FI973713L - Karboksi- tai tetratsolipääteryhmiä sisältävät dialkyylieetterit - Google Patents

Karboksi- tai tetratsolipääteryhmiä sisältävät dialkyylieetterit Download PDF

Info

Publication number
FI973713L
FI973713L FI973713A FI973713A FI973713L FI 973713 L FI973713 L FI 973713L FI 973713 A FI973713 A FI 973713A FI 973713 A FI973713 A FI 973713A FI 973713 L FI973713 L FI 973713L
Authority
FI
Finland
Prior art keywords
tetrazole
end groups
dialkyl ethers
containing carboxyl
ethers containing
Prior art date
Application number
FI973713A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI973713A0 (fi
FI973713A7 (fi
Inventor
Charles Larry Bisgaier
Paul Leroy Creger
Alan Robert Saltiel
Sherrie Rae Tafuri
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI973713A0 publication Critical patent/FI973713A0/fi
Publication of FI973713A7 publication Critical patent/FI973713A7/fi
Publication of FI973713L publication Critical patent/FI973713L/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/28—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/37—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C07C59/315—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
    • C07C59/353—Saturated compounds containing more than one carboxyl group containing keto groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Dental Preparations (AREA)
  • Medicinal Preparation (AREA)
FI973713A 1995-03-24 1996-02-05 Karboksi- tai tetratsolipääteryhmiä sisältävät dialkyylieetterit FI973713L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/409,780 US5648387A (en) 1995-03-24 1995-03-24 Carboxyalkylethers, formulations, and treatment of vascular diseases
PCT/US1996/001639 WO1996030328A1 (en) 1995-03-24 1996-02-05 Terminal carboxy or tetrazole groups containing dialkyl ethers

Publications (3)

Publication Number Publication Date
FI973713A0 FI973713A0 (fi) 1997-09-17
FI973713A7 FI973713A7 (fi) 1997-09-24
FI973713L true FI973713L (fi) 1997-09-24

Family

ID=23621941

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973713A FI973713L (fi) 1995-03-24 1996-02-05 Karboksi- tai tetratsolipääteryhmiä sisältävät dialkyylieetterit

Country Status (26)

Country Link
US (4) US5648387A (da)
EP (1) EP0820428B1 (da)
JP (1) JP3885115B2 (da)
KR (1) KR100408612B1 (da)
CN (1) CN1100747C (da)
AT (1) ATE192732T1 (da)
AU (1) AU692359B2 (da)
BG (1) BG63534B1 (da)
CA (1) CA2215233C (da)
CZ (1) CZ289556B6 (da)
DE (1) DE69608268T2 (da)
DK (1) DK0820428T3 (da)
EE (1) EE03520B1 (da)
ES (1) ES2148733T3 (da)
FI (1) FI973713L (da)
GR (1) GR3034109T3 (da)
HU (1) HUP9801825A3 (da)
NO (1) NO307878B1 (da)
NZ (1) NZ302170A (da)
PL (1) PL181673B1 (da)
PT (1) PT820428E (da)
RU (1) RU2191772C2 (da)
SK (1) SK282897B6 (da)
UA (1) UA46020C2 (da)
WO (1) WO1996030328A1 (da)
ZA (1) ZA962275B (da)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
SI1045691T1 (en) * 1997-12-12 2005-04-30 Warner-Lambert Company Llc Statin-carboxyalkylether combinations
US20030105154A1 (en) * 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
CA2299397A1 (en) * 1997-12-12 1999-06-24 Warner-Lambert Company Antihyperlipidemic statin-lp(a) inhibitor combinations
NZ503982A (en) * 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus
US6861555B2 (en) * 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
WO1999038498A1 (en) * 1998-01-28 1999-08-05 Warner-Lambert Company Method for treating alzheimer's disease
CZ20011035A3 (cs) * 1998-09-30 2001-10-17 Warner-Lambert Company Léčivo pro prevenci nebo oddálení revaskularizace pomocí katetru u pacientů postiľených chorobou koronární artérie
US6459003B1 (en) 1999-04-01 2002-10-01 Esperion Therapeutics, Inc. Ether compounds
EP1849760A1 (en) * 1999-04-01 2007-10-31 Esperion Therapeutics Inc. Ether compounds, compositions, and uses thereof
NZ519550A (en) 2000-01-25 2003-11-28 Warner Lambert Co Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
US20040092574A1 (en) * 2000-02-07 2004-05-13 Bisgaier Charles Larry Statin-Lp(a) inhibitor combinations
CZ20023459A3 (cs) * 2000-04-26 2003-05-14 Warner-Lambert Company Antihypertensní činidla a jejich použití
CA2414783A1 (en) * 2000-07-14 2002-01-24 Warner-Lambert Company Treatment of eating disorders using carboxyalkylethers
CN1962596A (zh) 2000-10-11 2007-05-16 埃斯佩里安医疗公司 用于控制胆固醇以及相关用途的酮化合物以及组合物
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
JP2004531459A (ja) 2000-10-11 2004-10-14 エスペリオン セラピューティクス，インコーポレイテッド コレステロールマネージメント用スルホキシドおよびビススルホキシド化合物ならびに組成物および関連する使用
MXPA03003021A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de eter y composiciones para el control del colesterol y usos relacionados.
WO2002030884A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20030225123A1 (en) * 2001-03-22 2003-12-04 Auerbach Bruce Jeffrey Antihypertensive agents and use
US20040072903A1 (en) * 2001-05-08 2004-04-15 Auerbach Bruce Jeffrey Carboxyalkylether-acat inhibitors combinations
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
CA2480415A1 (en) * 2002-04-10 2003-10-23 Esperion Therapeutics, Inc. Mimics of acyl coenzyme-a, compositions thereof, and methods of cholesterol management and related uses
JP2006501238A (ja) * 2002-08-22 2006-01-12 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 骨関節炎を治療する方法
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
WO2004045596A1 (en) * 2002-11-15 2004-06-03 Warner-Lambert Company Llc Method of lowering crp and reducing systemic inflammation
US7335689B2 (en) 2003-01-23 2008-02-26 Esperion Therapeutics, Inc. Dihydroxyl compounds and compositions for cholesterol management and related uses
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
US7390504B2 (en) * 2003-11-07 2008-06-24 Jj Pharma, Inc. HDL-boosting combination therapy complexes
US20050192347A1 (en) * 2003-12-23 2005-09-01 Dasseux Jean-Louis H. Urea and thiourea compounds and compositions for cholesterol management and related uses
AU2003300438A1 (en) * 2003-12-24 2005-08-03 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
US7705177B2 (en) 2003-12-24 2010-04-27 Esperion Therapuetics, Inc. Ketone compounds and compositions for cholesterol management and related uses
EP1753782A1 (en) * 2004-06-09 2007-02-21 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
KR20070043711A (ko) * 2004-06-09 2007-04-25 아바니르 파마슈티컬스 고콜레스테롤혈증과 관련 질환의 치료를 위한 소분자
MXJL06000069A (es) * 2004-06-09 2007-04-10 Avanir Pharmaceuticals Derivados heterociclicos para el tratamiento de hiperlipidemia y enfermedades relacionadas.
US7846915B2 (en) * 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
WO2007016525A2 (en) * 2005-07-29 2007-02-08 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US7777071B2 (en) * 2006-08-11 2010-08-17 Ssv Therapeutics, Inc. Production of carnitine conjugate intermediates
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
EP2431043A1 (en) 2007-05-23 2012-03-21 Amcol International Corporation Cholesterol-interacting layered phyllosilicates for suppressing gastrointestinal cholesterol absorption
US7985727B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Apo A-I mimetic peptides and methods of treatment
US9173890B2 (en) * 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US7985728B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US8044021B2 (en) * 2007-09-20 2011-10-25 Abbott Cardiovascular Systems Inc. Sustained release of apo A-I mimetic peptides and methods of treatment
US8101565B2 (en) * 2007-09-20 2012-01-24 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US8114995B2 (en) 2008-06-26 2012-02-14 Resverlogix Corp. Methods of preparing quinazolinone derivatives
ES2542835T3 (es) 2009-01-08 2015-08-12 Resverlogix Corporation Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
NZ617779A (en) 2009-03-18 2015-08-28 Resverlogix Corp Novel anti-inflammatory agents
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
KR101660578B1 (ko) 2009-09-03 2016-09-27 화이자 백신스 엘엘씨 Ｐｃｓｋ９ 백신
JP2013537240A (ja) 2010-09-20 2013-09-30 カリウス セラピューティクス エスエー 糖尿病および脂質異常症の処置のための方法および組成物
HRP20171587T1 (hr) 2010-10-18 2017-12-01 Cerenis Therapeutics Holding Sa Spojevi, pripravci i postupci pogodni za mobilizaciju kolesterola
ES2608177T3 (es) 2010-12-27 2017-04-06 Gemphire Therapeutics Inc. Gemcabeno y derivados para el tratamiento de la pancreatitis
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
JP6295205B2 (ja) * 2012-01-06 2018-03-14 ジェムファイア セラピューティクス インクＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 心血管疾患のリスクを低減する方法
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
EP3104877B1 (en) 2014-02-11 2020-01-22 The USA, as represented by The Secretary, Department of Health and Human Services Pcsk9 vaccine and methods of using the same
RU2016144908A (ru) 2014-05-02 2018-06-05 Серени Терапеутикс Холдинг Са Маркеры hdl-терапии
EP3218349A2 (en) * 2014-11-14 2017-09-20 Gemphire Therapeutics Inc. Processes and intermediates for preparing , -dicarboxylic acid-terminated dialkane ethers
MX392182B (es) 2015-03-13 2025-03-21 Esperion Therapeutics Inc Combinaciones de dosis fija y formulaciones que comprenden ácido 8-hidroxi-2,2,14,14 tetrametilpentadecanodioico (etc1002) y ezetimiba y métodos para tratar o reducir el riesgo de enfermedad cardiovascular.
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
MX2018005096A (es) * 2015-11-06 2018-08-15 Gemphire Therapeutics Inc Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular.
WO2018165120A1 (en) * 2017-03-06 2018-09-13 Gemphire Therapeutics Inc. Effect of carboxyalkylethers on obesity symptoms and lipodystropy
EP3612171A4 (en) * 2017-04-18 2020-10-21 Gemphire Therapeutics Inc. GEMCABENE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, COMPOSITIONS THEREOF AND PROCEDURES FOR THE USE OF THE SAME
CN112437765A (zh) 2019-06-21 2021-03-02 艾斯柏伦治疗公司 贝派地酸的盐形式及其使用方法
EP4003314B1 (en) 2019-07-26 2024-07-10 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids useful for the prevention or treatment of disease
WO2021262992A1 (en) 2020-06-24 2021-12-30 Neurobo Pharmaceuticals, Inc. Gemcabene for treatment of cytokine storms and viral-induced inflammation
AU2022209835B2 (en) 2021-01-25 2026-05-21 Espervita Therapeutics, Inc. Functionalized long-chain carboxylic acids, and their use for treatment of disease
WO2022159811A1 (en) 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2466419A (en) * 1948-02-07 1949-04-05 Eastman Kodak Co beta, beta'-oxydipropionic acids and process of preparation
US3320079A (en) * 1960-07-11 1967-05-16 Eastman Kodak Co Ether-acid polyester composition
US3431298A (en) * 1965-01-05 1969-03-04 Asahi Chemical Ind Process for the preparation of oxadicarboxylic acids
US3674836A (en) * 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
BE755997A (fr) * 1969-09-11 1971-03-10 Bp Chem Int Ltd Production d'acides dicarboxyliques
US3742068A (en) * 1970-04-17 1973-06-26 G Moersch Ethers of 2,2,9,9-tetramethyl-1,10-decanediol
IT1168389B (it) * 1981-05-06 1987-05-20 Alfa Farmaceutici Spa Derivati di alcandioli con attivita' ipolipidemizzante,metodi per la loro preparazione e composizioni farmaceutiche che li contengono
DE3423166A1 (de) * 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
IL84953A (en) * 1987-12-28 1992-01-15 Bromine Compounds Ltd 3,3'-oxy-bis((2,2'-di(bromomethyl)propanoic acid)derivatives,processes for their preparation and their use as flame retardant agents
DE3814498A1 (de) * 1988-04-29 1989-11-09 Basf Ag Verfahren zur herstellung von hydroxicarbonsaeureestern
DE4142913A1 (de) * 1991-12-24 1993-07-01 Basf Ag Verfahren zur herstellung von oxadimethacrylsaeure
US5395917A (en) * 1993-05-21 1995-03-07 E. I. Du Pont De Nemours And Company Polyimides from 4-(3-aminophenoxy)benzoic acid

Also Published As

Publication number Publication date
US5750569A (en) 1998-05-12
CN1182415A (zh) 1998-05-20
WO1996030328A1 (en) 1996-10-03
BG101993A (bg) 1998-05-29
NO974397L (no) 1997-11-20
NO307878B1 (no) 2000-06-13
UA46020C2 (uk) 2002-05-15
RU2191772C2 (ru) 2002-10-27
PL322407A1 (en) 1998-01-19
NO974397D0 (no) 1997-09-23
CA2215233A1 (en) 1996-10-03
NZ302170A (en) 1999-04-29
ATE192732T1 (de) 2000-05-15
AU692359B2 (en) 1998-06-04
EP0820428A1 (en) 1998-01-28
SK282897B6 (sk) 2003-01-09
HK1009438A1 (en) 1999-09-10
BG63534B1 (bg) 2002-04-30
CA2215233C (en) 2006-07-11
ES2148733T3 (es) 2000-10-16
ZA962275B (en) 1996-11-27
KR100408612B1 (ko) 2004-03-26
MX9707198A (es) 1997-11-29
SK128697A3 (en) 1999-02-11
CZ289556B6 (cs) 2002-02-13
PT820428E (pt) 2000-09-29
PL181673B1 (pl) 2001-08-31
US5783600A (en) 1998-07-21
KR19980703233A (ko) 1998-10-15
HUP9801825A2 (hu) 1998-12-28
EE03520B1 (et) 2001-10-15
CZ292297A3 (cs) 1998-10-14
CN1100747C (zh) 2003-02-05
JPH11502532A (ja) 1999-03-02
EP0820428B1 (en) 2000-05-10
FI973713A0 (fi) 1997-09-17
AU4776896A (en) 1996-10-16
DE69608268D1 (de) 2000-06-15
JP3885115B2 (ja) 2007-02-21
US5756544A (en) 1998-05-26
GR3034109T3 (en) 2000-11-30
HUP9801825A3 (en) 2001-01-29
EE9700375A (et) 1998-06-15
DE69608268T2 (de) 2000-11-09
FI973713A7 (fi) 1997-09-24
DK0820428T3 (da) 2000-08-28
US5648387A (en) 1997-07-15

Similar Documents

Publication Publication Date Title
HUP9801825A3 (en) Terminal carboxy or tetrazole groups containing dialkyl ethers
DE69310037D1 (de) Endoskopisches Instrumentensystem
DE69626151D1 (de) Endoskop
DE19681437T1 (de) Endoskop
DE69605660D1 (de) Etheramintenside enthaltende glyphosatformulierungen
DE69625739D1 (de) Schlauchaufbau enthaltend Fluorterpolymere
FI950950A0 (fi) Kaukokäyttöinen pelijärjestelmä
ATE225949T1 (de) Motorgesteuertes chirurgisches system
DE69624058D1 (de) Desinfektionsgerät
DE59506126D1 (de) Kehrfahrzeug
DE59601627D1 (de) Kehrfahrzeug
DE59607738D1 (de) Kombinationsinstrument
DE19615678B4 (de) Tragbares Endoskopsystem
EP0837863A4 (en) DISODIUM ALENDRONATE PREPARATIONS
DE69609952D1 (de) Photostrukturierbare zusammensetzungen
NO951258D0 (no) Penselsystem
KR970020840U (ko) 내시경 시스템
FI1943U1 (fi) Bomsystem till skogmaskin
KR970043532U (ko) 튜브 컨넥터
SI0820428T1 (en) Terminal carboxy or tetrazole groups containing dialkyl ethers
KR970015747U (ko) 콘넥터 유니트
KR960032082U (ko) 호루라기 겸용 라이타
FI950811A0 (fi) Foerfarande och borrningsanordning foer att borra haol i jordmaon och i berggrund
BR9504717A (pt) Vaporizador universal aperfeiçoado
ATA9895A (de) Spritzwasserdichter geräte-anschluss-kasten

Legal Events

Date Code Title Description
MA Patent expired