FI91870B - Förfarande för framställning av benzoxazinderivat för användning som antidiabetiskt medel - Google Patents

Förfarande för framställning av benzoxazinderivat för användning som antidiabetiskt medel Download PDF

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Publication number
FI91870B
FI91870B FI881104A FI881104A FI91870B FI 91870 B FI91870 B FI 91870B FI 881104 A FI881104 A FI 881104A FI 881104 A FI881104 A FI 881104A FI 91870 B FI91870 B FI 91870B
Authority
FI
Finland
Prior art keywords
compound
mixture
salt
group
preparation
Prior art date
Application number
FI881104A
Other languages
English (en)
Finnish (fi)
Other versions
FI91870C (sv
FI881104A (sv
FI881104A0 (sv
Inventor
Ikuo Iijima
Masakatsu Ozeki
Kunihito Okumura
Masanori Inamasu
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of FI881104A0 publication Critical patent/FI881104A0/sv
Publication of FI881104A publication Critical patent/FI881104A/sv
Publication of FI91870B publication Critical patent/FI91870B/sv
Application granted granted Critical
Publication of FI91870C publication Critical patent/FI91870C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (4)

1. Metod enligt följande allmänna formel för framställning av benzoxazinderivat för användning som antidiabetiskt medel: r-«ocrx>0·
0 II 0 där R1 är en fenylgrupp eller 2-fenyltiazol-4-ylgrupp, R2 är en väteatom eller en C^-alkylgrupp; och Q är en enkel bindning eller en C^-alkylengrupp; eller för framställning av deras far-maceutiskt lämpliga salter, kännetecknad av att (1) en iminförening enligt följande formel hydrolyseras
0 II NR där symbolerna är desamma som definierats ovan, eller dess sait, eller (2) utsätts halogenid enligt följande formel: r.-u-cuco-m—J01 - ho " y där X1 är en halogenatom och de övriga symbolerna är desamma som definierats ovan, eller dess sait, för en intramolekulär cykli- 91870 senng, och (3) dk R2 är en väteatom, alternativt alkyleras produkten, och (4) vid behov omvandlas produkten vidare till sitt farmaceutiskt lämpliga salt.
FI881104A 1987-03-18 1988-03-09 Förfarande för framställning av benzoxazinderivat för användning som antidiabetiskt medel FI91870C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62065360A JPS63230689A (ja) 1987-03-18 1987-03-18 ベンゾオキサジン誘導体
JP6536087 1987-03-18

Publications (4)

Publication Number Publication Date
FI881104A0 FI881104A0 (sv) 1988-03-09
FI881104A FI881104A (sv) 1988-09-19
FI91870B true FI91870B (sv) 1994-05-13
FI91870C FI91870C (sv) 1994-08-25

Family

ID=13284716

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881104A FI91870C (sv) 1987-03-18 1988-03-09 Förfarande för framställning av benzoxazinderivat för användning som antidiabetiskt medel

Country Status (16)

Country Link
US (1) US4824833A (sv)
EP (1) EP0283036B1 (sv)
JP (1) JPS63230689A (sv)
KR (1) KR940003071B1 (sv)
CN (1) CN1019911C (sv)
AT (1) ATE67199T1 (sv)
CA (1) CA1305706C (sv)
DE (1) DE3864707D1 (sv)
DK (1) DK147588A (sv)
ES (1) ES2038710T3 (sv)
FI (1) FI91870C (sv)
FR (1) FR2612517B1 (sv)
GR (1) GR3002692T3 (sv)
HU (2) HU203548B (sv)
IE (1) IE60522B1 (sv)
IL (1) IL85768A (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018805A1 (fr) * 1992-09-21 1995-07-13 Senju Pharmaceutical Co., Ltd. Compose d'acide 1,4-benzoxazine-2-acetic, son procede de production et son utilisation
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US5635505A (en) * 1994-01-06 1997-06-03 Senju Pharmaceutical Co., Ltd. 1,4-benzoxazine-2-acetic acid compound, method for production thereof and use thereof
EA200200311A1 (ru) 1999-08-31 2002-08-29 Максиа Фармасьютикалз, Инк. Бензилиден-тиазолидиндионы и аналоги и их применение для лечения диабета
CA2473156A1 (en) * 2001-03-08 2002-09-19 Incyte San Diego, Inc. Rxr activating molecules
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
JP4782564B2 (ja) 2002-07-10 2011-09-28 メルク セローノ ソシエテ アノニム アゾリジノン−ビニル縮合−ベンゼン誘導体
JP2006510661A (ja) * 2002-12-06 2006-03-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Ｐｉ３ｋの阻害剤としてのベンズオキサジン−３−オン類及びその誘導体
KR100840465B1 (ko) * 2004-09-28 2008-06-20 오츠카 세이야쿠 가부시키가이샤 카르보스티릴 화합물
CN100455573C (zh) * 2005-11-11 2009-01-28 华东理工大学 一种制备1,4-苯并噁唑嗪-3-酮化合物的微波合成方法
CA2898482A1 (en) * 2013-02-22 2014-08-28 Linda L. Brockunier Antidiabetic bicyclic compounds
WO2016022742A1 (en) * 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4619687A (en) * 1984-09-27 1986-10-28 Sumitomo Chemical Company, Limited Triazolopyridazines and their use as herbicides
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
WO1986007056A1 (en) * 1985-05-21 1986-12-04 Pfizer Inc. Hypoglycemic thiazolidinediones
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
JPS6314782A (ja) * 1986-07-07 1988-01-21 Nippon Tokushu Noyaku Seizo Kk 新規ジアルキルマレインイミド類及び除草剤
US4734124A (en) * 1987-01-15 1988-03-29 Fmc Corporation Tetrazolinone herbicides
FI91869C (sv) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Förfarande för framställning av som antidiabetiskt användbara benzoxazolderivat

Also Published As

Publication number Publication date
IL85768A0 (en) 1988-09-30
EP0283036B1 (en) 1991-09-11
CN88101541A (zh) 1988-10-05
CA1305706C (en) 1992-07-28
ATE67199T1 (de) 1991-09-15
FR2612517B1 (fr) 1992-11-13
DK147588D0 (da) 1988-03-17
JPH0460597B2 (sv) 1992-09-28
HU203548B (en) 1991-08-28
FR2612517A1 (fr) 1988-09-23
FI91870C (sv) 1994-08-25
IE60522B1 (en) 1994-07-27
EP0283036A1 (en) 1988-09-21
KR880011154A (ko) 1988-10-26
HUT50337A (en) 1990-01-29
GR3002692T3 (en) 1993-01-25
AU1317688A (en) 1988-09-22
AU601029B2 (en) 1990-08-30
IL85768A (en) 1993-02-21
KR940003071B1 (ko) 1994-04-13
US4824833A (en) 1989-04-25
FI881104A (sv) 1988-09-19
IE880772L (en) 1988-09-18
ES2038710T3 (es) 1993-08-01
DK147588A (da) 1988-09-19
DE3864707D1 (de) 1991-10-17
JPS63230689A (ja) 1988-09-27
HU211596A9 (en) 1995-12-28
FI881104A0 (sv) 1988-03-09
CN1019911C (zh) 1993-02-17

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Owner name: TANABE SEIYAKU CO., . LTD.