FI951553A0 - 1H-indol-glyoxylamid-sPLA2-inhibitorer - Google Patents
1H-indol-glyoxylamid-sPLA2-inhibitorerInfo
- Publication number
- FI951553A0 FI951553A0 FI951553A FI951553A FI951553A0 FI 951553 A0 FI951553 A0 FI 951553A0 FI 951553 A FI951553 A FI 951553A FI 951553 A FI951553 A FI 951553A FI 951553 A0 FI951553 A0 FI 951553A0
- Authority
- FI
- Finland
- Prior art keywords
- indole
- spla2 inhibitors
- glyoxylamide spla2
- glyoxylamide
- sub
- Prior art date
Links
- SIYIBWRIGSGXKY-UHFFFAOYSA-N 2-(1h-indol-2-yl)-2-oxoacetamide Chemical compound C1=CC=C2NC(C(=O)C(=O)N)=CC2=C1 SIYIBWRIGSGXKY-UHFFFAOYSA-N 0.000 title 1
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 title 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- AWMLDBKLOPNOAR-UHFFFAOYSA-N 2-(1h-indol-3-yl)-2-oxoacetamide Chemical class C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22191694A | 1994-04-01 | 1994-04-01 | |
| US22191694 | 1994-04-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI951553A0 true FI951553A0 (sv) | 1995-03-31 |
| FI951553A FI951553A (sv) | 1995-10-02 |
| FI114793B FI114793B (sv) | 2004-12-31 |
Family
ID=22829963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI951553A FI114793B (sv) | 1994-04-01 | 1995-03-31 | 1H-indol-glyoxylamid-sPLA2-inhibitorer |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US5654326A (sv) |
| EP (5) | EP1950200B1 (sv) |
| JP (1) | JP3109974B2 (sv) |
| KR (1) | KR100368707B1 (sv) |
| CN (1) | CN1067054C (sv) |
| AT (2) | ATE220394T1 (sv) |
| AU (1) | AU688458B2 (sv) |
| BR (1) | BR9501404A (sv) |
| CA (1) | CA2146097C (sv) |
| CO (1) | CO4370099A1 (sv) |
| CZ (1) | CZ82295A3 (sv) |
| DE (1) | DE69527322T2 (sv) |
| DK (2) | DK1950200T3 (sv) |
| ES (2) | ES2377223T3 (sv) |
| FI (1) | FI114793B (sv) |
| HU (1) | HUT72048A (sv) |
| IL (1) | IL113210A (sv) |
| MX (1) | MX9501608A (sv) |
| MY (1) | MY112897A (sv) |
| NO (1) | NO304186B1 (sv) |
| NZ (1) | NZ270848A (sv) |
| PE (1) | PE18696A1 (sv) |
| PL (1) | PL180523B1 (sv) |
| PT (1) | PT675110E (sv) |
| RU (1) | RU2128169C1 (sv) |
| SI (1) | SI0675110T1 (sv) |
| TW (1) | TW383302B (sv) |
| UA (1) | UA47387C2 (sv) |
| ZA (1) | ZA952693B (sv) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL180523B1 (pl) * | 1994-04-01 | 2001-02-28 | Eli Lilly & Co | Nowy zwiazek, pochodna 1H-indolo-3-glioksylamidu i srodek farmaceutyczny PL PL PL PL PL PL PL PL PL PL |
| JPH08193074A (ja) * | 1994-11-18 | 1996-07-30 | Nippon Bayeragrochem Kk | 除草性１−シクロプロピルテトラゾリノン類 |
| CN1092639C (zh) * | 1995-01-06 | 2002-10-16 | 东丽株式会社 | 苯稠合杂环衍生物及其用途 |
| US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
| DE19636150A1 (de) | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
| US5919774A (en) * | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
| CA2279211A1 (en) * | 1997-02-20 | 1998-08-27 | Shionogi & Co., Ltd. | Indole dicarboxylic acid derivatives |
| US5972988A (en) * | 1997-03-26 | 1999-10-26 | Eli Lilly And Company | Method for treatment of chronic bronchitis using indole compounds |
| WO1998047507A1 (en) * | 1997-04-24 | 1998-10-29 | Shionogi & Co., Ltd. | Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds |
| TW455581B (en) * | 1997-06-26 | 2001-09-21 | Lilly Co Eli | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
| JP2001513555A (ja) * | 1997-08-28 | 2001-09-04 | イーライ・リリー・アンド・カンパニー | 非リウマチ様関節炎の処置方法 |
| CA2309135A1 (en) * | 1997-10-27 | 1999-05-06 | Michael Lyle Denney | N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors |
| DE69830335T2 (de) | 1997-10-27 | 2006-02-02 | Eli Lilly And Co., Indianapolis | MORPHOLINO-N-ETHYL ESTER PRODROGEN VON INDOL sPLA 2 HEMMER |
| WO1999021545A1 (en) * | 1997-10-27 | 1999-05-06 | Eli Lilly And Company | ISOPROPYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS |
| WO1999024033A1 (en) * | 1997-11-12 | 1999-05-20 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds |
| EP1039901A1 (en) * | 1997-11-14 | 2000-10-04 | Eli Lilly And Company | Treatment for alzheimer's disease |
| AU1407399A (en) * | 1997-11-14 | 1999-06-07 | Eli Lilly And Company | Treatment for alzheimer's disease |
| US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| EP1062205A2 (en) * | 1998-02-25 | 2000-12-27 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
| US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| EP1058547B1 (en) * | 1998-03-03 | 2005-11-23 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing the phospholipase inhibitor sodium 3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-phenylmethyl)-1h-indol-4-yl]oxy]acetate |
| EP1066290A1 (en) | 1998-03-31 | 2001-01-10 | Shionogi & Co., Ltd. | PYRROLO[1,2-a]PYRAZINE sPLA 2 INHIBITOR |
| DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| CZ302588B6 (cs) * | 1998-04-02 | 2011-07-27 | Ziopharm Oncology, Inc. | Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva |
| DZ2770A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
| JP2002512222A (ja) * | 1998-04-17 | 2002-04-23 | イーライ・リリー・アンド・カンパニー | ４−ヒドロキシインドール、インダゾール、及び、カルバゾール化合物の製造方法 |
| US6407261B1 (en) | 1998-04-17 | 2002-06-18 | Eli Lilly And Company | Process for preparing 4-hdyroxy indole, indazole and carbazole compounds |
| ID27153A (id) | 1998-05-01 | 2001-03-08 | Lilly Co Eli | Senyawa inhibitor spla2 untuk mengobati penyakit |
| IL139203A0 (en) * | 1998-05-01 | 2001-11-25 | Lilly Co Eli | Spla2 inhibitor ester |
| EP1085021A4 (en) | 1998-05-21 | 2003-01-08 | Shionogi & Co | DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2? |
| ATE326963T1 (de) * | 1998-08-03 | 2006-06-15 | Lilly Co Eli | Indolverbindungen als spla2 inhibitoren |
| WO2000007591A1 (en) * | 1998-08-03 | 2000-02-17 | Eli Lilly And Company | INDOLE sPLA2 INHIBITORS |
| WO2000010568A1 (en) | 1998-08-24 | 2000-03-02 | Draheim Susan E | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase a¿2? |
| US6576654B1 (en) | 1998-09-23 | 2003-06-10 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
| DZ2771A1 (fr) * | 1998-10-09 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
| DE69931963D1 (de) * | 1998-10-14 | 2006-07-27 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
| US20030149000A1 (en) * | 1998-11-10 | 2003-08-07 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds |
| EP1214041A2 (en) * | 1998-12-21 | 2002-06-19 | Eli Lilly And Company | Combination therapy for the treatment of sepsis |
| WO2000037472A2 (en) * | 1998-12-22 | 2000-06-29 | Eli Lilly And Company | Substituted pirroloindoles |
| AU2373600A (en) * | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Novel spla2 inhibitors |
| US6380397B1 (en) | 1999-04-15 | 2002-04-30 | Eli Lilly And Company | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
| US6274578B1 (en) | 1999-04-20 | 2001-08-14 | Eli Lilly And Company | sPLA2 inhibitor ester |
| US6140327A (en) * | 1999-05-12 | 2000-10-31 | Eli Lilly And Company | Morpholino-n-ethyl ester derivative of an indole sPLA2 inhibitor |
| US6703385B1 (en) | 1999-07-19 | 2004-03-09 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
| US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
| CA2379208A1 (en) * | 1999-07-19 | 2001-01-25 | Eli Lilly & Company | Spla2 inhibitors |
| US6673781B1 (en) | 1999-08-02 | 2004-01-06 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
| WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
| WO2001021587A2 (en) * | 1999-09-20 | 2001-03-29 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as spla2 inhibitors |
| US6831095B1 (en) | 1999-09-20 | 2004-12-14 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors |
| WO2001026653A1 (fr) * | 1999-10-15 | 2001-04-19 | Shionogi & Co., Ltd. | Inhibiteurs spla2 du type v et/ou du type x |
| WO2001036420A1 (fr) | 1999-11-15 | 2001-05-25 | Shionogi & Co., Ltd. | Derives d'aza-indolizine tricyclique ayant un effet inhibiteur sur spla¿2? |
| WO2001044185A1 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Carbon monoxide-based synthesis of spla2 inhibitors |
| WO2001044184A1 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Synthesis of indole-containing spla2 inhibitors |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| JP2003519198A (ja) * | 2000-01-06 | 2003-06-17 | イーライ・リリー・アンド・カンパニー | 炎症性疾患および呼吸器疾患の処置のための併用療法 |
| US20030096854A1 (en) * | 2002-06-12 | 2003-05-22 | Ho-Shen Lin | Substituted tricyclics |
| WO2001049662A2 (en) * | 2000-01-07 | 2001-07-12 | Eli Lilly And Company | Carbazole derivatives as inhibitors of spla2 |
| EP1265607A2 (en) * | 2000-03-09 | 2002-12-18 | Eli Lilly And Company | METHOD FOR THE TREATMENT OF RENAL DYSFUNCTION WITH sPLA 2 INHIBITORS |
| BR0002188A (pt) * | 2000-03-30 | 2001-11-13 | Brasil Compressores Sa | Processo de formação do pacote de lâminasmetálicas de estator de motor elétrico e pacotede lâminas metálicas |
| AU2001252922A1 (en) * | 2000-04-19 | 2001-11-07 | Eli Lilly And Company | Azide cyclization-based synthesis and intermediates for spla2 inhibitors |
| ES2294003T3 (es) * | 2000-06-29 | 2008-04-01 | Anthera Pharmaceuticals, Inc. | Remedios contra el cancer. |
| US20040102442A1 (en) * | 2000-06-29 | 2004-05-27 | Kohji Hanasaki | Remedies for alzheimer's disease |
| US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
| AU2001267823A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
| BR0112460A (pt) * | 2000-07-14 | 2003-07-22 | Lilly Co Eli | Método para tratamento de sépsis |
| WO2002012249A2 (en) * | 2000-08-04 | 2002-02-14 | Eli Lilly And Company | Substituted pyrrole compounds and their use as spla2 inhibitors |
| EP1358156B1 (en) * | 2000-12-18 | 2007-02-21 | Eli Lilly And Company | Benz(g) indoles and their use as spla2 inhibitors |
| TWI314457B (sv) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| US6730694B1 (en) | 2001-07-20 | 2004-05-04 | Eli Lilly And Company | sPLA2 inhibitors |
| TWI323658B (en) | 2001-12-06 | 2010-04-21 | Nat Health Research Institutes | Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
| JP2009515837A (ja) * | 2005-11-03 | 2009-04-16 | イリプサ， インコーポレイテッド | Ｃ４−酸性置換基を有するインドール化合物およびホスホリパーゼａ２インヒビターとしてのその使用 |
| EP1948602A2 (en) * | 2005-11-03 | 2008-07-30 | Ilypsa, Inc. | Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors |
| CA2627043A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors |
| JP2009514883A (ja) * | 2005-11-03 | 2009-04-09 | イリプサ， インコーポレイテッド | アザインドール化合物およびホスホリパーゼａ２インヒビターとしてのその使用 |
| US8048880B2 (en) * | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
| WO2009133831A1 (ja) * | 2008-04-28 | 2009-11-05 | 旭化成ファーマ株式会社 | フェニルプロピオン酸誘導体及びその用途 |
| JP2012514652A (ja) * | 2009-01-08 | 2012-06-28 | アンセラ・ファーマシューティカルズ・インコーポレイテッド | 心血管疾患および脂質異常症を治療するための分泌ホスホリパーゼａ２（ｓｐｌａ２）インヒビターとナイアシン薬との組成物および方法 |
| MY198422A (en) | 2009-04-29 | 2023-08-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| CN101838232B (zh) * | 2009-07-07 | 2012-02-22 | 爱斯医药科技(南京)有限公司 | Varespladib的制备方法 |
| MA40998A (fr) | 2014-11-21 | 2017-09-26 | Ophirex Inc | Thérapies contre une envenimation, ainsi que compositions, systèmes et kits pharmaceutiques associés |
| CN108463221A (zh) * | 2015-08-31 | 2018-08-28 | 迪亚库雷特公司 | 吲哚类化合物刺激免疫系统的用途 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2825734A (en) | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
| US2825743A (en) | 1955-08-30 | 1958-03-04 | Celanese Corp | Catalytic hydrogenation of unsaturated aldehydes and ketones |
| US3242163A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
| US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
| GB1089071A (en) | 1964-02-28 | 1967-11-01 | Merck & Co Inc | Indole derivatives |
| NL287416A (sv) | 1964-04-25 | |||
| US3449363A (en) | 1966-12-22 | 1969-06-10 | American Cyanamid Co | 3-substituted 4-trifluoromethyl indoles |
| IT1036004B (it) * | 1968-05-21 | 1979-10-30 | Abc Ist Biolog Chem Spa | Acidt 3 indolil adetoidrossamici |
| US3691194A (en) * | 1970-07-30 | 1972-09-12 | Little Inc A | 3-indole-glyoxamides |
| US3686213A (en) | 1970-08-28 | 1972-08-22 | American Cyanamid Co | Substituted aminoethyl indoles |
| US4012513A (en) * | 1971-11-03 | 1977-03-15 | Imperial Chemical Industries Limited | Indole derivatives for providing analgesic and anti-inflammatory effects |
| US4397850A (en) | 1981-10-07 | 1983-08-09 | Sandoz, Inc. | Isoxazolyl indolamines |
| US4552876A (en) * | 1984-07-09 | 1985-11-12 | Usv Pharmaceutical Corp. | Bisbenzoxazines and pharmaceutical use |
| US4792555A (en) * | 1987-03-20 | 1988-12-20 | American Home Products Corporation | Phospholipase A2 inhibitors |
| NZ234883A (en) * | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
| US5334719A (en) * | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| PL180523B1 (pl) | 1994-04-01 | 2001-02-28 | Eli Lilly & Co | Nowy zwiazek, pochodna 1H-indolo-3-glioksylamidu i srodek farmaceutyczny PL PL PL PL PL PL PL PL PL PL |
| US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| IL124613A0 (en) | 1995-12-14 | 1998-12-06 | Merck & Co Inc | Antagonists of gonadotropin releasing hormone |
| DE69620241T2 (de) * | 1995-12-14 | 2002-10-02 | MERCK & CO., INC. (A NEW JERSEY CORP.) | Gonadotropin releasing hormon- antagonisten |
| CA2309135A1 (en) * | 1997-10-27 | 1999-05-06 | Michael Lyle Denney | N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors |
-
1995
- 1995-03-31 PL PL95307951A patent/PL180523B1/pl not_active IP Right Cessation
- 1995-03-31 PE PE1995265383A patent/PE18696A1/es not_active Application Discontinuation
- 1995-03-31 AT AT95302166T patent/ATE220394T1/de active
- 1995-03-31 EP EP08001265A patent/EP1950200B1/en not_active Expired - Lifetime
- 1995-03-31 AT AT08001265T patent/ATE540923T1/de active
- 1995-03-31 EP EP00203897A patent/EP1081135A3/en not_active Withdrawn
- 1995-03-31 MX MX9501608A patent/MX9501608A/es unknown
- 1995-03-31 EP EP95302166A patent/EP0675110B1/en not_active Expired - Lifetime
- 1995-03-31 KR KR1019950007267A patent/KR100368707B1/ko not_active IP Right Cessation
- 1995-03-31 HU HU9500957A patent/HUT72048A/hu unknown
- 1995-03-31 ES ES08001265T patent/ES2377223T3/es not_active Expired - Lifetime
- 1995-03-31 NO NO951252A patent/NO304186B1/no not_active IP Right Cessation
- 1995-03-31 JP JP07076117A patent/JP3109974B2/ja not_active Expired - Fee Related
- 1995-03-31 SI SI9530616T patent/SI0675110T1/xx unknown
- 1995-03-31 AU AU16217/95A patent/AU688458B2/en not_active Ceased
- 1995-03-31 EP EP10180825A patent/EP2341045A1/en not_active Withdrawn
- 1995-03-31 CZ CZ95822A patent/CZ82295A3/cs unknown
- 1995-03-31 MY MYPI95000820A patent/MY112897A/en unknown
- 1995-03-31 DK DK08001265.1T patent/DK1950200T3/da active
- 1995-03-31 UA UA95038298A patent/UA47387C2/uk unknown
- 1995-03-31 CA CA002146097A patent/CA2146097C/en not_active Expired - Fee Related
- 1995-03-31 DK DK95302166T patent/DK0675110T3/da active
- 1995-03-31 TW TW084103168A patent/TW383302B/zh not_active IP Right Cessation
- 1995-03-31 ES ES95302166T patent/ES2179088T3/es not_active Expired - Lifetime
- 1995-03-31 PT PT95302166T patent/PT675110E/pt unknown
- 1995-03-31 DE DE69527322T patent/DE69527322T2/de not_active Expired - Lifetime
- 1995-03-31 BR BR9501404A patent/BR9501404A/pt not_active IP Right Cessation
- 1995-03-31 FI FI951553A patent/FI114793B/sv not_active IP Right Cessation
- 1995-03-31 NZ NZ270848A patent/NZ270848A/en unknown
- 1995-03-31 ZA ZA952693A patent/ZA952693B/xx unknown
- 1995-03-31 CN CN95103320A patent/CN1067054C/zh not_active Expired - Fee Related
- 1995-03-31 RU RU95104885/04A patent/RU2128169C1/ru not_active IP Right Cessation
- 1995-03-31 CO CO95013251A patent/CO4370099A1/es unknown
- 1995-03-31 EP EP01130290A patent/EP1197484A2/en not_active Withdrawn
- 1995-03-31 IL IL11321095A patent/IL113210A/en not_active IP Right Cessation
- 1995-06-06 US US08/469,954 patent/US5654326A/en not_active Expired - Lifetime
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1997
- 1997-03-28 US US08/825,453 patent/US5733923A/en not_active Expired - Lifetime
- 1997-05-14 US US08/856,271 patent/US5919810A/en not_active Expired - Lifetime
- 1997-12-16 US US08/991,149 patent/US5919943A/en not_active Expired - Lifetime
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1999
- 1999-02-26 US US09/258,680 patent/US6175021B1/en not_active Expired - Fee Related
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2000
- 2000-11-16 US US09/714,364 patent/US6433001B1/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| MM | Patent lapsed |