FI932249A - Dubbelverkande inhibitorer - Google Patents
Dubbelverkande inhibitorer Download PDFInfo
- Publication number
- FI932249A FI932249A FI932249A FI932249A FI932249A FI 932249 A FI932249 A FI 932249A FI 932249 A FI932249 A FI 932249A FI 932249 A FI932249 A FI 932249A FI 932249 A FI932249 A FI 932249A
- Authority
- FI
- Finland
- Prior art keywords
- compounds
- disclosed
- double inhibitor
- inhibotory
- nep
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88466492A | 1992-05-18 | 1992-05-18 | |
US88466492 | 1992-05-18 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI932249A0 FI932249A0 (fi) | 1993-05-18 |
FI932249A true FI932249A (fi) | 1993-11-19 |
FI103337B1 FI103337B1 (fi) | 1999-06-15 |
FI103337B FI103337B (fi) | 1999-06-15 |
Family
ID=25385092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI932249A FI103337B (fi) | 1992-05-18 | 1993-05-18 | Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-okso-1H-a tsepiinien valmistamiseksi |
Country Status (28)
Country | Link |
---|---|
EP (2) | EP0783002A3 (fi) |
JP (1) | JP3487611B2 (fi) |
KR (2) | KR100288722B1 (fi) |
CN (1) | CN1039008C (fi) |
AT (1) | ATE162800T1 (fi) |
AU (2) | AU659550B2 (fi) |
BR (1) | BR1101081A (fi) |
CA (1) | CA2096460C (fi) |
CY (1) | CY2093B1 (fi) |
CZ (1) | CZ289824B6 (fi) |
DE (1) | DE69316717T2 (fi) |
DK (1) | DK0599444T3 (fi) |
ES (1) | ES2111712T3 (fi) |
FI (1) | FI103337B (fi) |
GR (1) | GR3026665T3 (fi) |
HK (1) | HK1003597A1 (fi) |
HU (1) | HU217078B (fi) |
IL (1) | IL105729A (fi) |
MX (1) | MX9302876A (fi) |
MY (1) | MY111370A (fi) |
NO (1) | NO304372B1 (fi) |
NZ (1) | NZ247642A (fi) |
PL (1) | PL173036B1 (fi) |
RU (1) | RU2124503C1 (fi) |
SG (1) | SG54138A1 (fi) |
SK (1) | SK283556B6 (fi) |
TW (1) | TW290544B (fi) |
ZA (1) | ZA933461B (fi) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
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US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
CA2078758C (en) * | 1991-09-27 | 2003-12-09 | Alan M. Warshawsky | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
CA2078759C (en) * | 1991-09-27 | 2003-09-16 | Alan M. Warshawsky | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace |
US5674863A (en) * | 1991-10-18 | 1997-10-07 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
KR100276029B1 (ko) * | 1992-02-14 | 2000-12-15 | 슈테펜엘.네스비트 | 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법 |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
GB9310075D0 (en) * | 1993-05-17 | 1993-06-30 | Fujisawa Pharmaceutical Co | New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
WO1994028901A1 (fr) * | 1993-06-11 | 1994-12-22 | Eisai Co., Ltd. | Derive aminoacide |
ES2076096B1 (es) * | 1993-07-14 | 1996-03-16 | Squibb & Sons Inc | Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos. |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
PT750631E (pt) * | 1994-02-14 | 2000-07-31 | Merrell Pharma Inc | Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace |
US5750521A (en) * | 1994-02-14 | 1998-05-12 | Hoechst Marion Roussel Inc. | Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
WO1995021857A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
DK0745081T3 (da) * | 1994-02-14 | 2002-05-21 | Merrell Pharma Inc | Indan-2-mercaptoacetylamiddisulfidderivater, der er anvendelige som enkephalinase-inhibitorer |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
ES2141923T3 (es) * | 1994-03-24 | 2000-04-01 | Merrell Pharma Inc | Uso hipocolesterolemico, antiaterosclerotico e hipotrigliceridemico de derivados aminoacetilmercapto. |
PT751774E (pt) * | 1994-03-24 | 2003-11-28 | Merrell Pharma Inc | Derivados de dissulfureto de mercaptoacetilamida hipocolesterolemicos |
KR100284247B1 (ko) * | 1994-07-18 | 2001-10-24 | 다니구치 미즈오 | 치환티아졸로(3,2,-a)아제핀유도체 |
US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
DE69515517T2 (de) * | 1994-12-21 | 2000-07-06 | Hoechst Marion Roussel Inc | Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon |
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US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
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US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
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US6777550B1 (en) | 1996-04-12 | 2004-08-17 | Bristol-Myers Squibb Company | N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors |
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US6117896A (en) * | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
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JP4588877B2 (ja) | 1998-06-17 | 2010-12-01 | ブリストル−マイヤーズ スクイブ カンパニー | Adp−受容体抗血小板物質と抗高血圧薬の組合せ投与による脳梗塞の予防 |
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US6770640B1 (en) | 1998-12-31 | 2004-08-03 | Aventis Pharmaceuticals Inc. | 1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12 |
WO2001055074A1 (fr) | 2000-01-25 | 2001-08-02 | Kaneka Corporation | Processus de production d'acide carboxylique optiquement actif substitue en position 2 |
US6509330B2 (en) | 2000-02-17 | 2003-01-21 | Bristol-Myers Squibb Company | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors |
DE10020818A1 (de) * | 2000-04-28 | 2001-10-31 | Degussa | 2,6-Diamino-6-methyl-heptansäure und Derivate, Verfahren zu deren Herstellung und deren Verwendung |
ATE309977T1 (de) | 2000-09-29 | 2005-12-15 | Bristol Myers Squibb Co | Dynamische trennung von isomeren und getrennte isomere |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
WO2002094787A1 (en) | 2001-05-23 | 2002-11-28 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
US6984645B2 (en) | 2001-11-16 | 2006-01-10 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
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WO2015027021A1 (en) | 2013-08-22 | 2015-02-26 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
DK3177627T3 (da) | 2014-08-07 | 2019-10-21 | Intra Cellular Therapies Inc | Imidazo[1,2-a]-pyrazolo[4,3-e]-pyrimidin-4-on-derivater med pde1-hæmmende aktivitet |
US10961258B2 (en) | 2015-12-21 | 2021-03-30 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
JP2019510039A (ja) | 2016-03-28 | 2019-04-11 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規組成物および方法 |
CN106674228B (zh) * | 2016-12-09 | 2018-12-04 | 河南农业大学 | 多元杂环化合物及其制备方法和用途 |
WO2019152697A1 (en) | 2018-01-31 | 2019-08-08 | Intra-Cellular Therapies, Inc. | Novel uses |
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-
1993
- 1993-05-17 RU RU93036185/04A patent/RU2124503C1/ru not_active IP Right Cessation
- 1993-05-18 CZ CZ1993936A patent/CZ289824B6/cs not_active IP Right Cessation
- 1993-05-18 EP EP97200315A patent/EP0783002A3/en not_active Withdrawn
- 1993-05-18 ES ES93303835T patent/ES2111712T3/es not_active Expired - Lifetime
- 1993-05-18 JP JP11587493A patent/JP3487611B2/ja not_active Expired - Fee Related
- 1993-05-18 DE DE69316717T patent/DE69316717T2/de not_active Expired - Fee Related
- 1993-05-18 CN CN93107593A patent/CN1039008C/zh not_active Expired - Fee Related
- 1993-05-18 SG SG1996001951A patent/SG54138A1/en unknown
- 1993-05-18 AU AU38627/93A patent/AU659550B2/en not_active Ceased
- 1993-05-18 DK DK93303835T patent/DK0599444T3/da active
- 1993-05-18 HU HU9301448A patent/HU217078B/hu not_active IP Right Cessation
- 1993-05-18 MX MX9302876A patent/MX9302876A/es not_active IP Right Cessation
- 1993-05-18 AT AT93303835T patent/ATE162800T1/de not_active IP Right Cessation
- 1993-05-18 IL IL105729A patent/IL105729A/en not_active IP Right Cessation
- 1993-05-18 PL PL93298988A patent/PL173036B1/pl not_active IP Right Cessation
- 1993-05-18 FI FI932249A patent/FI103337B/fi active
- 1993-05-18 EP EP93303835A patent/EP0599444B1/en not_active Expired - Lifetime
- 1993-05-18 SK SK499-93A patent/SK283556B6/sk unknown
- 1993-05-18 MY MYPI93000910A patent/MY111370A/en unknown
- 1993-05-18 KR KR1019930008448A patent/KR100288722B1/ko not_active IP Right Cessation
- 1993-05-18 NZ NZ247642A patent/NZ247642A/xx unknown
- 1993-05-18 CA CA002096460A patent/CA2096460C/en not_active Expired - Fee Related
- 1993-05-18 ZA ZA933461A patent/ZA933461B/xx unknown
- 1993-05-18 NO NO931795A patent/NO304372B1/no not_active IP Right Cessation
- 1993-05-19 TW TW082103946A patent/TW290544B/zh active
-
1995
- 1995-08-14 AU AU28525/95A patent/AU674629B2/en not_active Ceased
-
1997
- 1997-05-14 BR BR1101081-9A patent/BR1101081A/pt active IP Right Grant
-
1998
- 1998-03-27 HK HK98102619A patent/HK1003597A1/xx not_active IP Right Cessation
- 1998-04-15 GR GR980400870T patent/GR3026665T3/el unknown
- 1998-07-01 CY CY9800015A patent/CY2093B1/xx unknown
-
2000
- 2000-04-28 KR KR1020000022662A patent/KR100277453B1/ko not_active IP Right Cessation
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