FR12C0053I2 - Dihydropyridines a activite courte - Google Patents

Dihydropyridines a activite courte

Info

Publication number
FR12C0053I2
FR12C0053I2 FR12C0053C FR12C0053C FR12C0053I2 FR 12C0053 I2 FR12C0053 I2 FR 12C0053I2 FR 12C0053 C FR12C0053 C FR 12C0053C FR 12C0053 C FR12C0053 C FR 12C0053C FR 12C0053 I2 FR12C0053 I2 FR 12C0053I2
Authority
FR
France
Prior art keywords
dihydropyridines
short activity
activity
short
activity dihydropyridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR12C0053C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of FR12C0053I1 publication Critical patent/FR12C0053I1/fr
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of FR12C0053I2 publication Critical patent/FR12C0053I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
FR12C0053C 1993-11-05 2012-09-18 Dihydropyridines a activite courte Active FR12C0053I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines
PCT/SE1994/001031 WO1995012578A1 (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines

Publications (2)

Publication Number Publication Date
FR12C0053I1 FR12C0053I1 (de) 2012-02-11
FR12C0053I2 true FR12C0053I2 (fr) 2013-08-16

Family

ID=20391655

Family Applications (1)

Application Number Title Priority Date Filing Date
FR12C0053C Active FR12C0053I2 (fr) 1993-11-05 2012-09-18 Dihydropyridines a activite courte

Country Status (36)

Country Link
US (1) US5856346A (de)
EP (1) EP0726894B1 (de)
JP (1) JP3712209B2 (de)
KR (1) KR100331663B1 (de)
CN (1) CN1049428C (de)
AT (1) ATE194330T1 (de)
AU (1) AU685532B2 (de)
BR (1) BR9407946A (de)
CA (1) CA2174969C (de)
CZ (1) CZ285691B6 (de)
DE (1) DE69425152T2 (de)
DK (1) DK0726894T3 (de)
EE (1) EE03230B1 (de)
EG (1) EG20539A (de)
ES (1) ES2150544T3 (de)
FI (1) FI110429B (de)
FR (1) FR12C0053I2 (de)
GR (1) GR3034469T3 (de)
HK (1) HK1013292A1 (de)
HU (1) HU215591B (de)
IL (1) IL111127A (de)
IS (1) IS1674B (de)
LU (1) LU92209I2 (de)
MY (1) MY111770A (de)
NO (1) NO305656B1 (de)
NZ (1) NZ275915A (de)
PL (1) PL185099B1 (de)
PT (1) PT726894E (de)
RU (1) RU2139278C1 (de)
SA (1) SA94150250B1 (de)
SE (1) SE9303657D0 (de)
SK (1) SK281467B6 (de)
TW (1) TW279859B (de)
UA (1) UA45959C2 (de)
WO (1) WO1995012578A1 (de)
ZA (1) ZA947570B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
JP4580649B2 (ja) * 2001-12-21 2010-11-17 アルコン、インコーポレイテッド ナノ粒子を殺生物剤の担体として眼科用組成物に使用する方法
FR2922439B1 (fr) * 2007-10-18 2010-12-10 Hill Rom Ind Sa Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
JP5674660B2 (ja) * 2008-08-01 2015-02-25 ザ メディシンズ カンパニー 医薬組成物および不純物の濃度が低い医薬組成物の製造方法
KR20120100945A (ko) * 2009-09-30 2012-09-12 마이크로도스 테라퓨특스, 인코포레이티드 레이노 증후군의 치료를 위한 방법들 및 조성물들
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
EP2386544B1 (de) 2010-05-07 2016-02-10 Laboratorios Lesvi, S.L. Herstellung von Dihydropyridinen
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
EA022849B1 (ru) 2010-10-12 2016-03-31 Дзе Медсинз Компани Эмульсионные композиции клевидипина, содержащие противомикробные агенты
RU2623039C2 (ru) * 2011-04-01 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Дигидропиридины (клевидипин) кратковременного действия для применения в восстановлении после инсульта
EP2747757A1 (de) 2011-08-26 2014-07-02 Wockhardt Limited Verfahren zur behandlung kardiovaskulärer erkrankungen
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
PL2925128T3 (pl) 2012-10-26 2018-10-31 Chiesi Farmaceutici S.P.A. Sposoby kontrolowania ciśnienia krwi i zmniejszania duszności w niewydolności serca
CN103073485B (zh) * 2013-01-17 2015-09-02 北京嘉林药业股份有限公司 一种丁酸氯维地平的制备方法
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
CA2947486C (en) 2014-05-19 2023-09-26 The Medicines Company Clevidipine nanoparticles and pharmaceutical compositions thereof
CN105367487A (zh) * 2014-08-23 2016-03-02 南京海纳医药科技有限公司 一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) * 2014-09-24 2015-02-25 北京蓝丹医药科技有限公司 氯维地平衍生物及其制备方法
RU2707298C2 (ru) 2015-05-20 2019-11-26 Мериал, Инк. Противогельминтные депсипептидные соединения
RU2715556C2 (ru) 2015-12-28 2020-03-02 Мериал, Инк. Противогельминтные депсипептидные соединения
JP2020504710A (ja) 2016-11-16 2020-02-13 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
US5134139A (en) * 1989-08-31 1992-07-28 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and preparation thereof
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
JP3712209B2 (ja) 2005-11-02
WO1995012578A1 (en) 1995-05-11
SA94150250B1 (ar) 2006-03-01
MY111770A (en) 2000-12-30
PL185099B1 (pl) 2003-02-28
RU2139278C1 (ru) 1999-10-10
SK55996A3 (en) 1996-12-04
SE9303657D0 (sv) 1993-11-05
PT726894E (pt) 2000-10-31
NZ275915A (en) 1997-04-24
ATE194330T1 (de) 2000-07-15
DE69425152T2 (de) 2001-03-22
IL111127A0 (en) 1994-12-29
CZ127396A3 (en) 1996-09-11
IS4218A (is) 1995-05-06
CN1049428C (zh) 2000-02-16
CA2174969A1 (en) 1995-05-11
FI110429B (fi) 2003-01-31
CN1137269A (zh) 1996-12-04
GR3034469T3 (en) 2000-12-29
FR12C0053I1 (de) 2012-02-11
HUT75316A (en) 1997-05-28
CA2174969C (en) 2005-05-17
EP0726894B1 (de) 2000-07-05
NO961776L (no) 1996-05-02
JPH09504542A (ja) 1997-05-06
SK281467B6 (sk) 2001-04-09
HK1013292A1 (en) 1999-08-20
ES2150544T3 (es) 2000-12-01
BR9407946A (pt) 1996-11-26
NO305656B1 (no) 1999-07-05
EP0726894A1 (de) 1996-08-21
KR100331663B1 (ko) 2002-09-26
CZ285691B6 (cs) 1999-10-13
UA45959C2 (uk) 2002-05-15
HU215591B (hu) 1999-01-28
LU92209I2 (fr) 2013-08-23
TW279859B (de) 1996-07-01
IL111127A (en) 2000-11-21
NO961776D0 (no) 1996-05-02
EG20539A (en) 1999-07-31
ZA947570B (en) 1995-05-29
FI961914A0 (fi) 1996-05-06
HU9601187D0 (en) 1996-07-29
DE69425152D1 (de) 2000-08-10
US5856346A (en) 1999-01-05
DK0726894T3 (da) 2000-10-23
EE03230B1 (et) 1999-10-15
PL314128A1 (en) 1996-08-19
AU685532B2 (en) 1998-01-22
IS1674B (is) 1997-12-31
FI961914A (fi) 1996-05-06
AU8119694A (en) 1995-05-23

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