ATE220208T1 - Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur - Google Patents

Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur

Info

Publication number
ATE220208T1
ATE220208T1 AT96929635T AT96929635T ATE220208T1 AT E220208 T1 ATE220208 T1 AT E220208T1 AT 96929635 T AT96929635 T AT 96929635T AT 96929635 T AT96929635 T AT 96929635T AT E220208 T1 ATE220208 T1 AT E220208T1
Authority
AT
Austria
Prior art keywords
film layer
intensity signal
interaction
light intensity
pct
Prior art date
Application number
AT96929635T
Other languages
English (en)
Inventor
Bengt Ivarsson
Esa Stenberg
Original Assignee
Biacore Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore Ab filed Critical Biacore Ab
Application granted granted Critical
Publication of ATE220208T1 publication Critical patent/ATE220208T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT96929635T 1995-09-01 1996-08-30 Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur ATE220208T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9503028A SE9503028D0 (sv) 1995-09-01 1995-09-01 Method of analysing chemical and physical interactions at a sensor surface
PCT/SE1996/001074 WO1997009618A1 (en) 1995-09-01 1996-08-30 Monitoring of refractive index of optical sensor for determination of surface structure changes

Publications (1)

Publication Number Publication Date
ATE220208T1 true ATE220208T1 (de) 2002-07-15

Family

ID=20399349

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96929635T ATE220208T1 (de) 1995-09-01 1996-08-30 Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur

Country Status (7)

Country Link
US (1) US6127183A (de)
EP (1) EP0852010B1 (de)
JP (1) JP3490458B2 (de)
AT (1) ATE220208T1 (de)
DE (1) DE69622176T2 (de)
SE (1) SE9503028D0 (de)
WO (1) WO1997009618A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
SE9604575D0 (sv) * 1996-12-12 1996-12-12 Biacore Ab Method and system for analyte determination
EP1012580B1 (de) * 1997-09-10 2004-06-23 Artificial Sensing Instruments ASI AG Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz
WO1999030135A1 (en) * 1997-12-12 1999-06-17 The Perkin-Elmer Corporation Optical resonance analysis system
DE60020119T2 (de) 1999-06-18 2005-10-06 Biacore Ab Verfahren und Vorrichtung zur Untersuchung von Wirksstoffskandidaten und zur Bestimmung ihrer pharmakokinetischen Parametern
AU5824300A (en) 1999-07-05 2001-01-22 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US10013075B2 (en) 1999-09-15 2018-07-03 Michael Shipman Illuminated keyboard
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
DE10006083B4 (de) 2000-02-11 2004-01-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zur quantitativen und/oder qualitativen Bestimmung von Schichtdicken sowie ein Mikroreaktionsgefäß und eine Titerplatte
US6728429B1 (en) 2000-02-16 2004-04-27 Biotell, Inc. Optical detection
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6833920B2 (en) * 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US6798511B1 (en) 2000-10-18 2004-09-28 Regents Of The University Of Minnesota Imaging ellipsometry
US6934024B2 (en) * 2000-10-18 2005-08-23 Regents Of The University Of Minnesota Ellipsometry methods and apparatus using solid immersion tunneling
SE0100889D0 (sv) 2001-03-14 2001-03-14 Biacore Ab Method and apparatus for attenuated total reflection spectrosopy
US20030003018A1 (en) * 2001-04-02 2003-01-02 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
US7208322B2 (en) * 2001-04-02 2007-04-24 Agilent Technologies, Inc. Sensor surfaces for detecting analytes
GB0112079D0 (en) * 2001-05-18 2001-07-11 Farfield Sensors Ltd Sensor Assembly
JP2004529358A (ja) * 2001-05-18 2004-09-24 ファーフィールド・センサーズ・リミテッド 方法
US6717663B2 (en) 2002-03-08 2004-04-06 Reichert, Inc. Optical configuration and method for differential refractive index measurements
WO2003081245A1 (en) * 2002-03-27 2003-10-02 Biacore Ab Method, system and computer program for detecting molecular binding interactions comprising response curve quality control
SE0200949D0 (sv) 2002-03-27 2002-03-27 Biacore Ab Method and system for curve quality control
US20040036881A1 (en) * 2002-08-22 2004-02-26 Leica Microsystems Inc. Optical configuration for SPR measurement
WO2004023170A2 (en) * 2002-09-07 2004-03-18 Lightwave Bioapplications Bioanalysis systems including optical integrated circuit
US7015471B2 (en) * 2002-09-25 2006-03-21 North Carolina State University Surface plasmon resonance systems and methods having a variable charge density layer
GB0225491D0 (en) * 2002-11-01 2002-12-11 Farfield Sensors Ltd Device
EP1668363A1 (de) * 2003-09-24 2006-06-14 Biacore AB Verfahren und system zur analyse molekularer wechselwirkungen
CN100595573C (zh) * 2003-10-16 2010-03-24 株式会社纳德研究所 表面等离子共振的测定方法及用于该方法的贵金属化合物
US7804592B2 (en) 2003-10-16 2010-09-28 Nard Institute, Ltd. Method for measuring a surface plasmon resonance and noble metal compound used for the same
US7417737B2 (en) * 2003-12-02 2008-08-26 Fujilfilm Corporation Method for measuring surface plasmon resonance
JP4664298B2 (ja) 2004-08-24 2011-04-06 富士フイルム株式会社 表面プラズモン共鳴分析における解離定数の算出方法
US11216078B2 (en) 2005-01-18 2022-01-04 Michael Shipman Illuminated keyboard
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7586614B2 (en) * 2005-08-24 2009-09-08 Agilent Technologies, Inc. System and method for self-referenced SPR measurements
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
JP4663590B2 (ja) * 2006-06-14 2011-04-06 日本電信電話株式会社 ピーク位置変動量測定装置、その測定方法及びプログラム
US7867783B2 (en) * 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US7758190B2 (en) 2007-06-20 2010-07-20 Tearscience, Inc. Tear film measurement
US8192026B2 (en) 2007-06-20 2012-06-05 Tearscience, Inc. Tear film measurement
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
WO2009033056A1 (en) 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
CN101836102B (zh) * 2007-10-25 2012-02-29 皇家飞利浦电子股份有限公司 用于样品中靶粒子的传感器装置
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8746883B2 (en) 2009-04-01 2014-06-10 Tearscience, Inc. Ocular surface interferometery (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film
US8888286B2 (en) 2009-04-01 2014-11-18 Tearscience, Inc. Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography
US8915592B2 (en) 2009-04-01 2014-12-23 Tearscience, Inc. Apparatuses and methods of ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film
US9888839B2 (en) 2009-04-01 2018-02-13 Tearscience, Inc. Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms
US9642520B2 (en) 2009-04-01 2017-05-09 Tearscience, Inc. Background reduction apparatuses and methods of ocular surface interferometry (OSI) employing polarization for imaging, processing, and/or displaying an ocular tear film
US8163561B2 (en) 2009-11-30 2012-04-24 Corning Incorporated Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors
US8243276B2 (en) 2009-11-30 2012-08-14 Corning Incorporated Variable penetration depth biosensor
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
JP5873810B2 (ja) * 2010-01-29 2016-03-01 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 凝集体決定法
US8507294B2 (en) * 2011-07-13 2013-08-13 Empire Technology Development Llc Method and system for analyte monitoring using surface plasmons with a refreshable surface
US9885682B2 (en) * 2011-12-02 2018-02-06 The Johns Hopkins University Biosensor systems and related methods for detecting analytes in aqueous and biological environments
US9339177B2 (en) 2012-12-21 2016-05-17 Tearscience, Inc. Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography
WO2014179795A2 (en) 2013-05-03 2014-11-06 Tearscience, Inc. Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis
US9795290B2 (en) 2013-11-15 2017-10-24 Tearscience, Inc. Ocular tear film peak detection and stabilization detection systems and methods for determining tear film layer characteristics
US11474109B2 (en) 2018-11-16 2022-10-18 Scintimetrics, Inc. Compositions and methods for controllably merging emulsion droplets and sample analysis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
US5359681A (en) * 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto

Also Published As

Publication number Publication date
JPH11512186A (ja) 1999-10-19
SE9503028D0 (sv) 1995-09-01
EP0852010B1 (de) 2002-07-03
WO1997009618A1 (en) 1997-03-13
DE69622176D1 (de) 2002-08-08
DE69622176T2 (de) 2002-12-12
JP3490458B2 (ja) 2004-01-26
US6127183A (en) 2000-10-03
EP0852010A1 (de) 1998-07-08

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