DE69622176D1 - Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur - Google Patents

Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur

Info

Publication number
DE69622176D1
DE69622176D1 DE69622176T DE69622176T DE69622176D1 DE 69622176 D1 DE69622176 D1 DE 69622176D1 DE 69622176 T DE69622176 T DE 69622176T DE 69622176 T DE69622176 T DE 69622176T DE 69622176 D1 DE69622176 D1 DE 69622176D1
Authority
DE
Germany
Prior art keywords
film layer
intensity signal
interaction
light intensity
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69622176T
Other languages
English (en)
Other versions
DE69622176T2 (de
Inventor
Bengt Ivarsson
Esa Stenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Biacore AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore AB filed Critical Biacore AB
Publication of DE69622176D1 publication Critical patent/DE69622176D1/de
Application granted granted Critical
Publication of DE69622176T2 publication Critical patent/DE69622176T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69622176T 1995-09-01 1996-08-30 Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur Expired - Lifetime DE69622176T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9503028A SE9503028D0 (sv) 1995-09-01 1995-09-01 Method of analysing chemical and physical interactions at a sensor surface
PCT/SE1996/001074 WO1997009618A1 (en) 1995-09-01 1996-08-30 Monitoring of refractive index of optical sensor for determination of surface structure changes

Publications (2)

Publication Number Publication Date
DE69622176D1 true DE69622176D1 (de) 2002-08-08
DE69622176T2 DE69622176T2 (de) 2002-12-12

Family

ID=20399349

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69622176T Expired - Lifetime DE69622176T2 (de) 1995-09-01 1996-08-30 Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur

Country Status (7)

Country Link
US (1) US6127183A (de)
EP (1) EP0852010B1 (de)
JP (1) JP3490458B2 (de)
AT (1) ATE220208T1 (de)
DE (1) DE69622176T2 (de)
SE (1) SE9503028D0 (de)
WO (1) WO1997009618A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
SE9604575D0 (sv) * 1996-12-12 1996-12-12 Biacore Ab Method and system for analyte determination
DE59811600D1 (de) * 1997-09-10 2004-07-29 Artificial Sensing Instr Asi A Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz
WO1999030135A1 (en) * 1997-12-12 1999-06-17 The Perkin-Elmer Corporation Optical resonance analysis system
ATE295541T1 (de) 1999-06-18 2005-05-15 Biacore Ab Verfahren und vorrichtung zur untersuchung von wirksstoffskandidaten und zur bestimmung ihrer pharmakokinetischen parametern
WO2001002839A1 (en) 1999-07-05 2001-01-11 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US10013075B2 (en) 1999-09-15 2018-07-03 Michael Shipman Illuminated keyboard
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
DE10006083B4 (de) * 2000-02-11 2004-01-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zur quantitativen und/oder qualitativen Bestimmung von Schichtdicken sowie ein Mikroreaktionsgefäß und eine Titerplatte
US6728429B1 (en) 2000-02-16 2004-04-27 Biotell, Inc. Optical detection
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US6833920B2 (en) * 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US6934024B2 (en) * 2000-10-18 2005-08-23 Regents Of The University Of Minnesota Ellipsometry methods and apparatus using solid immersion tunneling
US6798511B1 (en) 2000-10-18 2004-09-28 Regents Of The University Of Minnesota Imaging ellipsometry
SE0100889D0 (sv) 2001-03-14 2001-03-14 Biacore Ab Method and apparatus for attenuated total reflection spectrosopy
AU2002258702A1 (en) * 2001-04-02 2002-10-15 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
US7208322B2 (en) * 2001-04-02 2007-04-24 Agilent Technologies, Inc. Sensor surfaces for detecting analytes
JP2004529358A (ja) * 2001-05-18 2004-09-24 ファーフィールド・センサーズ・リミテッド 方法
GB0112079D0 (en) * 2001-05-18 2001-07-11 Farfield Sensors Ltd Sensor Assembly
US6717663B2 (en) 2002-03-08 2004-04-06 Reichert, Inc. Optical configuration and method for differential refractive index measurements
SE0200949D0 (sv) 2002-03-27 2002-03-27 Biacore Ab Method and system for curve quality control
EP1488237B1 (de) * 2002-03-27 2011-05-11 GE Healthcare Bio-Sciences AB Verfahren, system und computerprogramm zum nachweis molekularer bindungswechselwirkungen mit reaktionskurven-qualitätskontrolle
US20040036881A1 (en) * 2002-08-22 2004-02-26 Leica Microsystems Inc. Optical configuration for SPR measurement
AU2003276870A1 (en) * 2002-09-07 2004-03-29 Lightwave Bioapplications Bioanalysis systems including optical integrated circuit
US7015471B2 (en) * 2002-09-25 2006-03-21 North Carolina State University Surface plasmon resonance systems and methods having a variable charge density layer
GB0225491D0 (en) * 2002-11-01 2002-12-11 Farfield Sensors Ltd Device
AU2004274843A1 (en) * 2003-09-24 2005-03-31 Ge Healthcare Bio-Sciences Ab Method and system for molecular interaction analysis
CN100595573C (zh) * 2003-10-16 2010-03-24 株式会社纳德研究所 表面等离子共振的测定方法及用于该方法的贵金属化合物
US7804592B2 (en) 2003-10-16 2010-09-28 Nard Institute, Ltd. Method for measuring a surface plasmon resonance and noble metal compound used for the same
US7417737B2 (en) 2003-12-02 2008-08-26 Fujilfilm Corporation Method for measuring surface plasmon resonance
WO2006022277A1 (ja) 2004-08-24 2006-03-02 Fujifilm Corporation 表面プラズモン共鳴分析における解離定数の算出方法
US11216078B2 (en) 2005-01-18 2022-01-04 Michael Shipman Illuminated keyboard
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7586614B2 (en) * 2005-08-24 2009-09-08 Agilent Technologies, Inc. System and method for self-referenced SPR measurements
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
JP4663590B2 (ja) * 2006-06-14 2011-04-06 日本電信電話株式会社 ピーク位置変動量測定装置、その測定方法及びプログラム
US7867783B2 (en) * 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US7758190B2 (en) 2007-06-20 2010-07-20 Tearscience, Inc. Tear film measurement
US8192026B2 (en) 2007-06-20 2012-06-05 Tearscience, Inc. Tear film measurement
WO2009033056A1 (en) 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
US8797028B2 (en) * 2007-10-25 2014-08-05 Koninklijke Philips N.V. Sensor device for target particles in a sample
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8915592B2 (en) 2009-04-01 2014-12-23 Tearscience, Inc. Apparatuses and methods of ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film
EP2413699B1 (de) 2009-04-01 2019-11-20 Tearscience, Inc. Osi-apparat zur abbildung eines augentränenfilms
US8888286B2 (en) 2009-04-01 2014-11-18 Tearscience, Inc. Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography
US9888839B2 (en) 2009-04-01 2018-02-13 Tearscience, Inc. Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms
US9642520B2 (en) 2009-04-01 2017-05-09 Tearscience, Inc. Background reduction apparatuses and methods of ocular surface interferometry (OSI) employing polarization for imaging, processing, and/or displaying an ocular tear film
US8163561B2 (en) 2009-11-30 2012-04-24 Corning Incorporated Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors
US8243276B2 (en) 2009-11-30 2012-08-14 Corning Incorporated Variable penetration depth biosensor
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
US9470683B2 (en) 2010-01-29 2016-10-18 Ge Healthcare Bio-Sciences Ab Method for determination of aggregates
US8507294B2 (en) * 2011-07-13 2013-08-13 Empire Technology Development Llc Method and system for analyte monitoring using surface plasmons with a refreshable surface
US9885682B2 (en) * 2011-12-02 2018-02-06 The Johns Hopkins University Biosensor systems and related methods for detecting analytes in aqueous and biological environments
US9339177B2 (en) 2012-12-21 2016-05-17 Tearscience, Inc. Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography
CN105792729B (zh) 2013-05-03 2018-04-27 眼泪科学公司 用于对睑板腺进行成像以供睑板腺分析的眼睑照明系统和方法
US9795290B2 (en) 2013-11-15 2017-10-24 Tearscience, Inc. Ocular tear film peak detection and stabilization detection systems and methods for determining tear film layer characteristics
US11474109B2 (en) 2018-11-16 2022-10-18 Scintimetrics, Inc. Compositions and methods for controllably merging emulsion droplets and sample analysis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
US5359681A (en) * 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto

Also Published As

Publication number Publication date
EP0852010B1 (de) 2002-07-03
EP0852010A1 (de) 1998-07-08
US6127183A (en) 2000-10-03
SE9503028D0 (sv) 1995-09-01
JPH11512186A (ja) 1999-10-19
WO1997009618A1 (en) 1997-03-13
JP3490458B2 (ja) 2004-01-26
DE69622176T2 (de) 2002-12-12
ATE220208T1 (de) 2002-07-15

Similar Documents

Publication Publication Date Title
DE69622176D1 (de) Überwachung des refraktionsindex von optischen sensoren zur bestimmung von änderungen in der oberflächenstruktur
FI964684A0 (fi) Menetelmä aaltomaisesti lähetetyn luminanssin havaitsemiseksi
SE0201191D0 (sv) Optical component based temperature measurement in analyte detection devices
ATE272211T1 (de) Hochempfindliches, genaues und präzises automatisiertes messverfahren und vorrichtung zur identifizierung und quantifizierung von blutplättchen und zur bestimmung des blutplättchenaktivitätszustands unter verwendung von ganzblutproben
WO1992019957A3 (en) Method for optically measuring chemical analytes
EP0903573A3 (de) Optode zur Bestimmung von Gasen
GB8801807D0 (en) Biological sensors
EP0604582A1 (de) Zwei-wellenlängen-photometer und faseroptischer sensor
DK2325622T3 (da) Optisk-baseret føleindretning
DE665425T1 (de) Spektral-Modulationssensor.
CA2231771A1 (en) Simultaneous dual excitation/single emission fluorescent sensing method for ph and pco2
CA2089649A1 (en) Self-compensating focs and other chemical sensors
EP0346016A3 (en) Biological sensors
WO1997033147A3 (de) Analyseverfahren unter verwendung von porösem silicium zur erfassung einer substanz oder der konzentration einer substanz in lösungen sowie eine analyseeinrichtung für ein solches verfahren
US6590665B2 (en) Optical sensing devices
DK0981734T3 (da) Flourescenssensorindretning
Wolfbeis Capillary waveguide sensors
DE69904122D1 (de) Verfahren und Vorrrichtung zur Messung des Blutzuckerspiegels
GB2197068A (en) Optical sensor device
SE9403078D0 (sv) Milk assay
DE69322242D1 (de) Turbidimetrisches Immunassay mit Messung der Geschwindigkeit der Trübungsveränderung nach dem Anfang der Immunpräzipitationsreaktion
EP0394041A3 (de) Kapillärdurchflussgerät und Ablesevorrichtung
SE9600914D0 (sv) Gassensor
JPS5713316A (en) Method and device for measurement of sample flowing at low speed
CA2341073C (en) Optical sensing devices

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE BIO-SCIENCES AB, UPPSALA, SE

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

Ref document number: 852010

Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB