FI964664A - Menetelmä aaltomaisesti lähetetyn luminanssin havaitsemiseksi - Google Patents

Menetelmä aaltomaisesti lähetetyn luminanssin havaitsemiseksi Download PDF

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Publication number
FI964664A
FI964664A FI964664A FI964664A FI964664A FI 964664 A FI964664 A FI 964664A FI 964664 A FI964664 A FI 964664A FI 964664 A FI964664 A FI 964664A FI 964664 A FI964664 A FI 964664A
Authority
FI
Finland
Prior art keywords
pct
luminescence
layer
sec
substances
Prior art date
Application number
FI964664A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI964664A0 (fi
Inventor
Burkhard Danielzik
Gert Ludwig Duveneck
Martin Heming
Dieter Neuschaefer
Johannes Segner
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of FI964664A0 publication Critical patent/FI964664A0/fi
Publication of FI964664A publication Critical patent/FI964664A/fi

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
  • Manufacture, Treatment Of Glass Fibers (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
FI964664A 1994-05-27 1996-11-22 Menetelmä aaltomaisesti lähetetyn luminanssin havaitsemiseksi FI964664A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH164394 1994-05-27
PCT/IB1995/000368 WO1995033198A1 (en) 1994-05-27 1995-05-17 Process for detecting evanescently excited luminescence

Publications (2)

Publication Number Publication Date
FI964664A0 FI964664A0 (fi) 1996-11-22
FI964664A true FI964664A (fi) 1997-01-24

Family

ID=4215258

Family Applications (2)

Application Number Title Priority Date Filing Date
FI964664A FI964664A (fi) 1994-05-27 1996-11-22 Menetelmä aaltomaisesti lähetetyn luminanssin havaitsemiseksi
FI964684A FI964684A (fi) 1994-05-27 1996-11-25 Menetelmä aaltomaisesti lähetetyn luminanssin havaitsemiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI964684A FI964684A (fi) 1994-05-27 1996-11-25 Menetelmä aaltomaisesti lähetetyn luminanssin havaitsemiseksi

Country Status (21)

Country Link
US (2) US5822472A (sk)
EP (2) EP0759159B1 (sk)
JP (3) JPH10501616A (sk)
KR (1) KR970703527A (sk)
CN (2) CN1149335A (sk)
AT (2) ATE216491T1 (sk)
AU (2) AU689604B2 (sk)
CA (2) CA2190362A1 (sk)
CZ (2) CZ347196A3 (sk)
DE (2) DE69526438T2 (sk)
DK (1) DK0760944T3 (sk)
ES (1) ES2174948T3 (sk)
FI (2) FI964664A (sk)
HU (2) HUT76407A (sk)
IL (2) IL113854A0 (sk)
MX (1) MXPA96005828A (sk)
PL (2) PL317379A1 (sk)
SK (2) SK151396A3 (sk)
TW (2) TW295624B (sk)
WO (2) WO1995033198A1 (sk)
ZA (2) ZA954325B (sk)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5822472A (en) * 1994-05-27 1998-10-13 Novartis Corporation Process for detecting evanescently excited luminescence
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
PL323257A1 (en) 1995-05-12 1998-03-16 Ciba Geigy Ag Detection platform for simultaneously detecting plurality of analytes using hypercritically excited luminescence
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
JP3872817B2 (ja) 1996-03-30 2007-01-24 ノバルティス アクチエンゲゼルシャフト 集積化された光学的ルミネセンスセンサ
JPH102860A (ja) * 1996-06-17 1998-01-06 Olympus Optical Co Ltd 微小物質検鏡装置
US6395558B1 (en) 1996-08-29 2002-05-28 Zeptosens Ag Optical chemical/biochemical sensor
EP0843173A1 (de) 1996-11-18 1998-05-20 Novartis AG Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
WO1998022799A2 (de) 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
EP1012580B1 (de) * 1997-09-10 2004-06-23 Artificial Sensing Instruments ASI AG Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz
EP1057008B1 (de) 1998-02-05 2009-09-09 Novartis AG Verfahren und vorrichtung zur lumineszenzmessung
EP2112501A1 (de) 1998-02-05 2009-10-28 Novartis Ag Verfahren und Vorrichtung zur Lumineszenzmessung
US6758337B2 (en) * 1999-03-02 2004-07-06 Meadwestvaco Packaging Systems, Llc Beverage carton with strap type carrying handle
EP0957354A3 (en) * 1998-03-20 2000-03-22 IA Inc. Method and apparatus for measuring binding between biological molecules
DE19815109A1 (de) * 1998-04-03 1999-10-07 Bodenseewerk Perkin Elmer Co Vorrichtung zum Nachweis eines Fluoreszenzfarbstoffs
FR2778986B1 (fr) 1998-05-22 2000-07-21 Suisse Electronique Microtech Capteur optique utilisant une reaction immunologique et un marqueur fluorescent
JP2002521666A (ja) * 1998-07-21 2002-07-16 バースタイン テクノロジーズ，インコーポレイティド 光ディスクをベースとするアッセイ装置および方法
US6320991B1 (en) 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
US6245518B1 (en) 1998-12-11 2001-06-12 Hyseq, Inc. Polynucleotide arrays and methods of making and using the same
DE69933193T2 (de) * 1999-02-25 2007-08-02 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique S.A. Integrierter optischer Sensor und Verfahren zum integrierten optischen Nachweis einer Substanz
US6192168B1 (en) * 1999-04-09 2001-02-20 The United States Of America As Represented By The Secretary Of The Navy Reflectively coated optical waveguide and fluidics cell integration
US6137117A (en) * 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
AU5760500A (en) * 1999-06-23 2001-01-09 Patrick Toomey Water detection and source identification methods for structures using electromagnetic radiation spectroscopy
AU5824300A (en) 1999-07-05 2001-01-22 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US7708945B1 (en) 1999-08-13 2010-05-04 Bayer Technology Services Gmbh Device and method for determining multiple analytes
US6667179B1 (en) * 1999-10-28 2003-12-23 The Board Of Trustees Of The University Of Illinois Semiconductor luminescence quenchers for detecting proximal molecular binding events
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
FR2801977B1 (fr) * 1999-12-02 2002-05-17 Commissariat Energie Atomique Amplification d'un signal de fluorescence emis par un echantillon surfacique
EP1237654B9 (de) 1999-12-17 2004-07-21 Zeptosens AG Anordnung von probenbehältnissen und deren verwendung zur multianalytbestimmung
US6510263B1 (en) * 2000-01-27 2003-01-21 Unaxis Balzers Aktiengesellschaft Waveguide plate and process for its production and microtitre plate
US20030108291A1 (en) * 2000-04-14 2003-06-12 Duveneck Gert Ludwig Grid-waveguide structure for reinforcing an excitation field and use thereof
US7175811B2 (en) 2000-04-28 2007-02-13 Edgelight Biosciences Micro-array evanescent wave fluorescence detection device
EP1287360A2 (de) 2000-06-02 2003-03-05 Zeptosens AG Kit und verfahren zur multianalytbestimmung
WO2002001194A1 (en) * 2000-06-25 2002-01-03 Affymetrix, Inc. Optically active substrates
AU2001281632A1 (en) 2000-08-09 2002-02-18 Artificial Sensing Instruments Asi Ag Waveguide grid array and optical measurement arrangement
AU2001289853A1 (en) * 2000-09-04 2002-03-22 Zeptosens Ag Multianalyte determination system and methods
AU2001289859A1 (en) * 2000-09-05 2002-03-22 Zeptosens Ag Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof
ATE508363T1 (de) 2000-12-06 2011-05-15 Ecole Polytech Verfahren zur herstellung eines bioanalytischen reagenzes, nachweisverfahren beruhend auf der verwendung des bioanalytischen reagenz, sowie dessen verwendung
FR2818382B1 (fr) * 2000-12-20 2003-02-21 Commissariat Energie Atomique Support pour determiner un analyte tel qu'une cible adn ou arn, comportant un filtre spectral selectif
DE10108483A1 (de) 2001-02-22 2002-09-05 Bayer Ag Phosphorhaltige Polymere für optischen Signalwandler
ES2392395T3 (es) 2001-03-01 2012-12-10 Sicpa Holding Sa Detector mejorado de características de luminiscencia
AU2002257671A1 (en) * 2001-04-02 2002-10-15 Zeptosens Ag Optical structure for multi-photon excitation and the use thereof
DE10133844B4 (de) * 2001-07-18 2006-08-17 Micronas Gmbh Verfahren und Vorrichtung zur Detektion von Analyten
US6782013B2 (en) * 2001-07-25 2004-08-24 Jds Uniphase Corporation Waveguide wavelength locker
US6671304B2 (en) * 2001-08-28 2003-12-30 The United States Of America As Represented By The Secretary Of The Navy Amplitude-modulated laser for high-bandwidth communications systems
ATE528117T1 (de) * 2001-08-30 2011-10-15 Bayer Technology Services Gmbh Verfahren zur herstellung von abformkörpern, insbesondere optischen strukturen, und deren verwendung
US20030124599A1 (en) * 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
DE10158149A1 (de) * 2001-11-28 2003-06-18 Bayer Ag Silangruppen enthaltende Polymere
US7179654B2 (en) * 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
JP2003308714A (ja) * 2002-04-17 2003-10-31 Fuji Photo Film Co Ltd 導光フィルム
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
US7154598B2 (en) * 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
CA2496287A1 (en) 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based optical identification element
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
WO2004020654A2 (en) * 2002-08-30 2004-03-11 Bayer Healthcare Llc Solid phase based nucleic acid assays combining high affinity and high specificity
AU2003298412A1 (en) 2002-09-03 2004-03-29 Zeptosens Ag Analytical platform and identification method
WO2004023142A1 (de) * 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
WO2004025562A1 (en) 2002-09-12 2004-03-25 Cyvera Corp. Method and apparatus for labelling using diffraction grating-based encoded optical identification elements
CA2498916A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
DE10245435B4 (de) * 2002-09-27 2006-03-16 Micronas Gmbh Vorrichtung zur Detektion mindestens eines in einer zu untersuchenden Probe enthaltenen Liganden
US7027163B2 (en) * 2003-01-24 2006-04-11 General Dynamics Advanced Information Systems, Inc. Grating sensor
US7445938B2 (en) * 2003-01-24 2008-11-04 General Dynamics Advanced Information Systems, Inc. System and method for detecting presence of analytes using gratings
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
DE10353694A1 (de) * 2003-11-18 2005-06-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikroskopievorrichtung
GB0327755D0 (en) * 2003-12-01 2003-12-31 Elliott Stephen R Optical-sensor chip
JP4480130B2 (ja) * 2003-12-16 2010-06-16 キヤノン株式会社 光学分析装置
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
WO2005095965A1 (en) * 2004-03-03 2005-10-13 Bayer Technology Services Gmbh Analytical platform and method for generating protein expression profiles of cell populations
US7080839B2 (en) * 2004-06-29 2006-07-25 Michael Shackleford Blackjack variations
DE602005026943D1 (de) 2004-07-02 2011-04-28 Bayer Healthcare Llc Verfahren und lichtleitertestsensor für die analytbestimmungen in einer flüssigprobe
ES2292273B1 (es) * 2004-07-13 2009-02-16 Fabrica Nacional De Moneda Y Timbre - Real Casa De La Moneda Pigmentos luminiscentes utilizados en documentos de seguridad y procedimiento de deteccion de los mismos.
US7678567B2 (en) * 2004-07-26 2010-03-16 Kabushiki Kaisha Toshiba Optical biosensor
EP1621869B1 (en) * 2004-07-26 2015-08-19 Kabushiki Kaisha Toshiba Optical biosensor
CN101696937B (zh) * 2004-07-30 2012-07-04 株式会社东芝 光学式生物传感器
CN100449313C (zh) * 2004-07-30 2009-01-07 株式会社东芝 光学式生物传感器
CA2587674A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. Method and apparatus for reading coded microbeads
US7403284B2 (en) * 2004-12-16 2008-07-22 Andevices, Inc. Integrated optics based high-resolution spectrophotometer
JP2005099054A (ja) * 2004-12-27 2005-04-14 Olympus Corp 微小物質の蛍光測定装置
US7327908B1 (en) * 2005-03-07 2008-02-05 Lightsmyth Technologies Inc. Integrated optical sensor incorporating sets of diffractive elements
GB0507835D0 (en) * 2005-04-18 2005-05-25 Solexa Ltd Method and device for nucleic acid sequencing using a planar wave guide
ES2525324T3 (es) 2005-04-26 2014-12-22 Bayer Intellectual Property Gmbh Nuevo aparato y procedimiento de recubrimiento de sustratos portadores para la detección de analitos mediante un procedimiento de detección por afinidad
US7136005B1 (en) * 2005-05-05 2006-11-14 Analog Devices, Inc. Accurate low noise analog to digital converter system
WO2007019039A1 (en) * 2005-08-08 2007-02-15 Corning Incorporated Method for increasing a read-out speed of a ccd-detector
WO2007043005A1 (en) 2005-10-12 2007-04-19 Koninklijke Philips Electronics N. V. All polymer optical waveguide sensor
US7955837B2 (en) * 2005-10-29 2011-06-07 Bayer Technology Services Gmbh Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
DE102005062785A1 (de) * 2005-12-28 2007-07-05 Robert Bosch Gmbh Regensensor, insbesondere für ein Kraftfahrzeug, und Verfahren zur Herstellung des Regensensors
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
SE529711C2 (sv) * 2006-03-22 2007-11-06 Aamic Ab Fluorescensläsare
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
EP2411530A2 (en) 2006-04-26 2012-02-01 Bayer Technology Services GmbH Solid phase based nucleic acid assays combining high affinity capturing and detection by specific hybridization
US20080101744A1 (en) * 2006-10-31 2008-05-01 Honeywell International Inc. Optical Waveguide Sensor Devices and Methods For Making and Using Them
WO2008076367A2 (en) * 2006-12-14 2008-06-26 University Of Massachusetts Polymer-protein substrates for immunosorbent fluorescence assays
US9475051B2 (en) 2007-02-27 2016-10-25 Sony Corporation Nucleic acid amplifier
JP4458133B2 (ja) * 2007-02-27 2010-04-28 ソニー株式会社 核酸増幅装置
US20090325211A1 (en) * 2007-10-06 2009-12-31 Ye Fang System and method for dual-detection of a cellular response
AT506177B1 (de) * 2008-03-26 2009-07-15 Univ Graz Tech Optischer sensor
EP2110694B1 (en) 2008-04-18 2013-08-14 Sony DADC Austria AG Method for manufacturing an optical waveguide, optical waveguide, and sensor arrangement
DE102008019928A1 (de) 2008-04-21 2009-12-31 Siemens Healthcare Diagnostics Gmbh Polyelektrolyt-Monoschichten mit kovalenten Bindungsstellen für optische Signalwandler
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US8331751B2 (en) 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
BRPI1015212A2 (pt) 2009-04-09 2016-05-03 Bayer Cropscience Ag dispositivo e método para a detecção e para a análise quantitativa de analitos, especialmente micotoxinas
DE102009016712A1 (de) 2009-04-09 2010-10-14 Bayer Technology Services Gmbh Einweg-Mikrofluidik-Testkassette zur Bioassay von Analyten
WO2010127001A1 (en) 2009-04-29 2010-11-04 Plc Diagnostics Inc. Waveguide-based detection system with scanning light source
US8154716B2 (en) * 2009-09-04 2012-04-10 Octrolix Bv Waveguide-based sensor
DE102010019095B4 (de) 2010-04-30 2016-12-08 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren und Vorrichtung zur Fluoreszenzlebensdauermessung
EP2616797B1 (en) 2010-09-15 2017-01-11 MBIO Diagnostics Inc. System and method for detecting multiple molecules in one assay
US8507294B2 (en) * 2011-07-13 2013-08-13 Empire Technology Development Llc Method and system for analyte monitoring using surface plasmons with a refreshable surface
US9989525B2 (en) 2013-03-15 2018-06-05 Axela Inc. Diffraction based biosensor containing two diffractive gratings
US20150077756A1 (en) * 2013-06-13 2015-03-19 Lumense, Inc. System and method for continuous real-time monitoring of water at contaminated sites
WO2015074005A1 (en) 2013-11-17 2015-05-21 Quantum-Si Incorporated Active-source-pixel, integrated device for rapid analysis of biological and chemical speciments
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US9702813B2 (en) * 2014-07-23 2017-07-11 Infineon Technologies Ag Sensing systems and methods using a coupling structure
US9921157B2 (en) 2014-08-08 2018-03-20 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
CN111710687B (zh) 2014-08-08 2023-11-14 宽腾矽公司 基于入射光子到达时间的识别、成像、测序法及存储介质
JP6930911B2 (ja) 2014-08-08 2021-09-01 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 分子の探索、検出、および解析のための外部光源を備える集積装置
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
CA3012705A1 (en) 2016-02-17 2017-08-24 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
CA3047133A1 (en) 2016-12-16 2018-06-21 Quantum-Si Incorporated Compact mode-locked laser module
MX2019007069A (es) 2016-12-16 2019-08-01 Quantum Si Inc Ensamblaje de conformacion y direccion de haz compacto.
BR112019012540A2 (pt) 2016-12-22 2019-11-12 Quantum-Si Incorporated fotodetector integrado com pixel de acondicionamento direto
TWI653449B (zh) 2018-01-31 2019-03-11 國立交通大學 光子晶體與磁珠結合的螢光免疫檢測裝置和方法
DE102018202591A1 (de) * 2018-02-21 2019-08-22 Robert Bosch Gmbh Optisches System sowie ein Verfahren zur Herstellung eines optischen Systems
RU2737056C1 (ru) * 2018-03-29 2020-11-24 Иллюмина, Инк. Освещение для флуоресцентной визуализации с помощью линзы объектива
US11808700B2 (en) 2018-06-15 2023-11-07 Quantum-Si Incorporated Data acquisition control for advanced analytic instruments having pulsed optical sources
CA3108295A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
CN111742212B (zh) 2019-01-08 2024-02-20 京东方科技集团股份有限公司 流体检测面板和流体检测装置
CN109632660B (zh) 2019-01-17 2022-04-05 京东方科技集团股份有限公司 流体检测面板
CA3142922A1 (en) 2019-06-14 2020-12-17 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
DE102021133357A1 (de) 2021-12-15 2023-06-15 Endress+Hauser Conducta Gmbh+Co. Kg Sensorelement, Sensorsystem und Verfahren zum Herstellen des Sensorelements
TWI796944B (zh) * 2022-01-28 2023-03-21 國立中山大學 螢光增強基板及螢光檢測裝置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
AU5815886A (en) * 1985-05-29 1986-12-24 Kurt Tiefenthaler Optical sensor for selectively determining the presence of substances and the variation of the refraction index in the measured substances
JPH03502726A (ja) * 1988-02-14 1991-06-20 ルーコズ　ヴァルタ 集積光学干渉法
GB8807486D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Waveguide sensor
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
US5082629A (en) * 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
DE69119750T2 (de) * 1990-03-02 1996-10-02 Fisons Plc Messzelle für chemische oder biochemische proben
DE69128123T2 (de) * 1990-08-31 1998-03-05 Texas Instruments Inc Verfahren zum Herstellen selbst-ausrichtender bipolarer Transistoren mit Heteroübergang
DE4228853C2 (de) * 1991-09-18 1993-10-21 Schott Glaswerke Optischer Wellenleiter mit einem planaren oder nur geringfügig gewölbten Substrat und Verfahren zu dessen Herstellung sowie Verwendung eines solchen
US5294799A (en) * 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
US5418371A (en) * 1993-02-01 1995-05-23 Aslund; Nils R. D. Apparatus for quantitative imaging of multiple fluorophores using dual detectors
US5822472A (en) * 1994-05-27 1998-10-13 Novartis Corporation Process for detecting evanescently excited luminescence

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