FI94837B - Vattenlösliga monoestrar som används som bärare för farmaceutiskt aktiva föreningar och som ämne som ökar farmaceutiskt hjälpmedels löslighet - Google Patents
Vattenlösliga monoestrar som används som bärare för farmaceutiskt aktiva föreningar och som ämne som ökar farmaceutiskt hjälpmedels löslighet Download PDFInfo
- Publication number
- FI94837B FI94837B FI884192A FI884192A FI94837B FI 94837 B FI94837 B FI 94837B FI 884192 A FI884192 A FI 884192A FI 884192 A FI884192 A FI 884192A FI 94837 B FI94837 B FI 94837B
- Authority
- FI
- Finland
- Prior art keywords
- water
- monoester
- solution
- solid solution
- solutions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. En vattenlöslig monoester av en mättad eller omättad C6 - C18 fettsyra ooh en sackarid avsedd 5 att användas som bärare för en farmaceutiskt aktiv polypeptid, kännetecknad därav, att den fungerar a) som ett ämne som väsentligen ökar en i vatten olös-lig förenings löslighet, och/eller 10 b) som en bildare av en kontinuerlig fas för en före-ning.
2. En monoester enligt patentkrav 1, kännetecknad därav, att monoestern (b) är avsedd att bilda en fast lösning.
3. En monoester enligt patentkrav 2, kän netecknad därav, att den fasta lösningen är avsedd att lösas i ett vattenhaltigt medium eller i ett med vatten blandbart lösningsmedel för bildande av en flytande lösning.
4. En monoester enligt nägot av patentkraven 1 -3, kännetecknad därav, att den kan användas tillsammans med ett valfritt väsentligen i vatten olösligt hjälpmedel.
5. En monoester enligt nägot av patentkraven 1 25 -4, kännetecknad därav, att monoestern utgörs av sackarosmonolaurat eller raffinosmonolaurat.
6. En monoester enligt patentkrav 2, k ä n -netecknat därav, att den kontinuerliga fasen i den fasta lösningen utgörs av sackarosmonolaurat eller 50 raffinosmonolaurat.
7. Förfarande för framställning av en fast • eller flytande lösning kännetecknat därav, att a) ett farmaceutiskt aktivt ämne samt en vattenlöslig 35 monoester av en mättad eller omättad Cg - C18 fettsyra och en sackarid löses i ett förängningsbart lösningsmedel och lösningsmedlet avdunstas, eller il i mu ui i äi i 94837 b) den nämnda monoestern bringas i vätskeform genom smältning, det farmaceutiskt aktiva ämnet loses i den erhallna smältan och den erhallna lösningen görs fast genom kylning; 5 och den sä erhallna fasta lösningen tas tillvara, vil-ken fasta lösning om sä önskas kan lösas i ett vatten-haltig medium eller i ett med vatten blandbart lös-ningsmedel för bildande av en flytande lösning .
8. Förfarande enligt patentkrav 7, k ä n - 10 netecknat därav, att den erhallna fasta lösningen bringas i en för farmaceutisk dosering lämplig ämnessammansättnig. » • · * *
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3730909 | 1987-09-15 | ||
| DE3730909 | 1987-09-15 | ||
| DE3802355 | 1988-01-27 | ||
| DE3802355 | 1988-01-27 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI884192A0 FI884192A0 (sv) | 1988-09-13 |
| FI884192A FI884192A (sv) | 1989-03-16 |
| FI94837B true FI94837B (sv) | 1995-07-31 |
| FI94837C FI94837C (sv) | 1995-11-10 |
Family
ID=25859774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI884192A FI94837C (sv) | 1987-09-15 | 1988-09-13 | Vattenlösliga monoestrar som används som bärare för farmaceutiskt aktiva föreningar och som ämne som ökar farmaceutiskt hjälpmedels löslighet |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JP3090666B2 (sv) |
| KR (1) | KR0131084B1 (sv) |
| AT (1) | AT395819B (sv) |
| AU (1) | AU628787B2 (sv) |
| BE (1) | BE1001204A5 (sv) |
| CA (1) | CA1338775C (sv) |
| CH (1) | CH683672A5 (sv) |
| DK (1) | DK175132B1 (sv) |
| ES (1) | ES2012118A6 (sv) |
| FI (1) | FI94837C (sv) |
| FR (1) | FR2620336B1 (sv) |
| GB (1) | GB2209671B (sv) |
| GR (1) | GR1002243B (sv) |
| HU (1) | HU205010B (sv) |
| IE (1) | IE61195B1 (sv) |
| IL (1) | IL87746A (sv) |
| IT (1) | IT1224886B (sv) |
| LU (1) | LU87335A1 (sv) |
| MY (1) | MY103769A (sv) |
| NL (1) | NL195094C (sv) |
| NO (1) | NO179434C (sv) |
| NZ (1) | NZ226163A (sv) |
| PT (1) | PT88492B (sv) |
| SE (1) | SE503279C2 (sv) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| GR1000466B (el) * | 1989-01-28 | 1992-07-30 | Sandoz Ag | Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης. |
| BE1003009A5 (fr) * | 1989-02-09 | 1991-10-22 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base de cyclosporines. |
| GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| ATE147619T1 (de) | 1992-05-13 | 1997-02-15 | Sandoz Ag | Opthalmische zusammensetzungen enthaltend ein cyclosporin |
| ES2168271T3 (es) | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
| SI1033128T2 (sl) * | 1993-09-28 | 2012-02-29 | Scherer Gmbh R P | Izdelava mehke Ĺľelatinaste kapsule |
| ATE218359T1 (de) | 1994-11-03 | 2002-06-15 | Novartis Erfind Verwalt Gmbh | Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung |
| US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19549852B4 (de) | 1995-11-29 | 2009-06-04 | Novartis Ag | Cyclosporin enthaltende Präparate |
| TW414696B (en) * | 1996-07-01 | 2000-12-11 | Mitsubishi Kagaku Foods Kk | Anti-bacteria agent |
| TR199901686T2 (xx) | 1997-01-30 | 1999-09-21 | Norvartis Ag | Esasen ya�s�z farmakolojik kompozisyonlar� i�eren sert jelatin kaps�ller. |
| GB2326337A (en) * | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| EP1558215A4 (en) * | 2003-10-14 | 2007-09-12 | Wockhardt Ltd | STERILE GELIFYING AGENTS |
| JP5422871B2 (ja) * | 2006-10-24 | 2014-02-19 | 不二製油株式会社 | イソフラボン類組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE624258A (sv) * | 1961-10-31 | |||
| GB1134878A (en) * | 1966-05-12 | 1968-11-27 | Suga Kazuo | Improvements in and relating to oryzanol solutions and compositions |
| FR5986M (sv) * | 1966-11-22 | 1968-06-21 | ||
| BE787842A (fr) * | 1971-08-25 | 1972-12-18 | Sumito Chemical Cy Ltd | Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol |
| JPS53107408A (en) * | 1977-02-28 | 1978-09-19 | Yamanouchi Pharmaceut Co Ltd | Micellar preparation for rectal infusion |
| FI65914C (fi) * | 1978-03-07 | 1984-08-10 | Sandoz Ag | Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a |
| JPS57128634A (en) * | 1981-02-03 | 1982-08-10 | Eisai Co Ltd | Elastase-containing compound increasing absorption |
| EP0179583A1 (en) * | 1984-10-04 | 1986-04-30 | Merck & Co. Inc. | A system for enhancing the water dissolution rate and solubility of poorly soluble drugs |
| JPS61280435A (ja) * | 1985-04-04 | 1986-12-11 | Kanji Takada | サイクロスポリン類のリンパ指向性製剤 |
-
1988
- 1988-09-01 HU HU884518A patent/HU205010B/hu unknown
- 1988-09-12 CH CH3398/88A patent/CH683672A5/de not_active IP Right Cessation
- 1988-09-12 LU LU87335A patent/LU87335A1/xx unknown
- 1988-09-12 FR FR888811953A patent/FR2620336B1/fr not_active Expired - Lifetime
- 1988-09-12 BE BE8801044A patent/BE1001204A5/fr not_active IP Right Cessation
- 1988-09-13 AU AU22172/88A patent/AU628787B2/en not_active Expired
- 1988-09-13 NZ NZ226163A patent/NZ226163A/xx unknown
- 1988-09-13 PT PT88492A patent/PT88492B/pt not_active IP Right Cessation
- 1988-09-13 GB GB8821443A patent/GB2209671B/en not_active Expired - Lifetime
- 1988-09-13 SE SE8803221A patent/SE503279C2/sv not_active IP Right Cessation
- 1988-09-13 IE IE277288A patent/IE61195B1/en not_active IP Right Cessation
- 1988-09-13 FI FI884192A patent/FI94837C/sv not_active IP Right Cessation
- 1988-09-13 NO NO884052A patent/NO179434C/no not_active IP Right Cessation
- 1988-09-13 CA CA000577214A patent/CA1338775C/en not_active Expired - Lifetime
- 1988-09-14 MY MYPI88001027A patent/MY103769A/en unknown
- 1988-09-14 JP JP63231396A patent/JP3090666B2/ja not_active Expired - Lifetime
- 1988-09-14 GR GR880100602A patent/GR1002243B/el not_active IP Right Cessation
- 1988-09-14 IT IT8848349A patent/IT1224886B/it active
- 1988-09-14 KR KR1019880011874A patent/KR0131084B1/ko not_active IP Right Cessation
- 1988-09-14 AT AT0224988A patent/AT395819B/de not_active IP Right Cessation
- 1988-09-14 IL IL87746A patent/IL87746A/xx active Protection Beyond IP Right Term
- 1988-09-14 DK DK198805111A patent/DK175132B1/da not_active IP Right Cessation
- 1988-09-15 NL NL8802275A patent/NL195094C/nl not_active IP Right Cessation
- 1988-09-15 ES ES8802831A patent/ES2012118A6/es not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI94837B (sv) | Vattenlösliga monoestrar som används som bärare för farmaceutiskt aktiva föreningar och som ämne som ökar farmaceutiskt hjälpmedels löslighet | |
| US5756450A (en) | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms | |
| DE69635720T2 (de) | Pharmazeutische Zusammensetzungen von Cyclosporine mit einer Polyethoxylierten hydroxy-fettsäure | |
| JP4073503B2 (ja) | サイクロスポリンを含有する液体製剤とその調製方法 | |
| US5543393A (en) | Cyclosporin containing powder composition | |
| JP4073641B2 (ja) | 新規シクロスポリン製剤 | |
| FI89065C (sv) | Förfarande för framställning av en ny siklosporin kristallform | |
| KR980008239A (ko) | 사이클로스포린-함유 약학적 조성물 | |
| KR100471680B1 (ko) | 사이클로스포린제제 | |
| BG62955B1 (bg) | Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим | |
| EP0982035B1 (en) | Cyclosporin composition comprising an hydrophilic carrier | |
| EP1151755B1 (en) | Pharmaceutical compositions comprising cyclosporin as active ingredient | |
| KR100308779B1 (ko) | 사이클로스포린을함유한신규조성물 | |
| WO2010141068A1 (en) | Opthalmic compositions of cyclosporin | |
| DE3830494B4 (de) | Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe | |
| AU3043400A (en) | Cyclosporin solution | |
| KR0173349B1 (ko) | 사이클로스포린-함유 고체 분산체 조성물 | |
| SK123299A3 (en) | Pharmaceutical compositions containing cyclosporin | |
| KR20220124891A (ko) | 나파모스타트 또는 이의 염을 포함하는 에멀젼을 포함하는 약제학적 제제 및 이의 제조 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| PC | Transfer of assignment of patent |
Owner name: NOVARTIS AG |
|
| FG | Patent granted |
Owner name: NOVARTIS AG |
|
| MA | Patent expired |