FI961951A - Piperidiinit, pyrrolidiinit ja heksahydro-1H-atsepiinit edistävät kasvuhormonin vapautumista - Google Patents
Piperidiinit, pyrrolidiinit ja heksahydro-1H-atsepiinit edistävät kasvuhormonin vapautumista Download PDFInfo
- Publication number
- FI961951A FI961951A FI961951A FI961951A FI961951A FI 961951 A FI961951 A FI 961951A FI 961951 A FI961951 A FI 961951A FI 961951 A FI961951 A FI 961951A FI 961951 A FI961951 A FI 961951A
- Authority
- FI
- Finland
- Prior art keywords
- azepines
- pyrrolidines
- piperidines
- hexahydro
- growth hormone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14944193A | 1993-11-09 | 1993-11-09 | |
| US16514993A | 1993-12-10 | 1993-12-10 | |
| US17344993A | 1993-12-23 | 1993-12-23 | |
| US08/323,994 US5494919A (en) | 1993-11-09 | 1994-10-17 | 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US08/323,998 US5492920A (en) | 1993-12-10 | 1994-10-17 | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
| US08/323,988 US5492916A (en) | 1993-12-23 | 1994-10-17 | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| PCT/US1994/012816 WO1995013069A1 (en) | 1993-11-09 | 1994-11-07 | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI961951A0 FI961951A0 (fi) | 1996-05-08 |
| FI961951A true FI961951A (fi) | 1996-05-08 |
Family
ID=27558364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI961951A FI961951A (fi) | 1993-11-09 | 1996-05-08 | Piperidiinit, pyrrolidiinit ja heksahydro-1H-atsepiinit edistävät kasvuhormonin vapautumista |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0739204A4 (de) |
| JP (1) | JPH10506091A (de) |
| KR (1) | KR960705808A (de) |
| CN (1) | CN1174504A (de) |
| AU (1) | AU1172995A (de) |
| BG (1) | BG100555A (de) |
| BR (1) | BR9408019A (de) |
| CA (1) | CA2175218A1 (de) |
| CZ (1) | CZ134296A3 (de) |
| FI (1) | FI961951A (de) |
| HU (1) | HUT74733A (de) |
| LV (1) | LV11525B (de) |
| NO (1) | NO961865L (de) |
| PL (1) | PL322706A1 (de) |
| SK (1) | SK56296A3 (de) |
| WO (1) | WO1995013069A1 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5721251A (en) * | 1993-12-10 | 1998-02-24 | Merck & Co., Inc. | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
| US5721250A (en) * | 1993-12-23 | 1998-02-24 | Merck & Co. Inc. | Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5767118A (en) * | 1994-10-26 | 1998-06-16 | Merck & Co., Inc. | 4-Heterocyclic peperidines promote release of growth hormone |
| US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| US20020111461A1 (en) | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
| US5731317A (en) * | 1995-03-10 | 1998-03-24 | Merck & Co., Inc. | Bridged piperidines promote release of growth hormone |
| US5559128A (en) * | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
| WO1996035713A1 (en) * | 1995-05-08 | 1996-11-14 | Pfizer, Inc. | Dipeptides which promote release of growth hormone |
| US5620993A (en) * | 1995-06-07 | 1997-04-15 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| ATE334394T1 (de) | 1995-12-13 | 2006-08-15 | Merck & Co Inc | Testverfahren für die sekretionsrezeptoren von wachstumshormonen |
| US6531314B1 (en) | 1996-12-10 | 2003-03-11 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
| GB9526645D0 (en) * | 1995-12-28 | 1996-02-28 | Chiroscience Ltd | Stereoselective synthesis |
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| HN1996000101A (es) | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
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| UA59384C2 (uk) | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
| JP3514774B2 (ja) | 1997-06-25 | 2004-03-31 | ファイザー・インク | 成長ホルモン分泌促進薬としてのジペプチド誘導体 |
| UA53716C2 (uk) * | 1997-06-25 | 2003-02-17 | Пфайзер Продактс Інк. | Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти) |
| UA64751C2 (uk) | 1997-06-25 | 2004-03-15 | Пфайзер Продактс Інк. | Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти) |
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| RU2243215C2 (ru) * | 1998-05-11 | 2004-12-27 | Ново Нордиск А/С | Производные пиперидинкарбоновых кислот, фармацевтические композиции, содержащие их, способ стимуляции секреции гормона роста |
| US6303620B1 (en) | 1998-05-11 | 2001-10-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| DZ2815A1 (fr) * | 1998-06-12 | 2003-12-01 | Smithkline Beecham Corp | Inhibiteurs de protéase. |
| US6682908B1 (en) | 1998-07-10 | 2004-01-27 | Merck & Co., Inc. | Mouse growth hormone secretagogue receptor |
| CA2333857A1 (en) | 1998-07-13 | 2000-01-20 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
| US6645726B1 (en) | 1998-08-10 | 2003-11-11 | Merck & Co., Inc. | Canine growth hormone secretagogue receptor |
| WO2000009537A2 (en) | 1998-08-14 | 2000-02-24 | Administrators Of The Tulane Educational Fund | Compounds having growth hormone releasing activity |
| CO5150173A1 (es) * | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
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| DE10105041A1 (de) * | 2001-02-05 | 2002-08-14 | Tell Pharm Ag Hergiswil | Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten |
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| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| JP3098082B2 (ja) * | 1991-12-12 | 2000-10-10 | 三井化学株式会社 | アミノ基含有化合物の製造方法 |
| US5366965A (en) * | 1993-01-29 | 1994-11-22 | Boehringer Mannheim Gmbh | Regimen for treatment or prophylaxis of osteoporosis |
| US5284841A (en) * | 1993-02-04 | 1994-02-08 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
-
1994
- 1994-11-07 EP EP95902467A patent/EP0739204A4/de not_active Withdrawn
- 1994-11-07 HU HU9601230A patent/HUT74733A/hu unknown
- 1994-11-07 CZ CZ961342A patent/CZ134296A3/cs unknown
- 1994-11-07 KR KR1019960702427A patent/KR960705808A/ko not_active Application Discontinuation
- 1994-11-07 CN CN94194738A patent/CN1174504A/zh active Pending
- 1994-11-07 CA CA002175218A patent/CA2175218A1/en not_active Abandoned
- 1994-11-07 AU AU11729/95A patent/AU1172995A/en not_active Abandoned
- 1994-11-07 WO PCT/US1994/012816 patent/WO1995013069A1/en not_active Application Discontinuation
- 1994-11-07 BR BR9408019A patent/BR9408019A/pt not_active Application Discontinuation
- 1994-11-07 JP JP7513932A patent/JPH10506091A/ja active Pending
- 1994-11-07 SK SK562-96A patent/SK56296A3/sk unknown
- 1994-11-07 PL PL94322706A patent/PL322706A1/xx unknown
-
1996
- 1996-05-02 BG BG100555A patent/BG100555A/bg unknown
- 1996-05-08 FI FI961951A patent/FI961951A/fi unknown
- 1996-05-08 NO NO961865A patent/NO961865L/no unknown
- 1996-05-22 LV LVP-96-151A patent/LV11525B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2175218A1 (en) | 1995-05-18 |
| LV11525A (lv) | 1996-10-20 |
| NO961865D0 (no) | 1996-05-08 |
| FI961951A0 (fi) | 1996-05-08 |
| CZ134296A3 (en) | 1996-12-11 |
| EP0739204A4 (de) | 2000-03-15 |
| BG100555A (bg) | 1996-10-31 |
| SK56296A3 (en) | 1997-02-05 |
| HUT74733A (en) | 1997-02-28 |
| HU9601230D0 (en) | 1996-07-29 |
| CN1174504A (zh) | 1998-02-25 |
| BR9408019A (pt) | 1997-08-26 |
| WO1995013069A1 (en) | 1995-05-18 |
| NO961865L (no) | 1996-07-08 |
| AU1172995A (en) | 1995-05-29 |
| JPH10506091A (ja) | 1998-06-16 |
| EP0739204A1 (de) | 1996-10-30 |
| KR960705808A (ko) | 1996-11-08 |
| PL322706A1 (en) | 1998-02-16 |
| LV11525B (en) | 1997-02-20 |
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