EE9700375A - Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid - Google Patents

Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid

Info

Publication number
EE9700375A
EE9700375A EE9700375A EE9700375A EE9700375A EE 9700375 A EE9700375 A EE 9700375A EE 9700375 A EE9700375 A EE 9700375A EE 9700375 A EE9700375 A EE 9700375A EE 9700375 A EE9700375 A EE 9700375A
Authority
EE
Estonia
Prior art keywords
dialkyl ethers
terminal carboxyl
containing terminal
ethers containing
tetrazolyl groups
Prior art date
Application number
EE9700375A
Other languages
English (en)
Other versions
EE03520B1 (et
Inventor
Larry Bisgaier Charles
Leroy Creger Paul
Robert Saltiel Alan
Rae Tafuri Sherrie
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700375A publication Critical patent/EE9700375A/et
Publication of EE03520B1 publication Critical patent/EE03520B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/28—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/37—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C07C59/315—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
    • C07C59/353—Saturated compounds containing more than one carboxyl group containing keto groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Dental Preparations (AREA)
EE9700375A 1995-03-24 1996-02-05 Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid EE03520B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/409,780 US5648387A (en) 1995-03-24 1995-03-24 Carboxyalkylethers, formulations, and treatment of vascular diseases
PCT/US1996/001639 WO1996030328A1 (en) 1995-03-24 1996-02-05 Terminal carboxy or tetrazole groups containing dialkyl ethers

Publications (2)

Publication Number Publication Date
EE9700375A true EE9700375A (et) 1998-06-15
EE03520B1 EE03520B1 (et) 2001-10-15

Family

ID=23621941

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700375A EE03520B1 (et) 1995-03-24 1996-02-05 Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid

Country Status (27)

Country Link
US (4) US5648387A (et)
EP (1) EP0820428B1 (et)
JP (1) JP3885115B2 (et)
KR (1) KR100408612B1 (et)
CN (1) CN1100747C (et)
AT (1) ATE192732T1 (et)
AU (1) AU692359B2 (et)
BG (1) BG63534B1 (et)
CA (1) CA2215233C (et)
CZ (1) CZ289556B6 (et)
DE (1) DE69608268T2 (et)
DK (1) DK0820428T3 (et)
EE (1) EE03520B1 (et)
ES (1) ES2148733T3 (et)
FI (1) FI973713A (et)
GR (1) GR3034109T3 (et)
HK (1) HK1009438A1 (et)
HU (1) HUP9801825A3 (et)
NO (1) NO307878B1 (et)
NZ (1) NZ302170A (et)
PL (1) PL181673B1 (et)
PT (1) PT820428E (et)
RU (1) RU2191772C2 (et)
SK (1) SK282897B6 (et)
UA (1) UA46020C2 (et)
WO (1) WO1996030328A1 (et)
ZA (1) ZA962275B (et)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
SI1045691T1 (en) * 1997-12-12 2005-04-30 Warner-Lambert Company Llc Statin-carboxyalkylether combinations
WO2001055078A1 (en) 2000-01-25 2001-08-02 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
NZ503982A (en) * 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus
US20030105154A1 (en) * 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
US6861555B2 (en) * 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
WO1999030706A1 (en) * 1997-12-12 1999-06-24 Warner-Lambert Company ANTIHYPERLIPIDEMIC STATIN-LP(a) INHIBITOR COMBINATIONS
DE69833971T2 (de) * 1998-01-28 2006-11-02 Warner-Lambert Co. Llc Verfahren zur behandlung der alzheimerschen krankheit
EA007427B1 (ru) * 1998-09-30 2006-10-27 Варнер Ламберт Компани Способ предотвращения или отсрочки катетерной реваскуляризации
IL145712A0 (en) * 1999-04-01 2002-07-25 Esperion Therapeutics Inc Ether compounds, compositions, and uses thereof
EP1862444A3 (en) * 1999-04-01 2008-01-09 Esperion Therapeutics, Inc. Ether compounds, compositions, and uses thereof
US20040092574A1 (en) * 2000-02-07 2004-05-13 Bisgaier Charles Larry Statin-Lp(a) inhibitor combinations
DE60107559T2 (de) * 2000-04-26 2005-04-14 Warner-Lambert Co. Kombination von carboxyalkylethern mit antihypertensiva und pharmazeutische verwendung
IL153788A0 (en) * 2000-07-14 2003-07-31 Warner Lambert Co Treatment of eating disorders using carboxyalkylethers
EP1326822A2 (en) 2000-10-11 2003-07-16 Esperion Therapeutics Inc. Ketone compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
WO2002030884A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
BR0114623A (pt) 2000-10-11 2005-12-13 Esperion Therapeutics Inc Composto, composição farmacêutica, métodos para tratar ou prevenir uma doença cardiovascular, uma dislipidemia, uma dislipoproteinemia, um distúrbio do metabolismo da glicose, trombótico e associado com o receptor ativado do proliferador de peroxissoma, a doença de alzheimer, a sìndrome x ou sìndrome metabólica, a septicemia, a obesidade, pancreatite, a hipertensão, doença renal, câncer, a inflamação e a impotência, em um paciente e para reduzir o teor de gordura da carne em animal de criação e de colesterol de ovos de aves domésticas
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
CA2425121A1 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
US20030225123A1 (en) * 2001-03-22 2003-12-04 Auerbach Bruce Jeffrey Antihypertensive agents and use
US20040072903A1 (en) * 2001-05-08 2004-04-15 Auerbach Bruce Jeffrey Carboxyalkylether-acat inhibitors combinations
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
MXPA04009832A (es) * 2002-04-10 2004-12-07 Esperion Therapeutics Inc Imitaciones de la coenzima-a de acilo, composiciones de las mismas y metodos de manejo del colesterol y usos relacionados.
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
AU2003255937A1 (en) * 2002-08-22 2004-03-11 Warner-Lambert Company Llc Method of treating osteoarthritis
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
AU2003274572A1 (en) * 2002-11-15 2004-06-15 Warner-Lambert Company Llc Method of lowering crp and reducing systemic inflammation
DK2404890T3 (en) * 2003-01-23 2017-10-16 Esperion Therapeutics Inc Hydroxyl compounds and compositions for controlling cholesterol and related uses
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
ATE428411T1 (de) * 2003-11-07 2009-05-15 Jj Pharma Inc Hdl-verstärkende kombinationstherapie-komplexe
US20050192347A1 (en) * 2003-12-23 2005-09-01 Dasseux Jean-Louis H. Urea and thiourea compounds and compositions for cholesterol management and related uses
WO2005068410A1 (en) * 2003-12-24 2005-07-28 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
JP2007525408A (ja) * 2003-12-24 2007-09-06 エスペリオン セラピューティクス，インコーポレイテッド コレステロール管理および関連使用のためのケトン化合物および組成物
CA2568543A1 (en) * 2004-06-09 2005-12-29 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
US20060009487A1 (en) * 2004-06-09 2006-01-12 Sircar Jagadish C Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
EP1753733A1 (en) * 2004-06-09 2007-02-21 Avanir Pharmaceuticals Small molecules for treatment of hypercholesterolemia and related diseases
CA2584507C (en) * 2004-10-20 2016-04-26 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US8410109B2 (en) * 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US7777071B2 (en) * 2006-08-11 2010-08-17 Ssv Therapeutics, Inc. Production of carnitine conjugate intermediates
WO2008092231A1 (en) 2007-02-01 2008-08-07 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
WO2008147807A2 (en) 2007-05-23 2008-12-04 Amcol International Corporation Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal
US8044021B2 (en) * 2007-09-20 2011-10-25 Abbott Cardiovascular Systems Inc. Sustained release of apo A-I mimetic peptides and methods of treatment
US9173890B2 (en) * 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US8101565B2 (en) * 2007-09-20 2012-01-24 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US7985727B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Apo A-I mimetic peptides and methods of treatment
US7985728B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
AU2009262252B2 (en) 2008-06-26 2013-05-02 Resverlogix Corp. Methods of preparing quinazolinone derivatives
ES2463097T3 (es) 2009-01-08 2014-05-27 Resverlogix Corp. Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
JP5795304B2 (ja) 2009-03-18 2015-10-14 レスバーロジックス コーポレイション 新規抗炎症剤
KR102215167B1 (ko) 2009-04-22 2021-02-16 리스버로직스 코퍼레이션 신규한 소염제
CA2846746A1 (en) 2009-09-03 2011-03-10 Pfizer Vaccines Llc Pcsk9 vaccine
WO2012040177A1 (en) 2010-09-20 2012-03-29 Kareus Therapeutics, Sa Methods and compositions for treatment of diabetes and dyslipidemia
EP3241833A1 (en) 2010-10-18 2017-11-08 Cerenis Therapeutics Holding SA Compounds, compositions and methods useful for cholesterol mobilisation
AU2011352449B2 (en) 2010-12-27 2015-06-18 Gemphire Therapeutics Inc. Gemcabene and derivatives for treating pancreatitis
EP2680883B1 (en) 2011-03-02 2018-09-05 Pfizer Inc Pcsk9 vaccine
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
EP3735967A1 (en) * 2012-01-06 2020-11-11 NeuroBo Pharmaceuticals, Inc. Compound for use in methods of reducing risk of cardiovascular disease
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
WO2014096965A2 (en) 2012-12-21 2014-06-26 Rvx Therapeutics Inc. Novel heterocyclic compounds as bromodomain inhibitors
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
SG11201609084QA (en) 2014-05-02 2016-11-29 Cerenis Therapeutics Holding Sa Hdl therapy markers
EP3218349A2 (en) 2014-11-14 2017-09-20 Gemphire Therapeutics Inc. Processes and intermediates for preparing , -dicarboxylic acid-terminated dialkane ethers
EP3268007B1 (en) 2015-03-13 2022-11-09 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
AU2016233485B2 (en) 2015-03-13 2021-05-20 Esperion Therapeutics, Inc. Fixed dose combinations and formulations comprising ETC1002 and Ezetimibe and methods of treating or reducing the risk of cardiovascular disease
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CA3000016A1 (en) * 2015-11-06 2017-05-11 Gemphire Therapeutics Inc. Gemcabene combinations for the treatment of cardiovascular disease
WO2018165120A1 (en) * 2017-03-06 2018-09-13 Gemphire Therapeutics Inc. Effect of carboxyalkylethers on obesity symptoms and lipodystropy
CA3059073A1 (en) * 2017-04-18 2018-10-25 Daniela Carmen Oniciu Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor
BR112021025928A2 (pt) 2019-06-21 2022-05-10 Esperion Therapeutics Inc Métodos de preparação de ácido bempedoico e composições do mesmo
EP4003314A4 (en) 2019-07-26 2023-09-20 Espervita Therapeutics, Inc. FUNCTIONALIZED LONG CHAIN HYDROCARBON MONO- AND DICARBONIC ACIDS FOR THE PREVENTION OR TREATMENT OF DISEASES
WO2021262992A1 (en) 2020-06-24 2021-12-30 Neurobo Pharmaceuticals, Inc. Gemcabene for treatment of cytokine storms and viral-induced inflammation
US11730712B2 (en) 2021-01-25 2023-08-22 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease
TW202237073A (zh) 2021-01-25 2022-10-01 美商艾斯佩維他治療學公司 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2466419A (en) * 1948-02-07 1949-04-05 Eastman Kodak Co beta, beta'-oxydipropionic acids and process of preparation
US3320079A (en) * 1960-07-11 1967-05-16 Eastman Kodak Co Ether-acid polyester composition
US3431298A (en) * 1965-01-05 1969-03-04 Asahi Chemical Ind Process for the preparation of oxadicarboxylic acids
US3674836A (en) * 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
BE755997A (fr) * 1969-09-11 1971-03-10 Bp Chem Int Ltd Production d'acides dicarboxyliques
US3742068A (en) * 1970-04-17 1973-06-26 G Moersch Ethers of 2,2,9,9-tetramethyl-1,10-decanediol
IT1168389B (it) * 1981-05-06 1987-05-20 Alfa Farmaceutici Spa Derivati di alcandioli con attivita' ipolipidemizzante,metodi per la loro preparazione e composizioni farmaceutiche che li contengono
DE3423166A1 (de) * 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
IL84953A (en) * 1987-12-28 1992-01-15 Bromine Compounds Ltd 3,3'-oxy-bis((2,2'-di(bromomethyl)propanoic acid)derivatives,processes for their preparation and their use as flame retardant agents
DE3814498A1 (de) * 1988-04-29 1989-11-09 Basf Ag Verfahren zur herstellung von hydroxicarbonsaeureestern
US5395917A (en) * 1993-05-21 1995-03-07 E. I. Du Pont De Nemours And Company Polyimides from 4-(3-aminophenoxy)benzoic acid

Also Published As

Publication number Publication date
BG63534B1 (bg) 2002-04-30
CZ289556B6 (cs) 2002-02-13
AU4776896A (en) 1996-10-16
ATE192732T1 (de) 2000-05-15
EP0820428B1 (en) 2000-05-10
NO974397L (no) 1997-11-20
PL322407A1 (en) 1998-01-19
HUP9801825A3 (en) 2001-01-29
FI973713A0 (fi) 1997-09-17
KR19980703233A (ko) 1998-10-15
JP3885115B2 (ja) 2007-02-21
NZ302170A (en) 1999-04-29
KR100408612B1 (ko) 2004-03-26
HK1009438A1 (en) 1999-09-10
CA2215233A1 (en) 1996-10-03
NO307878B1 (no) 2000-06-13
NO974397D0 (no) 1997-09-23
PT820428E (pt) 2000-09-29
BG101993A (en) 1998-05-29
ZA962275B (en) 1996-11-27
AU692359B2 (en) 1998-06-04
CA2215233C (en) 2006-07-11
MX9707198A (es) 1997-11-29
EP0820428A1 (en) 1998-01-28
ES2148733T3 (es) 2000-10-16
JPH11502532A (ja) 1999-03-02
DE69608268T2 (de) 2000-11-09
US5750569A (en) 1998-05-12
US5756544A (en) 1998-05-26
HUP9801825A2 (hu) 1998-12-28
US5783600A (en) 1998-07-21
CN1182415A (zh) 1998-05-20
CZ292297A3 (cs) 1998-10-14
RU2191772C2 (ru) 2002-10-27
FI973713A (fi) 1997-09-24
US5648387A (en) 1997-07-15
PL181673B1 (pl) 2001-08-31
DK0820428T3 (da) 2000-08-28
SK128697A3 (en) 1999-02-11
CN1100747C (zh) 2003-02-05
GR3034109T3 (en) 2000-11-30
EE03520B1 (et) 2001-10-15
UA46020C2 (uk) 2002-05-15
WO1996030328A1 (en) 1996-10-03
DE69608268D1 (de) 2000-06-15
SK282897B6 (sk) 2003-01-09

Similar Documents

Publication Publication Date Title
EE03520B1 (et) Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid
FI910625A (fi) Aetbar belagd komposition oh foerfarande foer dess framstaellning.
DE59106678D1 (de) Optisch nichtlineare Polymerschichten.
AU2307695A (en) High solubility multicomponent inclusion complexes consisting of an acidic drug, a cyclodextrin and a base
MA22828A1 (fr) Ameliorants de l'indice de viscosite et dispersants, constitues par un poly(meth) acrylate.
DE69104448D1 (de) Faserbehandlungsmittelzusammensetzung.
FI951511A0 (fi) IL-10:n käyttö insuliinista riippuvan diabetes mellituksen ennaltaestoon tai hoitoon
DE69108881D1 (de) Mechanismus zur Reduzierung von Druckverlusten in Rohrkrümmern.
ATE161557T1 (de) Polyisocyanatzusammensetzung
ITRM930634A0 (it) Complessi monoazoici del rame reattivi verso le fibre. (caso 150-5653)
DE59103730D1 (de) Manuell betätigbarer Flüssigkeitszerstäuber.
RU1774836C (ru) Устройство дл отделени клубней картофел от ботвы Ф.С.Осипова
RO117801B1 (ro) Adeziv bioartificial
IT1284413B1 (it) Impianto trattamento r.s.u.
FR2704705B3 (fr) Unité de source sonore utilisée en téléphonie.
ES1014575Y (es) Pantalla luminosa compacta, estanca, perfeccionada.
IT219716Z2 (it) Gruppo elettrico da muro, quale una luce notturna, un ricarica-pile e simili, avente una spiona destinata ad impegnare una presa a muro.
IT231478Y1 (it) Tabellario didattico, perfezionato.
ES1029479Y (es) Inyector urologico semiautomatico.
DE69108157T2 (de) Chirurgisches Nahtmaterial aus Polyvinylalkoholfasern.

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

LD4A Amendment in the specification
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

MM4A Lapsed by not paying the annual fees

Effective date: 20050205