FI955646A0 - Ligandeja FLT3-reseptoreita varten - Google Patents
Ligandeja FLT3-reseptoreita vartenInfo
- Publication number
- FI955646A0 FI955646A0 FI955646A FI955646A FI955646A0 FI 955646 A0 FI955646 A0 FI 955646A0 FI 955646 A FI955646 A FI 955646A FI 955646 A FI955646 A FI 955646A FI 955646 A0 FI955646 A0 FI 955646A0
- Authority
- FI
- Finland
- Prior art keywords
- ligands
- flt3 receptors
- flt3
- receptors
- Prior art date
Links
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 title 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/30—Animal model comprising expression system for selective cell killing, e.g. toxins, enzyme dependent prodrug therapy using ganciclovir
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6839493A | 1993-05-24 | 1993-05-24 | |
US10646393A | 1993-08-12 | 1993-08-12 | |
US11175893A | 1993-08-25 | 1993-08-25 | |
US16240793A | 1993-12-03 | 1993-12-03 | |
US20950294A | 1994-03-07 | 1994-03-07 | |
PCT/US1994/005365 WO1994028391A1 (en) | 1993-05-24 | 1994-05-12 | Ligands for flt3 receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
FI955646A0 true FI955646A0 (fi) | 1995-11-23 |
FI955646A FI955646A (fi) | 1996-01-23 |
Family
ID=27535798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI955646A FI955646A (fi) | 1993-05-24 | 1995-11-23 | Ligandeja FLT3-reseptoreita varten |
Country Status (16)
Country | Link |
---|---|
US (3) | US5554512A (fi) |
JP (1) | JP4028594B2 (fi) |
KR (1) | KR100319359B1 (fi) |
CN (1) | CN1123574C (fi) |
AU (1) | AU683472B2 (fi) |
BR (1) | BR9407073A (fi) |
CA (1) | CA2162397C (fi) |
FI (1) | FI955646A (fi) |
HU (1) | HUT74831A (fi) |
MY (1) | MY148148A (fi) |
NO (1) | NO322373B1 (fi) |
NZ (1) | NZ267541A (fi) |
OA (1) | OA10716A (fi) |
PL (1) | PL311756A1 (fi) |
UA (1) | UA42726C2 (fi) |
WO (1) | WO1994028391A1 (fi) |
Families Citing this family (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69426076T3 (de) * | 1993-05-19 | 2007-01-18 | Schering Corp. | Gereinigte flt3-liganden von saeugentieren, agonisten und antagonisten davon |
US7534867B1 (en) * | 1993-05-19 | 2009-05-19 | Schering Corporation | Purified mammalian Flt3 ligands; agonists; antagonists |
CZ307995A3 (en) * | 1993-05-24 | 1996-10-16 | Immunex Corp | Ligands for flt3 receptors |
US5554512A (en) * | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US7294331B2 (en) * | 1994-03-07 | 2007-11-13 | Immunex Corporation | Methods of using flt3-ligand in hematopoietic cell transplantation |
US5525708A (en) * | 1994-03-28 | 1996-06-11 | Cytomed, Inc. | Covalent dimer of kit ligand |
US5789655A (en) * | 1994-05-13 | 1998-08-04 | The Regents Of The University Of California | Transgenic animals expressing artificial epitope-tagged proteins |
JPH11509845A (ja) * | 1995-07-21 | 1999-08-31 | アメリカ合衆国 | 造血多分化性細胞移植のための放射線または放射線類似作用化学療法の減少方法 |
US6117850A (en) * | 1995-08-28 | 2000-09-12 | The Collaborative Group, Ltd. | Mobilization of peripheral blood precursor cells by β(1,3)-glucan |
GB9519776D0 (en) * | 1995-09-28 | 1995-11-29 | Casimir Colin | Materials and methods relating to the transfer of nucleic acid into stem cells |
SI9620116A (sl) | 1995-10-04 | 1999-08-31 | Immunex Corporation | Stimulatorni faktor dendritičnih celic |
US7150992B1 (en) | 1995-10-04 | 2006-12-19 | Innunex Corporation | Methods of preparing dendritic cells with flt3-ligand and antigen |
US7361330B2 (en) * | 1995-10-04 | 2008-04-22 | Immunex Corporation | Methods of using flt3-ligand in the treatment of fibrosarcoma |
US20030103988A1 (en) * | 1995-10-26 | 2003-06-05 | Leonard Chess | Regulation of activated t cells by recognition of t cell receptor beta chains and major histocompatibility complex class ib molecules |
US5849999A (en) * | 1996-10-16 | 1998-12-15 | The Mclean Hospital Corporation | Transgenic non-human mice expressing Flag-APP-C100 protein develop alzheimer's disease brain morphology and behavior |
US6660257B1 (en) | 1996-10-25 | 2003-12-09 | Pharmacia Corporation | Circular permuteins of flt3 ligand |
US6967092B1 (en) | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
WO1998057655A1 (en) * | 1997-06-17 | 1998-12-23 | Immunex Corporation | A method of enhancing antigen-specific peripheral immune tolerance |
AU1705599A (en) * | 1997-11-26 | 1999-06-15 | Allegheny University Of The Health Sciences | Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood |
EP1037927B1 (en) | 1997-12-08 | 2004-05-19 | Lexigen Pharmaceuticals Corp. | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
CA2316755C (en) * | 1998-01-23 | 2006-04-04 | Prolifaron, Inc. | Methods and compositions for the identification of growth factor mimetics, growth factors and inhibitors |
US6291661B1 (en) * | 1998-07-02 | 2001-09-18 | Immunex Corporation | flt3-L mutants and method of use |
US6376067B1 (en) * | 1998-12-21 | 2002-04-23 | Mitsubishi Polyester Film, Llc | Silicone coated film with back side slip control coating and method of controlling slip of such film |
US6649352B1 (en) * | 1999-01-29 | 2003-11-18 | Center For Molecular Medicine And Immunology | Method of evaluating myelosuppressive state |
US7112409B2 (en) * | 1999-01-29 | 2006-09-26 | Center For Molecular Medicine And Immunology | Method of determining cytokine dosage for myelosuppressive state |
DE60035871T2 (de) * | 1999-05-19 | 2008-06-05 | Merck Patent Gmbh | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
MXPA02001417A (es) | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
GB9924981D0 (en) * | 1999-10-21 | 1999-12-22 | Univ Manchester | Gene therapy |
CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
EP2298333A3 (en) | 1999-12-20 | 2012-05-02 | Immunex Corporation | Tweak receptor |
ES2269366T3 (es) | 2000-02-11 | 2007-04-01 | Merck Patent Gmbh | Mejoramiento de la vida media en circulacion de proteinas de fusion basadas en anticuerpos. |
US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
DE60129695T2 (de) | 2000-06-29 | 2008-06-05 | Merck Patent Gmbh | Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
US20030129162A1 (en) * | 2000-09-12 | 2003-07-10 | Lau Allan S. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
CA2422060A1 (en) * | 2000-09-12 | 2002-03-21 | Genetrol Biotherapeutics, Inc. | Compositions comprising mixtures of human cytokines and methods of producing the same |
US20020150541A1 (en) * | 2000-09-12 | 2002-10-17 | Gene Trol Biotherapeutics, Inc. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
CN100536919C (zh) | 2001-01-09 | 2009-09-09 | 贝勒研究院 | 干扰素拮抗剂和Flt3L拮抗剂的用途 |
CN1330664C (zh) | 2001-03-07 | 2007-08-08 | 默克专利有限公司 | 用于含杂合同种型抗体部分的蛋白质的表达技术 |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
WO2002087627A1 (en) * | 2001-04-27 | 2002-11-07 | Xcyte Therapies, Inc. | Maturation of antigen-presenting cells using activated t cells |
CN100503639C (zh) | 2001-05-03 | 2009-06-24 | 默克专利有限公司 | 重组肿瘤特异性抗体及其应用 |
US20030017529A1 (en) * | 2001-06-27 | 2003-01-23 | Applera Corporation | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
US7070996B2 (en) * | 2001-08-31 | 2006-07-04 | Rigel Pharmaceuticals, Inc. | Production of cultured human mast cells and basophils for high throughput small molecule drug discovery |
AU2002363322A1 (en) * | 2001-10-26 | 2003-05-19 | Large Scale Biology Corporation | Endothelial cell derived hemotopoietic growth factor |
MXPA04005266A (es) | 2001-12-04 | 2004-10-11 | Merck Patent Gmbh | Inmunocitocinas con selectividad modulada. |
EP1487477A4 (en) * | 2002-03-26 | 2006-07-19 | Immunex Corp | METHOD OF USE OF FLT3 LIGAND IN IMMUNIZATION PROTOCOLS |
EP1497444B1 (en) | 2002-03-27 | 2015-11-04 | Immunex Corporation | Methods for increasing polypeptide production |
US20050058622A1 (en) * | 2002-12-06 | 2005-03-17 | Lyman Stewart D. | Methods of using Flt3-Ligand in hematopoietic cell transplantation procedures incorporating nonmyeloablative conditioning regimens |
US7169904B2 (en) | 2002-12-17 | 2007-01-30 | Emd Lexigen Research Center Corp. | Immunocytokine sequences and uses thereof |
US20050232926A1 (en) * | 2003-06-06 | 2005-10-20 | Oncomax Acquisition Corp. | Antibodies specific for cancer associated antigen SM5-1 and uses thereof |
US20040254108A1 (en) * | 2003-06-13 | 2004-12-16 | Jing Ma | Preparation and application of anti-tumor bifunctional fusion proteins |
US20050232931A1 (en) * | 2003-06-13 | 2005-10-20 | Oncomax Acquisition Corp. | Preparation and application of anti-tumor bifunctional fusion proteins |
CA2528595A1 (en) * | 2003-06-13 | 2005-01-06 | Oncomax Acquisition Corp. | Preparation and application of anti-tumor bifunctional fusion proteins |
JP2007513083A (ja) * | 2003-11-10 | 2007-05-24 | アンジオテック インターナショナル アーゲー | 医療用移植片および繊維誘発剤 |
EP1697399B1 (en) | 2003-12-12 | 2016-11-23 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS | A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1 |
NZ547767A (en) * | 2003-12-24 | 2010-05-28 | Inst Medical W & E Hall | Therapeutic agents and uses therefor |
WO2005063820A2 (en) | 2003-12-30 | 2005-07-14 | Merck Patent Gmbh | Il-7 fusion proteins |
DK1699821T3 (da) | 2003-12-31 | 2012-07-16 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN-FUSIONSPROTEIN MED FORBEDREDE FARMAKOKINETIKKER |
WO2005070967A2 (en) * | 2004-01-22 | 2005-08-04 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
CN100404683C (zh) * | 2004-05-27 | 2008-07-23 | 中国医学科学院基础医学研究所 | 一种人fl多核苷酸及其与人gm-csf联合基因治疗恶性肿瘤的用途 |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
WO2006005360A1 (en) * | 2004-07-12 | 2006-01-19 | Sorin Group Italia S.R.L. | Devices and methods for growing human cells |
EP2338524B1 (en) * | 2004-08-12 | 2013-05-22 | Cedars-Sinai Medical Center | Combined gene therapy for the treatment of macroscopic gliomas |
US7589179B2 (en) * | 2004-12-09 | 2009-09-15 | Merck Patent Gmbh | IL-7 variants with reduced immunogenicity |
JP4964121B2 (ja) * | 2005-02-23 | 2012-06-27 | 財団法人先端医療振興財団 | 血管内皮前駆細胞の生体外増幅方法 |
US20090050204A1 (en) * | 2007-08-03 | 2009-02-26 | Illuminex Corporation. | Photovoltaic device using nanostructured material |
US20070048254A1 (en) * | 2005-08-24 | 2007-03-01 | Mirus Bio Corporation | Generation of dendritic cells |
US7482165B2 (en) * | 2005-08-24 | 2009-01-27 | Beckman Coulter, Inc. | Method of preventing white blood cell interferences to red blood cell measurements of a blood sample |
PT2270050E (pt) | 2005-12-30 | 2013-09-12 | Merck Patent Gmbh | Anticorpos anti-cd19 com imunogenicidade reduzida |
ES2384055T3 (es) | 2005-12-30 | 2012-06-28 | Merck Patent Gmbh | Variantes de la interleucina-12p40 con estabilidad mejorada |
ZA200807715B (en) * | 2006-03-09 | 2009-11-25 | Pharmacopeia Inc | 9-Heteroarylpurine MNK2 inhibitors for treating metabolic disorders |
WO2007109583A2 (en) | 2006-03-17 | 2007-09-27 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject |
US8883493B2 (en) * | 2007-01-30 | 2014-11-11 | Cedars-Sinai Medical Center | Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene |
AR071891A1 (es) | 2008-05-30 | 2010-07-21 | Imclone Llc | Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano) |
US8834409B2 (en) | 2008-07-29 | 2014-09-16 | Covidien Lp | Method for ablation volume determination and geometric reconstruction |
WO2010047928A2 (en) * | 2008-10-24 | 2010-04-29 | Mount Sinai School Of Medicine Of New York University | Methods and compositions for treatment of fibrosis |
DE102008061522A1 (de) | 2008-12-10 | 2010-06-17 | Biontech Ag | Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung |
CA2759013C (en) | 2009-04-17 | 2021-10-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy compositions against cancer and methods |
CA2759333A1 (en) | 2009-04-22 | 2010-10-28 | Merck Patent Gmbh | Antibody fusion proteins with modified fcrn binding sites |
CA2781522A1 (en) * | 2009-10-19 | 2011-04-28 | Tristem Trading (Cyprus) Limited | Treatment using reprogrammed mature adult cells |
DK2513311T4 (da) * | 2009-12-18 | 2021-06-14 | Bavarian Nordic As | Produktion af ifn-lambda ved hjælp af traditionelle dendritceller og anvendelser deraf |
CN103080300B (zh) | 2010-08-05 | 2015-11-25 | 安姆根有限公司 | 增加细胞培养物的产率和活力的二肽 |
WO2012065755A1 (en) | 2010-11-19 | 2012-05-24 | Bavarian Nordic A/S | Production of ifn-lambda by b cells |
US9133493B2 (en) | 2011-04-21 | 2015-09-15 | Amgen Inc. | Method for culturing mammalian cells to improve recombinant protein production |
PT2837680T (pt) | 2011-07-01 | 2020-04-17 | Amgen Inc | Cultura celular de mamífero |
AU2012301656A1 (en) | 2011-09-02 | 2014-01-16 | Amgen Inc. | Pharmaceutical product and method of analysing light exposure of a pharmaceutical product |
AR089231A1 (es) | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
JP6010112B2 (ja) * | 2012-03-28 | 2016-10-19 | 株式会社Quarrymen&Co. | 不死化幹細胞及びその産生物を有効成分とする医薬組成物並びに医薬製剤 |
WO2014109858A1 (en) | 2013-01-14 | 2014-07-17 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
PL2969099T5 (pl) | 2013-03-14 | 2022-06-13 | Amgen Inc. | Usuwanie wypłukanego ligandu do oczyszczania na zasadzie powinowactwa |
TWI832345B (zh) | 2013-03-14 | 2024-02-11 | 美商安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
US9481901B2 (en) | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
AU2014342232B2 (en) | 2013-10-31 | 2017-12-21 | Amgen Inc. | Use of monensin to regulate glycosylation of recombinant proteins |
SG11201605640UA (en) | 2014-01-13 | 2016-08-30 | Amgen Inc | Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins |
ES2709994T3 (es) | 2014-06-04 | 2019-04-22 | Amgen Inc | Métodos de recolección en cultivos de células de mamífero |
MX2017006463A (es) | 2014-11-19 | 2018-04-20 | Amgen Inc | Cuantificacion de porcion de glicano en glicoproteinas recombinantes. |
ES2784503T3 (es) | 2014-12-01 | 2020-09-28 | Amgen Inc | Procedimiento para manipular el nivel de contenido de glicano de una glicoproteína |
US11097014B2 (en) * | 2016-06-14 | 2021-08-24 | University Of Cincinnati | Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles |
JP7146732B2 (ja) | 2016-07-13 | 2022-10-04 | オハイオ ステート イノベーション ファウンデーション | 宿主抗原提示並びに宿主抗腫瘍及び抗病原体免疫を最適化するためのプラットフォーム及び方法 |
AU2018251898A1 (en) | 2017-04-13 | 2019-10-31 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
EP3737408A1 (en) | 2018-01-08 | 2020-11-18 | Novartis AG | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
WO2019147982A1 (en) | 2018-01-26 | 2019-08-01 | Celldex Therapeutics, Inc. | Methods of treating cancer with dendritic cell mobilizing agents |
CN111989117A (zh) * | 2018-02-14 | 2020-11-24 | 维埃拉生物股份有限公司 | 麦克唐纳猫肉瘤(fms)样酪氨酸激酶3受体配体(flt3l)的抗体及其用于治疗自身免疫性疾病和炎性疾病的用途 |
KR20210094534A (ko) | 2018-10-17 | 2021-07-29 | 센티 바이오사이언시스, 인코포레이티드 | 병용 암 면역 요법 |
US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
EP3946408A4 (en) * | 2019-03-28 | 2023-06-14 | Orionis Biosciences, Inc. | CHEMICAL PROTEINS AND CHEMICAL PROTEIN COMPLEXES AGAINST FMS-LIKE TYROSINE KINASE 3 (FLT3) |
CN114450013A (zh) * | 2019-04-12 | 2022-05-06 | 爱莫里大学 | 用于促进造血细胞的细胞毒性的组合物和方法 |
CR20210687A (es) | 2019-06-25 | 2022-03-03 | Gilead Sciences Inc | PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO |
EP4232070A1 (en) * | 2020-10-26 | 2023-08-30 | NeoImmuneTech, Inc. | Methods of inducing stem cell mobilization |
US20220389394A1 (en) | 2021-05-18 | 2022-12-08 | Gilead Sciences, Inc. | METHODS OF USING FLT3L-Fc FUSION PROTEINS |
WO2023129974A1 (en) | 2021-12-29 | 2023-07-06 | Bristol-Myers Squibb Company | Generation of landing pad cell lines |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4745099A (en) * | 1985-02-06 | 1988-05-17 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of malignant tumors |
US5013824A (en) * | 1985-11-19 | 1991-05-07 | Schering Corporation | Human interleukin-4 peptides and conjugates thereof |
US5057420A (en) * | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
JPH0611705B2 (ja) * | 1988-02-10 | 1994-02-16 | 新技術事業団 | 血小板減少症治療剤 |
US5437994A (en) * | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5763266A (en) * | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
US5635386A (en) * | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
US5326558A (en) * | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5270458A (en) * | 1991-04-02 | 1993-12-14 | The Trustees Of Princeton University | Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 |
US5367057A (en) * | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
US5409825A (en) * | 1991-04-09 | 1995-04-25 | Indiana University Foundation | Expansion of human hematopoietic progenitor cells in a liquid medium |
US5199942A (en) * | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
ES2180539T3 (es) * | 1991-10-23 | 2003-02-16 | Nexell Therapeutics Inc | Metodos para expandir selectivamente celulas madre. |
AU2882992A (en) * | 1991-11-06 | 1993-06-07 | Arthur A. Axelrad | Cell culture medium |
US5453357A (en) * | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
CZ307995A3 (en) * | 1993-05-24 | 1996-10-16 | Immunex Corp | Ligands for flt3 receptors |
US5554512A (en) * | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US5525708A (en) * | 1994-03-28 | 1996-06-11 | Cytomed, Inc. | Covalent dimer of kit ligand |
-
1994
- 1994-05-11 US US08/243,545 patent/US5554512A/en not_active Expired - Lifetime
- 1994-05-12 NZ NZ267541A patent/NZ267541A/en not_active IP Right Cessation
- 1994-05-12 JP JP50071595A patent/JP4028594B2/ja not_active Expired - Fee Related
- 1994-05-12 CA CA002162397A patent/CA2162397C/en not_active Expired - Fee Related
- 1994-05-12 HU HU9503341A patent/HUT74831A/hu unknown
- 1994-05-12 AU AU69877/94A patent/AU683472B2/en not_active Ceased
- 1994-05-12 UA UA95125567A patent/UA42726C2/uk unknown
- 1994-05-12 CN CN94192225A patent/CN1123574C/zh not_active Expired - Fee Related
- 1994-05-12 PL PL94311756A patent/PL311756A1/xx unknown
- 1994-05-12 KR KR1019950705236A patent/KR100319359B1/ko not_active IP Right Cessation
- 1994-05-12 WO PCT/US1994/005365 patent/WO1994028391A1/en not_active Application Discontinuation
- 1994-05-12 BR BR9407073A patent/BR9407073A/pt not_active Application Discontinuation
- 1994-05-24 MY MYPI94001321A patent/MY148148A/en unknown
-
1995
- 1995-11-21 OA OA60744A patent/OA10716A/en unknown
- 1995-11-23 FI FI955646A patent/FI955646A/fi not_active Application Discontinuation
- 1995-11-23 NO NO19954735A patent/NO322373B1/no unknown
-
1997
- 1997-12-18 US US08/993,962 patent/US5843423A/en not_active Expired - Lifetime
- 1997-12-19 US US08/994,468 patent/US6919206B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5554512A (en) | 1996-09-10 |
JP4028594B2 (ja) | 2007-12-26 |
NO954735D0 (no) | 1995-11-23 |
UA42726C2 (uk) | 2001-11-15 |
CA2162397A1 (en) | 1994-12-08 |
HU9503341D0 (en) | 1996-01-29 |
NO322373B1 (no) | 2006-09-25 |
MY148148A (en) | 2013-03-15 |
US20030148516A1 (en) | 2003-08-07 |
HUT74831A (en) | 1997-02-28 |
OA10716A (en) | 2002-12-09 |
KR100319359B1 (ko) | 2002-07-31 |
AU6987794A (en) | 1994-12-20 |
PL311756A1 (en) | 1996-03-18 |
NO954735L (no) | 1996-01-23 |
US6919206B2 (en) | 2005-07-19 |
CN1125479A (zh) | 1996-06-26 |
CA2162397C (en) | 2007-04-03 |
CN1123574C (zh) | 2003-10-08 |
JPH08511251A (ja) | 1996-11-26 |
WO1994028391A1 (en) | 1994-12-08 |
FI955646A (fi) | 1996-01-23 |
US5843423A (en) | 1998-12-01 |
AU683472B2 (en) | 1997-11-13 |
BR9407073A (pt) | 1996-08-27 |
NZ267541A (en) | 1997-06-24 |
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