FI95775B - Förfarande för framställning av ett transdermalt, terapeutiskt system för att administrera fysostigmin på huden - Google Patents
Förfarande för framställning av ett transdermalt, terapeutiskt system för att administrera fysostigmin på huden Download PDFInfo
- Publication number
- FI95775B FI95775B FI896099A FI896099A FI95775B FI 95775 B FI95775 B FI 95775B FI 896099 A FI896099 A FI 896099A FI 896099 A FI896099 A FI 896099A FI 95775 B FI95775 B FI 95775B
- Authority
- FI
- Finland
- Prior art keywords
- process according
- polymeric material
- storage layer
- material contains
- physostigmine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Claims (13)
1. Förfarande för framställning av ett transder-malt terapeutiskt system för att administrera fysostigmin 5 pä huden, vilket system omfattar ett täckskikt ogenom- trängligt för en aktiv substans, ett adhesivt reservoar-skikt och eventuellt ett äterlösgörbart skyddsskikt, (i) genom att blanda den aktiva substansen fysostigmin med beständsdelarna i det adhesiva reservoar- t10 skiktet homogen i en lösning, (ii) genom att breda ut denna lösning pä det för den aktiva substansen ogenomträngliga täckskiktet, (iii) genom att avlägsna lösningsmedlet och (iv) genom att eventuellt täcka det adhesiva reser-15 voarskiktet med ett skyddsskikt, kännetecknat av, att steg (i) utförs genom att upplösa beständsdelarna i reservoarskiktet, vilka bestär av a) 10-90 vikt-% polymermaterial, valt bland bloc-20 kkopolymerer baserade pä styren och 1,3-diener, polyisobu- tylen, pä akrylat- och/eller metakrylat baserade polymerer och vidare eventuellt estrar av hydrerat kolofonium, b) 0-30 vikt-% av en pä kolväten och/eller estrar baserad mjukgörare och . 25 c) 0,1 - 20 vikt-% fysostigmin, i ett lösningsmedel, som kokar vid en läg tempera-tur och är en lösningsmedelsblandning av butanon och n-heptan, och steg (iii) utförs genom torkning vid cirka 50 °C sä 30 att en maximirestfuktighet under 0,4 vikt-% erhälls.
2. Förfarande enligt patentkrav 1, kännetecknat av, att beständsdelarna i reservoarskiktet, dvs. polymerer, hartser och mjukgöraren innehäller varken fria hydroxylgrupper eller polyetoxigrupper. 35
3. Förfarande enligt patentkrav 1, känne tecknat av, att polymermaterialet innehäller en linear blockkopolymer av styren-isopren-styren. 95775 14
4. Förfarande enligt patentkrav 1, känne-tecknat av, att polymermaterialet innehäller en linear blockkopolymer av styren-butadien-styren.
5. Förfarande enligt patentkrav 1, känne- 5 tecknat av, att polymermaterialet innehäller en av sig själv tvärbindningsbar akrylatkopolymer av 2-etyl-hexyl-akrylat, vinylacetat, akrylsyra och titankelates-ter.
6. Förfarande enligt patentkrav 1, känne- 10 tecknat av, att polymermaterialet innehäller en av sig själv icke-tvärbindningsbar akrylatkopolymer av 2-etylhexylakrylat, vinylacetat och akrylsyra.
7. Förfarande enligt patentkrav 1, känne-tecknat av, att polymermaterialet som pä metakry- 15 latbaserad polymer innehäller en pä dimetylaminoetylme-takrylat och neutrala metakrylsyraestrar baserad kopoly-mer.
8. Förfarande enligt patentkrav 1, känne-tecknat av, att polymermaterialet som ester av hyd- 20 rerat kolofonium innehäller en metylester därav.
9. Förfarande enligt patentkrav 1, känne-tecknat av, att polymermaterialet som ester av hyd-rerat kolofonium innehäller en glycerinester därav.
10. Förfarande enligt patentkrav 1, känne- , , 25 tecknat av, att reservoarskiktet som mjukgörare innehäller dioktylcyklohexan.
11. Förfarande enligt patentkrav 1, känne-tecknat av, att reservoarskiktet som mjukgörare innehäller di-n-butyladipat. 30
12. Förfarande enligt patentkrav 1, känne- tecknat av, att reservoarskiktet som mjukgörare innehäller triglycerider.
13. Förfarande enligt patentkrav 1, känne-tecknat av, att reservoarskiktet som mjukgörare 35 innehäller isopropylmyristat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3843239A DE3843239C1 (sv) | 1988-12-22 | 1988-12-22 | |
| DE3843239 | 1988-12-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI896099A0 FI896099A0 (sv) | 1989-12-19 |
| FI95775B true FI95775B (sv) | 1995-12-15 |
| FI95775C FI95775C (sv) | 1996-03-25 |
Family
ID=6369855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI896099A FI95775C (sv) | 1988-12-22 | 1989-12-19 | Förfarande för framställning av ett transdermalt, terapeutiskt system för att administrera fysostigmin på huden |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5089267A (sv) |
| EP (1) | EP0376067B1 (sv) |
| JP (1) | JPH0784379B2 (sv) |
| KR (1) | KR950015058B1 (sv) |
| CN (1) | CN1045355A (sv) |
| AT (1) | ATE105488T1 (sv) |
| AU (1) | AU614209B2 (sv) |
| CA (1) | CA2006404C (sv) |
| CS (1) | CS277066B6 (sv) |
| DD (1) | DD290580A5 (sv) |
| DE (2) | DE3843239C1 (sv) |
| DK (1) | DK651289A (sv) |
| ES (1) | ES2056185T3 (sv) |
| FI (1) | FI95775C (sv) |
| GE (1) | GEP19960440B (sv) |
| HU (1) | HU205252B (sv) |
| IE (1) | IE64200B1 (sv) |
| IL (1) | IL92680A (sv) |
| LT (1) | LT3785B (sv) |
| MY (1) | MY104491A (sv) |
| NO (1) | NO180072C (sv) |
| NZ (1) | NZ231907A (sv) |
| PH (1) | PH25853A (sv) |
| PL (1) | PL162690B1 (sv) |
| PT (1) | PT92652B (sv) |
| RU (1) | RU2011384C1 (sv) |
| UA (1) | UA18868A (sv) |
| YU (1) | YU47077B (sv) |
| ZA (1) | ZA899878B (sv) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3843238C1 (sv) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
| US5332577A (en) * | 1988-12-27 | 1994-07-26 | Dermamed | Transdermal administration to humans and animals |
| US5241925A (en) * | 1988-12-27 | 1993-09-07 | Dermamed | Apparatus and techniques for administering veterinary medicaments |
| US5324521A (en) * | 1989-12-18 | 1994-06-28 | Dermamed | Systems for transdermal administration of medicaments |
| NZ237241A (en) * | 1990-03-02 | 1993-11-25 | Pharmetrix Corp | Method for increasing the storage stability of physostigmine |
| DE4010079A1 (de) * | 1990-03-29 | 1991-10-02 | Lohmann Therapie Syst Lts | Pharmazeutische formulierung zur behandlung des alkoholismus |
| EP0523150A4 (en) * | 1990-04-06 | 1993-09-29 | Pharmetrix Corporation | Device and method for enhanced administration of physostigmine |
| DE4020144A1 (de) * | 1990-06-25 | 1992-01-09 | Lohmann Therapie Syst Lts | Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen |
| DE4238223C1 (de) | 1992-11-12 | 1994-05-26 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Verabreichung von Physostigmin an die Haut und Verfahren zu dessen Herstellung |
| US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| DE4301783C1 (de) * | 1993-01-23 | 1994-02-03 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Galanthamin als wirksamem Bestandteil |
| DE4301782C1 (de) * | 1993-01-23 | 1994-08-25 | Lohmann Therapie Syst Lts | Verwendung von Galanthamin zur Behandlung der Nicotinabhängigkeit |
| DE4342174C1 (de) | 1993-12-10 | 1995-05-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung |
| DE4400770C1 (de) * | 1994-01-13 | 1995-02-02 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung |
| PL179757B1 (pl) | 1994-10-28 | 2000-10-31 | Kimberly Clark Co | Wyrób chlonny PL PL PL PL |
| TW304167B (sv) * | 1995-01-30 | 1997-05-01 | Lilly Co Eli | |
| US5810960A (en) * | 1995-03-08 | 1998-09-22 | Nitto Denko Corporation | Paint film-protective sheet |
| DE19706824C1 (de) * | 1997-02-21 | 1998-03-26 | Lohmann Therapie Syst Lts | Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften |
| DE19906979B4 (de) | 1999-02-19 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Verwendung von Desoxypeganin zur Behandlung der Nikotinabhängigkeit |
| DE10119862A1 (de) | 2001-04-24 | 2002-11-07 | Hf Arzneimittelforsch Gmbh | Verwendung von Galanthamin zur Behandlung von Krankheitserscheinungen des zentralen Nervensystems aufgrund von Intoxikationen mit psychotropen Substanzen |
| DE10119863A1 (de) * | 2001-04-24 | 2002-11-07 | Hf Arzneimittelforsch Gmbh | Verwendung von Desoxypeganin zur Behandlung von psychiatrischen oder zerebralen Krankheitserscheinungen |
| DE10129265A1 (de) * | 2001-06-18 | 2003-01-02 | Hf Arzneimittelforsch Gmbh | Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie |
| DE10134038A1 (de) * | 2001-07-12 | 2003-02-06 | Hf Arzneimittelforsch Gmbh | Wirkstoff-Kombination zur medikamentösen Therapie der Nikotinabhängigkeit |
| DE10159745A1 (de) | 2001-12-05 | 2003-07-03 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort |
| AU2003272237B2 (en) | 2002-08-30 | 2009-11-19 | Alza Corporation | Embossable and writable multilaminate backing construction |
| DE10318714B4 (de) * | 2003-04-25 | 2006-03-23 | Hf Arzneimittelforschung Gmbh | Wirkstoff-Kombinationen und Therapien zur Bekämpfung des Alkoholmissbrauches |
| US20050182044A1 (en) * | 2004-02-17 | 2005-08-18 | Bruinsma Gosse B. | Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate |
| AT500143A1 (de) * | 2004-04-22 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung |
| CA2508585A1 (en) * | 2004-06-01 | 2005-12-01 | Axonyx, Inc. | Transdermal delivery system for treatment of cognitive disorders |
| US20050272804A1 (en) * | 2004-06-08 | 2005-12-08 | Axonyx, Inc | Methods of delaying Alzheimer's disease progression using a beta-amyloid precursor protein inhibitor and a HMG CoA reductase inhibitor |
| CN1320009C (zh) * | 2005-03-24 | 2007-06-06 | 上海交通大学 | 包含酯基部分带羟基基团的丙烯酸酯的组合物 |
| CN1320008C (zh) * | 2005-03-24 | 2007-06-06 | 上海交通大学 | 包含酯基部分带羧基基团的丙烯酸酯的组合物 |
| CN1320005C (zh) * | 2005-03-24 | 2007-06-06 | 上海交通大学 | 包含酯基部分带烷烃基的丙烯酸酯的组合物 |
| CN1326894C (zh) * | 2005-03-24 | 2007-07-18 | 上海交通大学 | 包含酯基部分带烷氧基的丙烯酸酯的组合物 |
| CN1320006C (zh) * | 2005-03-24 | 2007-06-06 | 上海交通大学 | 包含酯基部分带酯基基团的丙烯酸酯的组合物 |
| CN1994290B (zh) * | 2006-01-04 | 2011-03-16 | 上海医药工业研究院 | 卡巴拉汀透皮贴剂及其制备方法 |
| GB0809905D0 (en) * | 2008-06-02 | 2008-07-09 | Secr Defence | A Transdermal drug delivery device |
| KR101317158B1 (ko) * | 2011-02-18 | 2013-10-15 | 조선대학교산학협력단 | 갈란타민 또는 그의 염을 함유하는 경피흡수제제 |
| DE102019201430A1 (de) | 2019-02-05 | 2020-08-06 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System (TTS) mit Transportmedium |
| DE102019201431A1 (de) | 2019-02-05 | 2020-08-06 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System (TTS) mit Feststoffreservoir |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3921363A (en) | 1974-05-17 | 1975-11-25 | Preston Metal & Roofing Prod | Cross member with end connector |
| JPS5620514A (en) * | 1979-07-27 | 1981-02-26 | Nitto Electric Ind Co Ltd | Plaster for remedy of skin disease |
| JPS596285B2 (ja) * | 1980-09-22 | 1984-02-10 | 日東電工株式会社 | 外用部材 |
| JPS57116011A (en) * | 1981-01-08 | 1982-07-19 | Nitto Electric Ind Co Ltd | Pharmaceutical preparation |
| JPS6066758A (ja) * | 1983-09-21 | 1985-04-16 | 日東電工株式会社 | 医薬製剤 |
| DE3344691A1 (de) * | 1983-12-10 | 1985-06-20 | Bayer Ag, 5090 Leverkusen | Wirkstoffabgasesysteme |
| GB2156215B (en) * | 1984-03-05 | 1988-03-02 | Nitto Electric Ind Co | Percutaneous absorption type adhesive pharmaceutical preparation |
| IL72684A (en) * | 1984-08-14 | 1989-02-28 | Israel State | Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs |
| US4765985A (en) * | 1985-03-05 | 1988-08-23 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
| US4680172A (en) * | 1985-03-05 | 1987-07-14 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
| US4668506A (en) * | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
| US4911707A (en) * | 1987-02-13 | 1990-03-27 | Ciba-Geigy Corporation | Monolithic user-activated transdermal therapeutic system |
| DE3743945A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von stoffen, verfahren zu ihrer herstellung sowie ihre verwendung |
| DE3843238C1 (sv) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts |
-
1988
- 1988-12-22 DE DE3843239A patent/DE3843239C1/de not_active Expired - Lifetime
-
1989
- 1989-12-13 IL IL92680A patent/IL92680A/xx unknown
- 1989-12-14 EP EP89123085A patent/EP0376067B1/de not_active Expired - Lifetime
- 1989-12-14 MY MYPI89001753A patent/MY104491A/en unknown
- 1989-12-14 AT AT8989123085T patent/ATE105488T1/de not_active IP Right Cessation
- 1989-12-14 ES ES89123085T patent/ES2056185T3/es not_active Expired - Lifetime
- 1989-12-14 DE DE58907647T patent/DE58907647D1/de not_active Expired - Lifetime
- 1989-12-18 US US07/452,529 patent/US5089267A/en not_active Expired - Fee Related
- 1989-12-18 AU AU46845/89A patent/AU614209B2/en not_active Ceased
- 1989-12-19 CS CS897191A patent/CS277066B6/cs not_active IP Right Cessation
- 1989-12-19 FI FI896099A patent/FI95775C/sv not_active IP Right Cessation
- 1989-12-19 IE IE407989A patent/IE64200B1/en not_active IP Right Cessation
- 1989-12-19 YU YU240789A patent/YU47077B/sh unknown
- 1989-12-20 PH PH39751A patent/PH25853A/en unknown
- 1989-12-20 NZ NZ231907A patent/NZ231907A/xx unknown
- 1989-12-20 DK DK651289A patent/DK651289A/da not_active Application Discontinuation
- 1989-12-21 PT PT92652A patent/PT92652B/pt not_active IP Right Cessation
- 1989-12-21 DD DD89336083A patent/DD290580A5/de not_active IP Right Cessation
- 1989-12-21 ZA ZA899878A patent/ZA899878B/xx unknown
- 1989-12-21 RU SU894742793A patent/RU2011384C1/ru active
- 1989-12-21 CA CA002006404A patent/CA2006404C/en not_active Expired - Fee Related
- 1989-12-21 HU HU896713A patent/HU205252B/hu not_active IP Right Cessation
- 1989-12-21 UA UA4742793A patent/UA18868A/uk unknown
- 1989-12-21 NO NO895171A patent/NO180072C/no not_active IP Right Cessation
- 1989-12-22 CN CN89109818A patent/CN1045355A/zh active Pending
- 1989-12-22 JP JP1331444A patent/JPH0784379B2/ja not_active Expired - Lifetime
- 1989-12-22 PL PL28294989A patent/PL162690B1/pl unknown
- 1989-12-22 KR KR1019890019756A patent/KR950015058B1/ko not_active IP Right Cessation
-
1993
- 1993-09-17 GE GEAP19931588A patent/GEP19960440B/en unknown
-
1994
- 1994-01-31 LT LTIP1842A patent/LT3785B/lt not_active IP Right Cessation
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