FI94836B - Förfarande för framställning av en antigen peptid eller ett antigent protein som härrör sig till den med melanom associerade antigenen p97 och härvid användbara rekombinantvirus, rekombinantvektorer och värdcell - Google Patents
Förfarande för framställning av en antigen peptid eller ett antigent protein som härrör sig till den med melanom associerade antigenen p97 och härvid användbara rekombinantvirus, rekombinantvektorer och värdcell Download PDFInfo
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- FI94836B FI94836B FI870501A FI870501A FI94836B FI 94836 B FI94836 B FI 94836B FI 870501 A FI870501 A FI 870501A FI 870501 A FI870501 A FI 870501A FI 94836 B FI94836 B FI 94836B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Claims (21)
1. Förfarande för framställning av en antigen pep-tid eller ett antigent protein som härrör sig tili den med 5 melanoma associerade antigenen p97 och som har den i figur 3 angivna av aminosyrorna 20-738 bildade aminosyrasekven-sen, kännetecknat därav, att en bakterie-eller djurcell odlas, vilken innehäller en nukleotidsek-vens som kodar för den antigena peptiden eller proteinet 10 under kontroll av en annan nukleotidsekvens som reglerar genexpression sä, att den odlade bakterie- eller djurcel-len uttrycker nämnda peptid eller protein, och den antigena peptiden eller det antigena proteinet tas tillvara frän odlingen. 15
2. Förfarande enligt patentkrav 1, känne tecknat därav, att den odlade cellen är en bakterie.
3. Förfarande enligt patentkrav 2, kännetecknat därav, att bakterien är E. coli, som depo- 20 nerats vid depositionsinstitutionen ATCC med depositions-nummer 53403.
4. Förfarande enligt patentkrav 1, kännetecknat därav, att den odlade cellen är en djur-cellinje. ‘ 25
5. Förfarande enligt patentkrav 4, känne tecknat därav, att djurcellinjen är mus-cellinjen TKMp97-12, som deponerats vid depositionsinstitutionen ATCC med depositionsnumret CRL 8985.
6. Förfarande för framställning av ett rekombinant-30 virus som styr expressionen av en antigen peptid eller ett antigent protein som härrör sig tili den med melanoma associerade antigenen p97 i en med rekombinantviruset infek-terad bakterie- eller djurcell, kännetecknat därav, att 7i 94836 (a) en bakterie- eller djurcell infekteras med ett rekom-binantvirus, vars genoro innehäller en nukleotidsekvens vilken kodar för den antigena peptiden eller proteinet som härrör sig till den med melanoma associerade antigenen p97 5 och har den i figur 3 angivna nukleotidsekvensen, och vilken stär under kontroll av en annan nukleotidsekvens som reglerar genexpression, och (b) rekombinantvirus produceras genom att den infekterade cellen bringas till expression. 10
7. Förfarande enligt patentkrav 6, känne- t e c k n a t därav, att viruset är ett höljevirus.
8. Förfarande enligt patentkrav 7, känne- t e c k n a t därav, att viruset är ett vaccinia-virus.
9. Förfarande enligt patentkrav 6, känne- 15 tecknat därav, att viruset är ett naket virus.
10. Förfarande enligt patentkrav 9, känne-tecknat därav, att viruset är ett adenovirus.
11. Förfarande enligt patentkrav 6, känne-tecknat därav, att viruset är ett baculovirus. 20
12. Förfarande enligt patentkrav 11, känne- tecknat därav, att viruset är ett nuclear polyhed-rosis-virus.
13. Förfarande enligt patentkrav 6, känne-tecknat därav, att viruset är en bakteriofag. 25
14. Förfarande enligt patentkrav 13, känne- tecknat därav, att bakteriofagen är en lambda-fag.
15. Rekombinant-DNA-vektor, känneteck-n a d därav, att den innehäller p97b, vilken har den i figur 2 angivna strukturen.
16. Escherichia coli, vilken deponerats vid deposi- tionsinstitutionen ATCC med depositionsnummer 53403.
17. Rekombinant-DNA-vektor, känneteck-n a d därav, att den innehäller pMT97b, vilken har inkor-porerats i den deponerade cellinjen CRL 8985. 72 94836
18. Cellinjen TKMp97-12, vilken deponerats vid de-positionsinstitutionen ATCC med depositionsnummer CRL 8985.
19. Rekombinant-DNA-vektor, känneteck- 5. a d därav, att den innehäller pSVp97a, vilken har den i figur 6 angivna strukturen.
20. Cellinjen B16SVp97a.14, vilken deponerats vid depositionsinstitutionen ATCC med depositionsnummer CRL 9304.
21. Virus Vp97a-NY, vilken deponerats vid deposi tionsinstitutionen ATCC med depositionsnummer VR 2159.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82731386A | 1986-02-07 | 1986-02-07 | |
| US82731386 | 1986-02-07 | ||
| US723087 | 1987-01-27 | ||
| US07/007,230 US5262177A (en) | 1986-02-07 | 1987-01-27 | Recombinant viruses encoding the human melanoma-associated antigen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI870501A0 FI870501A0 (sv) | 1987-02-06 |
| FI870501A FI870501A (sv) | 1987-08-08 |
| FI94836B true FI94836B (sv) | 1995-07-31 |
| FI94836C FI94836C (sv) | 1995-11-10 |
Family
ID=26676698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI870501A FI94836C (sv) | 1986-02-07 | 1987-02-06 | Förfarande för framställning av en antigen peptid eller ett antigent protein som härrör sig till den med melanom associerade antigenen p97 och härvid användbara rekombinantvirus, rekombinantvektorer och värdcell |
Country Status (18)
| Country | Link |
|---|---|
| JP (3) | JP2664673B2 (sv) |
| BE (1) | BE1000175A3 (sv) |
| CH (1) | CH675424A5 (sv) |
| DE (1) | DE3703702C2 (sv) |
| DK (1) | DK63287A (sv) |
| ES (2) | ES2012815A6 (sv) |
| FI (1) | FI94836C (sv) |
| GR (1) | GR870195B (sv) |
| HU (1) | HU209144B (sv) |
| IE (1) | IE59597B1 (sv) |
| IT (1) | IT1222359B (sv) |
| MX (1) | MX9203574A (sv) |
| NL (1) | NL8700285A (sv) |
| NO (1) | NO178931C (sv) |
| NZ (1) | NZ219192A (sv) |
| OA (1) | OA08478A (sv) |
| PT (1) | PT84255B (sv) |
| SE (2) | SE506024C2 (sv) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19821925A1 (de) * | 1998-05-15 | 1999-11-18 | Roehnisch Tim | Verfahren zur Herstellung einer Zusammensetzung zur Induktion einer tumorspezifischen Immunantwort, sowie Verwendung der Zusammensetzung zur Behandlung von Neoplasien |
| JP4414023B2 (ja) * | 1999-08-05 | 2010-02-10 | オリエンタル酵母工業株式会社 | 関節炎関連メラノトランスフェリンの測定方法および試薬 |
| JP4708027B2 (ja) * | 2002-10-01 | 2011-06-22 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 抗癌組成物および抗感染疾患組成物ならびにこれらを使用する方法 |
| US8207314B2 (en) * | 2003-05-16 | 2012-06-26 | Sanofi Pasteur Limited | Tumor antigens for prevention and/or treatment of cancer |
-
1987
- 1987-02-05 NZ NZ219192A patent/NZ219192A/xx unknown
- 1987-02-06 HU HU87472A patent/HU209144B/hu not_active IP Right Cessation
- 1987-02-06 DE DE3703702A patent/DE3703702C2/de not_active Expired - Fee Related
- 1987-02-06 IE IE31987A patent/IE59597B1/en not_active IP Right Cessation
- 1987-02-06 GR GR870195A patent/GR870195B/el unknown
- 1987-02-06 JP JP62026191A patent/JP2664673B2/ja not_active Expired - Lifetime
- 1987-02-06 DK DK063287A patent/DK63287A/da not_active Application Discontinuation
- 1987-02-06 OA OA59065A patent/OA08478A/xx unknown
- 1987-02-06 SE SE8700466A patent/SE506024C2/sv not_active IP Right Cessation
- 1987-02-06 NO NO870475A patent/NO178931C/no unknown
- 1987-02-06 IT IT19291/87A patent/IT1222359B/it active
- 1987-02-06 NL NL8700285A patent/NL8700285A/nl not_active Application Discontinuation
- 1987-02-06 ES ES8700288A patent/ES2012815A6/es not_active Expired - Fee Related
- 1987-02-06 PT PT84255A patent/PT84255B/pt not_active IP Right Cessation
- 1987-02-06 FI FI870501A patent/FI94836C/sv not_active IP Right Cessation
- 1987-02-06 BE BE8700094A patent/BE1000175A3/fr not_active IP Right Cessation
- 1987-02-09 CH CH471/87A patent/CH675424A5/de not_active IP Right Cessation
-
1989
- 1989-06-15 ES ES8902106A patent/ES2017258A6/es not_active Expired - Fee Related
-
1992
- 1992-06-26 MX MX9203574A patent/MX9203574A/es not_active Application Discontinuation
- 1992-10-07 SE SE9202934A patent/SE9202934D0/sv unknown
-
1996
- 1996-03-12 JP JP8054929A patent/JPH08280390A/ja active Pending
- 1996-03-12 JP JP8054928A patent/JPH09135692A/ja active Pending
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|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: ONCOGEN |