 | 1971-08-17 | Spezialchemie Gmbh & Co | Hydrogenation of pyrone compounds |
FR2098755A5 (en) * | 1970-07-27 | 1972-03-10 | Laire Produits Chimie | Mevalolactone and its homologues - prepd from 4-hydroxy-2-butanone and an acid |
JPS5612114B2 (fr) * | 1974-06-07 | 1981-03-18 | ||
JPS5119760A (fr) * | 1974-08-09 | 1976-02-17 | Nippon Soda Co |
-
1977
- 1977-05-24 JP JP6011077A patent/JPS53147073A/ja active Granted
-
1978
- 1978-05-08 US US05/903,575 patent/US4198425A/en not_active Expired - Lifetime
- 1978-05-23 SE SE7805879A patent/SE7805879L/xx unknown
- 1978-05-24 FR FR7815488A patent/FR2392016A1/fr not_active Withdrawn
- 1978-05-24 BE BE187992A patent/BE867421A/fr unknown
- 1978-05-24 DE DE19782822848 patent/DE2822848A1/de not_active Withdrawn
- 1978-05-24 ES ES470209A patent/ES470209A1/es not_active Expired
- 1978-05-24 NL NL7805647A patent/NL7805647A/xx not_active Application Discontinuation
- 1978-05-24 GB GB21898/78A patent/GB1586152A/en not_active Expired
-
1979
- 1979-08-03 US US06/063,549 patent/US4262013A/en not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0010951A1 (fr) * | 1978-10-30 | 1980-05-14 | Sankyo Company Limited | Dérivés de 4-hydroxy-2-pyrones, procédé pour leur préparation et leurs préparations pharmaceutiques |
US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
US4322563A (en) | 1980-04-14 | 1982-03-30 | Merck & Co., Inc. | Substituted biphenyl-2-carboxaldehydes |
US4801611A (en) * | 1987-05-07 | 1989-01-31 | G. D. Searle & Co. | 5-lipoxygenase inhibitors |
US5162365A (en) * | 1987-05-07 | 1992-11-10 | G. D. Searle & Co. | 5-lipoxygenase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
US4262013A (en) | 1981-04-14 |
FR2392016A1 (fr) | 1978-12-22 |
JPS53147073A (en) | 1978-12-21 |
NL7805647A (nl) | 1978-11-28 |
SE7805879L (sv) | 1978-11-25 |
US4198425A (en) | 1980-04-15 |
JPS6135987B2 (fr) | 1986-08-15 |
ES470209A1 (es) | 1979-09-16 |
GB1586152A (en) | 1981-03-18 |
DE2822848A1 (de) | 1978-11-30 |
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