IT1246778B
(it)
*
|
1991-04-12 |
1994-11-26 |
Boehringer Mannheim Italia |
Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
|
IT1246777B
(it)
*
|
1991-04-12 |
1994-11-26 |
Boehringer Mannheim Italia |
Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
|
US5270365A
(en)
*
|
1991-12-17 |
1993-12-14 |
Merck & Co., Inc. |
Prevention and treatment of periodontal disease with alendronate
|
US6399592B1
(en)
|
1992-12-23 |
2002-06-04 |
Merck & Co., Inc. |
Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
|
US5510517A
(en)
*
|
1993-08-25 |
1996-04-23 |
Merck & Co., Inc. |
Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
|
TW257765B
(sv)
*
|
1993-08-25 |
1995-09-21 |
Merck & Co Inc |
|
US5462932A
(en)
*
|
1994-05-17 |
1995-10-31 |
Merck & Co., Inc. |
Oral liquid alendronate formulations
|
US5449819A
(en)
*
|
1994-06-06 |
1995-09-12 |
Merck & Co., Inc. |
Process for removing waste pox, alendronate and its by products
|
US5589691A
(en)
*
|
1994-06-06 |
1996-12-31 |
Merck & Co., Inc. |
Process for recovery and recycle of methanesulfonic acid and phosphorous acid
|
US5780455A
(en)
*
|
1994-08-24 |
1998-07-14 |
Merck & Co., Inc. |
Intravenous alendronate formulations
|
NZ303022A
(en)
*
|
1995-02-17 |
2000-07-28 |
Merck & Co Inc |
Treatment of osteoporotic diseases with alendronate
|
TW393488B
(en)
*
|
1995-04-20 |
2000-06-11 |
Merck & Co Inc |
Process for making 1-hydrox-ybisphosphonates
|
AU713824B2
(en)
*
|
1995-05-12 |
1999-12-09 |
Merck Sharp & Dohme Corp. |
Prevention of tooth loss by the administration of alendronate or its salts
|
JP3344726B2
(ja)
*
|
1995-06-06 |
2002-11-18 |
メルク エンド カンパニー インコーポレーテッド |
無水アレンドロネート一ナトリウム塩製剤
|
AU5973496A
(en)
|
1995-06-06 |
1996-12-24 |
Merck & Co., Inc. |
Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
|
KR100192215B1
(ko)
*
|
1996-09-03 |
1999-06-15 |
강재헌 |
3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
|
BR9712197A
(pt)
*
|
1996-10-04 |
1999-08-31 |
Merck & Co Inc |
Formulação farmacêutica líquida aquosa e processos de preparação da mesma, e, de inibição de reabsorção de osso.
|
CA2197267C
(en)
*
|
1997-02-11 |
2000-02-08 |
Yong Tao |
Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
|
BR9910074A
(pt)
|
1998-04-29 |
2000-12-26 |
Procter & Gamble |
Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas
|
PL198951B1
(pl)
|
1998-04-29 |
2008-08-29 |
Procter & Gamble |
Sposób wytwarzania 1,3-dipodstawionych-4-oksocyklicznych moczników
|
US20030078211A1
(en)
*
|
1998-06-24 |
2003-04-24 |
Merck & Co., Inc. |
Compositions and methods for inhibiting bone resorption
|
WO1999067809A1
(en)
|
1998-06-24 |
1999-12-29 |
Merck & Co., Inc. |
Compositions and methods for inhibiting bone resorption
|
US6008207A
(en)
*
|
1998-08-13 |
1999-12-28 |
Merck & Co., Inc. |
Anhydrous alendronate monosodium salt formulations
|
DE69932620T2
(de)
*
|
1998-08-27 |
2006-12-14 |
Teva Pharmaceutical Industries Ltd. |
Hydratformen des natriumsalzes von alendronat, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die diese enthalten
|
EP1702924A3
(en)
*
|
1998-08-27 |
2007-07-18 |
Teva Pharmaceutical Industries Ltd |
Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
|
US6331533B1
(en)
|
1998-11-16 |
2001-12-18 |
Merck & Co., Inc. |
Method for inhibiting dental resorptive lesions
|
KR100327786B1
(ko)
*
|
1999-03-25 |
2002-03-14 |
유승필 |
4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법
|
US6315566B1
(en)
|
1999-05-18 |
2001-11-13 |
3M Innovative Properties Company |
Dental materials
|
US6143919A
(en)
*
|
1999-05-18 |
2000-11-07 |
3M Innovative Properties Company |
Polymerizable acidic compounds and methods of preparation
|
US6963008B2
(en)
*
|
1999-07-19 |
2005-11-08 |
Teva Pharmaceutical Industries Ltd. |
Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
|
ES2153794B1
(es)
*
|
1999-08-06 |
2001-10-16 |
Medichem Sa |
Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
|
US6677320B2
(en)
|
2000-01-20 |
2004-01-13 |
Hoffmann-La Roches Inc. |
Parenteral bisphosphonate composition with improved local tolerance
|
US6476006B2
(en)
|
2000-06-23 |
2002-11-05 |
Teva Pharmaceutical Industries, Ltd. |
Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
|
KR100327787B1
(ko)
*
|
2001-02-27 |
2002-03-15 |
유승필 |
4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법
|
US6558702B2
(en)
*
|
2001-04-13 |
2003-05-06 |
Alkermes Controlled Therapeutics, Inc. |
Method of modifying the release profile of sustained release compositions
|
US20060269602A1
(en)
*
|
2001-04-13 |
2006-11-30 |
Dasch James R |
Method of modifying the release profile of sustained release compositions
|
TR200101250A2
(tr)
*
|
2001-05-10 |
2003-04-21 |
E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. |
4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
|
GB0115824D0
(en)
*
|
2001-06-28 |
2001-08-22 |
Rhodia Cons Spec Ltd |
Improved solvent systems
|
MXPA04006027A
(es)
*
|
2001-12-21 |
2004-09-27 |
Procter & Gamble |
Metodo para el tratamiento de trastornos de los huesos.
|
CA2472578A1
(en)
*
|
2002-01-24 |
2003-07-31 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Anti-cancer combination and use thereof
|
ITMI20020908A1
(it)
*
|
2002-04-29 |
2003-10-29 |
Chemi Spa |
Processo di preparazione di sodio alendronato
|
JP2005522526A
(ja)
|
2002-05-10 |
2005-07-28 |
エフ.ホフマン−ラ ロシュ アーゲー |
骨粗鬆症の治療および予防用のビスホスホン酸
|
CN1665825A
(zh)
*
|
2002-05-17 |
2005-09-07 |
特瓦制药工业有限公司 |
用一定的稀释剂制备双膦酸
|
CA2487977A1
(en)
*
|
2002-06-06 |
2003-12-18 |
Merck Frosst Canada & Co./Merck Frosst Canada & Cie |
1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
|
JP4485117B2
(ja)
*
|
2002-06-27 |
2010-06-16 |
日東電工株式会社 |
保護剥離用フィルム
|
AU2003258433A1
(en)
*
|
2002-08-28 |
2004-03-19 |
Merck Frosst Canada Ltd |
Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
|
US20040138180A1
(en)
*
|
2002-10-03 |
2004-07-15 |
Barr Laboratories, Inc. |
Bisphosphonate composition and process for the preparation thereof
|
EP1790347B1
(en)
*
|
2002-12-20 |
2014-12-24 |
F. Hoffmann-La Roche AG |
High dose ibandronate formulation
|
US20040206932A1
(en)
*
|
2002-12-30 |
2004-10-21 |
Abuelyaman Ahmed S. |
Compositions including polymerizable bisphosphonic acids and methods
|
HUP0300227A2
(hu)
*
|
2003-01-28 |
2004-09-28 |
Richter Gedeon Vegyészeti Gyár Rt. |
Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
|
EP2279722B1
(en)
*
|
2003-08-12 |
2013-05-01 |
3M Innovative Properties Company |
Self-etching dental compositions and its use
|
CA2535359A1
(en)
|
2003-08-21 |
2005-03-03 |
Merck Frosst Canada Ltd. |
Cathepsin cysteine protease inhibitors
|
DK1656386T3
(da)
*
|
2003-08-21 |
2010-04-19 |
Sun Pharmaceuticals Ind Ltd |
Fremgangsmåde til fremstilling af bisphosphonsyreforbindelser
|
EP1667691A1
(en)
*
|
2003-09-19 |
2006-06-14 |
Pfizer Products Inc. |
Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
|
US20050113343A1
(en)
*
|
2003-10-14 |
2005-05-26 |
Pliva - Research And Development Ltd. |
Solid-state form of alendronate sodium and preparation thereof
|
US20050181043A1
(en)
*
|
2004-02-12 |
2005-08-18 |
Indranil Nandi |
Alendronate salt tablet compositions
|
JP4605221B2
(ja)
|
2004-05-24 |
2011-01-05 |
味の素株式会社 |
キレート剤を含有するビスホスホネートの腸溶性で固形の経口剤形
|
UA87854C2
(en)
|
2004-06-07 |
2009-08-25 |
Мерк Энд Ко., Инк. |
N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
|
AU2005269869B2
(en)
*
|
2004-07-08 |
2011-12-01 |
3M Innovative Properties Company |
Dental methods, compositions, and kits including acid-sensitive dyes
|
JP5037342B2
(ja)
*
|
2004-08-11 |
2012-09-26 |
スリーエム イノベイティブ プロパティズ カンパニー |
複数の酸性化合物を含む粘着性組成物
|
US7361761B2
(en)
*
|
2004-09-28 |
2008-04-22 |
Orchid Chemicals & Pharmaceuticals Ltd. |
Process for the preparation of bisphosphonic acid
|
EP2783687A1
(en)
|
2005-03-02 |
2014-10-01 |
Merck Sharp & Dohme Corp. |
Composition for inhibition of cathepsin K
|
US8158153B2
(en)
*
|
2005-03-17 |
2012-04-17 |
Alkermes Pharma Ireland Limited |
Nanoparticulate bisphosphonate compositions
|
EP1891081B1
(en)
*
|
2005-06-13 |
2014-08-20 |
Jubilant Organosys Limited |
Process for producing bisphosphonic acids and forms thereof
|
AR054673A1
(es)
|
2005-07-28 |
2007-07-11 |
Gador Sa |
Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
|
US8003820B2
(en)
*
|
2005-10-20 |
2011-08-23 |
Dr. Reddy's Laboratories Limited |
Process for preparing bisphosphonic acids
|
EP1803727B1
(en)
|
2005-12-27 |
2009-03-11 |
IPCA Laboratories Limited |
Improved process for manufacture of 4-amino-hydroxybutylidene-1,1-bisphosphonic acid and its salts
|
WO2007083240A2
(en)
|
2006-01-20 |
2007-07-26 |
Aurobindo Pharma Limited |
An improved process for the preparation of bisphosphonic acids
|
EP1987046A1
(en)
*
|
2006-02-20 |
2008-11-05 |
Alembic Limited |
An improved process for the preparation of biphosphonic derivatives
|
WO2007132478A2
(en)
*
|
2006-05-11 |
2007-11-22 |
Ind-Swift Laboratories Limited |
Process for the preparation of pure risedronic acid or salts
|
CA2570949A1
(en)
*
|
2006-12-12 |
2008-06-12 |
Apotex Pharmachem Inc. |
Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
|
WO2008076739A2
(en)
*
|
2006-12-13 |
2008-06-26 |
3M Innovative Properties Company |
Methods of using a dental composition having an acidic component and a photobleachable dye
|
US20090170815A1
(en)
*
|
2007-12-28 |
2009-07-02 |
Roxane Laboratories Incorporated. |
Alendronate oral liquid formulations
|
EP2310398A2
(en)
*
|
2008-07-11 |
2011-04-20 |
Synthon B.V. |
Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
|
US20100130746A1
(en)
*
|
2008-11-26 |
2010-05-27 |
Martin Kas |
Process for Making Zoledronic Acid
|
US20120100206A1
(en)
|
2009-06-11 |
2012-04-26 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Targeted liposomes comprising n-containing bisphosphonates and uses thereof
|
EP2470549B1
(en)
|
2009-08-28 |
2014-07-16 |
Synthon B.V. |
Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
|
AU2010302597B2
(en)
|
2009-10-02 |
2016-06-09 |
Monsanto Technology Llc |
Method for the manufacture of aminohydroxy diphosphonic acids
|
CA2738045C
(en)
|
2010-05-28 |
2019-02-19 |
Simon Fraser University |
Conjugate compounds, methods of making same, and uses thereof
|
KR102011505B1
(ko)
|
2010-12-06 |
2019-08-16 |
에프락스 파머슈티컬즈 소시에떼 아노님 |
신속한 용해 특성을 구비한 안정한 발포성 비스포스포네이트 제형
|
US8791162B2
(en)
|
2011-02-14 |
2014-07-29 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
RS61235B1
(sr)
|
2011-07-13 |
2021-01-29 |
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd |
Lipozomi koji ko-inkapsuliraju bisfosfonat i amfipatički agens
|
EP3055314B1
(en)
|
2013-10-08 |
2018-09-12 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
WO2015051479A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
WO2015120580A1
(en)
|
2014-02-11 |
2015-08-20 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
PL407922A1
(pl)
|
2014-04-16 |
2015-10-26 |
Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością |
Nowe bisfosfoniany i ich zastosowanie
|
KR20160147007A
(ko)
|
2014-05-30 |
2016-12-21 |
화이자 인코포레이티드 |
선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
|
US9650414B1
(en)
|
2014-05-30 |
2017-05-16 |
Simon Fraser University |
Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
|
EP3307747A4
(en)
|
2015-06-12 |
2019-02-27 |
Simon Fraser University |
AMIDE-LINKED EP4-BISPHOSPHONATE AGONIST COMPOUNDS AND USES THEREOF
|
EP3827010A4
(en)
|
2018-07-23 |
2022-03-16 |
Brise Pharmaceuticals Co., Ltd. |
BISPHOSPHONATE-DRUG CONJUGATES
|
WO2023275715A1
(en)
|
2021-06-30 |
2023-01-05 |
Pfizer Inc. |
Metabolites of selective androgen receptor modulators
|